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Dr. Ibler has been part of advisory boards and received personal fees from Astra Zeneca, Leo Pharma; Sanofi Genzymes and Eli Lilly. Dr Jemec and Ibler declare that none of the mentioned conflicts of interest had any influence in the content of this manuscript.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}]}}