{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T18:31:18Z","timestamp":1787509878830,"version":"build-2736575974"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2025,5,22]],"date-time":"2025-05-22T00:00:00Z","timestamp":1747872000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,5,22]],"date-time":"2025-05-22T00:00:00Z","timestamp":1747872000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Palacky University Olomouc"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Int Arch Occup Environ Health"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>Occupational asbestos exposure was widespread before regulatory bans, and it remains a risk during renovations or demolitions of older buildings. While asbestos-related diseases are well-documented, less is known about minor radiological changes in exposed individuals. This longitudinal study aimed to identify predictors of pleural and parenchymal lung disorders in individuals with previous occupational asbestos exposure, focusing on both established asbestos-related diseases and minor radiological abnormalities.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The study tracked 445 former employees (334 men, 111 women) of two Czech asbestos-processing plants, who underwent regular examinations from the 1980s to December 2022. Cox proportional hazards regression models were employed to analyse predictors of asbestos-related diseases, as well as minor radiological findings alone.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Over a median latency of 37 years, 127 participants (28.5%) developed asbestos-related diseases, mainly pleural mesothelioma (59 cases). An additional 168 participants (37.8%) exhibited minor radiological findings, predominantly pleural plaques (129 cases), while 150 (33.7%) had no abnormalities. Substantial cumulative exposure was a strong predictor for minor radiological findings (odds ratio [OR] 1.98, 95% confidence interval [CI] 1.18\u20133.35,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.010) and any endpoint, including diseases (OR 1.89, 95% CI 1.18\u20133.02,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.008). Respiratory symptoms and impaired spirometry results significantly increased the likelihood of endpoint occurrence. No significant differences emerged between settings with predominantly chrysotile exposure and those with a chrysotile-crocidolite mixture.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This study highlights the predictive value of cumulative exposure and the need for ongoing surveillance of occupationally exposed individuals to better understand radiological changes, their significance, and to refine risk assessment models.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00420-025-02143-w","type":"journal-article","created":{"date-parts":[[2025,5,22]],"date-time":"2025-05-22T11:53:10Z","timestamp":1747914790000},"page":"497-505","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Cumulative asbestos exposure as a key predictor of long-term pleuropulmonary outcomes: insights from decades of follow-up"],"prefix":"10.1007","volume":"98","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7261-1412","authenticated-orcid":false,"given":"Ladislav","family":"\u0160t\u011bp\u00e1nek","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7766-3158","authenticated-orcid":false,"given":"Marie","family":"Nakl\u00e1dalov\u00e1","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1210-9906","authenticated-orcid":false,"given":"Magdal\u00e9na","family":"Jano\u0161\u00edkov\u00e1","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8308-4304","authenticated-orcid":false,"given":"Lubom\u00edr","family":"\u0160t\u011bp\u00e1nek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0871-4350","authenticated-orcid":false,"given":"Alena","family":"Borikov\u00e1","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,5,22]]},"reference":[{"key":"2143_CR1","doi-asserted-by":"publisher","first-page":"143","DOI":"10.3390\/ijerph15010143","volume":"15","author":"X Baur","year":"2018","unstructured":"Baur X (2018) Asbestos-Related disorders in Germany: background, politics, incidence, diagnostics and compensation. Int J Environ Res Public Health 15:143. https:\/\/doi.org\/10.3390\/ijerph15010143","journal-title":"Int J Environ Res Public Health"},{"key":"2143_CR2","doi-asserted-by":"publisher","first-page":"611","DOI":"10.1080\/10408444.2023.2283169","volume":"53","author":"EM Beckett","year":"2023","unstructured":"Beckett EM, Abelmann A, Roberts B, Lewis RC, Cheatham D, Miller EW, Hall E, Pierce JS (2023) An updated evaluation of reported no-observed adverse effect levels for Chrysotile, Amosite, and crocidolite asbestos for lung cancer and mesothelioma. Crit Rev Toxicol 53:611\u2013657. https:\/\/doi.org\/10.1080\/10408444.2023.2283169","journal-title":"Crit Rev Toxicol"},{"key":"2143_CR3","doi-asserted-by":"publisher","first-page":"1713","DOI":"10.1002\/sim.2059","volume":"24","author":"R Bender","year":"2005","unstructured":"Bender R, Augustin T, Blettner M (2005) Generating survival times to simulate Cox proportional hazards models. Stat Med 24:1713\u20131723. https:\/\/doi.org\/10.1002\/sim.2059","journal-title":"Stat Med"},{"key":"2143_CR4","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1164\/rccm.201901-0096OC","volume":"201","author":"FJH Brims","year":"2020","unstructured":"Brims FJH, Kong K, Harris EJA, Sodhi-Berry N, Reid A, Murray CP, Franklin PJ, Musk AB, de Klerk NH (2020) Pleural plaques and the risk of lung Cancer in Asbestos-exposed subjects. Am J Respir Crit Care Med 201:57\u201362. https:\/\/doi.org\/10.1164\/rccm.201901-0096OC","journal-title":"Am J Respir Crit Care Med"},{"key":"#cr-split#-2143_CR5.1","unstructured":"Council of the European Union, European Parliament (2023) Directive"},{"key":"#cr-split#-2143_CR5.2","unstructured":"(EU) 2023\/2668 amending Directive 2009\/148\/EC on the protection of workers from the risks related to exposure to asbestos at work. https:\/\/www.europeansources.info\/record\/proposal-for-a-directive-amending-directive-2009-148-ec-on-the-protection-of-workers-from-the-risks-related-to-exposure-to-asbestos-at-work\/. Accessed 16 December 2024"},{"key":"2143_CR6","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1016\/j.taap.2018.06.016","volume":"361","author":"LAT Cox Jr","year":"2018","unstructured":"Cox LAT Jr (2018) Biological mechanisms of non-linear dose-response for respirable mineral fibers. Toxicol Appl Pharmacol 361:137\u2013144. https:\/\/doi.org\/10.1016\/j.taap.2018.06.016","journal-title":"Toxicol Appl Pharmacol"},{"key":"2143_CR7","doi-asserted-by":"publisher","first-page":"107828","DOI":"10.1016\/j.lungcan.2024.107828","volume":"193","author":"AL Frank","year":"2024","unstructured":"Frank AL, van Zandwijk N (2024) Asbestos history and use. Lung Cancer 193:107828. https:\/\/doi.org\/10.1016\/j.lungcan.2024.107828","journal-title":"Lung Cancer"},{"key":"2143_CR8","doi-asserted-by":"publisher","unstructured":"Gallet J, Laurent F, Paris C, Clin B, Gislard A, Thaon I, Chammings S, Gramond C, Ogier G, Ferretti G, Andujar P, Brochard P, Delva F, Pairon JC, Lacourt A (2022) Pleural plaques and risk of lung cancer in workers formerly occupationally exposed to asbestos: extension of follow-up. Occup Environ Med 108337. https:\/\/doi.org\/10.1136\/oemed-2022-108337","DOI":"10.1136\/oemed-2022-108337"},{"key":"2143_CR9","unstructured":"Government of the Czech Republic (2023) Government Regulation No. 290\/1995 Coll., on health protection conditions during work with asbestos. https:\/\/www.zakonyprolidi.cz\/cs\/1995-290 Accessed 26 December 2024"},{"key":"2143_CR11","unstructured":"International Labour Organization (2022) Guidelines for the use of the ILO International Classification of Radiographs of Pneumoconioses. https:\/\/www.ilo.org\/sites\/default\/files\/wcmsp5\/groups\/public\/---ed_dialogue\/---lab_admin\/documents\/publication\/wcms_867859.pdf. Accessed 16 December 2024"},{"key":"2143_CR10","unstructured":"International Agency for Research on Cancer (2012) Arsenic, metals, fibres, and dusts: Volume 100\u00a0C, A review of human carcinogens. https:\/\/publications.iarc.fr\/_publications\/media\/download\/6142\/a42c8909dfe1e862d1a1a5736ad4e8fe7a8ba9f3.pdf. Accessed 4 March 2025"},{"key":"2143_CR12","doi-asserted-by":"publisher","first-page":"258","DOI":"10.3390\/ijerph17010258","volume":"17","author":"S Klebe","year":"2019","unstructured":"Klebe S, Leigh J, Henderson DW, Nurminen M (2019) Asbestos, smoking and lung cancer: an update. Int J Environ Res Public Health 17:258. https:\/\/doi.org\/10.3390\/ijerph17010258","journal-title":"Int J Environ Res Public Health"},{"key":"2143_CR13","doi-asserted-by":"crossref","unstructured":"Kleinbaum DG, Klein M (2012) Survival analysis: a self-learning text, Third Edition. Springer Publishing, New York, pp 97\u2013159","DOI":"10.1007\/978-1-4419-6646-9_3"},{"key":"2143_CR14","doi-asserted-by":"publisher","first-page":"889","DOI":"10.36290\/vnl.2017.162","volume":"63","author":"J Koci\u00e1nov\u00e1","year":"2017","unstructured":"Koci\u00e1nov\u00e1 J (2017) [Spirometrie\u2013 z\u00e1kladn\u00ed Vy\u0161et\u0159en\u00ed Funkce Plic] in Czech. Vnit\u0159 L\u00e9k 63:889\u2013894","journal-title":"Vnit\u0159 L\u00e9k"},{"key":"2143_CR15","doi-asserted-by":"publisher","first-page":"471","DOI":"10.1002\/ajim.22985","volume":"62","author":"D Loomis","year":"2019","unstructured":"Loomis D, Richardson DB, Elliott L (2019) Quantitative relationships of exposure to Chrysotile asbestos and mesothelioma mortality. Am J Ind Med 62:471\u2013477. https:\/\/doi.org\/10.1002\/ajim.22985","journal-title":"Am J Ind Med"},{"key":"2143_CR16","doi-asserted-by":"publisher","first-page":"292","DOI":"10.4415\/ANN_20_03_07","volume":"56","author":"C Magnani","year":"2020","unstructured":"Magnani C, Silvestri S, Angelini A, Ranucci A, Azzolina D, Cena T, Chellini E, Merler E, Pavone V, Miligi L, Gorini G, Bressan V, Girardi P, Bauleo L, Romeo E, Luberto F, Sala O, Scarnato C, Menegozzo S, Oddone E (2020) Italian pool of asbestos workers cohorts: asbestos related mortality by industrial sector and cumulative exposure. Ann Ist Super Sanita 56:292\u2013302. https:\/\/doi.org\/10.4415\/ANN_20_03_07","journal-title":"Ann Ist Super Sanita"},{"key":"2143_CR17","doi-asserted-by":"publisher","first-page":"321","DOI":"10.3109\/08958378.2015.1051640","volume":"27","author":"LD Maxim","year":"2015","unstructured":"Maxim LD, Niebo R, Utell MJ (2015) Are pleural plaques an appropriate endpoint for risk analyses? Inhal Toxicol 27:321\u2013334. https:\/\/doi.org\/10.3109\/08958378.2015.1051640","journal-title":"Inhal Toxicol"},{"key":"2143_CR18","doi-asserted-by":"publisher","unstructured":"Mazzei MA, Contorni F, Gentili F, Guerrini S, Mazzei FG, Pinto A, Cioffi Squitieri N, Sisinni AG, Paolucci V, Romeo R, Sartorelli P, Volterrani L (2017) Incidental and underreported pleural plaques at chest CT: do not miss Them-Asbestos exposure still exists. Biomed Res Int 6797826. https:\/\/doi.org\/10.1155\/2017\/6797826","DOI":"10.1155\/2017\/6797826"},{"key":"2143_CR19","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1136\/oemed-2023-108975","volume":"81","author":"M Menant","year":"2024","unstructured":"Menant M, Benlala I, Thaon I, Andujar P, Julia B, Brochard P, Chouaid C, Clin B, Gislard A, Gramond C, Paris C, Pairon JC, Delva F (2024) Relationships between asbestos exposure and pleural plaques: dose and time effects using fractional polynomials. Occup Environ Med 81:313\u2013319. https:\/\/doi.org\/10.1136\/oemed-2023-108975","journal-title":"Occup Environ Med"},{"key":"2143_CR20","doi-asserted-by":"publisher","first-page":"1235189","DOI":"10.3389\/fpubh.2023.1235189","volume":"11","author":"S Moitra","year":"2023","unstructured":"Moitra S, Tabrizi AF, Khadour F, Henderson L, Melenka L, Lacy P (2023) Exposure to insulating materials and risk of coronary artery diseases: a cross-sectional study. Front Public Health 11:1235189. https:\/\/doi.org\/10.3389\/fpubh.2023.1235189","journal-title":"Front Public Health"},{"key":"2143_CR21","unstructured":"National Institute for Occupational Safety and Health (2024) ILO Classification for B Readers. https:\/\/www.cdc.gov\/niosh\/chestradiography\/php\/ilo-classification\/index.html. Accessed 2 March 2025"},{"key":"2143_CR22","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1067\/j.cpradiol.2014.10.002","volume":"44","author":"C Norbet","year":"2015","unstructured":"Norbet C, Joseph A, Rossi SS, Bhalla S, Gutierrez FR (2015) Asbestos-related lung disease: a pictorial review. Curr Probl Diagn Radiol 44:371\u2013382. https:\/\/doi.org\/10.1067\/j.cpradiol.2014.10.002","journal-title":"Curr Probl Diagn Radiol"},{"key":"2143_CR23","doi-asserted-by":"publisher","first-page":"105530","DOI":"10.1016\/j.envint.2020.105530","volume":"137","author":"D \u00d6ner","year":"2020","unstructured":"\u00d6ner D, Ghosh M, Coorens R, Bov\u00e9 H, Moisse M, Lambrechts D, Ameloot M, Godderis L, Hoet PHM (2020) Induction and recovery of CpG site specific methylation changes in human bronchial cells after long-term exposure to carbon nanotubes and asbestos. Environ Int 137:105530. https:\/\/doi.org\/10.1016\/j.envint.2020.105530","journal-title":"Environ Int"},{"key":"2143_CR24","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1093\/jnci\/djs513","volume":"105","author":"JC Pairon","year":"2013","unstructured":"Pairon JC, Laurent F, Rinaldo M, Clin B, Andujar P, Ameille J, Brochard P, Chammings S, Ferretti G, Galateau-Sall\u00e9 F, Gislard A, Letourneux M, Luc A, Schorl\u00e9 E, Paris C (2013) Pleural plaques and the risk of pleural mesothelioma. J Natl Cancer Inst 105:293\u2013301. https:\/\/doi.org\/10.1093\/jnci\/djs513","journal-title":"J Natl Cancer Inst"},{"key":"2143_CR25","unstructured":"Parliament of the Czech Republic (2024) Decree No. 79\/2013 Coll., on occupational health services and some kinds of medical examinations of employees. https:\/\/www.zakonyprolidi.cz\/cs\/2013-79 Accessed 16 December 2024"},{"key":"2143_CR26","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/782045","author":"JC Pfau","year":"2014","unstructured":"Pfau JC, Serve KM, Noonan CW (2014) Autoimmunity and asbestos exposure. Autoimmune Dis:782045. https:\/\/doi.org\/10.1155\/2014\/782045","journal-title":"Autoimmune Dis:782045"},{"key":"2143_CR27","doi-asserted-by":"publisher","first-page":"115716","DOI":"10.1016\/j.jenvman.2022.115716","volume":"319","author":"LP Thives","year":"2022","unstructured":"Thives LP, Ghisi E, Thives J\u00fanior JJ, Vieira AS (2022) Is asbestos still a problem in the world? A current review. J Environ Manage 319:115716. https:\/\/doi.org\/10.1016\/j.jenvman.2022.115716","journal-title":"J Environ Manage"},{"key":"2143_CR28","doi-asserted-by":"publisher","first-page":"650","DOI":"10.47626\/1679-4435-2022-733","volume":"20","author":"K Vicari","year":"2023","unstructured":"Vicari K, Ribeiro IM, Aguiar BF, Brey C, Boller S, Miranda FMD (2023) Occupational characterization of workers exposed to asbestos: an integrative review. Rev Bras Med Trab 20:650\u2013658. https:\/\/doi.org\/10.47626\/1679-4435-2022-733","journal-title":"Rev Bras Med Trab"},{"key":"2143_CR29","doi-asserted-by":"publisher","first-page":"927","DOI":"10.1007\/s10654-021-00769-x","volume":"36","author":"C Zunarelli","year":"2021","unstructured":"Zunarelli C, Godono A, Visci G, Violante FS, Boffetta P (2021) Occupational exposure to asbestos and risk of kidney cancer: an updated meta-analysis. Eur J Epidemiol 36:927\u2013936. https:\/\/doi.org\/10.1007\/s10654-021-00769-x","journal-title":"Eur J Epidemiol"}],"container-title":["International Archives of Occupational and Environmental Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00420-025-02143-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00420-025-02143-w\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00420-025-02143-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,6]],"date-time":"2025-09-06T15:18:42Z","timestamp":1757171922000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00420-025-02143-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,22]]},"references-count":30,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2025,8]]}},"alternative-id":["2143"],"URL":"https:\/\/doi.org\/10.1007\/s00420-025-02143-w","relation":{},"ISSN":["0340-0131","1432-1246"],"issn-type":[{"value":"0340-0131","type":"print"},{"value":"1432-1246","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5,22]]},"assertion":[{"value":"28 December 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 April 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 May 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The study was approved by the Ethics Committee of the University Hospital Olomouc and the Faculty of Medicine and Dentistry, Palack\u00fd University Olomouc (reference number 148\/19).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"None declared.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}