{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T20:10:41Z","timestamp":1791144641707,"version":"4.1.0"},"reference-count":26,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2012,7,17]],"date-time":"2012-07-17T00:00:00Z","timestamp":1342483200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Appl Physiol"],"published-print":{"date-parts":[[2013,2]]},"DOI":"10.1007\/s00421-012-2452-3","type":"journal-article","created":{"date-parts":[[2012,8,29]],"date-time":"2012-08-29T16:00:17Z","timestamp":1346256017000},"page":"467-478","source":"Crossref","is-referenced-by-count":34,"title":["Time-dependent changes in glucose and insulin regulation during intermittent hypoxia and continuous hypoxia"],"prefix":"10.1007","volume":"113","author":[{"given":"Euhan J.","family":"Lee","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura C.","family":"Alonso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Darko","family":"Stefanovski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hilary C.","family":"Strollo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lia C.","family":"Romano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baobo","family":"Zou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Srikanth","family":"Singamsetty","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keith A.","family":"Yester","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth R.","family":"McGaffin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adolfo","family":"Garcia-Ocana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher P.","family":"O\u2019Donnell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2012,7,17]]},"reference":[{"key":"2452_CR1","doi-asserted-by":"crossref","first-page":"1792","DOI":"10.2337\/db06-1513","volume":"56","author":"LC Alonso","year":"2007","unstructured":"Alonso LC, Yokoe T, Zhang P, Scott DK, Kim SK, O\u2019Donnell CP, Garcia-Ocana A (2007) Glucose infusion in mice: a new model to induce beta-cell replication. Diabetes 56:1792\u20131801","journal-title":"Diabetes"},{"key":"2452_CR2","doi-asserted-by":"crossref","unstructured":"Alonso LC, Watanabe Y, Stefanovski D, Lee EJ, Singamsetty S, Romano LC, Zou B, Garcia-Ocana A, Bergman RN, O\u2019Donnell CP (2012) Simultaneous measurement of insulin sensitivity, insulin secretion and the disposition index in conscious unhandled mice. Obesity 20(7):1403\u20131412","DOI":"10.1038\/oby.2012.36"},{"key":"2452_CR3","doi-asserted-by":"crossref","first-page":"1456","DOI":"10.1172\/JCI110398","volume":"68","author":"RN Bergman","year":"1981","unstructured":"Bergman RN, Phillips LS, Cobelli C (1981) Physiologic evaluation of factors controlling glucose tolerance in man: measurement of insulin sensitivity and beta-cell glucose sensitivity from the response to intravenous glucose. J Clin Invest 68:1456\u20131467","journal-title":"J Clin Invest"},{"key":"2452_CR4","doi-asserted-by":"crossref","first-page":"2028","DOI":"10.1152\/japplphysiol.00411.2005","volume":"99","author":"MJ Campen","year":"2005","unstructured":"Campen MJ, Shimoda LA, O\u2019Donnell CP (2005) Acute and chronic cardiovascular effects of intermittent hypoxia in C57BL\/6J mice. J Appl Physiol 99:2028\u20132035","journal-title":"J Appl Physiol"},{"key":"2452_CR5","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1089\/ham.2007.8407","volume":"8","author":"O Castillo","year":"2007","unstructured":"Castillo O, Woolcott OO, Gonzales E, Tello V, Tello L, Villarreal C, Mendez N, Damas L, Florentini E (2007) Residents at high altitude show a lower glucose profile than sea-level residents throughout 12-hour blood continuous monitoring. High Alt Med Biol 8:307\u2013311","journal-title":"High Alt Med Biol"},{"key":"2452_CR6","doi-asserted-by":"crossref","first-page":"17593","DOI":"10.1073\/pnas.0707462104","volume":"104","author":"SC Erzurum","year":"2007","unstructured":"Erzurum SC, Ghosh S, Janocha AJ, Xu W, Bauer S, Bryan NS, Tejero J, Hemann C, Hille R, Stuehr DJ, Feelisch M, Beall CM (2007) Higher blood flow and circulating NO products offset high-altitude hypoxia among Tibetans. Proc Natl Acad Sci USA 104:17593\u201317598","journal-title":"Proc Natl Acad Sci USA"},{"key":"2452_CR8","doi-asserted-by":"crossref","first-page":"R85","DOI":"10.1152\/ajpregu.00078.2010","volume":"300","author":"JL Gamboa","year":"2011","unstructured":"Gamboa JL, Garcia-Cazarin ML, Andrade FH (2011) Chronic hypoxia increases insulin-stimulated glucose uptake in mouse soleus muscle. Am J Physiol Regul Integr Comp Physiol 300:R85\u2013R91","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"2452_CR9","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1164\/rccm.200302-206OC","volume":"169","author":"IA Harsch","year":"2004","unstructured":"Harsch IA, Schahin SP, Radespiel-Troger M, Weintz O, Jahreiss H, Fuchs FS, Wiest GH, Hahn EG, Lohmann T, Konturek PC, Ficker JH (2004) Continuous positive airway pressure treatment rapidly improves insulin sensitivity in patients with obstructive sleep apnea syndrome. Am J Respir Crit Care Med 169:156\u2013162","journal-title":"Am J Respir Crit Care Med"},{"key":"2452_CR10","doi-asserted-by":"crossref","first-page":"E814","DOI":"10.1152\/ajpendo.00465.2005","volume":"290","author":"AV Hertzel","year":"2006","unstructured":"Hertzel AV, Smith LA, Berg AH, Cline GW, Shulman GI, Scherer PE, Bernlohr DA (2006) Lipid metabolism and adipokine levels in fatty acid-binding protein null and transgenic mice. Am J Physiol Endocrinol Metab 290:E814\u2013E823","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"2452_CR11","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1164\/rccm.200610-1527OC","volume":"175","author":"N Iiyori","year":"2007","unstructured":"Iiyori N, Alonso LC, Li J, Sanders MH, Garcia-Ocana A, O\u2019Doherty RM, Polotsky VY, O\u2019Donnell CP (2007) Intermittent hypoxia causes insulin resistance in lean mice independent of autonomic activity. Am J Respir Crit Care Med 175:851\u2013857","journal-title":"Am J Respir Crit Care Med"},{"key":"2452_CR12","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1164\/ajrccm.165.5.2103001","volume":"165","author":"MS Ip","year":"2002","unstructured":"Ip MS, Lam B, Ng MM, Lam WK, Tsang KW, Lam KS (2002) Obstructive sleep apnea is independently associated with insulin resistance. Am J Respir Crit Care Med 165:670\u2013676","journal-title":"Am J Respir Crit Care Med"},{"issue":"Pt 1","key":"2452_CR13","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1111\/j.1469-7793.1997.241bf.x","volume":"504","author":"JJ Larsen","year":"1997","unstructured":"Larsen JJ, Hansen JM, Olsen NV, Galbo H, Dela F (1997) The effect of altitude hypoxia on glucose homeostasis in men. J Physiol 504(Pt 1):241\u2013249","journal-title":"J Physiol"},{"key":"2452_CR14","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1152\/japplphysiol.91255.2008","volume":"107","author":"EJ Lee","year":"2009","unstructured":"Lee EJ, Woodske ME, Zou B, O\u2019Donnell CP (2009) Dynamic arterial blood gas analysis in conscious, unrestrained C57BL\/6J mice during exposure to intermittent hypoxia. J Appl Physiol 107:290\u2013294","journal-title":"J Appl Physiol"},{"key":"2452_CR15","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1089\/ham.2008.1011","volume":"9","author":"SY Lhamo","year":"2008","unstructured":"Lhamo SY, Supamai S, Virasakdi C (2008) Impaired glucose regulation in a Sherpa indigenous population living in the Everest region of Nepal and in Kathmandu Valley. High Alt Med Biol 9:217\u2013222","journal-title":"High Alt Med Biol"},{"key":"2452_CR16","doi-asserted-by":"crossref","first-page":"1538","DOI":"10.1152\/japplphysiol.91523.2008","volume":"106","author":"M Louis","year":"2009","unstructured":"Louis M, Punjabi NM (2009) Effects of acute intermittent hypoxia on glucose metabolism in awake healthy volunteers. J Appl Physiol 106:1538\u20131544","journal-title":"J Appl Physiol"},{"key":"2452_CR17","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1203\/01.pdr.0000196719.95046.19","volume":"59","author":"K Makikallio","year":"2006","unstructured":"Makikallio K, Rounioja S, Vuolteenaho O, Paakkari J, Hallman M, Rasanen J (2006) Fetal cardiac natriuretic peptide expression and cardiovascular hemodynamics in endotoxin-induced acute cardiac dysfunction in mouse. Pediatr Res 59:180\u2013184","journal-title":"Pediatr Res"},{"key":"2452_CR18","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1159\/000112940","volume":"45","author":"JM Pimiento","year":"2008","unstructured":"Pimiento JM, Maloney SP, Tang PC, Muto A, Westvik TS, Fitzgerald TN, Fancher TT, Tellides G, Dardik A (2008) Endothelial nitric oxide synthase stimulates aneurysm growth in aged mice. J Vasc Res 45:251\u2013258","journal-title":"J Vasc Res"},{"key":"2452_CR19","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1113\/jphysiol.2003.048173","volume":"552","author":"VY Polotsky","year":"2003","unstructured":"Polotsky VY, Li J, Punjabi NM, Rubin AE, Smith PL, Schwartz AR, O\u2019Donnell CP (2003) Intermittent hypoxia increases insulin resistance in genetically obese mice. J Physiol 552:253\u2013264","journal-title":"J Physiol"},{"key":"2452_CR20","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1164\/rccm.200809-1392OC","volume":"179","author":"NM Punjabi","year":"2009","unstructured":"Punjabi NM, Beamer BA (2009) Alterations in glucose disposal in sleep-disordered breathing. Am J Respir Crit Care Med 179:235\u2013240","journal-title":"Am J Respir Crit Care Med"},{"key":"2452_CR21","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1093\/aje\/kwh261","volume":"160","author":"NM Punjabi","year":"2004","unstructured":"Punjabi NM, Shahar E, Redline S, Gottlieb DJ, Givelber R, Resnick HE (2004) Sleep-disordered breathing, glucose intolerance, and insulin resistance: the Sleep Heart Health Study. Am J Epidemiol 160:521\u2013530","journal-title":"Am J Epidemiol"},{"key":"2452_CR22","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/S0899-9007(00)00551-7","volume":"17","author":"JL Santos","year":"2001","unstructured":"Santos JL, Perez-Bravo F, Carrasco E, Calvillan M, Albala C (2001) Low prevalence of type 2 diabetes despite a high average body mass index in the Aymara natives from Chile. Nutrition 17:305\u2013309","journal-title":"Nutrition"},{"key":"2452_CR24","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1007\/s00421-002-0736-8","volume":"88","author":"W Schobersberger","year":"2003","unstructured":"Schobersberger W, Schmid P, Lechleitner M, von Duvillard SP, Hortnagl H, Gunga HC, Klingler A, Fries D, Kirsch K, Spiesberger R, Pokan R, Hofmann P, Hoppichler F, Riedmann G, Baumgartner H, Humpeler E (2003) Austrian Moderate Altitude Study 2000 (AMAS 2000): the effects of moderate altitude (1,700\u00a0m) on cardiovascular and metabolic variables in patients with metabolic syndrome. Eur J Appl Physiol 88:506\u2013514","journal-title":"Eur J Appl Physiol"},{"key":"2452_CR25","doi-asserted-by":"crossref","first-page":"2758","DOI":"10.1152\/jappl.2001.91.6.2758","volume":"91","author":"Y Tagaito","year":"2001","unstructured":"Tagaito Y, Polotsky VY, Campen MJ, Wilson JA, Balbir A, Smith PL, Schwartz AR, O\u2019Donnell CP (2001) A model of sleep-disordered breathing in the C57BL\/6J mouse. J Appl Physiol 91:2758\u20132766","journal-title":"J Appl Physiol"},{"issue":"11","key":"2452_CR26","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1136\/thx.2006.074351","volume":"62","author":"SD West","year":"2007","unstructured":"West SD, Nicoll DJ, Wallace TM, Matthews DR, Stradling JR (2007) The effect of CPAP on insulin resistance and HbA1c in men with obstructive sleep apnoea and type 2 diabetes. Thorax 62(11):969\u2013974","journal-title":"Thorax"},{"key":"2452_CR27","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1113\/jphysiol.2007.143586","volume":"586","author":"T Yokoe","year":"2008","unstructured":"Yokoe T, Alonso LC, Romano LC, Rosa TC, O\u2019Doherty RM, Garcia-Ocana A, Minoguchi K, O\u2019Donnell CP (2008) Intermittent hypoxia reverses the diurnal glucose rhythm and causes pancreatic beta-cell replication in mice. J Physiol 586:899\u2013911","journal-title":"J Physiol"},{"key":"2452_CR28","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1172\/JCI5912","volume":"103","author":"AY Yu","year":"1999","unstructured":"Yu AY, Shimoda LA, Iyer NV, Huso DL, Sun X, McWilliams R, Beaty T, Sham JS, Wiener CM, Sylvester JT, Semenza GL (1999) Impaired physiological responses to chronic hypoxia in mice partially deficient for hypoxia-inducible factor 1alpha. J Clin Invest 103:691\u2013696","journal-title":"J Clin Invest"}],"container-title":["European Journal of Applied Physiology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00421-012-2452-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00421-012-2452-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00421-012-2452-3","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,7,3]],"date-time":"2019-07-03T02:07:10Z","timestamp":1562119630000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00421-012-2452-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,7,17]]},"references-count":26,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2013,2]]}},"alternative-id":["2452"],"URL":"https:\/\/doi.org\/10.1007\/s00421-012-2452-3","relation":{},"ISSN":["1439-6319","1439-6327"],"issn-type":[{"value":"1439-6319","type":"print"},{"value":"1439-6327","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,7,17]]}}}