{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T08:24:16Z","timestamp":1787214256771,"version":"build-2736575974"},"reference-count":35,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T00:00:00Z","timestamp":1787184000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T00:00:00Z","timestamp":1787184000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["CNPq, 302076\/2022-0"],"award-info":[{"award-number":["CNPq, 302076\/2022-0"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004901","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de Minas Gerais","doi-asserted-by":"publisher","award":["APQ 00946-23"],"award-info":[{"award-number":["APQ 00946-23"]}],"id":[{"id":"10.13039\/501100004901","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004901","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de Minas Gerais","doi-asserted-by":"publisher","award":["APQ 02029-21"],"award-info":[{"award-number":["APQ 02029-21"]}],"id":[{"id":"10.13039\/501100004901","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009730","name":"Universidade Federal De Ouro Preto","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100009730","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Histochem Cell Biol"],"DOI":"10.1007\/s00418-026-02523-4","type":"journal-article","created":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T07:46:44Z","timestamp":1787212004000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["High-sucrose diet induces MMP-9 activation and collagen deposition via oxidative stress in Swiss mice liver"],"prefix":"10.1007","volume":"164","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-2559-9178","authenticated-orcid":false,"given":"Mariana Alves","family":"Passos","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-7925-2146","authenticated-orcid":false,"given":"Juliana Leticia","family":"Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2586-5257","authenticated-orcid":false,"given":"T\u00falio C\u00e9sar Rodrigues","family":"Leite","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1645-6251","authenticated-orcid":false,"given":"Isabela Jesus","family":"de Deus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1970-2972","authenticated-orcid":false,"given":"Raianne","family":"dos Santos Baleeiro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-2804-4253","authenticated-orcid":false,"given":"Rafaella Dhom Ferrari Matos","family":"Gomes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9844-3472","authenticated-orcid":false,"given":"Wanderson Geraldo","family":"Lima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8882-5792","authenticated-orcid":false,"given":"Carla Speroni","family":"Ceron","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7866-3950","authenticated-orcid":false,"given":"S\u00edlvia","family":"Paula-Gomes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,8,20]]},"reference":[{"issue":"3","key":"2523_CR1","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1590\/0004-2730000002831","volume":"58","author":"IC Abreu","year":"2014","unstructured":"Abreu IC, Guerra JF, Pereira RR, Silva M, Lima WG, Silva ME, Pedrosa ML (2014) Hypercholesterolemic diet induces hepatic steatosis and alterations in mRNA expression of NADPH oxidase in rat livers. Arq Bras Endocrinol Metabol 58(3):251\u2013259. https:\/\/doi.org\/10.1590\/0004-2730000002831","journal-title":"Arq Bras Endocrinol Metabol"},{"issue":"1","key":"2523_CR2","doi-asserted-by":"publisher","DOI":"10.5812\/ijpr-143703","volume":"23","author":"B Aouey","year":"2024","unstructured":"Aouey B, Boukholda K, Ciobica A, Burlui V, Soulimani R, Chigr F, Fetoui H (2024) Renal fibrosis and oxidative stress induced by silica nanoparticles in male rats and its molecular mechanisms. Iran J Pharm Res 23(1):e143703. https:\/\/doi.org\/10.5812\/ijpr-143703","journal-title":"Iran J Pharm Res"},{"issue":"24","key":"2523_CR3","doi-asserted-by":"publisher","first-page":"7162","DOI":"10.1111\/febs.15701","volume":"288","author":"W Bassiouni","year":"2021","unstructured":"Bassiouni W, Ali MAM, Schulz R (2021) Multifunctional intracellular matrix metalloproteinases: implications in disease. FEBS J 288(24):7162\u20137182. https:\/\/doi.org\/10.1111\/febs.15701","journal-title":"FEBS J"},{"issue":"1","key":"2523_CR4","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1016\/S0021-9258(19)50881-X","volume":"195","author":"RF Beers","year":"1952","unstructured":"Beers RF, Sizer IW (1952) A spectrophotometric method for measuring the breakdown of hydrogen peroxide by catalase. J Biol Chem 195(1):133\u2013140. https:\/\/doi.org\/10.1016\/S0021-9258(19)50881-X","journal-title":"J Biol Chem"},{"issue":"24","key":"2523_CR5","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21249739","volume":"21","author":"GA Cabral-Pacheco","year":"2020","unstructured":"Cabral-Pacheco GA, Garza-Veloz I, Castruita-De la Rosa C, Ramirez-Acu\u00f1a JM, Perez-Romero BA, Guerrero-Rodriguez JF, Martinez-Avila N, Martinez-Fierro ML (2020) The roles of matrix metalloproteinases and their inhibitors in human diseases. Int J Mol Sci 21(24):9739. https:\/\/doi.org\/10.3390\/ijms21249739","journal-title":"Int J Mol Sci"},{"key":"2523_CR6","first-page":"318","volume":"35","author":"MMF Carvalho","year":"2018","unstructured":"Carvalho MMF, Reis LLT, Lopes JMM, Lage NN, Guerra JFC, Zago HP, Bonomo LF, Pereira RR, Lima WG, Silva ME, Pedrosa ML (2018) A\u00e7ai improves non-alcoholic fatty liver disease (NAFLD) induced by fructose. Nutr Hosp 35:318\u2013325","journal-title":"Nutr Hosp"},{"issue":"4","key":"2523_CR7","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1016\/j.matbio.2012.01.009","volume":"31","author":"CS Ceron","year":"2012","unstructured":"Ceron CS, Rizzi E, Guimar\u00e3es DA (2012) Time course involvement of matrix metalloproteinases in the vascular alterations of renovascular hypertension. Matrix Biol 31(4):261\u2013270. https:\/\/doi.org\/10.1016\/j.matbio.2012.01.009","journal-title":"Matrix Biol"},{"issue":"3","key":"2523_CR8","doi-asserted-by":"publisher","first-page":"4845","DOI":"10.4238\/2014.January.24.4","volume":"13","author":"JF Chi","year":"2014","unstructured":"Chi JF, Uzui H, Guo HY, Ueda T, Lee JD (2014) Effects of eplerenone on the activation of matrix metalloproteinase-2 stimulated by high glucose and interleukin-1\u03b2 in human cardiac fibroblasts. Genet Mol Res 13(3):4845\u20134855. https:\/\/doi.org\/10.4238\/2014.January.24.4","journal-title":"Genet Mol Res"},{"key":"2523_CR9","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/bs.pmbts.2017.02.005","volume":"147","author":"N Cui","year":"2017","unstructured":"Cui N, Hu M, Khalil RA (2017) Biochemical and biological attributes of matrix metalloproteinases. Prog Mol Biol Transl Sci 147:1\u201373. https:\/\/doi.org\/10.1016\/bs.pmbts.2017.02.005","journal-title":"Prog Mol Biol Transl Sci"},{"key":"2523_CR10","doi-asserted-by":"publisher","first-page":"e29","DOI":"10.1017\/S2040174425100123","volume":"16","author":"IJ de Deus","year":"2025","unstructured":"de Deus IJ, de Abreu ARR, de Andrade Fagundes MM, Silva JL, Breguez GS, Silva \u00c2A, de Queiroz KB (2025) Metabolic imprinting due to small litter size mitigates insulin resistance through interscapular brown adipose tissue activation in a high-sucrose diet model. J Develop Origins Health and Disease 16:e29. https:\/\/doi.org\/10.1017\/S2040174425100123","journal-title":"J Develop Origins Health and Disease"},{"issue":"12","key":"2523_CR11","doi-asserted-by":"publisher","first-page":"2331","DOI":"10.1002\/mnfr.201400241","volume":"58","author":"KB de Queiroz","year":"2014","unstructured":"de Queiroz KB, Coimbra RS, Ferreira AR, Carneiro CM, Paiva NCN, Costa DC, Guerra-S\u00e1 R (2014) Molecular mechanism driving retroperitoneal adipocyte hypertrophy and hyperplasia in response to a high-sugar diet. Mol Nutr Food Res 58(12):2331\u20132341. https:\/\/doi.org\/10.1002\/mnfr.201400241","journal-title":"Mol Nutr Food Res"},{"key":"2523_CR12","doi-asserted-by":"publisher","DOI":"10.1038\/s44324-024-00043-0","volume":"2","author":"SL Fisher","year":"2024","unstructured":"Fisher SL, Campbell GJ, Senior A, Bell-Anderson K (2024) The effect of high-sugar feeding on rodent metabolic phenotype: a systematic review and meta-analysis. NPJ Metab Health Dis 2:40. https:\/\/doi.org\/10.1038\/s44324-024-00043-0","journal-title":"NPJ Metab Health Dis"},{"issue":"5","key":"2523_CR13","doi-asserted-by":"publisher","first-page":"509","DOI":"10.1017\/S2040174420000598","volume":"11","author":"LM Fran\u00e7a","year":"2020","unstructured":"Fran\u00e7a LM, dos Santos PC, Barroso WA, Gondim RSD, Co\u00ealho CFF, Flister KFT, Paes AMA (2020) Post-weaning exposure to high-sucrose diet induces early non-alcoholic fatty liver disease onset and progression in male mice: role of dysfunctional white adipose tissue. J Dev Orig Health Dis 11(5):509\u2013520. https:\/\/doi.org\/10.1017\/S2040174420000598","journal-title":"J Dev Orig Health Dis"},{"issue":"5","key":"2523_CR14","doi-asserted-by":"publisher","DOI":"10.3390\/cells9051212","volume":"9","author":"E Geervliet","year":"2020","unstructured":"Geervliet E, Bansal R (2020) Matrix metalloproteinases as potential biomarkers and therapeutic targets in liver diseases. Cells 9(5):1212. https:\/\/doi.org\/10.3390\/cells9051212","journal-title":"Cells"},{"issue":"2","key":"2523_CR15","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.261898","volume":"137","author":"S Hey","year":"2024","unstructured":"Hey S, Linder S (2024) Matrix metalloproteinases at a glance. J Cell Sci 137(2):jcs261898. https:\/\/doi.org\/10.1242\/jcs.261898","journal-title":"J Cell Sci"},{"issue":"6","key":"2523_CR16","doi-asserted-by":"publisher","first-page":"1098","DOI":"10.1007\/s00125-016-3940-5","volume":"59","author":"JG Jones","year":"2016","unstructured":"Jones JG (2016) Hepatic glucose and lipid metabolism. Diabetologia 59(6):1098\u20131103. https:\/\/doi.org\/10.1007\/s00125-016-3940-5","journal-title":"Diabetologia"},{"issue":"4","key":"2523_CR17","doi-asserted-by":"publisher","first-page":"447","DOI":"10.1007\/BF01002772","volume":"11","author":"LC Junqueira","year":"1979","unstructured":"Junqueira LC, Bignolas G, Brentani RR (1979) Picrosirius staining plus polarization microscopy, a specific method for collagen detection in tissue sections. Histochem J 11(4):447\u2013455. https:\/\/doi.org\/10.1007\/BF01002772","journal-title":"Histochem J"},{"issue":"567","key":"2523_CR18","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aay6218","volume":"12","author":"S Khan","year":"2020","unstructured":"Khan S, Waliullah S, Godfrey V, Khan MAW, Ramachandran RA, Cantarel BL, Behrendt C, Peng L, Hooper LV, Zaki H (2020) Dietary simple sugars alter microbial ecology in the gut and promote colitis in mice. Sci Transl Med 12(567):eaay6218. https:\/\/doi.org\/10.1126\/scitranslmed.aay6218","journal-title":"Sci Transl Med"},{"issue":"3","key":"2523_CR19","doi-asserted-by":"publisher","first-page":"292","DOI":"10.1016\/S0022-3565(25)08738-5","volume":"82","author":"HI Kohn","year":"1944","unstructured":"Kohn HI, Liversedge M (1944) On a new aerobic metabolite whose production by brain is inhibited by apomorphine, emetine, ergotamine, epinephrine, and menadione. J Pharmacol Exp Ther 82(3):292\u2013300. https:\/\/doi.org\/10.1016\/S0022-3565(25)08738-5","journal-title":"J Pharmacol Exp Ther"},{"key":"2523_CR20","doi-asserted-by":"publisher","first-page":"346","DOI":"10.1016\/S0076-6879(94)33040-9","volume":"233","author":"RL Levine","year":"1994","unstructured":"Levine RL, Williams JA, Stadtman ER, Shacter E (1994) Carbonyl assays for determination of oxidatively modified proteins. Methods Enzymol 233:346\u2013357. https:\/\/doi.org\/10.1016\/S0076-6879(94)33040-9","journal-title":"Methods Enzymol"},{"issue":"7","key":"2523_CR21","doi-asserted-by":"publisher","first-page":"2496","DOI":"10.1111\/jocd.16295","volume":"23","author":"WZ Li","year":"2024","unstructured":"Li WZ, Liu XX, Shi YJ, Wang XR, Li L, Tai ML, Yi F (2024) Unveiling the mechanism of high sugar diet induced advanced glycosylation end products damage skin structure via extracellular matrix-receptor interaction pathway. J Cosmet Dermatol 23(7):2496\u20132508. https:\/\/doi.org\/10.1111\/jocd.16295","journal-title":"J Cosmet Dermatol"},{"key":"2523_CR22","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1016\/S0021-9258(19)52451-6","volume":"193","author":"OH Lowry","year":"1951","unstructured":"Lowry OH, Rosebrough NJ, Farr AL, Randall RJ (1951) Protein measurement with the Folin phenol reagent. J Biol Chem 193:265\u2013275. https:\/\/doi.org\/10.1016\/S0021-9258(19)52451-6","journal-title":"J Biol Chem"},{"issue":"3","key":"2523_CR23","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1111\/j.1432-1033.1974.tb03714.x","volume":"47","author":"S Marklund","year":"1974","unstructured":"Marklund S, Marklund G (1974) Involvement of the superoxide anion radical in the autoxidation of pyrogallol and a convenient assay for superoxide dismutase. Eur J Biochem 47(3):469\u2013474. https:\/\/doi.org\/10.1111\/j.1432-1033.1974.tb03714.x","journal-title":"Eur J Biochem"},{"issue":"12","key":"2523_CR24","doi-asserted-by":"publisher","first-page":"400","DOI":"10.1139\/cjpp-2025-0037","volume":"103","author":"BT Martins","year":"2025","unstructured":"Martins BT, de Deus IJ, Gutierres VV, Souza MV, da Silva TCA, de Andrade Fagundes MM, Ceron CS, Paula-Gomes S (2025) Insulin modulates MMP-2 and MMP-9 activities through the control of oxidative stress in the heart of diabetic rats. Can J Physiol Pharmacol 103(12):400\u2013408. https:\/\/doi.org\/10.1139\/cjpp-2025-0037","journal-title":"Can J Physiol Pharmacol"},{"issue":"1","key":"2523_CR25","doi-asserted-by":"publisher","first-page":"71","DOI":"10.20945\/2359-3997000000199","volume":"64","author":"DT Oliveira","year":"2020","unstructured":"Oliveira DT, Fernandes IC, Sousa GG, Santos TAP, Paiva NCN, Carneiro CM, Evangelista EA, Barboza NR, Guerra-S\u00e1 R (2020) High-sugar diet leads to obesity and metabolic diseases in ad libitum-fed rats irrespective of caloric intake. Arch Endocrinol Metab 64(1):71\u201381. https:\/\/doi.org\/10.20945\/2359-3997000000199","journal-title":"Arch Endocrinol Metab"},{"key":"2523_CR26","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2019.01370","volume":"9","author":"S Quintero-Fabi\u00e1n","year":"2019","unstructured":"Quintero-Fabi\u00e1n S, Arreola R, Becerril-Villanueva E, Torres-Romero JC, Arana-Arg\u00e1ez V, Lara-Riegos J, Ram\u00edrez-Camacho MA, Alvarez-S\u00e1nchez ME (2019) Role of matrix metalloproteinases in angiogenesis and cancer. Front Oncol 9:1370. https:\/\/doi.org\/10.3389\/fonc.2019.01370","journal-title":"Front Oncol"},{"issue":"11","key":"2523_CR27","doi-asserted-by":"publisher","first-page":"4932","DOI":"10.1002\/ptr.7959","volume":"37","author":"U Sabir","year":"2023","unstructured":"Sabir U, Gu HM, Zhang DW (2023) Extracellular matrix turnover: phytochemicals target and modulate the dual role of matrix metalloproteinases in liver fibrosis. Phytother Res 37(11):4932\u20134962. https:\/\/doi.org\/10.1002\/ptr.7959","journal-title":"Phytother Res"},{"issue":"11","key":"2523_CR28","doi-asserted-by":"publisher","first-page":"4059","DOI":"10.1172\/JCI94585","volume":"127","author":"S Softic","year":"2017","unstructured":"Softic S, Cohen DE, Kahn CR (2017) Divergent effects of glucose and fructose on hepatic lipogenesis and insulin signaling. J Clin Invest 127(11):4059\u20134074. https:\/\/doi.org\/10.1172\/JCI94585","journal-title":"J Clin Invest"},{"key":"2523_CR29","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1146\/annurev-med-042010-113026","volume":"63","author":"KL Stanhope","year":"2012","unstructured":"Stanhope KL (2012) Role of fructose-containing sugars in the epidemics of obesity and metabolic syndrome. Annu Rev Med 63:329\u2013343. https:\/\/doi.org\/10.1146\/annurev-med-042010-113026","journal-title":"Annu Rev Med"},{"key":"2523_CR30","doi-asserted-by":"publisher","DOI":"10.1016\/j.jnutbio.2021.108621","volume":"93","author":"S Sun","year":"2021","unstructured":"Sun S, Araki Y, Hanzawa F, Umeki M, Kojima T, Nishimura N, Ikeda S, Mochizuki S, Oda H (2021) High sucrose diet-induced dysbiosis of gut microbiota promotes fatty liver and hyperlipidemia in rats. J Nutr Biochem 93:108621. https:\/\/doi.org\/10.1016\/j.jnutbio.2021.108621","journal-title":"J Nutr Biochem"},{"key":"2523_CR31","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2474-14-255","volume":"14","author":"WC Tsai","year":"2013","unstructured":"Tsai WC, Liang FC, Cheng JW, Lin LP, Chang SC, Chen HH, Pang JHS (2013) High glucose concentration up-regulates the expression of matrix metalloproteinase-9 and -13 in tendon cells. BMC Musculoskelet Disord 14:255. https:\/\/doi.org\/10.1186\/1471-2474-14-255","journal-title":"BMC Musculoskelet Disord"},{"issue":"14","key":"2523_CR32","doi-asserted-by":"publisher","DOI":"10.3390\/nu14142940","volume":"14","author":"K Witek","year":"2022","unstructured":"Witek K, Wydra K, Filip M (2022) A high-sugar diet \u2013 Consumption, metabolism and health impacts with a focus on the development of substance use disorder: a narrative review. Nutrients 14(14):2940. https:\/\/doi.org\/10.3390\/nu14142940","journal-title":"Nutrients"},{"issue":"599","key":"2523_CR33","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.abe1692","volume":"13","author":"J Yu","year":"2021","unstructured":"Yu J, Zhu C, Wang X, Kim K, Bartolome A, Dongiovanni P, Valenti L, Pajvani UB (2021) Hepatocyte TLR4 triggers inter-hepatocyte Jagged1\/Notch signaling to determine NASH-induced fibrosis. Sci Transl Med 13(599):eabe1692. https:\/\/doi.org\/10.1126\/scitranslmed.abe1692","journal-title":"Sci Transl Med"},{"issue":"10","key":"2523_CR34","doi-asserted-by":"publisher","DOI":"10.3390\/nu12103181","volume":"12","author":"E \u017bebrowska","year":"2020","unstructured":"\u017bebrowska E, Chabowski A, Zalewska A, Maciejczyk M (2020) High-sugar diet disrupts hypothalamic but not cerebral cortex redox homeostasis. Nutrients 12(10):Article 3181. https:\/\/doi.org\/10.3390\/nu12103181","journal-title":"Nutrients"},{"issue":"5","key":"2523_CR35","doi-asserted-by":"publisher","first-page":"Article e210006","DOI":"10.1002\/cbdv.202100065","volume":"18","author":"X Zhang","year":"2021","unstructured":"Zhang X, Li J, Yang B, Leng Q, Li J, Wang X, Tang J (2021) Protective effects of polysaccharides from Cordyceps cicadae on high sugar\/high fat diet-induced metabolic syndrome in rats. Chem & Biodiversity 18(5):Article e2100065. https:\/\/doi.org\/10.1002\/cbdv.202100065","journal-title":"Chem & Biodiversity"}],"container-title":["Histochemistry and Cell Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00418-026-02523-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00418-026-02523-4","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00418-026-02523-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T07:46:45Z","timestamp":1787212005000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00418-026-02523-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,20]]},"references-count":35,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["2523"],"URL":"https:\/\/doi.org\/10.1007\/s00418-026-02523-4","relation":{},"ISSN":["1432-119X"],"issn-type":[{"value":"1432-119X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,20]]},"assertion":[{"value":"23 April 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 July 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 August 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.\n                      Ethical approval\n                      All experiments were performed in line with ethical principles for animal research adopted by the National Council for the Control of Animal Experimentation and approved by the Federal University of Ouro Preto Ethical Commission in Animal Research (no. 7422050723) and the Principles of Laboratory Animal Care published by the US National Institutes of Health (NIH publication no. 86\u201323, revised 1985).","order":1,"name":"Ethics","label":"Conflict of interest","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All authors agree with the content of this work, give consent to submit and approve the version to be published.","order":2,"name":"Ethics","label":"Consent to publication","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"75"}}