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A disintegrin and metalloprotease with thrombospondin type I motifs (ADAMTS-1) is a metalloproteinase responsible for the degradation of some proteoglycans, which are ECM components. In this study, ADAMTS-1 distribution was analyzed in the uterus of ovariectomized rats administered 17\u03b2-estradiol (E2) and progesterone (P4) and in the uterus at different estrous stages. Ovariectomized (OVX) rats were subjected to single and combined E2 (0.2\u00a0mg\/kg) and P4 (10\u00a0mg\/kg) hormone replacement therapies. E2 was administered for 3 consecutive days, followed by E2, P4, or E2\u2009+\u2009P4 for 4 consecutive days. The serum level of E2 decreased from the proestrus phase to the diestrus phase, but that of P4 was the highest in the estrus phase. During the estrus phase, the serum level of luteinizing hormone (LH) was the lowest and that of follicle-stimulating hormone (FSH) was the highest. P4 level increased significantly in the OVX\u2009+\u2009P4 and OVX\u2009+\u2009E2\u2009+\u2009P4 groups compared with the OVX group. The serum levels of LH and FSH decreased in the OVX\u2009+\u2009E2 and OVX\u2009+\u2009P4 groups compared with the OVX group, and were the lowest in the OVX\u2009+\u2009E2\u2009+\u2009P4 group. ADAMTS-1 immunoreactivity in luminal, glandular, and stromal cells of the uterus decreased from proestrus to diestrus. When immunoreactivity in hormone replacement groups was compared, weak immunoreactivity was observed in the OVX group. ADAMTS-1 immunoreactivity gradually increased in OVX\u2009+\u2009P4 and OVX\u2009+\u2009E2 groups, and was particularly notable in luminal, glandular, and stromal cells in the OVX\u2009+\u2009E2\u2009+\u2009P4 group. ADAMTS-1 distribution was affected by the estrous cycle process and hormone replacement therapy in the OVX procedure.<\/jats:p>","DOI":"10.1007\/s00418-025-02382-5","type":"journal-article","created":{"date-parts":[[2025,6,3]],"date-time":"2025-06-03T13:10:43Z","timestamp":1748956243000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["ADAMTS-1, a multifunctional proteinase, in the uterus of both estrous cycle rats and ovariectomized rats can be regulated via hormones"],"prefix":"10.1007","volume":"163","author":[{"given":"Tuba","family":"Parlak Ak","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mine","family":"Yaman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ali","family":"Bayrakdar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ozgur","family":"Bulmus","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,6,3]]},"reference":[{"key":"2382_CR1","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1186\/s40738-020-00074-3","volume":"6","author":"AF Ajayi","year":"2020","unstructured":"Ajayi AF, Akhigbe RE (2020) Staging of the estrous cycle and induction of estrus in experimental rodents: an update. 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