{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T06:34:19Z","timestamp":1772087659605,"version":"3.50.1"},"reference-count":38,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2021,3,17]],"date-time":"2021-03-17T00:00:00Z","timestamp":1615939200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,3,17]],"date-time":"2021-03-17T00:00:00Z","timestamp":1615939200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Int Arch Occup Environ Health"],"published-print":{"date-parts":[[2021,8]]},"DOI":"10.1007\/s00420-021-01679-x","type":"journal-article","created":{"date-parts":[[2021,3,17]],"date-time":"2021-03-17T20:18:50Z","timestamp":1616012330000},"page":"1317-1325","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Evaluation of a safe infusion device on reducing occupational exposure of nurses to antineoplastic drugs: a comparative prospective study. Contamoins-1"],"prefix":"10.1007","volume":"94","author":[{"given":"Fabien","family":"Forges","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emeline","family":"Blanc","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bastien","family":"Raymond","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandrine","family":"Menguy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Agn\u00e8s","family":"Mac\u00e9","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marion","family":"Hugues","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Corinne","family":"Macron","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wafa","family":"Bouleftour","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabien","family":"Tinquaut","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00e9r\u00f4me","family":"Guitton","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xavier","family":"Simo\u00ebns","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,3,17]]},"reference":[{"key":"1679_CR1","first-page":"428","volume":"65","author":"J-F Bussi\u00e8res","year":"2012","unstructured":"Bussi\u00e8res J-F, Tanguay C, Touzin K et al (2012) Environmental contamination with hazardous drugs in quebec hospitals. Can J Hosp Pharm 65:428\u2013435","journal-title":"Can J Hosp Pharm"},{"key":"1679_CR2","doi-asserted-by":"publisher","first-page":"1019","DOI":"10.1097\/JOM.0b013e3181f72b63","volume":"52","author":"TH Connor","year":"2010","unstructured":"Connor TH, DeBord DG, Pretty JR et al (2010) Evaluation of antineoplastic drug exposure of health care workers at three university-based US cancer centers. J Occup Environ Med 52:1019\u20131027. https:\/\/doi.org\/10.1097\/JOM.0b013e3181f72b63","journal-title":"J Occup Environ Med"},{"key":"1679_CR3","doi-asserted-by":"publisher","first-page":"619","DOI":"10.1093\/annhyg\/mei045","volume":"49","author":"S Crauste-Manciet","year":"2005","unstructured":"Crauste-Manciet S, Sessink PJM, Ferrari S et al (2005) Environmental contamination with cytotoxic drugs in healthcare using positive air pressure isolators. Ann Occup Hyg 49:619\u2013628. https:\/\/doi.org\/10.1093\/annhyg\/mei045","journal-title":"Ann Occup Hyg"},{"key":"1679_CR4","first-page":"900","volume":"35","author":"AL Donner","year":"1978","unstructured":"Donner AL (1978) Possible risk of working with antineoplastic drugs in horizontal laminar flow hoods. Am J Hosp Pharm 35:900","journal-title":"Am J Hosp Pharm"},{"key":"1679_CR5","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1191\/1078155205jp155oa","volume":"11","author":"G Dranitsaris","year":"2005","unstructured":"Dranitsaris G, Johnston M, Poirier S et al (2005) Are health care providers who work with cancer drugs at an increased risk for toxic events? A systematic review and meta-analysis of the literature. J Oncol Pharm Pract 11:69\u201378. https:\/\/doi.org\/10.1191\/1078155205jp155oa","journal-title":"J Oncol Pharm Pract"},{"key":"1679_CR6","doi-asserted-by":"publisher","first-page":"1250","DOI":"10.1016\/S0140-6736(79)91939-1","volume":"1","author":"K Falck","year":"1979","unstructured":"Falck K, Gr\u00f6hn P, Sorsa M et al (1979) Mutagenicity in urine of nurses handling cytostatic drugs. Lancet Lond Engl 1:1250\u20131251","journal-title":"Lancet Lond Engl"},{"issue":"1","key":"1679_CR7","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1191\/1078155203jp102oa","volume":"9","author":"B Favier","year":"2003","unstructured":"Favier B, Gilles L, Ardiet C, Latour JF (2003) External contamination of vials containing cytotoxic agents supplied by pharmaceutical manufacturers. J Oncol Pharm Pract 9(1):15\u201320","journal-title":"J Oncol Pharm Pract"},{"key":"1679_CR8","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1177\/1078155210380291","volume":"17","author":"F Forges","year":"2011","unstructured":"Forges F, Simoens X, Chauvin F (2011) Comparative parallel assessment of a transfer device in reducing 5-fluorouracil environmental contamination inside positive air pressure isolators. J Oncol Pharm Pract 17:61\u201367. https:\/\/doi.org\/10.1177\/1078155210380291","journal-title":"J Oncol Pharm Pract"},{"key":"1679_CR9","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1093\/annhyg\/meh017","volume":"48","author":"W Fransman","year":"2004","unstructured":"Fransman W, Vermeulen R, Kromhout H (2004) Occupational dermal exposure to cyclophosphamide in Dutch hospitals: a pilot study. Ann Occup Hyg 48:237\u2013244. https:\/\/doi.org\/10.1093\/annhyg\/meh017","journal-title":"Ann Occup Hyg"},{"key":"1679_CR10","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1097\/01.ede.0000246827.44093.c1","volume":"18","author":"W Fransman","year":"2007","unstructured":"Fransman W, Roeleveld N, Peelen S et al (2007) Nurses with dermal exposure to antineoplastic drugs: reproductive outcomes. Epidemiol Camb Mass 18:112\u2013119. https:\/\/doi.org\/10.1097\/01.ede.0000246827.44093.c1","journal-title":"Epidemiol Camb Mass"},{"key":"1679_CR11","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/S1775-8785(04)93002-0","volume":"65","author":"L Gilles","year":"2004","unstructured":"Gilles L, Favier B, Lombard I et al (2004) M\u00e9dicaments cytotoxiques\u202f: \u00e9valuation de l\u2019impact de la purge des lignes de perfusion sur l\u2019exposition du personnel infirmier. Arch Mal Prof Environ 65:9\u201317. https:\/\/doi.org\/10.1016\/S1775-8785(04)93002-0","journal-title":"Arch Mal Prof Environ"},{"key":"1679_CR12","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD012860.pub2","author":"KS Gurusamy","year":"2018","unstructured":"Gurusamy KS, Best LM, Tanguay C et al (2018) Closed-system drug-transfer devices plus safe handling of hazardous drugs versus safe handling alone for reducing exposure to infusional hazardous drugs in healthcare staff. Cochrane Database Syst Rev. https:\/\/doi.org\/10.1002\/14651858.CD012860.pub2","journal-title":"Cochrane Database Syst Rev"},{"key":"1679_CR13","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1136\/jech.39.2.141","volume":"39","author":"K Hemminki","year":"1985","unstructured":"Hemminki K, Kyyr\u00f6nen P, Lindbohm ML (1985) Spontaneous abortions and malformations in the offspring of nurses exposed to anaesthetic gases, cytostatic drugs, and other potential hazards in hospitals, based on registered information of outcome. J Epidemiol Commun Health 39:141\u2013147","journal-title":"J Epidemiol Commun Health"},{"key":"1679_CR14","doi-asserted-by":"publisher","first-page":"444","DOI":"10.1093\/annhyg\/mes081","volume":"57","author":"TK Kiffmeyer","year":"2013","unstructured":"Kiffmeyer TK, Tuerk J, Hahn M et al (2013) Application and assessment of a regular environmental monitoring of the antineoplastic drug contamination level in pharmacies\u2014the MEWIP project. Ann Occup Hyg 57:444\u2013455. https:\/\/doi.org\/10.1093\/annhyg\/mes081","journal-title":"Ann Occup Hyg"},{"key":"1679_CR15","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1007\/s00420-012-0742-z","volume":"86","author":"B Kopp","year":"2013","unstructured":"Kopp B, Schierl R, Nowak D (2013) Evaluation of working practices and surface contamination with antineoplastic drugs in outpatient oncology health care settings. Int Arch Occup Environ Health 86:47\u201355. https:\/\/doi.org\/10.1007\/s00420-012-0742-z","journal-title":"Int Arch Occup Environ Health"},{"key":"1679_CR16","doi-asserted-by":"publisher","first-page":"551","DOI":"10.1016\/S0003-4878(00)00050-8","volume":"44","author":"H Kromhout","year":"2000","unstructured":"Kromhout H, Hoek F, Uitterhoeve R et al (2000) Postulating a dermal pathway for exposure to anti-neoplastic drugs among hospital workers. Applying a conceptual model to the results of three workplace surveys. Ann Occup Hyg 44:551\u2013560","journal-title":"Ann Occup Hyg"},{"key":"1679_CR17","first-page":"432","volume":"94","author":"S Krstev","year":"2003","unstructured":"Krstev S, Perunici\u0107 B, Vidakovi\u0107 A (2003) Work practice and some adverse health effects in nurses handling antineoplastic drugs. Med Lav 94:432\u2013439","journal-title":"Med Lav"},{"issue":"Suppl 6","key":"1679_CR18","doi-asserted-by":"publisher","first-page":"S29","DOI":"10.1097\/NAN.0000000000000142","volume":"38","author":"L Lalande","year":"2015","unstructured":"Lalande L, Galy G, Dussossoy E et al (2015) Evaluation of safe infusion devices for antineoplastic administration. J Infus Nurs 38(Suppl 6):S29-35. https:\/\/doi.org\/10.1097\/NAN.0000000000000142","journal-title":"J Infus Nurs"},{"key":"1679_CR19","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1002\/em.21852","volume":"55","author":"MA McDiarmid","year":"2014","unstructured":"McDiarmid MA, Rogers B, Oliver MS (2014) Chromosomal effects of non-alkylating drug exposure in oncology personnel. Environ Mol Mutagen 55:369\u2013374. https:\/\/doi.org\/10.1002\/em.21852","journal-title":"Environ Mol Mutagen"},{"key":"1679_CR20","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1007\/s00420-013-0862-0","volume":"87","author":"D Merger","year":"2014","unstructured":"Merger D, Tanguay C, Langlois E et al (2014) Multicenter study of environmental contamination with antineoplastic drugs in 33 Canadian hospitals. Int Arch Occup Environ Health 87:307\u2013313. https:\/\/doi.org\/10.1007\/s00420-013-0862-0","journal-title":"Int Arch Occup Environ Health"},{"key":"1679_CR21","doi-asserted-by":"publisher","first-page":"240","DOI":"10.1093\/annhyg\/mes057","volume":"57","author":"P Odraska","year":"2013","unstructured":"Odraska P, Dolezalova L, Kuta J et al (2013) Evaluation of the efficacy of additional measures introduced for the protection of healthcare personnel handling antineoplastic drugs. Ann Occup Hyg 57:240\u2013250. https:\/\/doi.org\/10.1093\/annhyg\/mes057","journal-title":"Ann Occup Hyg"},{"key":"1679_CR22","doi-asserted-by":"publisher","DOI":"10.1177\/1078155216643860","author":"C Poupeau","year":"2016","unstructured":"Poupeau C, Tanguay C, Plante C et al (2016) Pilot study of biological monitoring of four antineoplastic drugs among Canadian healthcare workers. J Oncol Pharm Pract. https:\/\/doi.org\/10.1177\/1078155216643860","journal-title":"J Oncol Pharm Pract"},{"key":"1679_CR23","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1186\/1472-6955-9-15","volume":"9","author":"PA Ratner","year":"2010","unstructured":"Ratner PA, Spinelli JJ, Beking K et al (2010) Cancer incidence and adverse pregnancy outcome in registered nurses potentially exposed to antineoplastic drugs. BMC Nurs 9:15. https:\/\/doi.org\/10.1186\/1472-6955-9-15","journal-title":"BMC Nurs"},{"key":"1679_CR24","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1016\/j.clinthera.2014.01.016","volume":"36","author":"C Rioufol","year":"2014","unstructured":"Rioufol C, Ranchon F, Schwiertz V et al (2014) Administration of anticancer drugs: exposure in hospital nurses. Clin Ther 36:401\u2013407. https:\/\/doi.org\/10.1016\/j.clinthera.2014.01.016","journal-title":"Clin Ther"},{"key":"1679_CR25","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1002\/bmc.559","volume":"20","author":"FM Rubino","year":"2006","unstructured":"Rubino FM, Verduci C, Buratti M et al (2006) Assay of urinary alpha-fluoro-beta-alanine by gas chromatography-mass spectrometry for the biological monitoring of occupational exposure to 5-fluorouracil in oncology nurses and pharmacy technicians. Biomed Chromatogr 20:257\u2013266. https:\/\/doi.org\/10.1002\/bmc.559","journal-title":"Biomed Chromatogr"},{"key":"1679_CR26","doi-asserted-by":"publisher","first-page":"703","DOI":"10.1093\/annhyg\/mep050","volume":"53","author":"R Schierl","year":"2009","unstructured":"Schierl R, B\u00f6hlandt A, Nowak D (2009) Guidance values for surface monitoring of antineoplastic drugs in German pharmacies. Ann Occup Hyg 53:703\u2013711. https:\/\/doi.org\/10.1093\/annhyg\/mep050","journal-title":"Ann Occup Hyg"},{"key":"1679_CR27","doi-asserted-by":"publisher","first-page":"1173","DOI":"10.1056\/NEJM198511073131901","volume":"313","author":"SG Selevan","year":"1985","unstructured":"Selevan SG, Lindbohm ML, Hornung RW, Hemminki K (1985) A study of occupational exposure to antineoplastic drugs and fetal loss in nurses. N Engl J Med 313:1173\u20131178. https:\/\/doi.org\/10.1056\/NEJM198511073131901","journal-title":"N Engl J Med"},{"key":"1679_CR28","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1080\/00039896.1994.9940377","volume":"49","author":"PJ Sessink","year":"1994","unstructured":"Sessink PJ, Van de Kerkhof MC, Anzion RB et al (1994) Environmental contamination and assessment of exposure to antineoplastic agents by determination of cyclophosphamide in urine of exposed pharmacy technicians: is skin absorption an important exposure route? Arch Environ Health 49:165\u2013169. https:\/\/doi.org\/10.1080\/00039896.1994.9940377","journal-title":"Arch Environ Health"},{"key":"1679_CR29","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1007\/BF00385647","volume":"67","author":"PJ Sessink","year":"1995","unstructured":"Sessink PJ, Kroese ED, van Kranen HJ, Bos RP (1995) Cancer risk assessment for health care workers occupationally exposed to cyclophosphamide. Int Arch Occup Environ Health 67:317\u2013323","journal-title":"Int Arch Occup Environ Health"},{"key":"1679_CR30","doi-asserted-by":"publisher","first-page":"e0159052","DOI":"10.1371\/journal.pone.0159052","volume":"11","author":"N Simon","year":"2016","unstructured":"Simon N, Vasseur M, Pinturaud M et al (2016) Effectiveness of a closed-system transfer device in reducing surface contamination in a new antineoplastic drug-compounding unit: a prospective, controlled parallel study. PLoS ONE 11:e0159052. https:\/\/doi.org\/10.1371\/journal.pone.0159052","journal-title":"PLoS ONE"},{"key":"1679_CR31","first-page":"855","volume":"49","author":"T Skov","year":"1992","unstructured":"Skov T, Maarup B, Olsen J et al (1992) Leukaemia and reproductive outcome among nurses handling antineoplastic drugs. Br J Ind Med 49:855\u2013861","journal-title":"Br J Ind Med"},{"key":"1679_CR32","doi-asserted-by":"publisher","first-page":"2593","DOI":"10.1016\/j.jchromb.2010.04.030","volume":"878","author":"C Sottani","year":"2010","unstructured":"Sottani C, Porro B, Comelli M et al (2010) An analysis to study trends in occupational exposure to antineoplastic drugs among health care workers. J Chromatogr B Analyt Technol Biomed Life Sci 878:2593\u20132605. https:\/\/doi.org\/10.1016\/j.jchromb.2010.04.030","journal-title":"J Chromatogr B Analyt Technol Biomed Life Sci"},{"key":"1679_CR33","doi-asserted-by":"publisher","first-page":"102","DOI":"10.5271\/sjweh.1811","volume":"16","author":"I St\u00fccker","year":"1990","unstructured":"St\u00fccker I, Caillard JF, Collin R et al (1990) Risk of spontaneous abortion among nurses handling antineoplastic drugs. Scand J Work Environ Health 16:102\u2013107","journal-title":"Scand J Work Environ Health"},{"key":"1679_CR34","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1016\/S1570-0232(03)00100-4","volume":"789","author":"R Turci","year":"2003","unstructured":"Turci R, Sottani C, Spagnoli G, Minoia C (2003) Biological and environmental monitoring of hospital personnel exposed to antineoplastic agents: a review of analytical methods. J Chromatogr B Analyt Technol Biomed Life Sci 789:169\u2013209","journal-title":"J Chromatogr B Analyt Technol Biomed Life Sci"},{"key":"1679_CR35","doi-asserted-by":"publisher","first-page":"288","DOI":"10.1097\/00002820-199308000-00005","volume":"16","author":"BG Valanis","year":"1993","unstructured":"Valanis BG, Vollmer WM, Labuhn KT, Glass AG (1993a) Acute symptoms associated with antineoplastic drug handling among nurses. Cancer Nurs 16:288\u2013295","journal-title":"Cancer Nurs"},{"key":"1679_CR36","first-page":"455","volume":"50","author":"BG Valanis","year":"1993","unstructured":"Valanis BG, Vollmer WM, Labuhn KT, Glass AG (1993b) Association of antineoplastic drug handling with acute adverse effects in pharmacy personnel. Am J Hosp Pharm 50:455\u2013462","journal-title":"Am J Hosp Pharm"},{"key":"1679_CR37","doi-asserted-by":"publisher","first-page":"574","DOI":"10.1097\/00043764-199706000-00013","volume":"39","author":"B Valanis","year":"1997","unstructured":"Valanis B, Vollmer W, Labuhn K, Glass A (1997) Occupational exposure to antineoplastic agents and self-reported infertility among nurses and pharmacists. J Occup Environ Med 39:574\u2013580","journal-title":"J Occup Environ Med"},{"key":"1679_CR38","doi-asserted-by":"publisher","first-page":"278","DOI":"10.1177\/1078155213498630","volume":"20","author":"N Vyas","year":"2013","unstructured":"Vyas N, Yiannakis D, Turner A, Sewell GJ (2013) Occupational exposure to anti-cancer drugs: a review of effects of new technology. J Oncol Pharm Pract 20:278\u2013287. https:\/\/doi.org\/10.1177\/1078155213498630","journal-title":"J Oncol Pharm Pract"}],"container-title":["International Archives of Occupational and Environmental Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00420-021-01679-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00420-021-01679-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00420-021-01679-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,7,20]],"date-time":"2021-07-20T05:07:12Z","timestamp":1626757632000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00420-021-01679-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3,17]]},"references-count":38,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2021,8]]}},"alternative-id":["1679"],"URL":"https:\/\/doi.org\/10.1007\/s00420-021-01679-x","relation":{},"ISSN":["0340-0131","1432-1246"],"issn-type":[{"value":"0340-0131","type":"print"},{"value":"1432-1246","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,3,17]]},"assertion":[{"value":"24 June 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 January 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 March 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"No conflicts of interest to declare.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}