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Damage to the alveolar epithelial barrier (formed by junctions between alveolar epithelial cells I) has been described as a key mechanism of early fibrosis and therefore could be crucial for COVID-19-associated sequelae. The integrity of adherens junctions is regulated by p120 catenin and is crucial for barrier regulation in epithelial-mesenchymal-transition-driven diseases such as fibrogenesis and cancer. Abundance and expression of p120 catenin and intercellular contact regulating proteins (caveolin-1, P2X7R) were investigated retrospectively in COVID-19 lungs (acute, chronic) compared with healthy controls and interstitial lung disease of different etiologies (\n                    <jats:italic>n<\/jats:italic>\n                    = 6). p120 Catenin was further investigated in early injury models using profibrotic agents in murine lung and human alveolar epithelial cell culture. p120 Catenin abundance was higher in chronic COVID-19 compared with acute COVID-19, suggesting a role in fibrotic development. The interacting proteins caveolin-1 and P2X7R were simultaneously decreased in COVID-19, indicating a role in early pathophysiology. Early epithelial damage showed no changes in p120 catenin and its phospho-Y228 site in cell culture whereas p120 catenin was reduced in murine lung culture. Thus, alterations in and interactions between p120 catenin and caveolae associated proteins may represent a potential mechanism underlying COVID-19-induced pulmonary fibrosis.\n                  <\/jats:p>","DOI":"10.1007\/s00418-026-02533-2","type":"journal-article","created":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T08:42:04Z","timestamp":1789116124000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The role of alveolar epithelial junctions in early lung injury and COVID-19-induced fibrosis"],"prefix":"10.1007","volume":"164","author":[{"given":"Juli\u00e1n","family":"Wiegner","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Kasper","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mirko H. 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The funders had no role in the design of the study; in the collection, analyses, or interpretation of data, in the writing of the manuscript, or in the decision to publish the results.","order":1,"name":"Ethics","label":"Conflict of interest","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The human tissue study was performed in accordance with the ethical standards as laid down in the 1964 Declaration of Helsinki and approved by the Ethics Committee of the Technical University of Dresden (EK 59032007; 06 March 2007 and BO-EK-175052020; 22 March 2020). The animal study protocol was approved by the state directorate Dresden (DD24-5131\/365\/19 for TVT17\/2016; 20 December 2016).","order":2,"name":"Ethics","label":"Institutional review board statement","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All patients gave their informed consent prior to resection and approval was obtained from the local ethics committee at the TU Dresden (application number: EK 59032007; 06 March 2007). The data obtained from covid autopsies have been provided by the DeRegCovid register and in accordance with the Declaration of Helsinki and approved by the Ethics Committee at the Carl Gustav Carus University Clinic of the TU Dresden (application number: BO-EK-175052020; 22 March 2020).","order":3,"name":"Ethics","label":"Informed consent","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"85"}}