{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,8]],"date-time":"2026-08-08T11:42:43Z","timestamp":1786189363503,"version":"build-2736575974"},"reference-count":50,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,8,8]],"date-time":"2026-08-08T00:00:00Z","timestamp":1786147200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,8,8]],"date-time":"2026-08-08T00:00:00Z","timestamp":1786147200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Histochem Cell Biol"],"DOI":"10.1007\/s00418-026-02516-3","type":"journal-article","created":{"date-parts":[[2026,8,8]],"date-time":"2026-08-08T10:53:15Z","timestamp":1786186395000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Longitudinal progression of tissue remodeling in experimental pulmonary hypertension is accompanied by a continuously increasing re-expression of extra domain A-containing fibronectin"],"prefix":"10.1007","volume":"164","author":[{"given":"Laura","family":"Tempel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Schrepper","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Berndt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. Christian","family":"Schulze","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6543-4684","authenticated-orcid":false,"given":"Marcus","family":"Franz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katja","family":"Gr\u00fcn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,8,8]]},"reference":[{"issue":"6","key":"2516_CR1","doi-asserted-by":"publisher","first-page":"1335","DOI":"10.1046\/j.1471-4159.2003.02240.x","volume":"88","author":"F Bao","year":"2004","unstructured":"Bao F, Chen Y, Dekaban GA, Weaver LC (2004) Early anti-inflammatory treatment reduces lipid peroxidation and protein nitration after spinal cord injury in rats. J Neurochem 88(6):1335\u20131344. https:\/\/doi.org\/10.1046\/j.1471-4159.2003.02240.x","journal-title":"J Neurochem"},{"key":"2516_CR2","doi-asserted-by":"publisher","DOI":"10.3390\/jcm10122559","author":"L B\u00e4z","year":"2021","unstructured":"B\u00e4z L, Ro\u00dfberg M, Gr\u00fcn K, Kretzschmar D, Berndt A, Schulze PC, Jung C, Franz M (2021) Serum liberation of fetal fibronectin variants in patients with pulmonary hypertension: ED-A(+) Fn as promising novel biomarker of pulmonary vascular and right ventricular myocardial remodeling. J Clin Med. https:\/\/doi.org\/10.3390\/jcm10122559","journal-title":"J Clin Med"},{"issue":"1","key":"2516_CR3","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1093\/stcltm\/szad070","volume":"13","author":"P Bisaccia","year":"2024","unstructured":"Bisaccia P, Magarotto F, D\u2019Agostino S, Dedja A, Barbon S, Guidolin D, Liboni C, Angioni R, De Lazzari G, Caicci F, Viola A, Jurga M, Kundrotas G, Stevens D, Mancuso D, Gramegna E, Seitaj B, Kashyap R, De Vos B, Pozzobon M (2024) Extracellular vesicles from mesenchymal umbilical cord cells exert protection against oxidative stress and fibrosis in a rat model of bronchopulmonary dysplasia. Stem Cells Transl Med 13(1):43\u201359. https:\/\/doi.org\/10.1093\/stcltm\/szad070","journal-title":"Stem Cells Transl Med"},{"key":"2516_CR4","doi-asserted-by":"publisher","first-page":"794","DOI":"10.1378\/chest.08-0492","volume":"135","author":"HJ Bogaard","year":"2009","unstructured":"Bogaard HJ, Abe K, Vonk Noordegraaf A, Voelkel NF (2009) The right ventricle under pressure: cellular and molecular mechanisms of right-heart failure in pulmonary hypertension. Chest 135:794\u2013804","journal-title":"Chest"},{"key":"2516_CR5","doi-asserted-by":"publisher","first-page":"786","DOI":"10.1038\/nrm3904","volume":"15","author":"C Bonnans","year":"2014","unstructured":"Bonnans C, Chou J, Werb Z (2014) Remodelling the extracellular matrix in development and disease. Nat Rev Mol Cell Biol 15:786\u2013801","journal-title":"Nat Rev Mol Cell Biol"},{"key":"2516_CR6","doi-asserted-by":"publisher","first-page":"488","DOI":"10.1002\/path.1415","volume":"200","author":"R Chiquet-Ehrismann","year":"2003","unstructured":"Chiquet-Ehrismann R, Chiquet M (2003) Tenascins: regulation and putative functions during pathological stress. J Pathol 200:488\u2013499","journal-title":"J Pathol"},{"key":"2516_CR7","doi-asserted-by":"publisher","first-page":"1741","DOI":"10.1074\/mcp.M113.037267","volume":"13","author":"ML Decaris","year":"2014","unstructured":"Decaris ML, Gatmaitan M, FlorCruz S, Luo F, Li K, Holmes WE, Hellerstein MK, Turner SM, Emson CL (2014) Proteomic analysis of altered extracellular matrix turnover in bleomycin-induced pulmonary fibrosis. Mol Cell Proteomics 13:1741\u20131752","journal-title":"Mol Cell Proteomics"},{"key":"2516_CR8","doi-asserted-by":"publisher","first-page":"504","DOI":"10.1016\/j.yjmcc.2009.07.015","volume":"48","author":"M Dobaczewski","year":"2010","unstructured":"Dobaczewski M, Gonzalez-Quesada C, Frangogiannis NG (2010) The extracellular matrix as a modulator of the inflammatory and reparative response following myocardial infarction. J Mol Cell Cardiol 48:504\u2013511","journal-title":"J Mol Cell Cardiol"},{"key":"2516_CR9","doi-asserted-by":"publisher","first-page":"635","DOI":"10.1152\/physrev.00008.2011","volume":"92","author":"NG Frangogiannis","year":"2012","unstructured":"Frangogiannis NG (2012) Matricellular proteins in cardiac adaptation and disease. Physiol Rev 92:635\u2013688","journal-title":"Physiol Rev"},{"issue":"5","key":"2516_CR10","doi-asserted-by":"publisher","first-page":"503","DOI":"10.1007\/s00418-010-0750-6","volume":"134","author":"M Franz","year":"2010","unstructured":"Franz M, Gr\u00fcn K, Richter P, Brehm BR, Fritzenwanger M, Hekmat K, Neri D, Gummert J, Figulla HR, Kosmehl H, Berndt A, Renner A (2010) Extra cellular matrix remodelling after heterotopic rat heart transplantation: gene expression profiling and involvement of ED-A+ fibronectin, alpha-smooth muscle actin and B+ tenascin-C in chronic cardiac allograft rejection. Histochem Cell Biol 134(5):503\u2013517. https:\/\/doi.org\/10.1007\/s00418-010-0750-6","journal-title":"Histochem Cell Biol"},{"issue":"6","key":"2516_CR11","doi-asserted-by":"publisher","first-page":"5344","DOI":"10.1016\/j.ijcard.2013.08.005","volume":"168","author":"M Franz","year":"2013","unstructured":"Franz M, Berndt A, Neri D, Galler K, Gr\u00fcn K, Porrmann C, Reinbothe F, Mall G, Schlattmann P, Renner A, Figulla HR, Jung C, K\u00fcthe F (2013) Matrix metalloproteinase-9, tissue inhibitor of metalloproteinase-1, B\u207a tenascin-C and ED-A+ fibronectin in dilated cardiomyopathy: potential impact on disease progression and patients\u2019 prognosis. Int J Cardiol 168(6):5344\u20135351. https:\/\/doi.org\/10.1016\/j.ijcard.2013.08.005","journal-title":"Int J Cardiol"},{"key":"2516_CR12","doi-asserted-by":"publisher","first-page":"81241","DOI":"10.18632\/oncotarget.13220","volume":"7","author":"M Franz","year":"2016","unstructured":"Franz M, Gr\u00fcn K, Betge S, Rohm I, Ndongson-Dongmo B, Bauer R, Schulze PC, Lichtenauer M, Petersen I, Neri D, Berndt A, Jung C (2016) Lung tissue remodelling in MCT-induced pulmonary hypertension: a proposal for a novel scoring system and changes in extracellular matrix and fibrosis associated gene expression. Oncotarget 7:81241\u201381254","journal-title":"Oncotarget"},{"key":"2516_CR13","doi-asserted-by":"publisher","first-page":"659","DOI":"10.2353\/ajpath.2006.050599","volume":"168","author":"MG Frid","year":"2006","unstructured":"Frid MG, Brunetti JA, Burke DL, Carpenter TC, Davie NJ, Reeves JT, Roedersheimer MT, van Rooijen N, Stenmark KR (2006) Hypoxia-induced pulmonary vascular remodeling requires recruitment of circulating mesenchymal precursors of a monocyte\/macrophage lineage. Am J Pathol 168:659\u2013669","journal-title":"Am J Pathol"},{"key":"2516_CR14","doi-asserted-by":"publisher","first-page":"L363","DOI":"10.1152\/ajplung.00212.2011","volume":"302","author":"JG Gomez-Arroyo","year":"2012","unstructured":"Gomez-Arroyo JG, Farkas L, Alhussaini AA, Farkas D, Kraskauskas D, Voelkel NF, Bogaard HJ (2012) The monocrotaline model of pulmonary hypertension in perspective. Am J Physiol Lung Cell Mol Physiol 302:L363\u2013L369","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"2516_CR15","doi-asserted-by":"publisher","first-page":"927","DOI":"10.1002\/ejhf.2493","volume":"24","author":"A Gonz\u00e1lez","year":"2022","unstructured":"Gonz\u00e1lez A, Richards AM, de Boer RA, Thum T, Arfsten H, H\u00fclsmann M, Falcao-Pires I, D\u00edez J, Foo RSY, Chan MY, Aimo A, Anene-Nzelu CG, Abdelhamid M, Adamopoulos S, Anker SD, Belenkov Y, Ben Gal T, Cohen-Solal A, B\u00f6hm M, Chioncel O, Delgado V, Emdin M, Jankowska EA, Gustafsson F, Hill L, Jaarsma T, Januzzi JL, Jhund PS, Lopatin Y, Lund LH, Metra M, Milicic D, Moura B, Mueller C, Mullens W, N\u00fa\u00f1ez J, Piepoli MF, Rakisheva A, Risti\u0107 AD, Rossignol P, Savarese G, Tocchetti CG, Van Linthout S, Volterrani M, Seferovic P, Rosano G, Coats AJS, Bay\u00e9s-Gen\u00eds A (2022) Cardiac remodelling - Part 1: From cells and tissues to circulating biomarkers a review from the study group on biomarkers of the heart failure association of the European society of cardiology. Eur J Heart Fail 24:927\u2013943","journal-title":"Eur J Heart Fail"},{"key":"2516_CR16","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22073460","author":"B Gouyou","year":"2021","unstructured":"Gouyou B, Gr\u00fcn K, Kerschenmeyer A, Villa A, Matasci M, Schrepper A, Pfeil A, B\u00e4z L, Jung C, Schulze PC, Neri D, Franz M (2021) Therapeutic evaluation of antibody-based targeted delivery of interleukin 9 in experimental pulmonary hypertension. Int J Mol Sci. https:\/\/doi.org\/10.3390\/ijms22073460","journal-title":"Int J Mol Sci"},{"key":"2516_CR17","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1161\/CIRCULATIONAHA.108.829713","volume":"120","author":"ML Handoko","year":"2009","unstructured":"Handoko ML, de Man FS, Happ\u00e9 CM, Schalij I, Musters RJ, Westerhof N, Postmus PE, Paulus WJ, van der Laarse WJ, Vonk-Noordegraaf A (2009) Opposite effects of training in rats with stable and progressive pulmonary hypertension. Circulation 120:42\u201349","journal-title":"Circulation"},{"key":"2516_CR18","doi-asserted-by":"publisher","DOI":"10.1111\/eci.13907","volume":"53","author":"J Heiss","year":"2023","unstructured":"Heiss J, Grun K, Tempel L, Matasci M, Schrepper A, Schwarzer M, Bauer R, Forster M, Berndt A, Jung C, Schulze PC, Neri D, Franz M (2023) Targeted interleukin-9 delivery in pulmonary hypertension: comparison of immunocytokine formats and effector cell study. Eur J Clin Invest 53:e13907","journal-title":"Eur J Clin Invest"},{"key":"2516_CR19","doi-asserted-by":"publisher","first-page":"27","DOI":"10.3390\/arm92010005","volume":"92","author":"J Heiss","year":"2024","unstructured":"Heiss J, Gr\u00fcn K, Singerer I, Tempel L, Matasci M, Jung C, Pfeil A, Schulze PC, Neri D, Franz M (2024) Expression of inflammatory genes in murine lungs in a model of experimental pulmonary hypertension: effects of an antibody-based targeted delivery of interleukin-9. Adv Respir Med 92:27\u201335","journal-title":"Adv Respir Med"},{"key":"2516_CR20","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.01887-2018","author":"M Humbert","year":"2019","unstructured":"Humbert M, Guignabert C, Bonnet S, Dorfm\u00fcller P, Klinger JR, Nicolls MR, Olschewski AJ, Pullamsetti SS, Schermuly RT, Stenmark KR, Rabinovitch M (2019) Pathology and pathobiology of pulmonary hypertension: state of the art and research perspectives. Eur Respir J. https:\/\/doi.org\/10.1183\/13993003.01887-2018","journal-title":"Eur Respir J"},{"key":"2516_CR21","doi-asserted-by":"publisher","first-page":"3618","DOI":"10.1093\/eurheartj\/ehac237","volume":"43","author":"M Humbert","year":"2022","unstructured":"Humbert M, Kovacs G, Hoeper MM, Badagliacca R, Berger RMF, Brida M, Carlsen J, Coats AJS, Escribano-Subias P, Ferrari P, Ferreira DS, Ghofrani HA, Giannakoulas G, Kiely DG, Mayer E, Meszaros G, Nagavci B, Olsson KM, Pepke-Zaba J, Quint JK, Radegran G, Simonneau G, Sitbon O, Tonia T, Toshner M, Vachiery JL, Vonk Noordegraaf A, Delcroix M, Rosenkranz S, Esc Ers Scientific Document Group (2022) 2022 ESC\/ERS guidelines for the diagnosis and treatment of pulmonary hypertension. Eur Heart J 43:3618\u20133731","journal-title":"Eur Heart J"},{"key":"2516_CR22","doi-asserted-by":"publisher","first-page":"1216","DOI":"10.1126\/science.1176009","volume":"326","author":"RO Hynes","year":"2009","unstructured":"Hynes RO (2009) The extracellular matrix: not just pretty fibrils. Science 326:1216\u20131219","journal-title":"Science"},{"issue":"2","key":"2516_CR23","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1002\/(sici)1097-0177(200006)218:2<235::Aid-dvdy2>3.0.Co;2-g","volume":"218","author":"FS Jones","year":"2000","unstructured":"Jones FS, Jones PL (2000) The tenascin family of ECM glycoproteins: structure, function, and regulation during embryonic development and tissue remodeling. Dev Dyn 218(2):235\u2013259. https:\/\/doi.org\/10.1002\/(sici)1097-0177(200006)218:2%3c235::Aid-dvdy2%3e3.0.Co;2-g","journal-title":"Dev Dyn"},{"key":"2516_CR24","doi-asserted-by":"publisher","first-page":"e15","DOI":"10.1164\/rccm.201806-1160ST","volume":"198","author":"T Lahm","year":"2018","unstructured":"Lahm T, Douglas IS, Archer SL, Bogaard HJ, Chesler NC, Haddad F, Hemnes AR, Kawut SM, Kline JA, Kolb TM, Mathai SC, Mercier O, Michelakis ED, Naeije R, Tuder RM, Ventetuolo CE, Vieillard-Baron A, Voelkel NF, Vonk-Noordegraaf A, Hassoun PM, Circulation American Thoracic Society Assembly on Pulmonary (2018) Assessment of right ventricular function in the research setting: knowledge gaps and pathways forward an official American thoracic society research statement. Am J Respir Crit Care Med 198:e15\u2013e43","journal-title":"Am J Respir Crit Care Med"},{"issue":"11","key":"2516_CR25","doi-asserted-by":"publisher","first-page":"4327","DOI":"10.1158\/0008-5472.Can-09-3312","volume":"70","author":"G Malik","year":"2010","unstructured":"Malik G, Knowles LM, Dhir R, Xu S, Yang S, Ruoslahti E, Pilch J (2010) Plasma fibronectin promotes lung metastasis by contributions to fibrin clots and tumor cell invasion. Cancer Res 70(11):4327\u20134334. https:\/\/doi.org\/10.1158\/0008-5472.Can-09-3312","journal-title":"Cancer Res"},{"key":"2516_CR26","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1007\/s12079-009-0075-1","volume":"3","author":"KS Midwood","year":"2009","unstructured":"Midwood KS, Orend G (2009) The role of tenascin-C in tissue injury and tumorigenesis. J Cell Commun Signal 3:287\u2013310","journal-title":"J Cell Commun Signal"},{"key":"2516_CR27","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1083\/jcb.200212079","volume":"162","author":"AF Muro","year":"2003","unstructured":"Muro AF, Chauhan AK, Gajovic S, Iaconcig A, Porro F, Stanta G, Baralle FE (2003) Regulated splicing of the fibronectin EDA exon is essential for proper skin wound healing and normal lifespan. J Cell Biol 162:149\u2013160","journal-title":"J Cell Biol"},{"key":"2516_CR28","doi-asserted-by":"publisher","first-page":"10229","DOI":"10.1074\/jbc.M100099200","volume":"276","author":"Y Okamura","year":"2001","unstructured":"Okamura Y, Watari M, Jerud ES, Young DW, Ishizaka ST, Rose J, Chow JC, Strauss JF 3rd (2001) The extra domain A of fibronectin activates Toll-like receptor 4. J Biol Chem 276:10229\u201310233","journal-title":"J Biol Chem"},{"key":"2516_CR29","doi-asserted-by":"publisher","first-page":"3861","DOI":"10.1242\/jcs.00059","volume":"115","author":"R Pankov","year":"2002","unstructured":"Pankov R, Yamada KM (2002) Fibronectin at a glance. J Cell Sci 115:3861\u20133863","journal-title":"J Cell Sci"},{"issue":"6","key":"2516_CR30","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0039761","volume":"7","author":"O Preobrazhenska","year":"2012","unstructured":"Preobrazhenska O, Wright JL, Churg A (2012) Regional heterogeneity in murine lung fibroblasts from normal mice or mice exposed once to cigarette smoke. PLoS ONE 7(6):e39761. https:\/\/doi.org\/10.1371\/journal.pone.0039761","journal-title":"PLoS ONE"},{"key":"2516_CR31","doi-asserted-by":"publisher","first-page":"556","DOI":"10.1165\/rcmb.2017-0033ED","volume":"56","author":"SS Pullamsetti","year":"2017","unstructured":"Pullamsetti SS, Savai R (2017) Macrophage regulation during vascular remodeling: implications for pulmonary hypertension therapy. Am J Respir Cell Mol Biol 56:556\u2013558","journal-title":"Am J Respir Cell Mol Biol"},{"key":"2516_CR32","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1161\/CIRCRESAHA.113.301141","volume":"115","author":"M Rabinovitch","year":"2014","unstructured":"Rabinovitch M, Guignabert C, Humbert M, Nicolls MR (2014) Inflammation and immunity in the pathogenesis of pulmonary arterial hypertension. Circ Res 115:165\u2013175","journal-title":"Circ Res"},{"key":"2516_CR33","doi-asserted-by":"publisher","first-page":"497","DOI":"10.3233\/CH-180529","volume":"73","author":"I Rohm","year":"2019","unstructured":"Rohm I, Grun K, Muller LM, Baz L, Forster M, Schrepper A, Kretzschmar D, Pistulli R, Yilmaz A, Bauer R, Jung C, Berndt A, Schulze PC, Franz M (2019) Cellular inflammation in pulmonary hypertension: detailed analysis of lung and right ventricular tissue, circulating immune cells and effects of a dual endothelin receptor antagonist. Clin Hemorheol Microcirc 73:497\u2013522","journal-title":"Clin Hemorheol Microcirc"},{"key":"2516_CR34","doi-asserted-by":"publisher","first-page":"176","DOI":"10.1161\/CIRCRESAHA.113.301129","volume":"115","author":"JJ Ryan","year":"2014","unstructured":"Ryan JJ, Archer SL (2014) The right ventricle in pulmonary arterial hypertension: disorders of metabolism, angiogenesis and adrenergic signaling in right ventricular failure. Circ Res 115:176\u2013188","journal-title":"Circ Res"},{"key":"2516_CR35","doi-asserted-by":"publisher","first-page":"873","DOI":"10.1083\/jcb.142.3.873","volume":"142","author":"G Serini","year":"1998","unstructured":"Serini G, Bochaton-Piallat ML, Ropraz P, Geinoz A, Borsi L, Zardi L, Gabbiani G (1998) The fibronectin domain ED-A is crucial for myofibroblastic phenotype induction by transforming growth factor-beta1. J Cell Biol 142:873\u2013881","journal-title":"J Cell Biol"},{"key":"2516_CR36","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1016\/j.matbio.2014.11.004","volume":"41","author":"AV Shinde","year":"2015","unstructured":"Shinde AV, Kelsh R, Peters JH, Sekiguchi K, Van De Water L, McKeown-Longo PJ (2015) The alpha4beta1 integrin and the EDA domain of fibronectin regulate a profibrotic phenotype in dermal fibroblasts. Matrix Biol 41:26\u201335","journal-title":"Matrix Biol"},{"key":"2516_CR37","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.01913-2018","author":"G Simonneau","year":"2019","unstructured":"Simonneau G, Montani D, Celermajer DS, Denton CP, Gatzoulis MA, Krowka M, Williams PG, Souza R (2019) Haemodynamic definitions and updated clinical classification of pulmonary hypertension. Eur Respir J. https:\/\/doi.org\/10.1183\/13993003.01913-2018","journal-title":"Eur Respir J"},{"key":"2516_CR38","doi-asserted-by":"publisher","first-page":"1485","DOI":"10.1093\/cvr\/cvae146","volume":"120","author":"I Singerer","year":"2024","unstructured":"Singerer I, Tempel L, Gruen K, Hei\u00df J, Gutte C, Matasci M, Schrepper A, Bauer R, Berndt A, Jung C, Schulze PC, Neri D, Franz M (2024) Extra domain A-containing fibronectin in pulmonary hypertension and treatment effects of a function-blocking antibody. Cardiovasc Res 120:1485\u20131497","journal-title":"Cardiovasc Res"},{"key":"2516_CR39","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1164\/rccm.201201-0164OC","volume":"186","author":"E Stacher","year":"2012","unstructured":"Stacher E, Graham BB, Hunt JM, Gandjeva A, Groshong SD, McLaughlin VV, Jessup M, Grizzle WE, Aldred MA, Cool CD, Tuder RM (2012) Modern age pathology of pulmonary arterial hypertension. Am J Respir Crit Care Med 186:261\u2013272","journal-title":"Am J Respir Crit Care Med"},{"key":"2516_CR40","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1002\/j.2040-4603.2011.tb00317.x","volume":"1","author":"KR Stenmark","year":"2011","unstructured":"Stenmark KR, Nozik-Grayck E, Gerasimovskaya E, Anwar A, Li M, Riddle S, Frid M (2011) The adventitia: sssential role in pulmonary vascular remodeling. Compr Physiol 1:141\u2013161","journal-title":"Compr Physiol"},{"key":"2516_CR41","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.j5492","volume":"360","author":"T Thenappan","year":"2018","unstructured":"Thenappan T, Ormiston ML, Ryan JJ, Archer SL (2018) Pulmonary arterial hypertension: pathogenesis and clinical management. BMJ 360:j5492","journal-title":"BMJ"},{"key":"2516_CR42","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1016\/j.addr.2015.11.001","volume":"97","author":"AD Theocharis","year":"2016","unstructured":"Theocharis AD, Skandalis SS, Gialeli C, Karamanos NK (2016) Extracellular matrix structure. Adv Drug Deliv Rev 97:4\u201327","journal-title":"Adv Drug Deliv Rev"},{"key":"2516_CR43","doi-asserted-by":"publisher","first-page":"1555","DOI":"10.1183\/09031936.00046612","volume":"40","author":"NF Voelkel","year":"2012","unstructured":"Voelkel NF, Gomez-Arroyo J, Abbate A, Bogaard HJ, Nicolls MR (2012) Pathobiology of pulmonary arterial hypertension and right ventricular failure. Eur Respir J 40:1555\u20131565","journal-title":"Eur Respir J"},{"key":"2516_CR44","doi-asserted-by":"publisher","first-page":"236","DOI":"10.1016\/j.jacc.2016.10.047","volume":"69","author":"A Vonk Noordegraaf","year":"2017","unstructured":"Vonk Noordegraaf A, Westerhof BE, Westerhof N (2017) The relationship between the right ventricle and its load in pulmonary hypertension. J Am Coll Cardiol 69:236\u2013243","journal-title":"J Am Coll Cardiol"},{"key":"2516_CR45","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.01900-2018","author":"A Vonk Noordegraaf","year":"2019","unstructured":"Vonk Noordegraaf A, Chin KM, Haddad F, Hassoun PM, Hemnes AR, Hopkins SR, Kawut SM, Langleben D, Lumens J, Naeije R (2019) Pathophysiology of the right ventricle and\u00a0of the pulmonary circulation in pulmonary hypertension: an update. Eur Respir J. https:\/\/doi.org\/10.1183\/13993003.01900-2018","journal-title":"Eur Respir J"},{"key":"2516_CR46","doi-asserted-by":"publisher","first-page":"538","DOI":"10.1002\/iub.493","volume":"63","author":"ES White","year":"2011","unstructured":"White ES, Muro AF (2011) Fibronectin splice variants: understanding their multiple roles in health and disease using engineered mouse models. IUBMB Life 63:538\u2013546","journal-title":"IUBMB Life"},{"key":"2516_CR47","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1002\/path.2388","volume":"216","author":"ES White","year":"2008","unstructured":"White ES, Baralle FE, Muro AF (2008) New insights into form and function of fibronectin splice variants. J Pathol 216:1\u201314","journal-title":"J Pathol"},{"issue":"18","key":"2516_CR48","doi-asserted-by":"publisher","first-page":"7094","DOI":"10.1073\/pnas.0402004101","volume":"101","author":"L Wu","year":"2004","unstructured":"Wu L, Noyan Ashraf MH, Facci M, Wang R, Paterson PG, Ferrie A, Juurlink BH (2004) Dietary approach to attenuate oxidative stress, hypertension, and inflammation in the cardiovascular system. Proc Natl Acad Sci U S A 101(18):7094\u20137099. https:\/\/doi.org\/10.1073\/pnas.0402004101","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"1","key":"2516_CR49","doi-asserted-by":"publisher","first-page":"11","DOI":"10.4196\/kjpp.24.397","volume":"30","author":"T Zhu","year":"2026","unstructured":"Zhu T, Xiao X, Li X, Liu Z (2026) Eupatilin alleviates right ventricular fibrosis in rats with pulmonary hypertension induced by monocrotaline. Korean J Physiol Pharmacol 30(1):11\u201318. https:\/\/doi.org\/10.4196\/kjpp.24.397","journal-title":"Korean J Physiol Pharmacol"},{"key":"2516_CR50","doi-asserted-by":"publisher","first-page":"3695454","DOI":"10.1155\/2016\/3695454","volume":"2016","author":"B Ziffels","year":"2016","unstructured":"Ziffels B, Ospel J, Gr\u00fcn K, Neri D, Pfeil A, Fritzenwanger M, Figulla HR, Jung C, Berndt A, Franz M (2016) Detection of soluble ED-A(+) fibronectin and evaluation as novel serum biomarker for cardiac tissue remodeling. Dis Markers 2016:3695454","journal-title":"Dis Markers"}],"container-title":["Histochemistry and Cell Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00418-026-02516-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00418-026-02516-3","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00418-026-02516-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,8]],"date-time":"2026-08-08T10:53:16Z","timestamp":1786186396000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00418-026-02516-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,8]]},"references-count":50,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["2516"],"URL":"https:\/\/doi.org\/10.1007\/s00418-026-02516-3","relation":{},"ISSN":["1432-119X"],"issn-type":[{"value":"1432-119X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,8]]},"assertion":[{"value":"27 April 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 July 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 August 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","label":"Conflict of interest","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"74"}}