{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T00:09:34Z","timestamp":1792714174854,"version":"4.5.0"},"reference-count":38,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2013,7,20]],"date-time":"2013-07-20T00:00:00Z","timestamp":1374278400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Appl Physiol"],"published-print":{"date-parts":[[2013,10]]},"DOI":"10.1007\/s00421-013-2693-9","type":"journal-article","created":{"date-parts":[[2013,7,19]],"date-time":"2013-07-19T00:57:30Z","timestamp":1374195450000},"page":"2577-2586","source":"Crossref","is-referenced-by-count":52,"title":["Effect of cryotherapy on muscle recovery and inflammation following a bout of damaging exercise"],"prefix":"10.1007","volume":"113","author":[{"given":"Naomi J.","family":"Crystal","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David H.","family":"Townson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Summer B.","family":"Cook","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dain P.","family":"LaRoche","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2013,7,20]]},"reference":[{"issue":"9","key":"2693_CR1","doi-asserted-by":"crossref","first-page":"781","DOI":"10.2165\/00007256-200636090-00005","volume":"36","author":"A Barnett","year":"2006","unstructured":"Barnett A (2006) Using recovery modalities between training sessions in elite athletes: does it help? Sports Med 36(9):781\u2013796","journal-title":"Sports Med"},{"issue":"2","key":"2693_CR2","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/S1047-9651(18)30128-1","volume":"11","author":"TM Best","year":"2000","unstructured":"Best TM, Hunter KD (2000) Muscle injury and repair. Phys Med Rehabil Clin N Am 11(2):251\u2013266","journal-title":"Phys Med Rehabil Clin N Am"},{"issue":"1","key":"2693_CR3","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1152\/jappl.1999.87.1.74","volume":"87","author":"TM Best","year":"1999","unstructured":"Best TM, Fiebig R, Corr DT, Brickson S, Ji L (1999) Free radical activity, antioxidant enzyme, and glutathione changes with muscle stretch injury in rabbits. J Appl Physiol 87(1):74\u201382","journal-title":"J Appl Physiol"},{"issue":"3","key":"2693_CR4","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1136\/bjsm.2009.065565","volume":"44","author":"CM Bleakley","year":"2010","unstructured":"Bleakley CM, Davison GW (2010) What is the biochemical and physiological rationale for using cold-water immersion in sports recovery? A systematic review. Br J Sports Med 44(3):179\u2013187","journal-title":"Br J Sports Med"},{"issue":"12","key":"2693_CR5","doi-asserted-by":"crossref","first-page":"2010","DOI":"10.1097\/00005768-200112000-00006","volume":"33","author":"S Brickson","year":"2001","unstructured":"Brickson S, Hollander J, Corr DT, Ji LL, Best TM (2001) Oxidant production and immune response after stretch injury in skeletal muscle. Med Sci Sports Exerc 33(12):2010\u20132015","journal-title":"Med Sci Sports Exerc"},{"issue":"2","key":"2693_CR6","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.phrs.2008.06.008","volume":"58","author":"S Brunelli","year":"2008","unstructured":"Brunelli S, Rovere-Querini P (2008) The immune system and the repair of skeletal muscle. Pharmacol Res 58(2):117\u2013121","journal-title":"Pharmacol Res"},{"issue":"4","key":"2693_CR7","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1139\/H09-067","volume":"34","author":"TW Buford","year":"2009","unstructured":"Buford TW, Cooke MB, Shelmadine BD, Hudson GM, Redd L, Willoughby DS (2009) Effects of eccentric treadmill exercise on inflammatory gene expression in human skeletal muscle. Appl Physiol Nutr Metab 34(4):745\u2013753","journal-title":"Appl Physiol Nutr Metab"},{"issue":"4","key":"2693_CR8","first-page":"457","volume":"41","author":"TA Butterfield","year":"2006","unstructured":"Butterfield TA, Best TM, Merrick MA (2006) The dual roles of neutrophils and macrophages in inflammation: a critical balance between tissue damage and repair. J Athl Train 41(4):457\u2013465","journal-title":"J Athl Train"},{"issue":"5","key":"2693_CR9","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1155\/S0962935193000468","volume":"2","author":"G Camus","year":"1993","unstructured":"Camus G, Deby-Dupont G, Deby C, Juchmes-Ferir A, Pincemail J, Lamy M (1993) Inflammatory response to strenuous muscular exercise in man. Mediators Inflamm 2(5):335\u2013342","journal-title":"Mediators Inflamm"},{"issue":"1","key":"2693_CR10","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1097\/JES.0b013e318190ebdb","volume":"37","author":"B Chazaud","year":"2009","unstructured":"Chazaud B, Brigitte M, Yacoub-Youssef H, Arnold L, Gherardi R, Sonnet C, Lafuste P, Chretien F (2009) Dual and beneficial roles of macrophages during skeletal muscle regeneration. Exerc Sport Sci Rev 37(1):18\u201322","journal-title":"Exerc Sport Sci Rev"},{"issue":"2","key":"2693_CR11","doi-asserted-by":"crossref","first-page":"145","DOI":"10.2165\/00007256-200333020-00005","volume":"33","author":"K Cheung","year":"2003","unstructured":"Cheung K, Hume P, Maxwell L (2003) Delayed onset muscle soreness: treatment strategies and performance factors. Sports Med 33(2):145\u2013164","journal-title":"Sports Med"},{"issue":"1","key":"2693_CR12","first-page":"197","volume":"17","author":"DA Connolly","year":"2003","unstructured":"Connolly DA, Sayers SP, McHugh MP (2003) Treatment and prevention of delayed onset muscle soreness. J Strength Cond Res 17(1):197\u2013208","journal-title":"J Strength Cond Res"},{"issue":"3","key":"2693_CR13","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1080\/026404199366136","volume":"17","author":"R Eston","year":"1999","unstructured":"Eston R, Peters D (1999) Effects of cold water immersion on the symptoms of exercise-induced muscle damage. J Sports Sci 17(3):231\u2013238","journal-title":"J Sports Sci"},{"issue":"4","key":"2693_CR14","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1159\/000212384","volume":"16","author":"E Giraldo","year":"2009","unstructured":"Giraldo E, Garcia JJ, Hinchado MD, Ortega E (2009) Exercise intensity-dependent changes in the inflammatory response in sedentary women: role of neuroendocrine parameters in the neutrophil phagocytic process and the pro-\/anti-inflammatory cytokine balance. NeuroImmunoModulation 16(4):237\u2013244","journal-title":"NeuroImmunoModulation"},{"issue":"4","key":"2693_CR15","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1007\/s00421-008-0941-1","volume":"105","author":"G Howatson","year":"2009","unstructured":"Howatson G, Goodall S, van Someren KA (2009) The influence of cold water immersions on adaptation following a single bout of damaging exercise. Eur J Appl Physiol 105(4):615\u2013621","journal-title":"Eur J Appl Physiol"},{"issue":"5","key":"2693_CR16","doi-asserted-by":"crossref","first-page":"R1628","DOI":"10.1152\/ajpregu.00853.2007","volume":"294","author":"MJ Hubal","year":"2008","unstructured":"Hubal MJ, Chen TC, Thompson PD, Clarkson PM (2008) Inflammatory gene changes associated with the repeated-bout effect. Am J Physiol Regul Integr Comp Physiol 294(5):R1628\u2013R1637","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"issue":"3","key":"2693_CR17","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/j.jsams.2007.12.011","volume":"12","author":"J Ingram","year":"2009","unstructured":"Ingram J, Dawson B, Goodman C, Wallman K, Beilby J (2009) Effect of water immersion methods on post-exercise recovery from simulated team sport exercise. J Sci Med Sport 12(3):417\u2013421","journal-title":"J Sci Med Sport"},{"issue":"4","key":"2693_CR18","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1080\/00140130802707733","volume":"52","author":"JR Jakeman","year":"2009","unstructured":"Jakeman JR, Macrae R, Eston R (2009) A single 10-min bout of cold-water immersion therapy after strenuous polymetric exercise has no beneficial effect on recovery from the symptoms of exercise-induced muscle damage. Ergonomics 52(4):456\u2013460","journal-title":"Ergonomics"},{"issue":"4","key":"2693_CR19","first-page":"855","volume":"18","author":"KN Lane","year":"2004","unstructured":"Lane KN, Wenger HA (2004) Effect of selected recovery conditions on performance of repeated bouts of intermittent cycling separated by 24 hours. J Strength Cond Res 18(4):855\u2013860","journal-title":"J Strength Cond Res"},{"issue":"5","key":"2693_CR20","doi-asserted-by":"crossref","first-page":"1995","DOI":"10.1152\/japplphysiol.00803.2001","volume":"92","author":"BM Lapointe","year":"2002","unstructured":"Lapointe BM, Frenette J, Cote CH (2002) Lengthening contraction-induced inflammation is linked to secondary damage but devoid of neutrophil invasion. J Appl Physiol 92(5):1995\u20132004","journal-title":"J Appl Physiol"},{"issue":"6","key":"2693_CR21","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1177\/0363546505284238","volume":"34","author":"DP LaRoche","year":"2006","unstructured":"LaRoche DP, Connolly D (2006) Effects of stretching on passive muscle tension and response to eccentric exercise. Am J Sport Med 34(6):1000\u20131007","journal-title":"Am J Sport Med"},{"issue":"9","key":"2693_CR22","doi-asserted-by":"crossref","first-page":"1660","DOI":"10.1249\/MSS.0b013e3181761561","volume":"40","author":"DP LaRoche","year":"2008","unstructured":"LaRoche DP, Roy SJ, Knight CA, Dickie JL (2008) Elderly women have blunted response to resistance training despite reduced antagonist coactivation. Med Sci Sports Exerc 40(9):1660\u20131668","journal-title":"Med Sci Sports Exerc"},{"key":"2693_CR23","doi-asserted-by":"crossref","unstructured":"Lu H, Huang D, Ransohoff RM, Zhou L (2011) Acute skeletal muscle injury: CCL2 expression by both monocytes and injured muscle is required for repair. Faseb J 25(10):3344\u201355 (Epub 2011 Jun 22)","DOI":"10.1096\/fj.10-178939"},{"issue":"Pt 1","key":"2693_CR24","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1111\/j.1469-7793.2000.00243.x","volume":"529","author":"C Malm","year":"2000","unstructured":"Malm C, Nyberg P, Engstrom M, Sjodin B, Lenkei R, Ekblom B, Lundberg I (2000) Immunological changes in human skeletal muscle and blood after eccentric exercise and multiple biopsies. J Physiol 529(Pt 1):243\u2013262","journal-title":"J Physiol"},{"issue":"Pt 3","key":"2693_CR25","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1113\/jphysiol.2003.056598","volume":"556","author":"C Malm","year":"2004","unstructured":"Malm C, Sjodin TL, Sjoberg B, Lenkei R, Renstrom P, Lundberg IE, Ekblom B (2004) Leukocytes, cytokines, growth factors and hormones in human skeletal muscle and blood after uphill or downhill running. J Physiol 556(Pt 3):983\u20131000","journal-title":"J Physiol"},{"issue":"6","key":"2693_CR26","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1016\/S0899-9007(03)00040-6","volume":"19","author":"LA Moreno","year":"2003","unstructured":"Moreno LA, Joyanes M, Mesana MI, Gonzalez-Gross M, Gil CM, Sarria A, Gutierrez A, Garaulet M, Perez-Prieto R, Bueno M, Marcos A, AVENA Study Group (2003) Harmonization of anthropometric measurements for a multicenter nutrition survey in Spanish adolescents. Nutrition 19(6):481\u2013486","journal-title":"Nutrition"},{"issue":"8","key":"2693_CR27","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1055\/s-2007-972686","volume":"18","author":"DJ Paddon-Jones","year":"1997","unstructured":"Paddon-Jones DJ, Quigley BM (1997) Effect of cryotherapy on muscle soreness and strength following eccentric exercise. Int J Sports Med 18(8):588\u2013593","journal-title":"Int J Sports Med"},{"key":"2693_CR28","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1007\/s00421-005-0035-2","volume":"95","author":"JM Peake","year":"2005","unstructured":"Peake JM, Suzuki K, Hordem M, Wilson G, Nosaka K, Coombes JS (2005a) Plasma cytokine changes in relation to exercise intensity and muscle damage. Eur J Appl Physiol 95:514\u2013521","journal-title":"Eur J Appl Physiol"},{"key":"2693_CR29","first-page":"64","volume":"11","author":"J Peake","year":"2005","unstructured":"Peake J, Nosaka K, Suzuki K (2005b) Characterization of inflammatory responses to eccentric exercise in humans. Exerc Immunol Rev 11:64\u201385","journal-title":"Exerc Immunol Rev"},{"issue":"1","key":"2693_CR30","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/0304-3959(83)90126-4","volume":"17","author":"DD Price","year":"1983","unstructured":"Price DD, McGrath PA, Rafii A, Buckingham B (1983) The validation of visual analogue scales as ratio scale measures for chronic and experimental pain. Pain 17(1):45\u201356","journal-title":"Pain"},{"issue":"6","key":"2693_CR31","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1080\/02640410802603855","volume":"27","author":"GJ Rowsell","year":"2009","unstructured":"Rowsell GJ, Coutts AJ, Reaburn P, Hill-Haas S (2009) Effects of cold-water immersion on physical performance between successive matches in high-performance junior male soccer players. J Sports Sci 27(6):565\u2013573","journal-title":"J Sports Sci"},{"issue":"6","key":"2693_CR32","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1136\/bjsm.2006.033985","volume":"41","author":"KL Sellwood","year":"2007","unstructured":"Sellwood KL, Brukner P, Williams D, Nicol A, Hinman R (2007) Ice-water immersion and delayed-onset muscle soreness: a randomised controlled trial. Br J Sports Med 41(6):392\u2013397","journal-title":"Br J Sports Med"},{"key":"2693_CR33","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1189\/jlb.0506356","volume":"81","author":"PK Shireman","year":"2006","unstructured":"Shireman PK, Contreras-Shannon V, Ochoa O, Karia BP, Michalek JE, McManus LM (2006) MCP-1 deficiency causes altered inflammation with impaired skeletal muscle regeneration. J Leukoc Biol 81:775\u2013785","journal-title":"J Leukoc Biol"},{"issue":"2","key":"2693_CR34","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1139\/h06-106","volume":"32","author":"LL Smith","year":"2007","unstructured":"Smith LL, McKune AJ, Semple SJ, Sibanda E, Steel H, Anderson R (2007) Changes in serum cytokines after repeated bouts of downhill running. Appl Physiol Nutr Metab 32(2):233\u2013240","journal-title":"Appl Physiol Nutr Metab"},{"issue":"2","key":"2693_CR35","doi-asserted-by":"crossref","first-page":"R345","DOI":"10.1152\/ajpregu.00454.2004","volume":"288","author":"JG Tidball","year":"2005","unstructured":"Tidball JG (2005) Inflammatory processes in muscle injury and repair. Am J Physiol Regul Integr Comp Physiol 288(2):R345\u2013R353","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"issue":"Pt 1","key":"2693_CR36","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1113\/jphysiol.2006.118265","volume":"578","author":"JG Tidball","year":"2007","unstructured":"Tidball JG, Wehling-Henricks M (2007) Macrophages promote muscle membrane repair and muscle fibre growth and regeneration during modified muscle loading in mice in vivo. J Physiol 578(Pt 1):327\u2013336","journal-title":"J Physiol"},{"issue":"7","key":"2693_CR37","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1055\/s-2007-989267","volume":"29","author":"J Vaile","year":"2008","unstructured":"Vaile J, Halson S, Gill N, Dawson B (2008) Effect of hydrotherapy on recovery from fatigue. Int J Sports Med 29(7):539\u2013544","journal-title":"Int J Sports Med"},{"issue":"5","key":"2693_CR38","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1007\/s00421-005-0095-3","volume":"96","author":"M Yamane","year":"2006","unstructured":"Yamane M, Teruya H, Nakano M, Ogai R, Ohnishi N, Kosaka M (2006) Post-exercise leg and forearm flexor muscle cooling in humans attenuates endurance and resistance training effects on muscle performance and on circulatory adaptation. Eur J Appl Physiol 96(5):572\u2013580","journal-title":"Eur J Appl Physiol"}],"container-title":["European Journal of Applied Physiology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00421-013-2693-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00421-013-2693-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00421-013-2693-9","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,7,18]],"date-time":"2019-07-18T17:51:13Z","timestamp":1563472273000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00421-013-2693-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,7,20]]},"references-count":38,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2013,10]]}},"alternative-id":["2693"],"URL":"https:\/\/doi.org\/10.1007\/s00421-013-2693-9","relation":{},"ISSN":["1439-6319","1439-6327"],"issn-type":[{"value":"1439-6319","type":"print"},{"value":"1439-6327","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,7,20]]}}}