{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T12:59:02Z","timestamp":1788785942342,"version":"build-2803163510"},"reference-count":31,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,12,31]],"date-time":"2024-12-31T00:00:00Z","timestamp":1735603200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,12,31]],"date-time":"2024-12-31T00:00:00Z","timestamp":1735603200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Histochem Cell Biol"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    A20, an ubiquitin-editing enzyme, plays a pivotal role in regulating cell signaling and immune responses. Dysregulated A20 expression has been associated with various pathological conditions, including inflammatory diseases and malignancies, where its expression levels often correlate with differing prognoses in solid tumors. This study aimed to explore the expression and cellular localization of A20 in both nonpathological and diseased human gastric tissues to gain deeper insights into its involvement in gastric pathologies. We analyzed paraffin-embedded gastric tissue samples from 326 patients. A20 expression was assessed using immunohistochemistry (IHC) with results categorized according to the Remmele and Stegner immunoreactive score (IRS). The study compared A20 expression across a spectrum of gastric pathologies, including\n                    <jats:italic>Helicobacter pylori<\/jats:italic>\n                    (HP) gastritis, autoimmune gastritis (A-gastritis), reactive gastropathy (C-gastritis), Ex-HP-gastritis, adenomas, and adenocarcinomas, with nonpathological gastric mucosa serving as a baseline. Our findings demonstrate a significant increase in A20 expression in HP-gastritis (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.019), A-gastritis (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.001), adenomas (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001), and adenocarcinomas (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001). Conversely, no significant differences in A20 expression were observed in C-gastritis or Ex-HP-gastritis cases.\n                  <\/jats:p>","DOI":"10.1007\/s00418-024-02345-2","type":"journal-article","created":{"date-parts":[[2024,12,30]],"date-time":"2024-12-30T21:58:01Z","timestamp":1735595881000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Differential expression of the ubiquitin-editing enzyme A20 in gastric biopsies indicates the severity of disease"],"prefix":"10.1007","volume":"163","author":[{"given":"Stephan","family":"Schnizler","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Naumann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Vieth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,12,31]]},"reference":[{"key":"2345_CR1","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2016.154","volume":"7","author":"L Catrysse","year":"2016","unstructured":"Catrysse L, Farhang Ghahremani M, Vereecke L, Youssef SA, McGuire C, Sze M, Weber A, Heikenwalder M, de Bruin A, Beyaert R et al (2016) A20 prevents chronic liver inflammation and cancer by protecting hepatocytes from death. Cell Death Dis 7:e2250. https:\/\/doi.org\/10.1038\/cddis.2016.154","journal-title":"Cell Death Dis"},{"key":"2345_CR2","doi-asserted-by":"publisher","first-page":"186","DOI":"10.1186\/s12943-015-0454-6","volume":"14","author":"H Chen","year":"2015","unstructured":"Chen H, Hu L, Luo Z, Zhang J, Zhang C, Qiu B, Dong L, Tan Y, Ding J, Tang S, Shen F, Li Z, Wang H (2015) A20 suppresses hepatocellular carcinoma proliferation and metastasis through inhibition of twist1 expression. Mol Cancer 14:186. https:\/\/doi.org\/10.1186\/s12943-015-0454-6","journal-title":"Mol Cancer"},{"key":"2345_CR3","doi-asserted-by":"publisher","first-page":"2973","DOI":"10.1016\/S0021-9258(19)39896-5","volume":"265","author":"VM Dixit","year":"1990","unstructured":"Dixit VM, Green S, Sarma V, Holzman LB, Wolf FW, O\u2019Rourke K, Ward PA, Prochownik EV, Marks RM (1990) Tumor necrosis factor-alpha induction of novel gene products in human endothelial cells including a macrophage-specific chemotaxin. 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