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Furthermore, we elucidated CRP as a possible mediator and\/or moderator of effects of shift work on pain.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>Data from a 7\u00a0years follow\u2010up study were analyzed (<jats:italic>N<\/jats:italic>\u2009=\u20092323). Shift work and chronic pain of \u201cneck\/shoulder\u201d, \u201carm\/hand\u201d, \u201cupper back\u201d, \u201clow back\u201d, \u201chip\/leg\/feet\u201d, and \u201cother regions\u201d were measured by questionnaires. \u201cChronic widespread pain\u201d, \u201cnumber of chronic pain sites\u201d, and \u201cany chronic pain\u201d were computed. CRP was measured in serum samples. Logistic and Poisson regressions were conducted. Mediation was assessed by casual mediation analyses and moderation by the Relative Excess Risk due to Interaction (RERI).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Shift work was not associated with any chronic pain variable and no mediation was detected. CRP was associated with low back pain, hip\/leg pain, and \u201cnumber of pain sites\u201d, and also with the combination of shift work and CRP of 1\u20132.99\u00a0mg\/L (compared to: no shiftwork and CRP\u2009&lt;\u20091). Additionally, shiftwork and CRP 1\u20132.99\u00a0mg\/L was associated with risk of \u201cany chronic pain\u201d (OR: 1.76, 95% CI: 1.12, 2.85), which was not associated with CRP alone. Moderation analyses suggested the risks for \u201cany chronic pain\u201d and \u201cnumber of pain regions\u201d increased when individuals with elevated CRP worked shifts\u2014beyond what the separate effects of CRP and shift would suggest.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>We found no evidence of shift work in general affecting CRP or chronic pain. However, shift work and elevated CRP combined may influence chronic pain.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00420-020-01626-2","type":"journal-article","created":{"date-parts":[[2021,2,9]],"date-time":"2021-02-09T03:31:18Z","timestamp":1612841478000},"page":"1013-1022","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Shift work, low-grade inflammation, and chronic pain: a 7-year prospective study"],"prefix":"10.1007","volume":"94","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5530-7526","authenticated-orcid":false,"given":"Jan Olav","family":"Christensen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristian Bernhard","family":"Nilsen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laila Arnesdatter","family":"Hopstock","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00d3l\u00f6f Anna","family":"Steingr\u00edmsd\u00f3ttir","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher Sivert","family":"Nielsen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John-Anker","family":"Zwart","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dagfinn","family":"Matre","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,2,7]]},"reference":[{"issue":"2","key":"1626_CR1","doi-asserted-by":"publisher","first-page":"85","DOI":"10.5271\/sjweh.410","volume":"25","author":"H B\u00f8ggild","year":"1999","unstructured":"B\u00f8ggild H, Knutsson A (1999) Shift work, risk factors and cardiovascular disease. 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