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We performed a day\u00a01\u201314\u00a0histopathological time course of a reproducible sterile granuloma induced by implantation of a heat-coagulated egg white pellet into the murine peritoneum. The reaction showed a biphasic inflammatory pattern with early neutrophil predominance followed by a sustained eosinophil-rich phase that persisted through late remodeling. Across time points, lesions progressed from exudative inflammation with prominent fibrin to organized fibroplasia and neovascularization, culminating in collagen-dominated encapsulation by day\u00a014. Eosinophils concentrated at the pellet\u2013tissue interface, frequently displaying apoptosis and degranulation, and occurring in close spatial association with fibroblasts and macrophages. At late time points, the outer granuloma zone contained mononuclear phagocyte\/macrophage-like cells alongside dense connective tissue maturation. Together, these findings provide a temporal histopathology atlas of sterile implant granuloma maturation and introduce a semiquantitative framework that summarizes key tissue-composition transitions (fibrinous exudate\u2009\u2192\u2009fibroplasia\/collagen encapsulation) alongside eosinophil enrichment at the pellet\u2013tissue interface.<\/jats:p>","DOI":"10.1007\/s00418-026-02505-6","type":"journal-article","created":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T09:33:16Z","timestamp":1782379996000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Eosinophil-associated matrix remodeling in a sterile granulomatous inflammation model: a temporal histopathological analysis"],"prefix":"10.1007","volume":"164","author":[{"given":"Bruno Marques","family":"Vieira","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milla Bezerra","family":"Paiva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juliane Siqueira","family":"Francisco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebeca Sousa","family":"Brum","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucas Everton","family":"Sim\u00f5es","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Ignez Capella","family":"Gaspar-Elsas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pedro","family":"Xavier-Elsas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,6,25]]},"reference":[{"key":"2505_CR1","doi-asserted-by":"publisher","first-page":"873226","DOI":"10.3389\/fcell.2022.873226","volume":"10","author":"K Ahmadzadeh","year":"2022","unstructured":"Ahmadzadeh K, Vanoppen M, Rose CD et al (2022) Multinucleated giant cells: current insights in phenotype, biological activities, and mechanism of formation. 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