{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T15:50:23Z","timestamp":1791301823931,"version":"4.1.0"},"reference-count":81,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2013,6,28]],"date-time":"2013-06-28T00:00:00Z","timestamp":1372377600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Appl Physiol"],"published-print":{"date-parts":[[2013,10]]},"DOI":"10.1007\/s00421-013-2685-9","type":"journal-article","created":{"date-parts":[[2013,6,27]],"date-time":"2013-06-27T15:14:24Z","timestamp":1372346064000},"page":"2473-2486","source":"Crossref","is-referenced-by-count":98,"title":["Swimming exercise training-induced left ventricular hypertrophy involves microRNAs and synergistic regulation of the PI3K\/AKT\/mTOR signaling pathway"],"prefix":"10.1007","volume":"113","author":[{"given":"Zhichao","family":"Ma","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Qi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuai","family":"Meng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baoju","family":"Wen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2013,6,28]]},"reference":[{"key":"2685_CR1","doi-asserted-by":"crossref","first-page":"5061","DOI":"10.1128\/MCB.19.7.5061","volume":"19","author":"M Andjelkovic","year":"1999","unstructured":"Andjelkovic M, Maira SM, Cron P, Parker PJ, Hemmings BA (1999) Domain swapping used to investigate the mechanism of protein kinase B regulation by 3-phosphoinositide-dependent protein kinase 1 and Ser473 kinase. Mol Cell Biol 19:5061\u20135072","journal-title":"Mol Cell Biol"},{"key":"2685_CR2","doi-asserted-by":"crossref","first-page":"1818","DOI":"10.2174\/138161211796390976","volume":"17","author":"T Aoyagi","year":"2011","unstructured":"Aoyagi T, Matsui T (2011) Phosphoinositide-3 kinase signaling in cardiac hypertrophy and heart failure. Curr Pharm Des 17:1818\u20131824. doi: 10.2174\/138161211796390976","journal-title":"Curr Pharm Des"},{"issue":"143","key":"2685_CR3","doi-asserted-by":"crossref","first-page":"1072","DOI":"10.1016\/j.cell.2010.11.036","volume":"23","author":"P Bostr\u00f6m","year":"2010","unstructured":"Bostr\u00f6m P, Mann N, Wu J, Quintero PA, Plovie ER, Pan\u00e1kov\u00e1 D, Gupta RK, Xiao C, MacRae CA, Rosenzweig A, Spiegelman BM (2010) C\/EBP\u03b2 controls exercise-induced cardiac growth and protects against pathological cardiac remodeling. Cell 23(143):1072\u20131083. doi: 10.1016\/j.cell.2010.11.036","journal-title":"Cell"},{"key":"2685_CR4","doi-asserted-by":"crossref","first-page":"9133","DOI":"10.1074\/jbc.274.14.9133","volume":"274","author":"D Brodbeck","year":"1999","unstructured":"Brodbeck D, Cron P, Hemmings BA (1999) A human protein kinase Bgamma with regulatory phosphorylation sites in the activation loop and in the C-terminal hydrophobic domain. J Biol Chem 274:9133\u20139136. doi: 10.1074\/jbc.274.14.9133","journal-title":"J Biol Chem"},{"key":"2685_CR5","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1161\/01.RES.0000038488.38975.1A","volume":"91","author":"OF Bueno","year":"2002","unstructured":"Bueno OF, Molkentin JD (2002) Involvement of extracellular signal-regulated kinases 1\/2 in cardiac hypertrophy and cell death. Circ Res 91:776\u2013781. doi: 10.1161\/01.RES.0000038488.38975.1A","journal-title":"Circ Res"},{"key":"2685_CR6","doi-asserted-by":"crossref","first-page":"1655","DOI":"10.1126\/science.296.5573.1655","volume":"296","author":"LC Cantley","year":"2002","unstructured":"Cantley LC (2002) The phosphoinositide 3-kinase pathway. Science 296:1655\u20131657. doi: 10.1126\/science.296.5573.1655","journal-title":"Science"},{"issue":"5","key":"2685_CR7","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1002\/hed.23011","volume":"35","author":"P Cao","year":"2013","unstructured":"Cao P, Zhou L, Zhang J, Zheng F, Wang H, Ma D, Tian J (2013) Comprehensive expression profiling of microRNAs in laryngeal squamous cell carcinoma. Head Neck 35:720\u2013728. doi: 10.1002\/hed.23011","journal-title":"Head Neck"},{"key":"2685_CR8","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1016\/j.eururo.2011.01.044","volume":"59","author":"JW Catto","year":"2011","unstructured":"Catto JW, Alcaraz A, Bjartell AS, De White Vere R, Evans CP, Fussel S, Hamdy FC, Kallioniemi O, Mengual L, Schlomm T, Visakorpi T (2011) MicroRNA in prostate, bladder, and kidney cancer: a systematic review. Eur Urol 59:671\u2013681. doi: 10.1016\/j.eururo.2011.01.044","journal-title":"Eur Urol"},{"key":"2685_CR9","doi-asserted-by":"crossref","first-page":"1831","DOI":"10.2353\/ajpath.2007.061170","volume":"170","author":"Y Cheng","year":"2007","unstructured":"Cheng Y, Ji R, Yue J, Yang J, Liu X, Chen H, Dean DB, Zhang C (2007) MicroRNAs are aberrantly expressed in hypertrophic heart: do they play a role in cardiac hypertrophy? Am J Pathol 170:1831\u20131840. doi: 10.2353\/ajpath.2007.061170","journal-title":"Am J Pathol"},{"key":"2685_CR10","doi-asserted-by":"crossref","first-page":"1728","DOI":"10.1126\/science.292.5522.1728","volume":"292","author":"H Cho","year":"2001","unstructured":"Cho H, Mu J, Kim JK, Thorvaldsen JL, Chu Q, Crenshaw EB 3rd, Kaestner KH, Bartolomei MS, Shulman GI, Birnbaum MJ (2001a) Insulin resistance and a diabetes mellitus-like syndrome in mice lacking the protein kinase Akt2 (PKB beta). Science 292:1728\u20131731. doi: 10.1126\/science.292.5522.1728","journal-title":"Science"},{"key":"2685_CR11","doi-asserted-by":"crossref","first-page":"38349","DOI":"10.1074\/jbc.C100462200","volume":"276","author":"H Cho","year":"2001","unstructured":"Cho H, Thorvaldsen JL, Chu Q, Feng F, Birnbaum MJ (2001b) Akt1\/PKBalpha is required for normal growth but dispensable for maintenance of glucose homeostasis in mice. J Biol Chem 276:38349\u201338352. doi: 10.1074\/jbc.C100462200","journal-title":"J Biol Chem"},{"key":"2685_CR12","doi-asserted-by":"crossref","first-page":"12333","DOI":"10.1073\/pnas.172376399","volume":"99","author":"G Condorelli","year":"2002","unstructured":"Condorelli G, Drusco A, Stassi G, Bellacosa A, Roncarati R, Iaccarino G, Russo MA, Gu Y, Dalton N, Chung C, Latronico MV, Napoli C, Sadoshima J, Croce CM, Ross J Jr (2002) Akt induces enhanced myocardial contractility and cell size in vivo in transgenic mice. Proc Natl Acad Sci USA 99:12333\u201312338. doi: 10.1073\/pnas.172376399","journal-title":"Proc Natl Acad Sci USA"},{"key":"2685_CR13","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1016\/S0092-8674(02)00969-8","volume":"110","author":"MA Crackower","year":"2002","unstructured":"Crackower MA, Oudit GY, Kozieradzki I, Sarao R, Sun H, Sasaki T, Hirsch E, Suzuki A, Shioi T, Irie-Sasaki J, Sah R, Cheng HY, Rybin VO, Lembo G, Fratta L, Oliveira-dos-Santos AJ, Benovic JL, Kahn CR, Izumo S, Steinberg SF, Wymann MP, Backx PH, Penninger JM (2002) Regulation of myocardial contractility and cell size by distinct PI3K-PTEN signaling pathways. Cell 110:737\u2013749. doi: 10.1016\/S0092-8674(02)00969-8","journal-title":"Cell"},{"key":"2685_CR14","doi-asserted-by":"crossref","unstructured":"da Silva Jr ND, Fernandes T, Soci UP, Monteiro AW, Phillips MI, de Oliveira EM (2012) Swimming training in rats increases cardiac MicroRNA-126 expression and angiogenesis. Med Sci Sports Exerc 44: 1453\u20131462. doi: 10.1249\/MSS.0b013e31824e8a36","DOI":"10.1249\/MSS.0b013e31824e8a36"},{"key":"2685_CR15","doi-asserted-by":"crossref","first-page":"2097","DOI":"10.1161\/CIRCULATIONAHA.105.595231","volume":"113","author":"B DeBosch","year":"2006","unstructured":"DeBosch B, Treskov I, Lupu TS, Weinheimer C, Kovacs A, Courtois M, Muslin AJ (2006) Akt1 is required for physiological cardiac growth. Circulation 113:2097\u20132104. doi: 10.1161\/CIRCULATIONAHA.105.595231","journal-title":"Circulation"},{"key":"2685_CR16","doi-asserted-by":"crossref","first-page":"962","DOI":"10.1161\/HYPERTENSIONAHA.106.079426","volume":"49","author":"GW Dorn 2nd","year":"2007","unstructured":"Dorn GW 2nd (2007) The fuzzy logic of physiological cardiac hypertrophy. Hypertension 49:962\u2013970. doi: 10.1161\/HYPERTENSIONAHA.106.079426","journal-title":"Hypertension"},{"key":"2685_CR17","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1016\/j.yjmcc.2010.08.011","volume":"49","author":"S Etzion","year":"2010","unstructured":"Etzion S, Etzion Y, DeBosch B, Crawford PA, Muslin AJ (2010) Akt2 deficiency promotes cardiac induction of Rab4a and myocardial beta-adrenergic hypersensitivity. J Mol Cell Cardiol 49:931\u2013940. doi: 10.1016\/j.yjmcc.2010.08.011","journal-title":"J Mol Cell Cardiol"},{"key":"2685_CR18","doi-asserted-by":"crossref","first-page":"1942","DOI":"10.1126\/science.1066015","volume":"294","author":"Y Fang","year":"2001","unstructured":"Fang Y, Vilella-Bach M, Bachmann R, Flanigan A, Chen J (2001) Phosphatidic acid-mediated mitogenic activation of mTOR signaling. Science 294:1942\u20131945. doi: 10.1126\/science.1066015","journal-title":"Science"},{"key":"2685_CR19","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1161\/HYPERTENSIONAHA.110.168252","volume":"58","author":"T Fernandes","year":"2011","unstructured":"Fernandes T, Hashimoto NY, Magalh\u00e3es FC, Fernandes FB, Casarini DE, Carmona AK, Krieger JE, Phillips MI, Oliveira EM (2011) Aerobic exercise training-induced left ventricular hypertrophy involves regulatory microRNAs, decreased angiotensin-converting enzyme-angiotensin II, and synergistic regulation of angiotensin-converting enzyme 2-angiotensin (1\u20137). Hypertension 58:182\u2013189. doi: 10.1161\/HYPERTENSIONAHA.110.168252","journal-title":"Hypertension"},{"key":"2685_CR20","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1016\/j.yjmcc.2011.06.021","volume":"52","author":"KG Franchini","year":"2012","unstructured":"Franchini KG (2012) Focal adhesion kinase\u2014the basis of local hypertrophic signaling domains. J Mol Cell Cardiol 52:485\u2013492. doi: 10.1016\/j.yjmcc.2011.06.021","journal-title":"J Mol Cell Cardiol"},{"key":"2685_CR21","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1172\/JCI16885","volume":"112","author":"RS Garofalo","year":"2003","unstructured":"Garofalo RS, Orena SJ, Rafidi K, Torchia AJ, Stock JL, Hildebrandt AL, Coskran T, Black SC, Brees DJ, Wicks JR, McNeish JD, Coleman KG (2003) Severe diabetes, age-dependent loss of adipose tissue, and mild growth deficiency in mice lacking Akt2\/PKB beta. J Clin Invest 112:197\u2013208. doi: 10.1172\/JCI16885","journal-title":"J Clin Invest"},{"key":"2685_CR22","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/S0955-0674(99)80028-3","volume":"11","author":"TP Garrington","year":"1999","unstructured":"Garrington TP, Johnson GL (1999) Organization and regulation of mitogen-activated protein kinase signaling pathways. Curr Opin Cell Biol 11:211\u2013218. doi: 10.1016\/S0955-0674(99)80028-3","journal-title":"Curr Opin Cell Biol"},{"key":"2685_CR23","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.ccr.2007.05.008","volume":"12","author":"DA Guertin","year":"2007","unstructured":"Guertin DA, Sabatini DM (2007) Defining the role of mTOR in cancer. Cancer Cell 12:9\u201322. doi: 10.1016\/j.ccr.2007.05.008","journal-title":"Cancer Cell"},{"key":"2685_CR24","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1016\/j.gde.2005.06.012","volume":"15","author":"BD Harfe","year":"2005","unstructured":"Harfe BD (2005) MicroRNAs in vertebrate development. Curr Opin Genet Dev 15:410\u2013415. doi: 10.1016\/j.gde.2005.06.012","journal-title":"Curr Opin Genet Dev"},{"key":"2685_CR25","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1038\/nrm1983","volume":"7","author":"J Heineke","year":"2006","unstructured":"Heineke J, Molkentin JD (2006) Regulation of cardiac hypertrophy by intracellular signaling pathways. Nat Rev Mol Cell Biol 7:589\u2013600. doi: 10.1038\/nrm1983","journal-title":"Nat Rev Mol Cell Biol"},{"key":"2685_CR26","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1042\/BJ20080281","volume":"412","author":"J Huang","year":"2008","unstructured":"Huang J, Manning BD (2008) The TSC1-TSC2 complex: a molecular switchboard controlling cell growth. Biochem J 412:179\u2013190. doi: 10.1042\/BJ20080281","journal-title":"Biochem J"},{"key":"2685_CR27","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1038\/ncb839","volume":"4","author":"K Inoki","year":"2002","unstructured":"Inoki K, Li Y, Zhu T, Wu J, Guan KL (2002) TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling. Nat Cell Biol 4:648\u2013657. doi: 10.1038\/ncb839","journal-title":"Nat Cell Biol"},{"key":"2685_CR28","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1042\/BC20080213","volume":"101","author":"T Kaddar","year":"2009","unstructured":"Kaddar T, Rouault JP, Chien WW, Chebel A, Gadoux M, Salles G, Ffrench M, Magaud JP (2009) Two new miR-16 targets: caprin-1 and HMGA1, proteins implicated in cell proliferation. Biol Cell 101:511\u2013524. doi: 10.1042\/BC20080213","journal-title":"Biol Cell"},{"key":"2685_CR29","doi-asserted-by":"crossref","first-page":"2531","DOI":"10.1210\/me.2008-0265","volume":"22","author":"J Kim","year":"2008","unstructured":"Kim J, Wende AR, Sena S, Theobald HA, Soto J, Sloan C, Wayment BE, Litwin SE, Holzenberger M, LeRoith D, Abel ED (2008) Insulin-like growth factor I receptor signaling is required for exercise-induced cardiac hypertrophy. Mol Endocrinol 22:2531\u20132543. doi: 10.1210\/me.2008-0265","journal-title":"Mol Endocrinol"},{"key":"2685_CR30","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1247\/csf.28.11","volume":"28","author":"H Kishimoto","year":"2003","unstructured":"Kishimoto H, Hamada K, Saunders M, Backman S, Sasaki T, Nakano T, Mak TW, Suzuki A (2003) Physiological functions of Pten in mouse tissues. Cell Struct Funct 28:11\u201321. doi: 10.1247\/csf.28.11","journal-title":"Cell Struct Funct"},{"key":"2685_CR31","doi-asserted-by":"crossref","first-page":"7132","DOI":"10.1038\/sj.onc.1210520","volume":"26","author":"J Lackey","year":"2007","unstructured":"Lackey J, Barnett J, Davidson L, Batty IH, Leslie NR, Downes CP (2007) Loss of PTEN selectively desensitizes upstream IGF1 and insulin signaling. Oncogene 26:7132\u20137142. doi: 10.1038\/sj.onc.1210520","journal-title":"Oncogene"},{"issue":"426","key":"2685_CR32","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.bbrc.2012.08.075","volume":"21","author":"Q Lang","year":"2012","unstructured":"Lang Q, Ling C (2012) MiR-124 suppresses cell proliferation in hepatocellular carcinoma by targeting PIK3CA. Biochem Biophys Res Commun 21(426):247\u2013252. doi: 10.1016\/j.bbrc.2012.08.075","journal-title":"Biochem Biophys Res Commun"},{"key":"2685_CR33","doi-asserted-by":"crossref","first-page":"899","DOI":"10.18632\/aging.100528","volume":"4","author":"OV Leontieva","year":"2012","unstructured":"Leontieva OV, Paszkiewicz GM, Blagosklonny MV (2012) Mechanistic or mammalian target of rapamycin (mTOR) may determine robustness in young male mice at the cost of accelerated aging. Aging-US 4:899\u2013916","journal-title":"Aging-US"},{"key":"2685_CR34","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1042\/BJ20040825","volume":"382","author":"NR Leslie","year":"2004","unstructured":"Leslie NR, Downes CP (2004) PTEN function: how normal cells control it and tumour cells lose it. Biochem J 382:1\u201311. doi: 10.1042\/BJ20040825","journal-title":"Biochem J"},{"issue":"Pt 3","key":"2685_CR35","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1042\/0264-6021:3460827","volume":"346","author":"NR Leslie","year":"2000","unstructured":"Leslie NR, Gray A, Pass I, Orchiston EA, Downes CP (2000) Analysis of the cellular functions of PTEN using catalytic domain and C-terminal mutations: differential effects of C-terminal deletion on signalling pathways downstream of phosphoinositide 3-kinase. Biochem J 346(Pt 3):827\u2013833. doi: 10.1042\/0264-6021:3460827","journal-title":"Biochem J"},{"key":"2685_CR36","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.cub.2006.12.026","volume":"17","author":"NR Leslie","year":"2007","unstructured":"Leslie NR, Yang X, Downes CP, Weijer CJ (2007) PtdIns(3,4,5)P(3)-dependent and -independent roles for PTEN in the control of cell migration. Curr Biol 17:115\u2013125. doi: 10.1016\/j.cub.2006.12.026","journal-title":"Curr Biol"},{"key":"2685_CR37","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1055\/s-0032-1311644","volume":"120","author":"HY Ling","year":"2012","unstructured":"Ling HY, Hu B, Hu XB, Zhong J, Feng SD, Qin L, Liu G, Wen GB, Liao DF (2012) MiRNA-21 reverses high glucose and high insulin induced insulin resistance in 3T3-L1 adipocytes through targeting phosphatase and tensin homologue. Exp Clin Endocrinol Diabetes 120:553\u2013559. doi: 10.1055\/s-0032-1311644","journal-title":"Exp Clin Endocrinol Diabetes"},{"key":"2685_CR38","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1111\/j.1469-185X.2008.00061.x","volume":"84","author":"N Lynam-Lennon","year":"2009","unstructured":"Lynam-Lennon N, Maher SG, Reynolds JV (2009) The roles of microRNA in cancer and apoptosis. Biol Rev Camb Philos Soc 84:55\u201371. doi: 10.1111\/j.1469-185X.2008.00061.x","journal-title":"Biol Rev Camb Philos Soc"},{"key":"2685_CR39","doi-asserted-by":"crossref","first-page":"13375","DOI":"10.1074\/jbc.273.22.13375","volume":"273","author":"T Maehama","year":"1998","unstructured":"Maehama T, Dixon JE (1998) The tumor suppressor, PTEN\/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate. J Biol Chem 273:13375\u201313378. doi: 10.1074\/jbc.273.22.13375","journal-title":"J Biol Chem"},{"key":"2685_CR40","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/S0962-8924(99)01519-6","volume":"9","author":"T Maehama","year":"1999","unstructured":"Maehama T, Dixon JE (1999) PTEN: a tumour suppressor that functions as a phospholipid phosphatase. Trends Cell Biol 9:125\u2013128. doi: 10.1016\/S0962-8924(99)01519-6","journal-title":"Trends Cell Biol"},{"key":"2685_CR41","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1161\/CIRCRESAHA.108.179754","volume":"103","author":"TM Marin","year":"2008","unstructured":"Marin TM, Clemente CF, Santos AM, Picardi PK, Pascoal VD, Lopes-Cendes I, Saad MJ, Franchini KG (2008) Shp2 negatively regulates growth in cardiomyocytes by controlling focal adhesion kinase\/Src and mTOR pathways. Circ Res 103:813\u2013824. doi: 10.1161\/CIRCRESAHA.108.179754","journal-title":"Circ Res"},{"key":"2685_CR42","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.yjmcc.2004.11.005","volume":"38","author":"T Matsui","year":"2005","unstructured":"Matsui T, Rosenzweig A (2005) Convergent signal transduction pathways controlling cardiomyocyte survival and function: the role of PI 3-kinase and Akt. J Mol Cell Cardiol 38:63\u201371. doi: 10.1016\/j.yjmcc.2004.11.005","journal-title":"J Mol Cell Cardiol"},{"key":"2685_CR43","doi-asserted-by":"crossref","first-page":"22896","DOI":"10.1074\/jbc.M200347200","volume":"277","author":"T Matsui","year":"2002","unstructured":"Matsui T, Li L, Wu JC, Cook SA, Nagoshi T, Picard MH, Liao R, Rosenzweig A (2002) Phenotypic spectrum caused by transgenic overexpression of activated Akt in the heart. J Biol Chem 277:22896\u201322901. doi: 10.1074\/jbc.M200347200","journal-title":"J Biol Chem"},{"key":"2685_CR44","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1111\/j.1440-1681.2007.04585.x","volume":"34","author":"JR McMullen","year":"2007","unstructured":"McMullen JR, Jennings GL (2007) Differences between pathological and physiological cardiac hypertrophy: novel therapeutic strategies to treat heart failure. Clin Exp Pharmacol Physiol 34:255\u2013262. doi: 10.1111\/j.1440-1681.2007.04585.x","journal-title":"Clin Exp Pharmacol Physiol"},{"key":"2685_CR45","doi-asserted-by":"crossref","first-page":"12355","DOI":"10.1073\/pnas.1934654100","volume":"100","author":"JR McMullen","year":"2003","unstructured":"McMullen JR, Shioi T, Zhang L, Tarnavski O, Sherwood MC, Kang PM, Izumo S (2003) Phosphoinositide 3-kinase(p110alpha) plays a critical role for the induction of physiological, but not pathological, cardiac hypertrophy. Proc Natl Acad Sci USA 100:12355\u201312360. doi: 10.1073\/pnas.1934654100","journal-title":"Proc Natl Acad Sci USA"},{"key":"2685_CR46","doi-asserted-by":"crossref","first-page":"3050","DOI":"10.1161\/01.CIR.0000130641.08705.45","volume":"109","author":"JR McMullen","year":"2004","unstructured":"McMullen JR, Sherwood MC, Tarnavski O, Zhang L, Dorfman AL, Shioi T, Izumo S (2004) Inhibition of mTOR signaling with rapamycin regresses established cardiac hypertrophy induced by pressure overload. Circulation 109:3050\u20133055. doi: 10.1161\/01.CIR.0000130641.08705.45","journal-title":"Circulation"},{"key":"2685_CR47","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1073\/pnas.0606663104","volume":"104","author":"JR McMullen","year":"2007","unstructured":"McMullen JR, Amirahmadi F, Woodcock EA, Schinke-Braun M, Bouwman RD, Hewitt KA, Mollica JP, Zhang L, Zhang Y, Shioi T, Buerger A, Izumo S, Jay PY, Jennings GL (2007) Protective effects of exercise and phosphoinositide 3-kinase(p110alpha) signaling in dilated and hypertrophic cardiomyopathy. Proc Natl Acad Sci USA 104:612\u2013617. doi: 10.1073\/pnas.0606663104","journal-title":"Proc Natl Acad Sci USA"},{"key":"2685_CR48","doi-asserted-by":"crossref","first-page":"1909","DOI":"10.1590\/S0100-879X2004001200018","volume":"37","author":"A Medeiros","year":"2004","unstructured":"Medeiros A, Oliveira EM, Gianolla R, Casarini DE, Negra\u02dco CE, Brum PC (2004) Swimming training increases cardiac vagal activity and induces cardiac hypertrophy in rats. Braz J Med Biol Res 37:1909\u20131917. doi: 10.1590\/S0100-879X2004001200018","journal-title":"Braz J Med Biol Res"},{"key":"2685_CR49","doi-asserted-by":"crossref","unstructured":"Muslin AJ, DeBosch B (2006) Role of Akt in cardiac growth and metabolism. Novartis Found Symp 274:118\u2013126 (discussion 126\u2013131, 152\u2013155, 272\u2013276)","DOI":"10.1002\/0470029331.ch8"},{"key":"2685_CR50","doi-asserted-by":"crossref","first-page":"2775","DOI":"10.1271\/bbb.60274","volume":"70","author":"K Nakashima","year":"2006","unstructured":"Nakashima K, Yakabe Y, Yamazaki M, Abe H (2006) Effects of fasting and refeeding on expression of atrogin-1 and Akt\/FOXO signaling pathway in skeletal muscle of chicks. Biosci Biotechnol Biochem 70:2775\u20132778. doi: 10.1271\/bbb.60274","journal-title":"Biosci Biotechnol Biochem"},{"issue":"Pt 2","key":"2685_CR51","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1042\/0264-6021:3440427","volume":"344","author":"BT Nav\u00e9","year":"1999","unstructured":"Nav\u00e9 BT, Ouwens M, Withers DJ, Alessi DR, Shepherd PR (1999) Mammalian target of rapamycin is a direct target for protein kinase B: identification of a convergence point for opposing effects of insulin and amino-acid deficiency on protein translation. Biochem J 344(Pt 2):427\u2013431. doi: 10.1042\/0264-6021:3440427","journal-title":"Biochem J"},{"key":"2685_CR52","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/j.canlet.2012.10.017","volume":"328","author":"S Noguchi","year":"2013","unstructured":"Noguchi S, Yasui Y, Iwasaki J, Kumazaki M, Yamada N, Naito S, Akao Y (2013) Replacement treatment with microRNA-143 and -145 induces synergistic inhibition of the growth of human bladder cancer cells by regulating PI3K\/Akt and MAPK signaling pathways. Cancer Lett 328:353\u2013361. doi: 10.1016\/j.canlet.2012.10.017","journal-title":"Cancer Lett"},{"key":"2685_CR53","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1177\/1470320309102304","volume":"10","author":"EM Oliveira","year":"2009","unstructured":"Oliveira EM, Sasaki MS, Cer\u00eancio M, Bara\u00fana VG, Krieger JE (2009) Local reninangiotensin system regulates left ventricular hypertrophy induced by swimming training independent of circulating renin: a pharmacological study. J Renin Angiotensin Aldosterone Syst 10:15\u201323. doi: 10.1177\/1470320309102304","journal-title":"J Renin Angiotensin Aldosterone Syst"},{"key":"2685_CR54","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1016\/j.yjmcc.2004.05.015","volume":"37","author":"GY Oudit","year":"2004","unstructured":"Oudit GY, Sun H, Kerfant BG, Crackower MA, Penninger JM, Backx PH (2004) The role of phosphoinositide-3 kinase and PTEN in cardiovascular physiology and disease. J Mol Cell Cardiol 37:449\u2013471. doi: 10.1016\/j.yjmcc.2004.05.015","journal-title":"J Mol Cell Cardiol"},{"key":"2685_CR55","doi-asserted-by":"crossref","first-page":"14074","DOI":"10.1073\/pnas.0610906104","volume":"104","author":"NH Purcell","year":"2007","unstructured":"Purcell NH, Wilkins BJ, York A, Saba-El-Leil MK, Meloche S, Robbins J, Molkentin JD (2007) Genetic inhibition of cardiac ERK1\/2 promotes stress-induced apoptosis and heart failure but has no effect on hypertrophy in vivo. Proc Natl Acad Sci USA 104:14074\u201314079. doi: 10.1073\/pnas.0610906104","journal-title":"Proc Natl Acad Sci USA"},{"key":"2685_CR56","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1016\/j.biocel.2011.01.002","volume":"43","author":"R Qiang","year":"2011","unstructured":"Qiang R, Wang F, Shi LY, Liu M, Chen S, Wan HY, Li YX, Li X, Gao SY, Sun BC, Tang H (2011) Plexin-B1 is a target of miR-214 in cervical cancer and promotes the growth and invasion of HeLa cells. Int J Biochem Cell Biol 43:632\u2013641. doi: 10.1016\/j.biocel.2011.01.002","journal-title":"Int J Biochem Cell Biol"},{"key":"2685_CR57","doi-asserted-by":"crossref","first-page":"6683","DOI":"10.1093\/nar\/gks324","volume":"40","author":"M Sachdeva","year":"2012","unstructured":"Sachdeva M, Liu Q, Cao J, Lu Z, Mo YY (2012) Negative regulation of miR-145 by C\/EBP-\u03b2 through the Akt pathway in cancer cells. Nucleic Acids Res 40:6683\u20136692. doi: 10.1093\/nar\/gks324","journal-title":"Nucleic Acids Res"},{"key":"2685_CR58","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/S0092-8674(00)00117-3","volume":"103","author":"T Schmelzle","year":"2000","unstructured":"Schmelzle T, Hall MN (2000) TOR, a central controller of cell growth. Cell 103:253\u2013262. doi: 10.1016\/S0092-8674(00)00117-3","journal-title":"Cell"},{"key":"2685_CR59","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1677\/joe.0.1670107","volume":"167","author":"J Shao","year":"2000","unstructured":"Shao J, Yamashita H, Qiao L, Friedman JE (2000) Decreased Akt kinase activity and insulin resistance in C57BL\/KsJ-Leprdb\/db mice. J Endocrinol 167:107\u2013115. doi: 10.1677\/joe.0.1670107","journal-title":"J Endocrinol"},{"key":"2685_CR60","doi-asserted-by":"crossref","first-page":"13842","DOI":"10.1074\/jbc.M801510200","volume":"283","author":"WH Shen","year":"2008","unstructured":"Shen WH, Chen Z, Shi S, Chen H, Zhu W, Penner A, Bu G, Li W, Boyle DW, Rubart M, Field LJ, Abraham R, Liechty EA, Shou W (2008) Cardiac restricted overexpression of kinase-dead mammalian target of rapamycin (mTOR) mutant impairs the mTOR-mediated signaling and cardiac function. J Biol Chem 283:13842\u201313849. doi: 10.1074\/jbc.M801510200","journal-title":"J Biol Chem"},{"key":"2685_CR61","doi-asserted-by":"crossref","first-page":"2799","DOI":"10.1128\/MCB.22.8.2799-2809.2002","volume":"22","author":"T Shioi","year":"2002","unstructured":"Shioi T, McMullen JR, Kang PM, Douglas PS, Obata T, Franke TF, Cantley LC, Izumo S (2002) Akt\/protein kinase B promotes organ growth in transgenic mice. Mol Cell Biol 22:2799\u20132809. doi: 10.1128\/MCB.22.8.2799-2809","journal-title":"Mol Cell Biol"},{"key":"2685_CR62","doi-asserted-by":"crossref","first-page":"1664","DOI":"10.1161\/01.CIR.0000057979.36322.88","volume":"107","author":"T Shioi","year":"2003","unstructured":"Shioi T, McMullen JR, Tarnavski O, Converso K, Sherwood MC, Manning WJ, Izumo S (2003) Rapamycin attenuates load-induced cardiac hypertrophy in mice. Circulation 107:1664\u20131670. doi: 10.1161\/01.CIR.0000057979.36322.88","journal-title":"Circulation"},{"key":"2685_CR63","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1152\/physiolgenomics.00145.2010","volume":"43","author":"UP Soci","year":"2011","unstructured":"Soci UP, Fernandes T, Hashimoto NY, Mota GF, Amadeu MA, Rosa KT, Irigoyen MC, Phillips MI, Oliveira EM (2011) MicroRNAs 29 are involved in the improvement of ventricular compliance promoted by aerobic exercise training in rats. Physiol Genomics 43:665\u2013673. doi: 10.1152\/physiolgenomics.00145.2010","journal-title":"Physiol Genomics"},{"key":"2685_CR64","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.1161\/HYPERTENSIONAHA.109.138818","volume":"54","author":"W Soesanto","year":"2009","unstructured":"Soesanto W, Lin HY, Hu E, Lefler S, Litwin SE, Sena S, Abel ED, Symons JD, Jalili T (2009) Mammalian target of rapamycin is a critical regulator of cardiac hypertrophy in spontaneously hypertensive rats. Hypertension 54:1321\u20131327. doi: 10.1161\/HYPERTENSIONAHA.109.138818","journal-title":"Hypertension"},{"key":"2685_CR65","doi-asserted-by":"crossref","first-page":"C1256","DOI":"10.1152\/ajpcell.00338.2010","volume":"299","author":"X Song","year":"2010","unstructured":"Song X, Kusakari Y, Xiao CY, Kinsella SD, Rosenberg MA, Scherrer-Crosbie M, Hara K, Rosenzweig A, Matsui T (2010) mTOR attenuates the inflammatory response in cardiomyocytes and prevents cardiac dysfunction in pathological hypertrophy. Am J Physiol Cell Physiol 299:C1256\u2013C1266. doi: 10.1152\/ajpcell.00338.2010","journal-title":"Am J Physiol Cell Physiol"},{"key":"2685_CR66","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1161\/01.RES.83.4.345","volume":"24","author":"PH Sugden","year":"1998","unstructured":"Sugden PH, Clerk A (1998) \u201cStress-responsive\u201d mitogen-activated protein kinases (c-Jun N-terminal kinases and p38 mitogen-activated protein kinases) in the myocardium. Circ Res 24:345\u2013352. doi: 10.1161\/01.RES.83.4.345","journal-title":"Circ Res"},{"key":"2685_CR67","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1016\/j.yjmcc.2007.04.004","volume":"42","author":"M Tatsuguchi","year":"2007","unstructured":"Tatsuguchi M, Seok HY, Callis TE, Thomson JM, Chen JF, Newman M, Rojas M, Hammond SM, Wang DZ (2007) Expression of microRNAs is dynamically regulated during cardiomyocyte hypertrophy. J Mol Cell Cardiol 42:1137\u20131141. doi: 10.1016\/j.yjmcc.2007.04.004","journal-title":"J Mol Cell Cardiol"},{"key":"2685_CR68","doi-asserted-by":"crossref","first-page":"2812","DOI":"10.1073\/pnas.0809579106","volume":"106","author":"T Uziel","year":"2009","unstructured":"Uziel T, Karginov FV, Xie S, Parker JS, Wang YD, Gajjar A, He L, Ellison D, Gilbertson RJ, Hannon G, Roussel MF (2009) The miR-17\u201392 cluster collaborates with the Sonic Hedgehog pathway in medulloblastoma. Proc Natl Acad Sci USA 106:2812\u20132817. doi: 10.1073\/pnas.0809579106","journal-title":"Proc Natl Acad Sci USA"},{"key":"2685_CR69","doi-asserted-by":"crossref","first-page":"2369","DOI":"10.1172\/JCI33099","volume":"117","author":"E Rooij Van","year":"2007","unstructured":"Van Rooij E, Olson EN (2007) Micro RNAs: powerful new regulators of heart disease and provocative therapeutic agents. J Clin Invest 117:2369\u20132376. doi: 10.1172\/JCI33099","journal-title":"J Clin Invest"},{"key":"2685_CR70","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1161\/CIRCRESAHA.108.183426","volume":"103","author":"E Rooij Van","year":"2008","unstructured":"Van Rooij E, Marshall WS, Olson EN (2008) Toward microRNA-based therapeutics for heart disease: the sense in antisense. Circ Res 103:919\u2013928. doi: 10.1161\/CIRCRESAHA.108.183426","journal-title":"Circ Res"},{"key":"2685_CR71","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/S0968-0004(97)01061-X","volume":"22","author":"B Vanhaesebroeck","year":"1997","unstructured":"Vanhaesebroeck B, Leevers SJ, Panayotou G, Waterfield MD (1997) Phosphoinositide 3-kinases: a conserved family of signal transducers. Trends Biochem Sci 22:267\u2013272. doi: 10.1016\/S0968-0004(97)01061-X","journal-title":"Trends Biochem Sci"},{"key":"2685_CR72","doi-asserted-by":"crossref","first-page":"E190","DOI":"10.1152\/ajpendo.00207.2011","volume":"302","author":"MH Vendelbo","year":"2012","unstructured":"Vendelbo MH, Clasen BF, Treebak JT, M\u00f8ller L, Krusenstjerna- Hafstr\u00f8m T, Madsen M, Nielsen TS, St\u00f8dkilde-J\u00f8rgensen H, Pedersen SB, J\u00f8rgensen JO, Goodyear LJ, Wojtaszewski JF, M\u00f8ller N, Jessen N (2012) Insulin resistance after a 72-h fast is associated with impaired AS160 phosphorylation and accumulation of lipid and glycogen in human skeletal muscle. Am J Physiol Endocrinol Metab 302:E190\u2013E200. doi: 10.1152\/ajpendo.00207.2011","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"2685_CR73","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1002\/emmm.201201369","volume":"5","author":"RH Wang","year":"2013","unstructured":"Wang RH, He JP, Su ML, Luo J, Xu M, Du XD, Chen HZ, Wang WJ, Wang Y, Zhang N, Zhao BX, Zhao WX, Shan ZG, Han JH, Chang CS, Wu Q (2013) The orphan receptor TR3 participates in angiotensin II-induced cardiac hypertrophy by controlling mTOR signaling. EMBO Mol Med 5:137\u2013148. doi: 10.1002\/emmm.201201369","journal-title":"EMBO Mol Med"},{"key":"2685_CR74","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1128\/MCB.25.3.1135-1145.2005","volume":"25","author":"N Wijesekara","year":"2005","unstructured":"Wijesekara N, Konrad D, Eweida M, Jefferies C, Liadis N, Giacca A, Crackower M, Suzuki A, Mak TW, Kahn CR, Klip A, Woo M (2005) Muscle-specific Pten deletion protects against insulin resistance and diabetes. Mol Cell Biol 25:1135\u20131145. doi: 10.1128\/MCB.25.3.1135-1145.2005","journal-title":"Mol Cell Biol"},{"key":"2685_CR75","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1016\/j.cell.2006.01.016","volume":"124","author":"S Wullschleger","year":"2006","unstructured":"Wullschleger S, Loewith R, Hall MN (2006) TOR signaling in growth and metabolism. Cell 124:471\u2013484. doi: 10.1016\/j.cell.2006.01.016","journal-title":"Cell"},{"key":"2685_CR76","doi-asserted-by":"crossref","first-page":"1391","DOI":"10.1002\/jcp.22852","volume":"227","author":"XD Xu","year":"2012","unstructured":"Xu XD, Song XW, Li Q, Wang GK, Jing Q, Qin YW (2012) Attenuation of microRNA-22 derepressed PTEN to effectively protect rat cardiomyocytes from hypertrophy. J Cell Physiol 227:1391\u20131398. doi: 10.1002\/jcp.22852","journal-title":"J Cell Physiol"},{"key":"2685_CR77","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1038\/cr.2007.64","volume":"17","author":"Q Yang","year":"2007","unstructured":"Yang Q, Guan KL (2007) Expanding mTOR signaling. Cell Res 17:666\u2013681. doi: 10.1038\/cr.2007.64","journal-title":"Cell Res"},{"key":"2685_CR78","doi-asserted-by":"crossref","first-page":"4586","DOI":"10.1182\/blood-2008-09-178186","volume":"113","author":"J Zhang","year":"2009","unstructured":"Zhang J, Jima DD, Jacobs C, Fischer R, Gottwein E, Huang G, Lugar PL, Lagoo AS, Rizzieri DA, Friedman DR, Weinberg JB, Lipsky PE, Dave SS (2009) Patterns of microRNA expression characterize stages of human B-cell differentiation. Blood 113:4586\u20134594. doi: 10.1182\/blood-2008-09-178186","journal-title":"Blood"},{"key":"2685_CR79","doi-asserted-by":"crossref","first-page":"2805","DOI":"10.1172\/JCI43008","volume":"120","author":"D Zhang","year":"2010","unstructured":"Zhang D, Contu R, Latronico MV, Zhang J, Rizzi R, Catalucci D, Miyamoto S, Huang K, Ceci M, Gu Y, Dalton ND, Peterson KL, Guan KL, Brown JH, Chen J, Sonenberg N, Condorelli G (2010) MTORC1 regulates cardiac function and myocyte survival through 4E-BP1 inhibition in mice. J Clin Invest 120:2805\u20132816. doi: 10.1172\/JCI43008","journal-title":"J Clin Invest"},{"key":"2685_CR80","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1093\/carcin\/bgs346","volume":"34","author":"LY Zhang","year":"2013","unstructured":"Zhang LY, Ho-Fun Lee V, Wong AM, Kwong DL, Zhu YH, Dong SS, Kong KL, Chen J, Tsao SW, Guan XY, Fu L (2013) microRNA-144 promotes cell proliferation, migration and invasion in nasopharyngeal carcinoma through repression of PTEN. Carcinogenesis 34:454\u2013463. doi: 10.1093\/carcin\/bgs346","journal-title":"Carcinogenesis"},{"key":"2685_CR81","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1038\/nrm3025","volume":"12","author":"R Zoncu","year":"2011","unstructured":"Zoncu R, Efeyan A, Sabatini DM (2011) mTOR: from growth signal integration to cancer, diabetes and ageing. Nat Rev Mol Cell Biol 12:21\u201335. doi: 10.1038\/nrm3025","journal-title":"Nat Rev Mol Cell Biol"}],"container-title":["European Journal of Applied Physiology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00421-013-2685-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00421-013-2685-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00421-013-2685-9","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T03:20:00Z","timestamp":1715570400000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00421-013-2685-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,6,28]]},"references-count":81,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2013,10]]}},"alternative-id":["2685"],"URL":"https:\/\/doi.org\/10.1007\/s00421-013-2685-9","relation":{},"ISSN":["1439-6319","1439-6327"],"issn-type":[{"value":"1439-6319","type":"print"},{"value":"1439-6327","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,6,28]]}}}