{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T06:46:59Z","timestamp":1789195619912,"version":"build-2803163510"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T00:00:00Z","timestamp":1779062400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T00:00:00Z","timestamp":1779062400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Histochem Cell Biol"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    DEAH-box RNA helicase 37 (DHX37) is a highly conserved RNA helicase involved in ribosome biogenesis, RNA metabolism and immune regulation. Dysregulation of RNA helicases has been implicated in tumourigenesis; however, the clinical significance of DHX37 expression in tumours is still emerging and requires further study. This study investigated the expression of DHX37 in large breast and ovarian cancer patient cohorts using immunohistochemistry in 1512 breast and 420 ovarian cancer cases and complementary transcriptomic datasets. In breast cancer, low cytoplasmic DHX37 protein expression was significantly associated with adverse clinicopathological parameters including larger tumour size, higher grade, lymphovascular invasion and positive nodal status (all\n                    <jats:italic>P<\/jats:italic>\n                    \u2009&lt;\u20090.001). Low DHX37 expression was associated with poor breast cancer-specific survival (\n                    <jats:italic>P<\/jats:italic>\n                    \u2009&lt;\u20090.001), particularly among oestrogen receptor-positive patients. In ovarian cancer, low DHX37 expression was associated with lower FIGO stage, absence of residual disease and improved overall survival (\n                    <jats:italic>P<\/jats:italic>\n                    \u2009=\u20090.013). DHX37 shows contrasting prognostic associations in breast and ovarian cancer, suggesting context-dependent biological functions. Reduced DHX37 expression may promote tumour progression in ER-positive breast cancer, but is associated with favourable outcomes in ovarian cancer. These findings highlight DHX37 as a potential prognostic biomarker and underscore the need for functional studies to elucidate its mechanistic role in tumour biology and immune modulation.\n                  <\/jats:p>","DOI":"10.1007\/s00418-026-02491-9","type":"journal-article","created":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T16:34:39Z","timestamp":1779122079000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["DHX37 protein and mRNA expression patterns in breast and ovarian cancer and their prognostic implications"],"prefix":"10.1007","volume":"164","author":[{"given":"Denys","family":"Ndeke","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"Sam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nuanphan","family":"Polchai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khalid","family":"Alshammari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Megan R.","family":"Greener","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tangkam R.","family":"Marak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jimmy","family":"Joyce","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maisie","family":"Henman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suha","family":"Deen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew R.","family":"Green","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian O.","family":"Ellis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emad A.","family":"Rakha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stewart G.","family":"Martin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah J.","family":"Storr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,5,18]]},"reference":[{"key":"2491_CR1","doi-asserted-by":"publisher","DOI":"10.3390\/diseases12100227","author":"KS Al-Hadyan","year":"2024","unstructured":"Al-Hadyan KS, Storr SJ, Zaitoun AM, Lobo DN, Martin SG (2024) Thioredoxin system protein expression in carcinomas of the pancreas, distal bile duct, and ampulla in the United Kingdom. Diseases. https:\/\/doi.org\/10.3390\/diseases12100227","journal-title":"Diseases"},{"issue":"6","key":"2491_CR2","doi-asserted-by":"publisher","first-page":"685","DOI":"10.1261\/rna.069609.118","volume":"25","author":"FM Boneberg","year":"2019","unstructured":"Boneberg FM, Brandmann T, Kobel L, van den Heuvel J, Bargsten K, Bammert L, Kutay U, Jinek M (2019) Molecular mechanism of the RNA helicase DHX37 and its activation by UTP14A in ribosome biogenesis. RNA 25(6):685\u2013701. https:\/\/doi.org\/10.1261\/rna.069609.118","journal-title":"RNA"},{"issue":"12","key":"2491_CR3","doi-asserted-by":"publisher","first-page":"2341","DOI":"10.1210\/js.2019-00306","volume":"3","author":"F Buonocore","year":"2019","unstructured":"Buonocore F, Clifford-Mobley O, King TFJ, Striglioni N, Man E, Suntharalingham JP, Del Valle I, Lin L, Lagos CF, Rumsby G, Conway GS, Achermann JC (2019) Next-generation sequencing reveals novel genetic variants (SRY, DMRT1, NR5A1, DHH, DHX37) in adults with 46,XY DSD. J Endocr Soc 3(12):2341\u20132360. https:\/\/doi.org\/10.1210\/js.2019-00306","journal-title":"J Endocr Soc"},{"issue":"21","key":"2491_CR4","doi-asserted-by":"publisher","first-page":"7252","DOI":"10.1158\/1078-0432.CCR-04-0713","volume":"10","author":"RL Camp","year":"2004","unstructured":"Camp RL, Dolled-Filhart M, Rimm DL (2004) X-tile: a new bio-informatics tool for biomarker assessment and outcome-based cut-point optimization. Clin Cancer Res 10(21):7252\u20137259. https:\/\/doi.org\/10.1158\/1078-0432.CCR-04-0713","journal-title":"Clin Cancer Res"},{"issue":"10","key":"2491_CR5","doi-asserted-by":"publisher","first-page":"1113","DOI":"10.1038\/ng.2764","volume":"45","author":"JN Weinstein","year":"2013","unstructured":"Cancer Genome Atlas Research N, Weinstein JN, Collisson EA, Mills GB, Shaw KR, Ozenberger BA, Ellrott K, Shmulevich D, Sander C, Stuart JM (2013) The Cancer Genome Atlas Pan-Cancer analysis project. Nat Genet 45(10):1113\u20131120. https:\/\/doi.org\/10.1038\/ng.2764","journal-title":"Nat Genet"},{"issue":"5","key":"2491_CR6","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1158\/2159-8290.CD-12-0095","volume":"2","author":"E Cerami","year":"2012","unstructured":"Cerami E, Gao J, Dogrusoz U, Gross BE, Sumer SO, Aksoy BA, Jacobsen A, Byrne CJ, Heuer ML, Larsson E, Antipin Y, Reva B, Goldberg AP, Sander C, Schultz N (2012) The cBio cancer genomics portal: an open platform for exploring multidimensional cancer genomics data. Cancer Discov 2(5):401\u2013404. https:\/\/doi.org\/10.1158\/2159-8290.CD-12-0095","journal-title":"Cancer Discov"},{"issue":"1","key":"2491_CR7","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1080\/15476286.2018.1556149","volume":"16","author":"P Choudhury","year":"2019","unstructured":"Choudhury P, Hackert P, Memet I, Sloan KE, Bohnsack MT (2019) The human RNA helicase DHX37 is required for release of the U3 snoRNP from pre-ribosomal particles. RNA Biol 16(1):54\u201368. https:\/\/doi.org\/10.1080\/15476286.2018.1556149","journal-title":"RNA Biol"},{"issue":"12","key":"2491_CR8","doi-asserted-by":"publisher","first-page":"5923","DOI":"10.1210\/jc.2019-00984","volume":"104","author":"TE da Silva","year":"2019","unstructured":"da Silva TE, Gomes NL, Lerario AM, Keegan CE, Nishi MY, Carvalho FM, Vilain E, Barseghyan H, Martinez-Aguayo A, Forclaz MV, Papazian R, Pedroso de Paula LC, Costa EC, Carvalho LR, Jorge AAL, Elias FM, Mitchell R, Costa EMF, Mendonca BB, Domenice S (2019) Genetic evidence of the association of DEAH-box helicase 37 defects with 46,XY gonadal dysgenesis spectrum. J Clin Endocrinol Metab 104(12):5923\u20135934. https:\/\/doi.org\/10.1210\/jc.2019-00984","journal-title":"J Clin Endocrinol Metab"},{"issue":"1","key":"2491_CR9","doi-asserted-by":"publisher","first-page":"292","DOI":"10.1186\/s12964-025-02225-9","volume":"23","author":"R Devasahayam Arokia Balaya","year":"2025","unstructured":"Devasahayam Arokia Balaya R, Kanekar S, Kumar S, Kandasamy RK (2025) Role of DEAD\/DEAH-box helicases in immunity, infection and cancers. Cell Commun Signal 23(1):292. https:\/\/doi.org\/10.1186\/s12964-025-02225-9","journal-title":"Cell Commun Signal"},{"issue":"5","key":"2491_CR10","doi-asserted-by":"publisher","first-page":"1189","DOI":"10.1016\/j.cell.2019.07.044","volume":"178","author":"MB Dong","year":"2019","unstructured":"Dong MB, Wang G, Chow RD, Ye L, Zhu L, Dai X, Park JJ, Kim HR, Errami Y, Guzman CD, Zhou X, Chen KY, Renauer PA, Du Y, Shen J, Lam SZ, Zhou JJ, Lannin DR, Herbst RS, Chen S (2019) Systematic immunotherapy target discovery using genome-scale in vivo CRISPR screens in CD8 T cells. Cell 178(5):1189-1204 e1123. https:\/\/doi.org\/10.1016\/j.cell.2019.07.044","journal-title":"Cell"},{"issue":"5","key":"2491_CR11","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1016\/j.tig.2024.12.006","volume":"41","author":"C Fiorenzani","year":"2025","unstructured":"Fiorenzani C, Mossa A, De Rubeis S (2025) DEAD\/DEAH-box RNA helicases shape the risk of neurodevelopmental disorders. Trends Genet 41(5):437\u2013449. https:\/\/doi.org\/10.1016\/j.tig.2024.12.006","journal-title":"Trends Genet"},{"issue":"1","key":"2491_CR12","doi-asserted-by":"publisher","first-page":"121","DOI":"10.4161\/rna.23312","volume":"10","author":"FV Fuller-Pace","year":"2013","unstructured":"Fuller-Pace FV (2013) DEAD box RNA helicase functions in cancer. RNA Biol 10(1):121\u2013132. https:\/\/doi.org\/10.4161\/rna.23312","journal-title":"RNA Biol"},{"issue":"269","key":"2491_CR13","doi-asserted-by":"publisher","DOI":"10.1126\/scisignal.2004088","volume":"6","author":"J Gao","year":"2013","unstructured":"Gao J, Aksoy BA, Dogrusoz U, Dresdner G, Gross B, Sumer SO, Sun Y, Jacobsen A, Sinha R, Larsson E, Cerami E, Sander C, Schultz N (2013) Integrative analysis of complex cancer genomics and clinical profiles using the cBioPortal. Sci Signal 6(269):pl1. https:\/\/doi.org\/10.1126\/scisignal.2004088","journal-title":"Sci Signal"},{"issue":"3","key":"2491_CR14","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1038\/s41588-021-00791-5","volume":"53","author":"AP Heath","year":"2021","unstructured":"Heath AP, Ferretti V, Agrawal S, An M, Angelakos JC, Arya R, Bajari R, Baqar B, Barnowski JHB, Burt J, Catton A, Chan BF, Chu F, Cullion K, Davidsen T, Do PM, Dompierre C, Ferguson ML, Fitzsimons MS, Ford M, Fukuma M, Gaheen S, Ganji GL, Garcia TI, George SS, Gerhard DS, Gerthoffert F, Gomez F, Han K, Hernandez KM, Issac B, Jackson R, Jensen MA, Joshi S, Kadam A, Khurana A, Kim KMJ, Kraft VE, Li S, Lichtenberg TM, Lodato J, Lolla L, Martinov P, Mazzone JA, Miller DP, Miller I, Miller JS, Miyauchi K, Murphy MW, Nullet T, Ogwara RO, Ortuno FM, Pedrosa J, Pham PL, Popov MY, Porter JJ, Powell R, Rademacher K, Reid CP, Rich S, Rogel B, Sahni H, Savage JH, Schmitt KA, Simmons TJ, Sislow J, Spring J, Stein L, Sullivan S, Tang Y, Thiagarajan M, Troyer HD, Wang C, Wang Z, West BL, Wilmer A, Wilson S, Wu K, Wysocki WP, Xiang L, Yamada JT, Yang L, Yu C, Yung CK, Zenklusen JC, Zhang J, Zhang Z, Zhao Y, Zubair A, Staudt LM, Grossman RL (2021) The NCI genomic data commons. Nat Genet 53(3):257\u2013262. https:\/\/doi.org\/10.1038\/s41588-021-00791-5","journal-title":"Nat Genet"},{"key":"2491_CR15","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/6576210","volume":"2021","author":"K Huang","year":"2021","unstructured":"Huang K, Pang T, Tong C, Chen H, Nie Y, Wu J, Zhang Y, Chen G, Zhou W, Yang D (2021) Integrative expression and prognosis analysis of DHX37 in human cancers by data mining. BioMed Res Int 2021:6576210. https:\/\/doi.org\/10.1155\/2021\/6576210","journal-title":"BioMed Res Int"},{"issue":"1","key":"2491_CR16","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1016\/j.tibs.2010.07.008","volume":"36","author":"E Jankowsky","year":"2011","unstructured":"Jankowsky E (2011) RNA helicases at work: binding and rearranging. Trends Biochem Sci 36(1):19\u201329. https:\/\/doi.org\/10.1016\/j.tibs.2010.07.008","journal-title":"Trends Biochem Sci"},{"issue":"3","key":"2491_CR17","doi-asserted-by":"publisher","first-page":"208","DOI":"10.1002\/cjp2.311","volume":"9","author":"M Kobel","year":"2023","unstructured":"Kobel M, Kang EY, Weir A, Rambau PF, Lee CH, Nelson GS, Ghatage P, Meagher NS, Riggan MJ, Alsop J, Anglesio MS, Beckmann MW, Bisinotto C, Boisen M, Boros J, Brand AH, Brooks-Wilson A, Carney ME, Coulson P, Courtney-Brooks M, Cushing-Haugen KL, Cybulski C, Deen S, El-Bahrawy MA, Elishaev E, Erber R, Fereday S, Group A, Fischer A, Gayther SA, Barquin-Garcia A, Gentry-Maharaj A, Gilks CB, Gronwald H, Grube M, Harnett PR, Harris HR, Hartkopf AD, Hartmann A, Hein A, Hendley J, Hernandez BY, Huang Y, Jakubowska J, Jimenez-Linan M, Jones ME, Kennedy CJ, Kluz T, Koziak JM, Lesnock J, Lester J, Lubinski J, Longacre TA, Lycke M, Mateoiu C, McCauley BM, McGuire V, Ney B, Olawaiye A, Orsulic S, Osorio A, Paz-Ares L, Ramon YCT, Rothstein JH, Ruebner M, Schoemaker MJ, Shah M, Sharma R, Sherman ME, Shvetsov YB, Singh N, Steed H, Storr SJ, Talhouk A, Traficante N, Wang C, Whittemore AS, Widschwendter M, Wilkens LR, Winham SJ, Benitez J, Berchuck A, Bowtell DD, Candido Dos Reis FJ, Campbell I, Cook LS, DeFazio A, Doherty JA, Fasching PA, Fortner RT, Garcia MJ, Goodman MT, Goode EL, Gronwald J, Huntsman DG, Karlan BY, Kelemen LE, Kommoss S, Le ND, Martin SG, Menon U, Modugno F, Pharoah PD, Schildkraut JM, Sieh W, Staebler A, Sundfeldt K, Swerdlow AJ, Ramus SJ, Brenton JD (2023) p53 and ovarian carcinoma survival: an ovarian tumor tissue analysis consortium study. J Pathol Clin Res 9(3):208\u2013222. https:\/\/doi.org\/10.1002\/cjp2.311","journal-title":"J Pathol Clin Res"},{"key":"2491_CR18","doi-asserted-by":"publisher","DOI":"10.3390\/cancers16183206","author":"K Lacey","year":"2024","unstructured":"Lacey K, Greener MR, Marak TR, Rakha EA, Green AR, Ellis IO, Martin SG, Storr SJ (2024) Protein tyrosine kinase 7 (PTK7) in breast cancer: a retrospective analysis of tumour expression and association with clinical outcome. Cancers (Basel). https:\/\/doi.org\/10.3390\/cancers16183206","journal-title":"Cancers (Basel)"},{"issue":"8","key":"2491_CR19","doi-asserted-by":"publisher","first-page":"5083","DOI":"10.1093\/nar\/gku130","volume":"42","author":"R Liu","year":"2014","unstructured":"Liu R, Iadevaia V, Averous J, Taylor PM, Zhang Z, Proud CG (2014) Impairing the production of ribosomal RNA activates mammalian target of rapamycin complex 1 signalling and downstream translation factors. Nucleic Acids Res 42(8):5083\u20135096. https:\/\/doi.org\/10.1093\/nar\/gku130","journal-title":"Nucleic Acids Res"},{"issue":"10","key":"2491_CR20","doi-asserted-by":"publisher","first-page":"1937","DOI":"10.1158\/0008-5472.CAN-21-3038","volume":"82","author":"Z Liu","year":"2022","unstructured":"Liu Z, Ye Y, Liu Y, Liu Y, Chen H, Shen M, Wang Z, Huang S, Han L, Chen Z, He X (2022) RNA helicase DHX37 facilitates liver cancer progression by cooperating with PLRG1 to drive superenhancer-mediated transcription of Cyclin D1. Cancer Res 82(10):1937\u20131952. https:\/\/doi.org\/10.1158\/0008-5472.CAN-21-3038","journal-title":"Cancer Res"},{"issue":"1","key":"2491_CR21","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1038\/s41436-019-0606-y","volume":"22","author":"K McElreavey","year":"2020","unstructured":"McElreavey K, Jorgensen A, Eozenou C, Merel T, Bignon-Topalovic J, Tan DS, Houzelstein D, Buonocore F, Warr N, Kay RGG, Peycelon M, Siffroi JP, Mazen I, Achermann JC, Shcherbak Y, Leger J, Sallai A, Carel JC, Martinerie L, Le Ru R, Conway GS, Mignot B, Van Maldergem L, Bertalan R, Globa E, Brauner R, Jauch R, Nef S, Greenfield A, Bashamboo A (2020) Pathogenic variants in the DEAH-box RNA helicase DHX37 are a frequent cause of 46,XY Gonadal Dysgenesis and 46,XY Testicular Regression Syndrome. Genet Med 22(1):150\u2013159. https:\/\/doi.org\/10.1038\/s41436-019-0606-y","journal-title":"Genet Med"},{"issue":"3","key":"2491_CR22","doi-asserted-by":"publisher","first-page":"468","DOI":"10.1158\/2159-8290.CD-23-0486","volume":"14","author":"T Murayama","year":"2024","unstructured":"Murayama T, Nakayama J, Jiang X, Miyata K, Morris AD, Cai KQ, Prasad RM, Ma X, Efimov A, Belani N, Gerstein ER, Tan Y, Zhou Y, Kim W, Maruyama R, Campbell KS, Chen L, Yang Y, Balachandran S, Canadas I (2024) Targeting DHX9 triggers tumor-intrinsic Interferon response and replication stress in small cell lung cancer. Cancer Discov 14(3):468\u2013491. https:\/\/doi.org\/10.1158\/2159-8290.CD-23-0486","journal-title":"Cancer Discov"},{"issue":"2","key":"2491_CR23","doi-asserted-by":"publisher","first-page":"302","DOI":"10.1016\/j.ajhg.2019.06.001","volume":"105","author":"I Paine","year":"2019","unstructured":"Paine I, Posey JE, Grochowski CM, Jhangiani SN, Rosenheck S, Kleyner R, Marmorale T, Yoon M, Wang K, Robison R, Cappuccio G, Pinelli M, Magli A, Coban Akdemir Z, Hui J, Yeung WL, Wong BKY, Ortega L, Bekheirnia MR, Bierhals T, Hempel M, Johannsen J, Santer R, Aktas D, Alikasifoglu M, Bozdogan S, Aydin H, Karaca E, Bayram Y, Ityel H, Dorschner M, White JJ, Wilichowski E, Wortmann SB, Casella EB, Kitajima JP, Kok F, Monteiro F, Muzny DM, Bamshad M, Gibbs RA, Sutton VR, University of Washington Center for Mendelian Genomics B-HCfMGTUDP, Van Esch H, Brunetti-Pierri N, Hildebrandt F, Brautbar A, Van den Veyver IB, Glass I, Lessel D, Lyon GJ, Lupski JR (2019) Paralog studies augment gene discovery: DDX and DHX genes. Am J Hum Genet 105(2):302\u2013316. https:\/\/doi.org\/10.1016\/j.ajhg.2019.06.001","journal-title":"Am J Hum Genet"},{"key":"2491_CR24","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2025.1507749","volume":"16","author":"H Peng","year":"2025","unstructured":"Peng H, Peng W, Chen J, Hu K, Zhang Y, Ma Y, Jiang H (2025) Profile of DHX37 gene defects in human genetic diseases: 46,XY disorders of sex development. Front Endocrinol (Lausanne) 16:1507749. https:\/\/doi.org\/10.3389\/fendo.2025.1507749","journal-title":"Front Endocrinol (Lausanne)"},{"issue":"1","key":"2491_CR25","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-023-48198-y","volume":"13","author":"B Saidy","year":"2023","unstructured":"Saidy B, Vasan R, Durant R, Greener MR, Immanuel A, Green AR, Rakha E, Ellis I, Ball G, Martin SG, Storr SJ (2023) Unravelling transcriptomic complexity in breast cancer through modulation of DARPP-32 expression and signalling pathways. Sci Rep 13(1):21163. https:\/\/doi.org\/10.1038\/s41598-023-48198-y","journal-title":"Sci Rep"},{"issue":"4","key":"2491_CR26","doi-asserted-by":"publisher","first-page":"1035","DOI":"10.1007\/s13402-025-01062-9","volume":"48","author":"B Saidy","year":"2025","unstructured":"Saidy B, Gull L, Hacker AG, Rakha EA, Green AR, Ellis IO, Martin SG, Storr SJ (2025) Expression of the zinc-finger transcription factor Osterix (SP7) in invasive breast cancer and its prognostic significance. Cell Oncol Dordr 48(4):1035\u20131045. https:\/\/doi.org\/10.1007\/s13402-025-01062-9","journal-title":"Cell Oncol Dordr"},{"issue":"21","key":"2491_CR27","doi-asserted-by":"publisher","first-page":"3378","DOI":"10.1111\/jcmm.17951","volume":"27","author":"R Vasan","year":"2023","unstructured":"Vasan R, Yadav J, Aiyappa-Maudsley R, Deen S, Storr SJ, Martin SG (2023) High BMP7 expression is associated with poor prognosis in ovarian cancer. J Cell Mol Med 27(21):3378\u20133387. https:\/\/doi.org\/10.1111\/jcmm.17951","journal-title":"J Cell Mol Med"},{"key":"2491_CR28","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/8835393","volume":"2020","author":"Y Xu","year":"2020","unstructured":"Xu Y, Jiang Q, Liu H, Xiao X, Yang D, Saw PE, Luo B (2020) DHX37 impacts prognosis of Hepatocellular Carcinoma and Lung Adenocarcinoma through immune infiltration. J Immunol Res 2020:8835393. https:\/\/doi.org\/10.1155\/2020\/8835393","journal-title":"J Immunol Res"},{"issue":"8","key":"2491_CR29","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmg.2023.104804","volume":"66","author":"M Yamada","year":"2023","unstructured":"Yamada M, Nitta Y, Uehara T, Suzuki H, Miya F, Takenouchi T, Tamura M, Ayabe S, Yoshiki A, Maeno A, Saga Y, Furuse T, Yamada I, Okamoto N, Kosaki K, Sugie A (2023) Heterozygous loss-of-function DHX9 variants are associated with neurodevelopmental disorders: human genetic and experimental evidences. Eur J Med Genet 66(8):104804. https:\/\/doi.org\/10.1016\/j.ejmg.2023.104804","journal-title":"Eur J Med Genet"},{"issue":"4","key":"2491_CR30","doi-asserted-by":"publisher","first-page":"244","DOI":"10.1159\/000515924","volume":"15","author":"H Zidoune","year":"2021","unstructured":"Zidoune H, Martinerie L, Tan DS, Askari M, Rezgoune D, Ladjouze A, Boukri A, Benelmadani Y, Sifi K, Abadi N, Satta D, Rastari M, Seresht-Ahmadi M, Bignon-Topalovic J, Mazen I, Leger J, Simon D, Brauner R, Totonchi M, Jauch R, Bashamboo A, McElreavey K (2021) Expanding DSD phenotypes associated with variants in the DEAH-box RNA helicase DHX37. Sex Dev 15(4):244\u2013252. https:\/\/doi.org\/10.1159\/000515924","journal-title":"Sex Dev"}],"container-title":["Histochemistry and Cell Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00418-026-02491-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00418-026-02491-9","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00418-026-02491-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T16:34:40Z","timestamp":1779122080000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00418-026-02491-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,18]]},"references-count":30,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["2491"],"URL":"https:\/\/doi.org\/10.1007\/s00418-026-02491-9","relation":{},"ISSN":["1432-119X"],"issn-type":[{"value":"1432-119X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,18]]},"assertion":[{"value":"20 January 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 May 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 May 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and\/or national research committee, as well as the 1964 Helsinki declaration and its later amendments or comparable ethical standards. All samples collected from Nottingham used in this study were pseudo-anonymised; those collected prior to 2006 did not require informed patient consent under the Human Tissue Act; for samples collected after 2006, informed consent was obtained from all individual participants included in the study. Ethical approval for the breast cancer cohort was issued by the North West-Greater Manchester Central Research Ethics Committee under the title \u2018Nottingham Health Science Biobank (NHSB)\u2019 reference number 15\/NM\/0685. Ethical approval for the ovarian cancer cohort was obtained from the Derbyshire Ethics Committee (07\/H0401\/156).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval and consent to participate"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}}],"article-number":"36"}}