{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T04:21:48Z","timestamp":1768450908397,"version":"3.49.0"},"reference-count":66,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,4,14]],"date-time":"2025-04-14T00:00:00Z","timestamp":1744588800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,4,14]],"date-time":"2025-04-14T00:00:00Z","timestamp":1744588800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"Minist\u00e8re de l\u2019Enseignement et de la Recherche and the CNRST,","award":["17UHP2019, Morocco"],"award-info":[{"award-number":["17UHP2019, Morocco"]}]},{"name":"Minist\u00e8re de l\u2019Enseignement et de la Recherche and the CNRST,","award":["17UHP2019, Morocco"],"award-info":[{"award-number":["17UHP2019, Morocco"]}]},{"name":"Minist\u00e8re de l\u2019Enseignement et de la Recherche and the CNRST,","award":["17UHP2019, Morocco"],"award-info":[{"award-number":["17UHP2019, Morocco"]}]},{"name":"Minist\u00e8re de l\u2019Enseignement et de la Recherche and the CNRST,","award":["17UHP2019, Morocco"],"award-info":[{"award-number":["17UHP2019, Morocco"]}]},{"name":"Minist\u00e8re de l\u2019Enseignement et de la Recherche and the CNRST,","award":["17UHP2019, Morocco"],"award-info":[{"award-number":["17UHP2019, Morocco"]}]},{"name":"PHC Toubkal program","award":["TBK 19\/92 n\u00b0 n\u00b0 Campus France: 41501RJ"],"award-info":[{"award-number":["TBK 19\/92 n\u00b0 n\u00b0 Campus France: 41501RJ"]}]},{"name":"PHC Toubkal program","award":["TBK 19\/92 n\u00b0 n\u00b0 Campus France: 41501RJ"],"award-info":[{"award-number":["TBK 19\/92 n\u00b0 n\u00b0 Campus France: 41501RJ"]}]},{"name":"PHC Toubkal program","award":["TBK 19\/92 n\u00b0 n\u00b0 Campus France: 41501RJ"],"award-info":[{"award-number":["TBK 19\/92 n\u00b0 n\u00b0 Campus France: 41501RJ"]}]},{"name":"PHC Toubkal program","award":["TBK 19\/92 n\u00b0 n\u00b0 Campus France: 41501RJ"],"award-info":[{"award-number":["TBK 19\/92 n\u00b0 n\u00b0 Campus France: 41501RJ"]}]},{"name":"PHC Toubkal program","award":["TBK 19\/92 n\u00b0 n\u00b0 Campus France: 41501RJ"],"award-info":[{"award-number":["TBK 19\/92 n\u00b0 n\u00b0 Campus France: 41501RJ"]}]},{"name":"PHC Toubkal program","award":["TBK 19\/92 n\u00b0 n\u00b0 Campus France: 41501RJ"],"award-info":[{"award-number":["TBK 19\/92 n\u00b0 n\u00b0 Campus France: 41501RJ"]}]},{"name":"PHC Toubkal program","award":["TBK 19\/92 n\u00b0 n\u00b0 Campus France: 41501RJ"],"award-info":[{"award-number":["TBK 19\/92 n\u00b0 n\u00b0 Campus France: 41501RJ"]}]},{"name":"COST Action","award":["CA 16112"],"award-info":[{"award-number":["CA 16112"]}]},{"name":"COST Action","award":["CA 16112"],"award-info":[{"award-number":["CA 16112"]}]},{"name":"COST Action","award":["CA 16112"],"award-info":[{"award-number":["CA 16112"]}]},{"name":"COST Action","award":["CA 16112"],"award-info":[{"award-number":["CA 16112"]}]},{"name":"COST Action","award":["CA 16112"],"award-info":[{"award-number":["CA 16112"]}]},{"name":"COST Action","award":["CA 16112"],"award-info":[{"award-number":["CA 16112"]}]},{"name":"COST Action","award":["CA 16112"],"award-info":[{"award-number":["CA 16112"]}]},{"name":"Projet d\u2019Envergure Neurosens","award":["2022Y-14248"],"award-info":[{"award-number":["2022Y-14248"]}]},{"name":"Projet d\u2019Envergure Neurosens","award":["2022Y-14248"],"award-info":[{"award-number":["2022Y-14248"]}]},{"name":"Projet d\u2019Envergure Neurosens","award":["2022Y-14248"],"award-info":[{"award-number":["2022Y-14248"]}]},{"name":"Projet d\u2019Envergure Neurosens","award":["2022Y-14248"],"award-info":[{"award-number":["2022Y-14248"]}]},{"name":"Projet d\u2019Envergure Neurosens","award":["2022Y-14248"],"award-info":[{"award-number":["2022Y-14248"]}]},{"name":"Projet d\u2019Envergure Neurosens","award":["2022Y-14248"],"award-info":[{"award-number":["2022Y-14248"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Histochem Cell Biol"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1007\/s00418-025-02372-7","type":"journal-article","created":{"date-parts":[[2025,4,15]],"date-time":"2025-04-15T13:26:02Z","timestamp":1744723562000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Analytical subcellular fractionation of microglial BV-2 cells with peroxisomal beta-oxidation defect"],"prefix":"10.1007","volume":"163","author":[{"given":"Mounia","family":"Tahri-Joutey","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isabelle","family":"Hamer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Virginie","family":"Tevel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Quentin","family":"Raas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catherine","family":"Gondcaille","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Doriane","family":"Trompier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Riad","family":"El Kebbaj","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Franck","family":"M\u00e9n\u00e9trier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Norbert","family":"Latruffe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G\u00e9rard","family":"Lizard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Boubker","family":"Nasser","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"St\u00e9phane","family":"Savary","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michel","family":"Jadot","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mustapha","family":"Cherkaoui-Malki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pierre","family":"Andreoletti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,4,14]]},"reference":[{"issue":"1","key":"2372_CR1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1002\/cne.21448","volume":"505","author":"B Ahlemeyer","year":"2007","unstructured":"Ahlemeyer B, Neubert I, Kovacs WJ, Baumgart-Vogt E (2007) Differential expression of peroxisomal matrix and membrane proteins during postnatal development of mouse brain. J Comp Neurol 505(1):1\u201317. https:\/\/doi.org\/10.1002\/cne.21448","journal-title":"J Comp Neurol"},{"issue":"22","key":"2372_CR2","doi-asserted-by":"publisher","first-page":"10084","DOI":"10.1073\/pnas.88.22.10084","volume":"88","author":"J Aikawa","year":"1991","unstructured":"Aikawa J, Chen WW, Kelley RI, Tada K, Moser HW, Chen GL (1991) Low-density particles (W-particles) containing catalase in zellweger syndrome and normal fibroblasts. Proc Natl Acad Sci U S A 88(22):10084\u201310088. https:\/\/doi.org\/10.1073\/pnas.88.22.10084","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2372_CR3","doi-asserted-by":"publisher","first-page":"230","DOI":"10.1177\/31.1A_SUPPL.6186726","volume":"31","author":"S Angermuller","year":"1983","unstructured":"Angermuller S, Fahimi HD (1983) Selective staining of cell organelles in rat liver with 3,3\u2032-diaminobenzidine. J Histochem Cytochem 31:230\u2013232. https:\/\/doi.org\/10.1177\/31.1A_SUPPL.6186726","journal-title":"J Histochem Cytochem"},{"issue":"3","key":"2372_CR4","doi-asserted-by":"publisher","first-page":"438","DOI":"10.1042\/bj0590438","volume":"59","author":"F Appelmans","year":"1955","unstructured":"Appelmans F, Wattiaux R, de Duve C (1955) Tissue fractionation studies. 5. The association of acid phosphatase with a special class of cytoplasmic granules in rat liver. Biochem J 59(3):438\u2013445. https:\/\/doi.org\/10.1042\/bj0590438","journal-title":"Biochem J"},{"key":"2372_CR5","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1083\/jcb.26.1.219","volume":"26","author":"P Baudhuin","year":"1965","unstructured":"Baudhuin P, Beaufay H, de Duve C (1965) Combined biochemical and morphological study of particulate fractions from rat liver analysis of preparations enriched in lysosomes or in particles containing urate oxidase, d-amino acid oxidase, and catalase. J Cell Biol 26:219\u2013243","journal-title":"J Cell Biol"},{"issue":"4","key":"2372_CR6","doi-asserted-by":"publisher","first-page":"628","DOI":"10.1042\/bj0730628","volume":"73","author":"H Beaufay","year":"1959","unstructured":"Beaufay H, Bendall DS, Baudhun P, Wattiaux R, de Duve C (1959) Tissue fractionation studies 13 analysis of mitochondrial fractions from rat liver by density-gradient centrifuging. Biochem J 73(4):628\u2013637. https:\/\/doi.org\/10.1042\/bj0730628","journal-title":"Biochem J"},{"key":"2372_CR7","doi-asserted-by":"publisher","first-page":"184","DOI":"10.1042\/bj0920184","volume":"92","author":"HJP Beaufay","year":"1964","unstructured":"Beaufay HJP, Baudhuin P, Sellinger Z, Berthet J, de Duve C (1964) Resolution of mitochondrial fractions from rat liver into three distinct populations of cytoplasmic particles by means of density equilibration in various gradients. Biochem J 92:184\u2013205","journal-title":"Biochem J"},{"issue":"2\u20133","key":"2372_CR8","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1016\/0165-5728(90)90073-v","volume":"27","author":"E Blasi","year":"1990","unstructured":"Blasi E, Barluzzi R, Bocchini V, Mazzolla R, Bistoni F (1990) Immortalization of murine microglial cells by a V-Raf\/V-Myc Carrying retrovirus. J Neuroimmunol 27(2\u20133):229\u2013237. https:\/\/doi.org\/10.1016\/0165-5728(90)90073-v","journal-title":"J Neuroimmunol"},{"issue":"23","key":"2372_CR9","doi-asserted-by":"publisher","first-page":"9638","DOI":"10.1073\/pnas.0701015104","volume":"104","author":"MJ Bruno","year":"2007","unstructured":"Bruno MJ, Koeppe RE 2nd, Andersen OS (2007) Docosahexaenoic acid alters bilayer elastic properties. Proc Natl Acad Sci U S A 104(23):9638\u20139643. https:\/\/doi.org\/10.1073\/pnas.0701015104","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"2","key":"2372_CR10","doi-asserted-by":"publisher","first-page":"896","DOI":"10.1016\/j.neuroscience.2008.10.004","volume":"158","author":"L Cao","year":"2009","unstructured":"Cao L, Tanga FY, Deleo JA (2009) The contributing role of Cd14 in toll-like receptor 4 dependent neuropathic pain. Neuroscience 158(2):896\u2013903. https:\/\/doi.org\/10.1016\/j.neuroscience.2008.10.004","journal-title":"Neuroscience"},{"key":"2372_CR11","doi-asserted-by":"publisher","DOI":"10.1002\/0471142735.im0801bs56","author":"JD Castle","year":"2003","unstructured":"Castle JD (2003) Purification of organelles from mammalian cells. Curr Protoc Immunol. https:\/\/doi.org\/10.1002\/0471142735.im0801bs56","journal-title":"Curr Protoc Immunol"},{"key":"2372_CR12","doi-asserted-by":"publisher","DOI":"10.1002\/0471140864.ps0401s37","author":"JD Castle","year":"2004","unstructured":"Castle JD (2004) Overview of cell fractionation. Curr Protoc Protein Sci. https:\/\/doi.org\/10.1002\/0471140864.ps0401s37","journal-title":"Curr Protoc Protein Sci"},{"issue":"R2","key":"2372_CR13","doi-asserted-by":"publisher","first-page":"R169","DOI":"10.1093\/hmg\/ddp326","volume":"18","author":"H Chen","year":"2009","unstructured":"Chen H, Chan DC (2009) Mitochondrial dynamics-fusion, fission, movement, and mitophagy\u2013in neurodegenerative diseases. Hum Mol Genet 18(R2):R169-176. https:\/\/doi.org\/10.1093\/hmg\/ddp326","journal-title":"Hum Mol Genet"},{"issue":"2","key":"2372_CR14","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1111\/j.1768-322x.1990.tb00002.x","volume":"69","author":"M Cherkaoui Malki","year":"1990","unstructured":"Cherkaoui Malki M, Bardot O, Lhuguenot JC, Latruffe N (1990) Expression of liver peroxisomal proteins as compared to other organelle marker enzymes in rats treated with hypolipidemic agents. Biol Cell 69(2):83\u201392. https:\/\/doi.org\/10.1111\/j.1768-322x.1990.tb00002.x","journal-title":"Biol Cell"},{"issue":"7","key":"2372_CR15","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1007\/s00018-023-04827-3","volume":"80","author":"L Chi","year":"2023","unstructured":"Chi L, Lee D, Leung S, Hu G, Wen B, Delgado-Olguin P, Vissa M, Li R, Brumell JH, Kim PK, Bandsma RHJ (2023) Loss of functional peroxisomes leads to increased mitochondrial biogenesis and reduced autophagy that preserve mitochondrial function. Cell Mol Life Sci 80(7):183. https:\/\/doi.org\/10.1007\/s00018-023-04827-3","journal-title":"Cell Mol Life Sci"},{"issue":"1","key":"2372_CR16","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1016\/s0304-4165(98)00049-x","volume":"1425","author":"AM Cimini","year":"1998","unstructured":"Cimini AM, Singh I, Farioli-Vecchioli S, Cristiano L, Ceru MP (1998) Presence of heterogeneous peroxisomal populations in the rat nervous tissue. Biochim Biophys Acta 1425(1):13\u201326. https:\/\/doi.org\/10.1016\/s0304-4165(98)00049-x","journal-title":"Biochim Biophys Acta"},{"issue":"1","key":"2372_CR17","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1016\/0005-2760(92)90224-j","volume":"1126","author":"LH Cohen","year":"1992","unstructured":"Cohen LH, Griffioen M, Van Roermund CW, Wanders RJ (1992) Subcellular localization of squalene synthase in human hepatoma cell line hep G2. Biochim Biophys Acta 1126(1):114\u2013118. https:\/\/doi.org\/10.1016\/0005-2760(92)90224-j","journal-title":"Biochim Biophys Acta"},{"issue":"2","key":"2372_CR18","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1152\/physrev.1966.46.2.323","volume":"46","author":"C De Duve","year":"1966","unstructured":"De Duve C, Baudhuin P (1966) Peroxisomes (Microbodies and Related Particles). Physiol Rev 46(2):323\u2013357. https:\/\/doi.org\/10.1152\/physrev.1966.46.2.323","journal-title":"Physiol Rev"},{"issue":"4","key":"2372_CR19","doi-asserted-by":"publisher","first-page":"604","DOI":"10.1042\/bj0600604","volume":"60","author":"C De Duve","year":"1955","unstructured":"De Duve C, Pressman BC, Gianetto R, Wattiaux R, Appelmans F (1955) Tissue fractionation studies 6 intracellular distribution patterns of enzymes in rat-liver tissue. Biochem J 60(4):604\u2013617. https:\/\/doi.org\/10.1042\/bj0600604","journal-title":"Biochem J"},{"issue":"1","key":"2372_CR20","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1016\/j.tcb.2022.06.001","volume":"33","author":"F Di Cara","year":"2023","unstructured":"Di Cara F, Savary S, Kovacs WJ, Kim P, Rachubinski RA (2023) The peroxisome: an up-and-coming organelle in immunometabolism. Trends Cell Biol 33(1):70\u201386. https:\/\/doi.org\/10.1016\/j.tcb.2022.06.001","journal-title":"Trends Cell Biol"},{"issue":"4","key":"2372_CR21","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1002\/cyto.990080410","volume":"8","author":"GB Dubelaar","year":"1987","unstructured":"Dubelaar GB, Visser JW, Donze M (1987) Anomalous behaviour of forward and perpendicular light scattering of a cyanobacterium owing to intracellular gas vacuoles. Cytometry 8(4):405\u2013412. https:\/\/doi.org\/10.1002\/cyto.990080410","journal-title":"Cytometry"},{"issue":"6","key":"2372_CR22","doi-asserted-by":"publisher","first-page":"2568","DOI":"10.1210\/en.2012-1137","volume":"153","author":"HI El Hajj","year":"2012","unstructured":"El Hajj HI, Vluggens A, Andreoletti P, Ragot K, Mandard S, Kersten S, Waterham HR, Lizard G, Wanders RJ, Reddy JK, Cherkaoui-Malki M (2012) The inflammatory response in Acyl-Coa oxidase 1 deficiency (Pseudoneonatal Adrenoleukodystrophy). Endocrinology 153(6):2568\u20132575. https:\/\/doi.org\/10.1210\/en.2012-1137","journal-title":"Endocrinology"},{"key":"2372_CR23","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1186\/1750-1172-7-51","volume":"7","author":"M Engelen","year":"2012","unstructured":"Engelen M, Kemp S, De Visser M, Van Geel BM, Wanders RJ, Aubourg P, Poll-The BT (2012) X-linked adrenoleukodystrophy (X-Ald): clinical presentation and guidelines for diagnosis, follow-up and management. Orphanet J Rare Dis 7:51. https:\/\/doi.org\/10.1186\/1750-1172-7-51","journal-title":"Orphanet J Rare Dis"},{"issue":"2","key":"2372_CR24","doi-asserted-by":"publisher","first-page":"526","DOI":"10.1172\/JCI117365","volume":"94","author":"B Fournier","year":"1994","unstructured":"Fournier B, Saudubray JM, Benichou B, Lyonnet S, Munnich A, Clevers H, Poll-The BT (1994) Large deletion of the peroxisomal acyl-coa oxidase gene in pseudoneonatal adrenoleukodystrophy. J Clin Invest 94(2):526\u2013531. https:\/\/doi.org\/10.1172\/JCI117365","journal-title":"J Clin Invest"},{"key":"2372_CR25","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbpa.2024.102426","volume":"78","author":"M Fransen","year":"2024","unstructured":"Fransen M, Lismont C (2024) Peroxisomal hydrogen peroxide signaling: a new chapter in intracellular communication research. Curr Opin Chem Biol 78:102426. https:\/\/doi.org\/10.1016\/j.cbpa.2024.102426","journal-title":"Curr Opin Chem Biol"},{"key":"2372_CR26","doi-asserted-by":"publisher","first-page":"1363","DOI":"10.1016\/j.bbadis.2011.12.001","volume":"9","author":"M Fransen","year":"1822","unstructured":"Fransen M, Nordgren M, Wang B (1822) Apanasets O (2012) Role of Peroxisomes in Ros\/Rns-Metabolism: Implications for Human Disease. Biochim Biophys Acta 9:1363\u20131373. https:\/\/doi.org\/10.1016\/j.bbadis.2011.12.001","journal-title":"Biochim Biophys Acta"},{"issue":"5","key":"2372_CR27","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1016\/j.braindev.2005.10.010","volume":"28","author":"M Funato","year":"2006","unstructured":"Funato M, Shimozawa N, Nagase T, Takemoto Y, Suzuki Y, Imamura Y, Matsumoto T, Tsukamoto T, Kojidani T, Osumi T, Fukao T, Kondo N (2006) Aberrant peroxisome morphology in peroxisomal beta-oxidation enzyme deficiencies. Brain Dev 28(5):287\u2013292. https:\/\/doi.org\/10.1016\/j.braindev.2005.10.010","journal-title":"Brain Dev"},{"issue":"4","key":"2372_CR28","doi-asserted-by":"publisher","first-page":"749","DOI":"10.1111\/j.1471-4159.1976.tb04448.x","volume":"26","author":"GL Gaunt","year":"1976","unstructured":"Gaunt GL, de Duve C (1976) Subcellular distribution of D-amino acid oxidase and catalase in rat brain. J Neurochem 26(4):749\u2013759. https:\/\/doi.org\/10.1111\/j.1471-4159.1976.tb04448.x","journal-title":"J Neurochem"},{"key":"2372_CR29","doi-asserted-by":"publisher","first-page":"1400","DOI":"10.1100\/tsw.2002.837","volume":"2","author":"JM Graham","year":"2002","unstructured":"Graham JM (2002) Purification of peroxisomes using a density barrier in a swinging-bucket rotor. ScientificWorldJournal 2:1400\u20131403. https:\/\/doi.org\/10.1100\/tsw.2002.837","journal-title":"ScientificWorldJournal"},{"issue":"1","key":"2372_CR30","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1016\/0003-9861(85)90261-9","volume":"237","author":"JWW Hartl Franz-Ulrich","year":"1985","unstructured":"Hartl Franz-Ulrich JWW, Andrea K, Hans S (1985) Improved Isolation and purification of rat liver peroxisomes by combined rate zonal and equilibrium density centrifugation. Arch Biochem Biophys 237(1):124\u2013134","journal-title":"Arch Biochem Biophys"},{"issue":"Pt 3","key":"2372_CR31","doi-asserted-by":"publisher","first-page":"589","DOI":"10.1242\/jcs.087452","volume":"125","author":"A Itoyama","year":"2012","unstructured":"Itoyama A, Honsho M, Abe Y, Moser A, Yoshida Y, Fujiki Y (2012) Docosahexaenoic acid mediates peroxisomal elongation, a prerequisite for peroxisome division. J Cell Sci 125(Pt 3):589\u2013602. https:\/\/doi.org\/10.1242\/jcs.087452","journal-title":"J Cell Sci"},{"issue":"1","key":"2372_CR32","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1186\/s12974-022-02637-1","volume":"19","author":"N Javanmehr","year":"2022","unstructured":"Javanmehr N, Saleki K, Alijanizadeh P, Rezaei N (2022) Microglia dynamics in aging-related neurobehavioral and neuroinflammatory diseases. J Neuroinflammation 19(1):273. https:\/\/doi.org\/10.1186\/s12974-022-02637-1","journal-title":"J Neuroinflammation"},{"issue":"3","key":"2372_CR33","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1016\/s0304-3940(00)01068-5","volume":"285","author":"A Knoll","year":"2000","unstructured":"Knoll A, Salles J, Sargueil F, Cassagne C, Garbay B (2000) Peroxisomal beta-oxidation enzyme gene expression in the developing mouse brain. Neurosci Lett 285(3):201\u2013204. https:\/\/doi.org\/10.1016\/s0304-3940(00)01068-5","journal-title":"Neurosci Lett"},{"key":"2372_CR34","doi-asserted-by":"publisher","DOI":"10.1007\/s00418-023-02259-5","author":"R Kumar","year":"2024","unstructured":"Kumar R, Islinger M, Worthy H, Carmichael R, Schrader M (2024) The peroxisome: an update on mysteries 30. Histochem Cell Biol. https:\/\/doi.org\/10.1007\/s00418-023-02259-5","journal-title":"Histochem Cell Biol"},{"key":"2372_CR35","doi-asserted-by":"publisher","first-page":"7647","DOI":"10.1073\/pnas.85.20.7647","volume":"85","author":"OCM Lazo","year":"1988","unstructured":"Lazo OCM, Hashmi M, Stanley W, Irazu C, Singh I (1988) Peroxisomal lignoceroyl-coa ligase deficiency in childhood adrenoleukodystrophy and adrenomyeloneuropathy. PNAS 85:7647\u20137651","journal-title":"PNAS"},{"issue":"4","key":"2372_CR36","doi-asserted-by":"publisher","first-page":"1343","DOI":"10.1111\/j.1471-4159.1991.tb11431.x","volume":"56","author":"O Lazo","year":"1991","unstructured":"Lazo O, Singh AK, Singh I (1991) Postnatal development and isolation of peroxisomes from brain. J Neurochem 56(4):1343\u20131353. https:\/\/doi.org\/10.1111\/j.1471-4159.1991.tb11431.x","journal-title":"J Neurochem"},{"issue":"2","key":"2372_CR37","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1002\/jgm.328","volume":"5","author":"M Lecocq","year":"2003","unstructured":"Lecocq M, Andrianaivo F, Warnier MT, Wattiaux-De Coninck S, Wattiaux R, Jadot M (2003) Uptake by mouse liver and intracellular fate of plasmid DNA after a rapid tail vein injection of a small or a large volume. J Gene Med 5(2):142\u2013156. https:\/\/doi.org\/10.1002\/jgm.328","journal-title":"J Gene Med"},{"key":"2372_CR38","doi-asserted-by":"publisher","first-page":"482","DOI":"10.1083\/jcb.37.2.482","volume":"37","author":"F Leighton","year":"1968","unstructured":"Leighton F, Poole B, Beaufay H, Baudhuin P, Coffey JW, Fowler S, de Duve C (1968) The large-scale separation of peroxisomes, mitochondria, and lysosomes from the livers of rats injected with triton Wr-1339. J Cell Biol 37:482\u2013513","journal-title":"J Cell Biol"},{"issue":"2","key":"2372_CR39","doi-asserted-by":"publisher","first-page":"296","DOI":"10.1364\/BOE.3.000296","volume":"3","author":"OC Marina","year":"2012","unstructured":"Marina OC, Sanders CK, Mourant JR (2012) Correlating light scattering with internal cellular structures. Biomed Opt Express 3(2):296\u2013312. https:\/\/doi.org\/10.1364\/BOE.3.000296","journal-title":"Biomed Opt Express"},{"issue":"2","key":"2372_CR40","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1016\/j.neuint.2006.04.002","volume":"49","author":"B Melchior","year":"2006","unstructured":"Melchior B, Puntambekar SS, Carson MJ (2006) Microglia and the control of autoreactive T cell responses. Neurochem Int 49(2):145\u2013153. https:\/\/doi.org\/10.1016\/j.neuint.2006.04.002","journal-title":"Neurochem Int"},{"issue":"11","key":"2372_CR41","doi-asserted-by":"publisher","first-page":"1848","DOI":"10.1002\/glia.22562","volume":"61","author":"J Melief","year":"2013","unstructured":"Melief J, Schuurman KG, Van De Garde MD, Smolders J, Van Eijk M, Hamann J, Huitinga I (2013) Microglia in normal appearing white matter of multiple sclerosis are alerted but immunosuppressed. Glia 61(11):1848\u20131861. https:\/\/doi.org\/10.1002\/glia.22562","journal-title":"Glia"},{"issue":"1","key":"2372_CR42","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1016\/s1389-1723(02)80050-0","volume":"93","author":"J Ni","year":"2002","unstructured":"Ni J, Sasaki Y, Tokuyama S, Sogabe A, Tahara Y (2002) Conversion of a typical catalase from bacillus Sp Te124 to a catalase-peroxidase by directed evolution. J Biosci Bioeng 93(1):31\u201336. https:\/\/doi.org\/10.1016\/s1389-1723(02)80050-0","journal-title":"J Biosci Bioeng"},{"issue":"1","key":"2372_CR43","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1177\/1.1.27","volume":"1","author":"AB Novikoff","year":"1953","unstructured":"Novikoff AB, Podber E, Ryan J, Noe E (1953) Biochemical heterogeneity of the cytoplasmic particles isolated from rat liver homogenate. J Histochem Cytochem 1(1):27\u201346. https:\/\/doi.org\/10.1177\/1.1.27","journal-title":"J Histochem Cytochem"},{"issue":"2","key":"2372_CR44","doi-asserted-by":"publisher","first-page":"314","DOI":"10.1016\/j.bbrc.2007.06.059","volume":"360","author":"D Oaxaca-Castillo","year":"2007","unstructured":"Oaxaca-Castillo D, Andreoletti P, Vluggens A, Yu S, Van Veldhoven PP, Reddy JK, Cherkaoui-Malki M (2007) Biochemical characterization of two functional human liver acyl-coa oxidase isoforms 1a and 1b encoded by a single gene. Biochem Biophys Res Commun 360(2):314\u2013319. https:\/\/doi.org\/10.1016\/j.bbrc.2007.06.059","journal-title":"Biochem Biophys Res Commun"},{"issue":"4","key":"2372_CR45","doi-asserted-by":"publisher","first-page":"649","DOI":"10.1111\/bph.13139","volume":"173","author":"R Orihuela","year":"2016","unstructured":"Orihuela R, Mcpherson CA, Harry GJ (2016) Microglial M1\/M2 polarization and metabolic states. Br J Pharmacol 173(4):649\u2013665. https:\/\/doi.org\/10.1111\/bph.13139","journal-title":"Br J Pharmacol"},{"issue":"2","key":"2372_CR46","doi-asserted-by":"publisher","first-page":"375","DOI":"10.1042\/bj1550375","volume":"155","author":"ME Parsons","year":"1976","unstructured":"Parsons ME, Pennington RJ (1976) Separation of rat muscle aminopeptidases. Biochem J 155(2):375\u2013381. https:\/\/doi.org\/10.1042\/bj1550375","journal-title":"Biochem J"},{"issue":"3","key":"2372_CR47","first-page":"422","volume":"42","author":"BT Poll-The","year":"1988","unstructured":"Poll-The BT, Roels F, Ogier H, Scotto J, Vamecq J, Schutgens RB, Wanders RJ, Van Roermund CW, Van Wijland MJ, Schram AW et al (1988) A new peroxisomal disorder with enlarged peroxisomes and a specific deficiency of acyl-coa oxidase (Pseudo-Neonatal Adrenoleukodystrophy). Am J Hum Genet 42(3):422\u2013434","journal-title":"Am J Hum Genet"},{"issue":"2","key":"2372_CR48","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1093\/jnen\/59.2.89","volume":"59","author":"JM Powers","year":"2000","unstructured":"Powers JM, Deciero DP, Ito M, Moser AB, Moser HW (2000) Adrenomyeloneuropathy: a neuropathologic review featuring its noninflammatory myelopathy. J Neuropathol Exp Neurol 59(2):89\u2013102. https:\/\/doi.org\/10.1093\/jnen\/59.2.89","journal-title":"J Neuropathol Exp Neurol"},{"key":"2372_CR49","doi-asserted-by":"publisher","first-page":"704","DOI":"10.1016\/j.bbalip.2019.02.006","volume":"5","author":"Q Raas","year":"2019","unstructured":"Raas Q, Gondcaille C, Hamon Y, Leoni V, Caccia C, Menetrier F, Lizard G, Trompier D, Savary S (2019a) CRISPR\/Cas9-mediated knockout of Abcd1 and Abcd2 genes in BV-2 cells: novel microglial models for X-linked adrenoleukodystrophy. Biochim Biophys Acta Mol Cell Biol Lipids 1864(5):704\u2013714. https:\/\/doi.org\/10.1016\/j.bbalip.2019.02.006","journal-title":"Biochim Biophys Acta Mol Cell Biol Lipids"},{"key":"2372_CR50","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbalip.2018.10.005","author":"Q Raas","year":"2019","unstructured":"Raas Q, Saih FE, Gondcaille C, Trompier D, Hamon Y, Leoni V, Caccia C, Nasser B, Jadot M, Menetrier F, Lizard G, Cherkaoui-Malki M, Andreoletti P, Savary S (2019b) A microglial cell model for acyl-coa oxidase 1 deficiency. Biochim Biophys Acta Mol Cell Biol Lipids. https:\/\/doi.org\/10.1016\/j.bbalip.2018.10.005","journal-title":"Biochim Biophys Acta Mol Cell Biol Lipids"},{"key":"2372_CR51","doi-asserted-by":"publisher","first-page":"1170313","DOI":"10.3389\/fnmol.2023.1170313","volume":"16","author":"Q Raas","year":"2023","unstructured":"Raas Q, Tawbeh A, Tahri-Joutey M, Gondcaille C, Keime C, Kaiser R, Trompier D, Nasser B, Leoni V, Bellanger E, Boussand M, Hamon Y, Benani A, Di Cara F, Truntzer C, Cherkaoui-Malki M, Andreoletti P, Savary S (2023) Peroxisomal defects in microglial cells induce a disease-associated microglial signature. Front Mol Neurosci 16:1170313. https:\/\/doi.org\/10.3389\/fnmol.2023.1170313","journal-title":"Front Mol Neurosci"},{"issue":"4","key":"2372_CR52","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1007\/s00418-004-0673-1","volume":"122","author":"M Schrader","year":"2004","unstructured":"Schrader M, Fahimi HD (2004) Mammalian peroxisomes and reactive oxygen species. Histochem Cell Biol 122(4):383\u2013393. https:\/\/doi.org\/10.1007\/s00418-004-0673-1","journal-title":"Histochem Cell Biol"},{"issue":"4","key":"2372_CR53","doi-asserted-by":"publisher","first-page":"412","DOI":"10.1002\/glia.20468","volume":"55","author":"A Sierra","year":"2007","unstructured":"Sierra A, Gottfried-Blackmore AC, Mcewen BS, Bulloch K (2007) Microglia derived from aging mice exhibit an altered inflammatory profile. Glia 55(4):412\u2013424. https:\/\/doi.org\/10.1002\/glia.20468","journal-title":"Glia"},{"issue":"3","key":"2372_CR54","doi-asserted-by":"publisher","first-page":"256","DOI":"10.1002\/1098-1136(200103)33:3<256::AID-GLIA1024>3.0.CO;2-J","volume":"33","author":"N Stence","year":"2001","unstructured":"Stence N, Waite M, Dailey ME (2001) Dynamics of microglial activation: a confocal time-lapse analysis in hippocampal slices. Glia 33(3):256\u2013266","journal-title":"Glia"},{"key":"2372_CR55","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22168969","author":"M Tahri-Joutey","year":"2021","unstructured":"Tahri-Joutey M, Andreoletti P, Surapureddi S, Nasser B, Cherkaoui-Malki M, Latruffe N (2021) Mechanisms mediating the regulation of peroxisomal fatty acid beta-oxidation by PPAR\u03b1. Int J Mol Sci. https:\/\/doi.org\/10.3390\/ijms22168969","journal-title":"Int J Mol Sci"},{"key":"2372_CR56","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22116093","author":"A Tawbeh","year":"2021","unstructured":"Tawbeh A, Gondcaille C, Trompier D, Savary S (2021) Peroxisomal ABC transporters: an update. Int J Mol Sci. https:\/\/doi.org\/10.3390\/ijms22116093","journal-title":"Int J Mol Sci"},{"key":"2372_CR57","doi-asserted-by":"publisher","first-page":"1299314","DOI":"10.3389\/fnmol.2023.1299314","volume":"16","author":"A Tawbeh","year":"2023","unstructured":"Tawbeh A, Raas Q, Tahri-Joutey M, Keime C, Kaiser R, Trompier D, Nasser B, Bellanger E, Dessard M, Hamon Y, Benani A, Di Cara F, Cunha Alves T, Berger J, Weinhofer I, Mandard S, Cherkaoui-Malki M, Andreoletti P, Gondcaille C, Savary S (2023) Immune response of BV-2 microglial cells is impacted by peroxisomal beta-oxidation. Front Mol Neurosci 16:1299314. https:\/\/doi.org\/10.3389\/fnmol.2023.1299314","journal-title":"Front Mol Neurosci"},{"key":"2372_CR58","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1016\/j.biochi.2013.09.009","volume":"98","author":"D Trompier","year":"2014","unstructured":"Trompier D, Vejux A, Zarrouk A, Gondcaille C, Geillon F, Nury T, Savary S, Lizard G (2014) Brain peroxisomes. Biochimie 98:102\u2013110. https:\/\/doi.org\/10.1016\/j.biochi.2013.09.009","journal-title":"Biochimie"},{"issue":"2","key":"2372_CR59","doi-asserted-by":"publisher","first-page":"380","DOI":"10.1042\/bj0970380","volume":"97","author":"G Vaes","year":"1965","unstructured":"Vaes G, Jacques P (1965) Studies on bone enzymes the assay of acid hydrolases and other enzymes in bone tissue. Biochem J 97(2):380\u2013388. https:\/\/doi.org\/10.1042\/bj0970380","journal-title":"Biochem J"},{"key":"2372_CR60","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1016\/j.biochi.2013.09.019","volume":"98","author":"J Vamecq","year":"2014","unstructured":"Vamecq J, Cherkaoui-Malki M, Andreoletti P, Latruffe N (2014) The human peroxisome in health and disease: the story of an oddity becoming a vital organelle. Biochimie 98:4\u201315. https:\/\/doi.org\/10.1016\/j.biochi.2013.09.019","journal-title":"Biochimie"},{"key":"2372_CR61","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1006\/abio.1996.0194","volume":"237","author":"P Van Veldhoven","year":"1996","unstructured":"Van Veldhoven P, Paul BE, Mannaerts GP (1996) Iodixanol (Optiprep), an improved density gradient medium for the iso-osmotic isolation of rat liver peroxisomes. Anal Biochem 237:17\u201323","journal-title":"Anal Biochem"},{"key":"2372_CR62","doi-asserted-by":"publisher","first-page":"124","DOI":"10.3389\/fnagi.2015.00124","volume":"7","author":"R Von Bernhardi","year":"2015","unstructured":"Von Bernhardi R, Eugenin-Von Bernhardi L, Eugenin J (2015) Microglial cell dysregulation in brain aging and neurodegeneration. Front Aging Neurosci 7:124. https:\/\/doi.org\/10.3389\/fnagi.2015.00124","journal-title":"Front Aging Neurosci"},{"issue":"1","key":"2372_CR63","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1016\/0304-4165(91)90011-5","volume":"1115","author":"RJ Wanders","year":"1991","unstructured":"Wanders RJ, Van Roermund CW, Griffioen M, Cohen L (1991) Peroxisomal enzyme activities in the human hepatoblastoma cell line hepg2 as compared to human liver. Biochim Biophys Acta 1115(1):54\u201359. https:\/\/doi.org\/10.1016\/0304-4165(91)90011-5","journal-title":"Biochim Biophys Acta"},{"issue":"1","key":"2372_CR64","doi-asserted-by":"publisher","first-page":"957","DOI":"10.1152\/physrev.00051.2021","volume":"103","author":"RJA Wanders","year":"2023","unstructured":"Wanders RJA, Baes M, Ribeiro D, Ferdinandusse S, Waterham HR (2023) The physiological functions of human peroxisomes. Physiol Rev 103(1):957\u20131024. https:\/\/doi.org\/10.1152\/physrev.00051.2021","journal-title":"Physiol Rev"},{"issue":"2","key":"2372_CR65","doi-asserted-by":"publisher","first-page":"1298","DOI":"10.1529\/biophysj.104.042135","volume":"87","author":"D Watson","year":"2004","unstructured":"Watson D, Hagen N, Diver J, Marchand P, Chachisvilis M (2004) Elastic light scattering from single cells: orientational dynamics in optical trap. Biophys J 87(2):1298\u20131306. https:\/\/doi.org\/10.1529\/biophysj.104.042135","journal-title":"Biophys J"},{"key":"2372_CR66","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1083\/jcb.78.2.349","volume":"78","author":"R Wattiaux","year":"1978","unstructured":"Wattiaux R, Wattiaux-De Coninck S, Ronveaux-Dupal MF, Dubois F (1978) Isolation of rat liver lysosomes by isopycnic centrifugation in a metrizamide gradient. J Cell Biol 78:349\u2013368","journal-title":"J Cell Biol"}],"container-title":["Histochemistry and Cell Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00418-025-02372-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00418-025-02372-7","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00418-025-02372-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T11:26:45Z","timestamp":1768390005000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00418-025-02372-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,14]]},"references-count":66,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["2372"],"URL":"https:\/\/doi.org\/10.1007\/s00418-025-02372-7","relation":{},"ISSN":["0948-6143","1432-119X"],"issn-type":[{"value":"0948-6143","type":"print"},{"value":"1432-119X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,4,14]]},"assertion":[{"value":"14 March 2025","order":1,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 April 2025","order":2,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 June 2025","order":4,"name":"change_date","label":"Change Date","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Update","order":5,"name":"change_type","label":"Change Type","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The original online version of this article was revised: for the update on author name- El Kebbaj R.","order":6,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflicts of interest"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}],"article-number":"44"}}