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Follow-up ended mid-2015. Early Exit comprised episodes of either pensioning, long-term sickness absence or unemployment\u2009\u2265\u200918\u00a0months. Total follow-up years were 8.422. Working conditions were partly assessed by the Copenhagen Psychosocial Questionnaire (COPSOQ). Through Cox regressions, associations of baseline working conditions with time to event of exit were estimated\u2014adjusting for baseline age, gender, poverty, fixed-term contract and socioeconomic position.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In multiple regressions, awkward body postures (HR\u2009=\u20091.24; 95% CI\u2009=\u20091.07\u20131.44), heavy lifting (1.17; 1.00\u20131.37) and high work pace (1.41; 1.16\u20131.72) were associated with exit. The estimated attributable fraction of exit for being exposed to less than optimal work environment was 25%. Regarding specific exit routes, repetitive movements (1.25; 1.03\u20131.53) increased the risk for the long-term sickness absence; work pace (1.86; 1.22\u20132.86) and role clarity (0.55; 0.31\u20131.00) were associated to unemployment; and control over working time (0.72; 0.56\u20130.95) decreased the risk of the early retirement.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Work environment seems to be important for subsequent early exit from work. Physical and psychosocial demands seem to be associated to exit to a stronger extent than resources at work.<\/jats:p><\/jats:sec>","DOI":"10.1007\/s00420-020-01566-x","type":"journal-article","created":{"date-parts":[[2020,9,15]],"date-time":"2020-09-15T04:12:36Z","timestamp":1600143156000},"page":"117-138","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Working conditions as risk factors for early exit from work\u2014in a cohort of 2351 employees in Germany"],"prefix":"10.1007","volume":"94","author":[{"given":"Angelo","family":"d\u2019Errico","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3864-6347","authenticated-orcid":false,"given":"Hermann","family":"Burr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dagmar","family":"Pattloch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norbert","family":"Kersten","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uwe","family":"Rose","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,9,15]]},"reference":[{"issue":"1","key":"1566_CR1","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1080\/14034940600858474","volume":"35","author":"K Albertsen","year":"2007","unstructured":"Albertsen K, Lund T, Christensen KB, Kristensen TS, Villadsen E (2007) Predictors of disability pension over a 10-year period for men and women. 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