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Jackson Foundation","doi-asserted-by":"publisher","award":["HT94252320052"],"award-info":[{"award-number":["HT94252320052"]}],"id":[{"id":"10.13039\/100003896","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Int Arch Occup Environ Health"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>\n                      <jats:italic>Deepwater Horizon<\/jats:italic>\n                      oil spill (DWHOS) responders potentially experienced multiple stressors. We examined associations between DWHOS deployment-related stressor patterns and neurological and endocrine\/metabolic conditions among U.S. Coast Guard active duty responders who completed post-deployment surveys (n\u2009=\u20093102).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Deployment-related stressor patterns were identified using principal component analysis of self-reported stressors. Neurological and endocrine\/metabolic outcomes were classified from military health encounter records. Associations between principal components (PCs) and incident outcomes (2010\u20132015) were estimated through Cox proportional hazards regression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A five-component solution explained 79.2% of the variance. PC1 (high physical\/moderate chemical stressor pattern) was associated with\n                      <jats:italic>migraine<\/jats:italic>\n                      [adjusted hazard ratio (aHR): 1.25, 95% confidence interval (CI): 1.01\u20131.56]. PC2 (high crude oil\/dispersant stressor pattern) was associated with several migraine\/headache conditions including\n                      <jats:italic>migraine with aura<\/jats:italic>\n                      (1.54, 1.14\u20132.07),\n                      <jats:italic>mononeuritis of upper limb and mononeuritis multiplex<\/jats:italic>\n                      (1.36, 1.11\u20131.68),\n                      <jats:italic>disorders of lipid metabolism<\/jats:italic>\n                      (1.11, 1.01\u20131.23\n                      <jats:italic>)<\/jats:italic>\n                      and its subcategory\n                      <jats:italic>other and unspecified hyperlipidemia<\/jats:italic>\n                      (1.11, 1.01\u20131.24), and\n                      <jats:italic>dysmetabolic syndrome X<\/jats:italic>\n                      (1.74, 1.19\u20132.54). PC3 (high fatigue\/moderate chemical inhalation stressor pattern) was associated with several migraine\/headache conditions (aHR range: 1.18\u20131.60),\n                      <jats:italic>disorders of lipid metabolism<\/jats:italic>\n                      (1.11, 1.00\u20131.23) including\n                      <jats:italic>other and unspecified hyperlipidemia<\/jats:italic>\n                      (1.13, 1.01\u20131.26)\n                      <jats:italic>,<\/jats:italic>\n                      and\n                      <jats:italic>overweight and obesity<\/jats:italic>\n                      (1.13, 1.00\u20131.27). PC4 (high anxiety\/modest fatigue stressor pattern) was associated with\n                      <jats:italic>abnormality of gait<\/jats:italic>\n                      (1.34, 1.03\u20131.73). PC5 (high back pain) was associated with\n                      <jats:italic>mononeuritis of lower limb,<\/jats:italic>\n                      several balance and gait-related conditions\n                      <jats:italic>,<\/jats:italic>\n                      thyroid disorders, and\n                      <jats:italic>obesity<\/jats:italic>\n                      (aHRs range: 1.16\u20131.67).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Oil spill response stressor patterns were associated with increased risks of multiple longer-term neurological and endocrine\/metabolic conditions, with associations varying by PC.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00420-026-02228-0","type":"journal-article","created":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T09:41:56Z","timestamp":1786527716000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Longer-term neurological and endocrine\/metabolic conditions in the deepwater horizon oil spill coast guard cohort study: A principal component analysis"],"prefix":"10.1007","volume":"99","author":[{"given":"Hristina","family":"Denic-Roberts","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3881-8695","authenticated-orcid":false,"given":"Jordan","family":"McAdam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lawrence S.","family":"Engel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeanine M.","family":"Buchanich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel G.","family":"Miller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evelyn O.","family":"Talbott","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dana L.","family":"Thomas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Glen A.","family":"Cook","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Blake","family":"Hansen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jill E.","family":"Emerick","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tina","family":"Costacou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer A.","family":"Rusiecki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,8,12]]},"reference":[{"issue":"7","key":"2228_CR1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.aaw8863","volume":"6","author":"I Berenshtein","year":"2020","unstructured":"Berenshtein I, Paris CB, Perlin N, Alloy MM, Joye SB, Murawski S (2020) Invisible oil beyond the deepwater horizon satellite footprint. 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