{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T05:13:11Z","timestamp":1776402791157,"version":"3.51.2"},"reference-count":41,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2005,4,8]],"date-time":"2005-04-08T00:00:00Z","timestamp":1112918400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int Arch Occup Environ Health"],"published-print":{"date-parts":[[2005,5]]},"DOI":"10.1007\/s00420-004-0590-6","type":"journal-article","created":{"date-parts":[[2005,4,7]],"date-time":"2005-04-07T15:10:27Z","timestamp":1112886627000},"page":"279-286","source":"Crossref","is-referenced-by-count":31,"title":["Enzymes as occupational and environmental respiratory sensitisers"],"prefix":"10.1007","volume":"78","author":[{"given":"Xaver","family":"Baur","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2005,4,8]]},"reference":[{"key":"590_CR1","first-page":"199","volume":"4","author":"NR Ackerman","year":"1977","unstructured":"Ackerman NR, Corkey R, Perkins D (1977) Pathogenesis of papain emphysema in the hamster. Am Rev Respir Dis 4:199","journal-title":"Am Rev Respir Dis"},{"key":"590_CR2","doi-asserted-by":"crossref","first-page":"4572","DOI":"10.4049\/jimmunol.169.8.4572","volume":"169","author":"N Asokananthan","year":"2002","unstructured":"Asokananthan N, Graham PT, Stewart DJ, Bakker AJ, Eidne KA, Thompson PJ, Stewart GA (2002) House dust mite allergens induce proinflammatory cytokines from respiratory epithelial cells: the cysteine protease allergen, Der\u00a0p\u00a01, activates protease-activated receptor (PAR)-2 and inactivates PAR-1. J Immunol 169:4572\u20134578","journal-title":"J Immunol"},{"key":"590_CR3","unstructured":"Association of Manufacturers and Formulators of Enzyme Products (AMFEP) (2001) List of commercial enzymes. Updated 1 October 2001 .Brussels. http:\/\/www.amfep.org"},{"key":"590_CR4","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1111\/j.1365-2222.1982.tb03121.x","volume":"12","author":"X Baur","year":"1982","unstructured":"Baur X, K\u00f6nig G, Bencze K, Fruhmann G (1982) Clinical symptoms and results of skin test, RAST and bronchial provocation test in thirty three papain workers: evidence for strong immunogenic potency and clinically relevant \u201cproteolytic effects of airborne papain\u201d. Clin Allergy 12:9\u201317","journal-title":"Clin Allergy"},{"key":"590_CR7","first-page":"13","volume":"11","author":"X Baur","year":"1989","unstructured":"Baur X, Sauer W, Weiss W, Fruhmann G (1989) Inhalant allergens in the modern baking industry. Immunol Allergy Pract 11:13\u201315","journal-title":"Immunol Allergy Pract"},{"issue":"30","key":"590_CR6","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1055\/s-2000-7046","volume":"125","author":"X Baur","year":"2000","unstructured":"Baur X, Sander I, van Kampen V (2000) Aerogene Enzyme sind aggressive berufliche Inhalationsallergene. Dtsch Med Wochenschr 125.30:912\u2013917","journal-title":"Dtsch Med Wochenschr"},{"key":"590_CR5","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1034\/j.1398-9995.2002.23702.x","volume":"57","author":"X Baur","year":"2002","unstructured":"Baur X, Melching-Kollmuss S, Koops F, Strassburger K, Zober A (2002) IgE-mediated allergy to phytase\u2014a new animal feed additive. Allergy 57:943\u2013945","journal-title":"Allergy"},{"key":"590_CR8","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1136\/oem.2002.006395","volume":"61","author":"J Brisman","year":"2004","unstructured":"Brisman J, Nieuwenhuijsen MJ, Venables KM, Putcha V, Gordon S, Taylor AJ (2004) Exposure\u2013response relations for work related respiratory symptoms and sensitisation in a cohort exposed to alpha-amylase. Occup Environ Med 61:551\u2013553","journal-title":"Occup Environ Med"},{"key":"590_CR9","doi-asserted-by":"crossref","first-page":"1899","DOI":"10.1016\/S0140-6736(00)03264-5","volume":"356","author":"P Cullinan","year":"2000","unstructured":"Cullinan P, Harris JM, Newman Taylor AJ, Hole AM, Jones M, Barnes F, Jolliffe G (2000) An outbreak of asthma in a modern detergent factory. Lancet 356:1899\u20131900","journal-title":"Lancet"},{"key":"590_CR10","volume-title":"List of MAK and BAT values 2004","author":"Deutsche Forschungsgemeinschaft","year":"2004","unstructured":"Deutsche Forschungsgemeinschaft (2004) List of MAK and BAT values 2004. Wiley-VCH, Weinheim"},{"key":"590_CR11","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.1016\/S0140-6736(69)92165-5","volume":"I","author":"MLH Flindt","year":"1969","unstructured":"Flindt MLH (1969) Pulmonary disease due to inhalation of derivatives of Bacillus subtilis containing proteolytic enzyme. Lancet I:1177\u20131181","journal-title":"Lancet"},{"key":"590_CR12","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.5694\/j.1326-5377.1971.tb88014.x","volume":"1","author":"B Gandevia","year":"1971","unstructured":"Gandevia B, Mitchel C (1971) The dangers of proteolytic enzymes to workers. Med J Aust 1:1032","journal-title":"Med J Aust"},{"key":"590_CR13","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1080\/00039896.1968.10665015","volume":"16","author":"I Goldring","year":"1968","unstructured":"Goldring I, Greenburg L, Ratner I (1968) On the production of emphysema in Syrian hamsters by aerosol inhalation of papain. Arch Environ Health 16:59\u201360","journal-title":"Arch Environ Health"},{"key":"590_CR14","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1046\/j.1365-2222.2003.01716.x","volume":"33","author":"L Gough","year":"2003","unstructured":"Gough L, Campbell E, Bayley D, Van Heeke G, Shakib F (2003) Proteolytic activity of the house dust mite allergen Der\u00a0p\u00a01 enhances allergenicity in a mouse inhalation model. Clin Exp Allergy 33:1159\u20131163","journal-title":"Clin Exp Allergy"},{"key":"590_CR15","first-page":"481","volume":"6","author":"P Gross","year":"1964","unstructured":"Gross P, Babyak A, Tolker E, Kaschak M (1964) Enzymatically produced pulmonary emphysema. J Occup Med 6:481","journal-title":"J Occup Med"},{"key":"590_CR16","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1080\/00039896.1965.10664169","volume":"11","author":"P Gross","year":"1965","unstructured":"Gross P, Pfitzer EA, Tolker E, Babyak MA, Kaschak M (1965) Experimental emphysema. Arch Environ Health 11:50\u201358","journal-title":"Arch Environ Health"},{"key":"590_CR17","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1136\/thx.53.5.368","volume":"53","author":"Z Hassim","year":"1998","unstructured":"Hassim Z, Maronese SE, Kumar RK (1998) Injury to murine airway epithelial cells by pollen enzymes. Thorax 53:368\u2013371","journal-title":"Thorax"},{"key":"590_CR18","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1093\/acprof:oso\/9780198528616.003.0013","volume-title":"Exposure assessment in occupational and environmental epidemiology","author":"D Heederik","year":"2003","unstructured":"Heederik D (2003) Allergen exposure and occupational respiratory allergy and asthma. In: Nieuwenhuijsen MJ (ed) Exposure assessment in occupational and environmental epidemiology. University Press, Oxford, pp. 203\u2013219"},{"key":"590_CR19","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/j.jaci.2003.11.026","volume":"113","author":"JH Hong","year":"2004","unstructured":"Hong JH, Lee SI, Kim KE, Yong TS, Seo JT, Sohn MH, Shin DM (2004) German cockroach extract activates protease-activated receptor 2 in human airway epithelial cells. J Allergy Clin Immunol 113:315\u2013319","journal-title":"J Allergy Clin Immunol"},{"key":"590_CR20","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1164\/ajrccm.154.1.8680668","volume":"154","author":"R Houba","year":"1996","unstructured":"Houba R, Heederik DJJ, Doekes G, van Run PEM (1996) Exposure\u2013sensitization relationship for \u03b1-amylase allergens in the baking industry. Am J Respir Crit Care Med 154:130\u2013136","journal-title":"Am J Respir Crit Care Med"},{"key":"590_CR21","unstructured":"International Union of Immunological Societies (IUIS). Allergen Nomenclature Sub-Committee (ed) List of allergens as of 7 June 2004, http:\/\/www.allergen.org\/list.htm"},{"key":"590_CR22","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1136\/oem.54.9.671","volume":"54","author":"CR Johnsen","year":"1997","unstructured":"Johnsen CR, Sorensen TB, Larsen AI, Secher AB, Andreasen E, Kofoed GS, Nielsen LF, Gyntelberg F (1997) Allergy risk in an enzyme producing plant: a retrospective follow up study. Occup Environ Med 54:671\u2013675","journal-title":"Occup Environ Med"},{"key":"590_CR23","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1093\/occmed\/27.1.3","volume":"27","author":"CP Juniper","year":"1977","unstructured":"Juniper CP, How MJ, Goodwin BF, Kinshott AK (1977) Bacillus subtilis enzymes: A 7-year clinical, epidemiological and immunological study of an industrial allergen. J Soc Occup Med 27:3\u201312","journal-title":"J Soc Occup Med"},{"key":"590_CR24","first-page":"120","volume":"19","author":"M K\u00e4mpe","year":"1989","unstructured":"K\u00e4mpe M, Stalenheim G, Edling C, Norb\u00e4ck D, Almby B (1989) Enzyme allergies in research laboratories. Clin Exp Allergy 19:120","journal-title":"Clin Exp Allergy"},{"key":"590_CR25","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1007\/s00420-002-0326-4","volume":"75","author":"O Kizkin","year":"2002","unstructured":"Kizkin O, Suleyman GT, Hacievliyagil S, Gunen H (2002) Proteolytic enzyme sensitivity and decrease in respiratory function (a 10-year follow-up). Int Arch Occup Environ Health 75:441\u2013444","journal-title":"Int Arch Occup Environ Health"},{"key":"590_CR26","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1159\/000065882","volume":"129","author":"VP Kurup","year":"2002","unstructured":"Kurup VP, Xia JQ, Shen HD, Rickaby DA, Henderson JD Jr, Fink JN, Chou H, Kelly KJ, Dawson CA (2002) Alkaline serine proteinase from Aspergillus fumigatus has synergistic effects on Asp-f-2-induced immune response in mice. Int Arch Allergy Immunol 129:129\u2013137","journal-title":"Int Arch Allergy Immunol"},{"key":"590_CR27","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1002\/(SICI)1097-0274(199705)31:5<570::AID-AJIM11>3.0.CO;2-W","volume":"31","author":"DC Muir","year":"1997","unstructured":"Muir DC, Verrall AB, Julian JA, Millman JM, Beaudin MA, Dolovich J (1997) Occupational sensitization to lactase. Am J Ind Med 31:570\u2013571","journal-title":"Am J Ind Med"},{"key":"590_CR28","first-page":"158","volume":"33","author":"AW Musk","year":"1976","unstructured":"Musk AW, Gandevia B (1976) Loss of pulmonary elastic recoil in workers formerly exposed to proteolytic enzyme (alcalase) in the detergent industry. Br J Ind Med 33:158\u2013165","journal-title":"Br J Ind Med"},{"key":"590_CR29","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1016\/S0140-6736(70)90924-4","volume":"1","author":"ML Newhouse","year":"1970","unstructured":"Newhouse ML, Tagg B, Pocock SJ, McEwan AC (1970) An epidemiological study of workers producing enzyme washing powders. Lancet 1:689\u2013693","journal-title":"Lancet"},{"key":"590_CR30","unstructured":"Nomenclature Committee of the International Union of Biochemistry and Molecular Biology (NC-IUBMB). Enzyme nomenclature. Recommendations of the Nomenclature Committee of the International Union of Biochemistry and Molecular Biology on the nomenclature and classification of enzyme-catalysed reactions. http:\/\/www.chem.qmul.ac.uk\/iubmb\/enzyme\/"},{"key":"590_CR31","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1080\/00039896.1967.10664929","volume":"15","author":"F Palecek","year":"1967","unstructured":"Palecek F, Palecekova M, Aviado DM (1967) Emphysema in immature rats. Condition produced by tracheal constriction and papain. Arch Environ Health 15:332\u2013342","journal-title":"Arch Environ Health"},{"key":"590_CR32","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1016\/S0091-6749(98)70109-5","volume":"102","author":"I Sander","year":"1998","unstructured":"Sander I, Raulf-Heimsoth M, Siethoff C, Lohaus C, Meyer HE, Baur X (1998) Allergy to Aspergillus-derived enzymes in baking industry: identification of \u03b2-xylosidase from Aspergillus niger as new allergen (Asp\u00a0n\u00a014). J Allergy Clin Immunol 102:256\u2013264","journal-title":"J Allergy Clin Immunol"},{"key":"590_CR33","doi-asserted-by":"crossref","first-page":"1511","DOI":"10.1046\/j.1365-2222.2000.00893.x","volume":"30","author":"MK Schweigert","year":"2000","unstructured":"Schweigert MK, Mackenzie DP, Sarlo K (2000) Occupational asthma and allergy associated with the use of enzymes in the detergent industry\u2014a review of the epidemiology, toxicology and methods of prevention. Clin Exp Allergy 30:1511\u20131518","journal-title":"Clin Exp Allergy"},{"key":"590_CR35","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1097\/00130832-200102000-00016","volume":"1","author":"GA Stewart","year":"2001","unstructured":"Stewart GA, McWilliam AS (2001) Endogenous function and biological significance of aeroallergens: an update. Curr Opin Allergy Clin Immunol 1:95\u2013103","journal-title":"Curr Opin Allergy Clin Immunol"},{"key":"590_CR34","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1111\/j.1399-3038.1993.tb00087.x","volume":"4","author":"GA Stewart","year":"1993","unstructured":"Stewart GA, Thomsen PJ, McWilliam AS (1993) Biochemical properties of aeroallergens: contributory factors in allergic sensitization. Pediatr Allergy Immunol 4:163\u2013172","journal-title":"Pediatr Allergy Immunol"},{"key":"590_CR36","unstructured":"Strassburger K, Bossert J, Baur X, Zober A (1999) Sensibilisierungen durch die Enzyme Phytase und Xylanase. In: Hallier E, B\u00fcnger J (eds) Gesundheitsgefahren durch biologische Arbeitsstoffe. 38. Jahrestagung der Deutschen Gesellschaft f\u00fcr Arbeitsmedizin und Umweltmedizin e.V. Rindt, Fulda, pp 525\u2013527"},{"key":"590_CR37","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1136\/oem.53.10.670","volume":"53","author":"M Vanhanen","year":"1996","unstructured":"Vanhanen M, Tuomi T, Hokkanen H, Tupasela O, Tuomainen A, Holmberg PC, Leisola M, Nordman H (1996) Enzyme exposure and enzyme sensitisation in the baking industry. Occup Environ Med 53:670\u2013676","journal-title":"Occup Environ Med"},{"key":"590_CR38","doi-asserted-by":"crossref","first-page":"385","DOI":"10.5271\/sjweh.236","volume":"23","author":"M Vanhanen","year":"1997","unstructured":"Vanhanen M, Tuomi T, Nordman H, Tupasela O, Holmberg PC, Miettinen M, Mutanen P, Leisola M (1997) Sensitization to industrial enzymes in enzyme research and production. Scand J Work Environ Health 23:385\u2013391","journal-title":"Scand J Work Environ Health"},{"key":"590_CR39","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1001\/jama.1971.03190040019005","volume":"217","author":"H Weill","year":"1971","unstructured":"Weill H, Waddell LC, Ziskind M (1971) A study of workers exposed to detergent enzymes. J Am Med Assoc 217:425\u2013433","journal-title":"J Am Med Assoc"},{"key":"590_CR40","first-page":"1584","volume":"99","author":"B W\u00fcthrich","year":"1969","unstructured":"W\u00fcthrich B, Ott F (1969) Berufsasthma durch Proteasen in der Waschmittelindustrie. Schweiz Med Wochenschr 99:1584\u20131586","journal-title":"Schweiz Med Wochenschr"},{"key":"590_CR41","doi-asserted-by":"crossref","first-page":"1678","DOI":"10.1126\/science.1095336","volume":"304","author":"Zhu","year":"2004","unstructured":"Zhu Z, Zheng T, Homer RH, Kim Y-K, Chen NY, Cohn L, Hamid Q, Elias (2004) Acidic mammalian chitinase in asthmatic Th1 inflammation and IL-13 pathway activation. Science 304:1678\u20131682","journal-title":"Science"}],"container-title":["International Archives of Occupational and Environmental Health"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00420-004-0590-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00420-004-0590-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00420-004-0590-6","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,4,6]],"date-time":"2020-04-06T18:16:10Z","timestamp":1586196970000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00420-004-0590-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,4,8]]},"references-count":41,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2005,5]]}},"alternative-id":["590"],"URL":"https:\/\/doi.org\/10.1007\/s00420-004-0590-6","relation":{},"ISSN":["0340-0131","1432-1246"],"issn-type":[{"value":"0340-0131","type":"print"},{"value":"1432-1246","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,4,8]]}}}