{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T11:27:01Z","timestamp":1790681221742,"version":"4.1.0"},"reference-count":37,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2014,4,19]],"date-time":"2014-04-19T00:00:00Z","timestamp":1397865600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur J Appl Physiol"],"published-print":{"date-parts":[[2014,7]]},"DOI":"10.1007\/s00421-014-2883-0","type":"journal-article","created":{"date-parts":[[2014,4,18]],"date-time":"2014-04-18T22:06:33Z","timestamp":1397858793000},"page":"1521-1532","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":45,"title":["Combining heat stress and moderate hypoxia reduces cycling time to exhaustion without modifying neuromuscular fatigue characteristics"],"prefix":"10.1007","volume":"114","author":[{"given":"Olivier","family":"Girard","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00e9bastien","family":"Racinais","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2014,4,19]]},"reference":[{"key":"2883_CR1","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1152\/physrev.00015.2007","volume":"88","author":"DG Allen","year":"2008","unstructured":"Allen DG, Lamb GD, Westerblad H (2008) Skeletal muscle fatigue: cellular mechanisms. Physiol Rev 88:287\u2013332","journal-title":"Physiol Rev"},{"issue":"11","key":"2883_CR2","doi-asserted-by":"crossref","first-page":"2039","DOI":"10.1249\/MSS.0b013e31821f59ab","volume":"43","author":"M Amann","year":"2011","unstructured":"Amann M (2011) Central and peripheral fatigue: interaction during cycling exercise in humans. Med Sci Sports Exerc 43(11):2039\u20132045","journal-title":"Med Sci Sports Exerc"},{"issue":"3","key":"2883_CR3","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1113\/jphysiol.2006.113936","volume":"575","author":"M Amann","year":"2006","unstructured":"Amann M, Eldridge MW, Lovering AT, Stickland MK, Pegelow DF, Dempsey JA (2006) Arterial oxygenation influences central motor output and exercise performance via effects on peripheral locomotor muscle fatigue in humans. J Physiol 575(3):937\u2013952","journal-title":"J Physiol"},{"issue":"1","key":"2883_CR4","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1113\/jphysiol.2007.129700","volume":"581","author":"M Amann","year":"2007","unstructured":"Amann M, Romer LM, Subudhi AW, Pegelow DF, Dempsey JA (2007) Severity of hypoxemia affects the relative contributions of peripheral muscle fatigue to exercise performance in healthy humans. J Physiol 581(1):389\u2013403","journal-title":"J Physiol"},{"issue":"5","key":"2883_CR5","first-page":"759","volume":"44","author":"MJ Buono","year":"2012","unstructured":"Buono MJ, Green M, Jones D, Heaney JH (2012) Increases in heart rate and RPE are additive during prolonged exercise in heat and hypoxia. Med Sci Sports Exerc 44(5):759\u2013760 (Abstract 2912)","journal-title":"Med Sci Sports Exerc"},{"key":"2883_CR6","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1152\/japplphysiol.91220.2008a","volume":"107","author":"A Haan De","year":"2009","unstructured":"De Haan A, Gerrits KH, de Ruiter CJ (2009) Counterpoint: the interpolated twitch does not provide a valid measure of the voluntary activation of muscle. J Appl Physiol 107:355\u2013357","journal-title":"J Appl Physiol"},{"key":"2883_CR7","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1152\/japplphysiol.00477.2006","volume":"103","author":"C Balso Del","year":"2007","unstructured":"Del Balso C, Cafarelli E (2007) Adaptations in the activation of human skeletal muscle induced by short-term isometric resistance training. J Appl Physiol 103:402\u2013411","journal-title":"J Appl Physiol"},{"key":"2883_CR8","doi-asserted-by":"crossref","first-page":"3555","DOI":"10.1152\/jn.00348.2005","volume":"94","author":"J Duclay","year":"2005","unstructured":"Duclay J, Martin A (2005) Evoked H-reflex and V-wave responses during maximal isometric, concentric, and eccentric muscle contraction. J Neurophysiol 94:3555\u20133562","journal-title":"J Neurophysiol"},{"issue":"1","key":"2883_CR9","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1249\/MSS.0b013e3181adb9fb","volume":"42","author":"BR Ely","year":"2010","unstructured":"Ely BR, Cheuvront SN, Kenefick RW, Sawka MN (2010) Aerobic performance is degraded, despite modest hyperthermia, in hot environments. Med Sci Sports Exerc 42(1):135\u2013141","journal-title":"Med Sci Sports Exerc"},{"issue":"5","key":"2883_CR10","doi-asserted-by":"crossref","first-page":"1339","DOI":"10.1113\/jphysiol.2012.245316","volume":"591","author":"C Froyd","year":"2013","unstructured":"Froyd C, Millet GY, Noakes TD (2013) The development of peripheral fatigue and short-term recovery during self-paced high-intensity exercise. J Physiol 591(5):1339\u20131346","journal-title":"J Physiol"},{"issue":"6","key":"2883_CR11","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1016\/j.apergo.2010.01.008","volume":"41","author":"F Ftaiti","year":"2010","unstructured":"Ftaiti F, Kacem A, Jaidane N, Tabka Z, Dogui M (2010) Changes in EEG activity before and after exhaustive exercise in sedentary women in neutral and hot environments. Appl Ergon 41(6):806\u2013811","journal-title":"Appl Ergon"},{"issue":"9","key":"2883_CR12","doi-asserted-by":"crossref","first-page":"1240","DOI":"10.1097\/00005768-199709000-00018","volume":"29","author":"SD Galloway","year":"1997","unstructured":"Galloway SD, Maughan RJ (1997) Effects of ambient temperature on the capacity to perform prolonged cycle exercise in man. Med Sci Sports Exerc 29(9):1240\u20131249","journal-title":"Med Sci Sports Exerc"},{"issue":"3","key":"2883_CR13","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1111\/j.1600-0838.2009.01032.x","volume":"21","author":"O Girard","year":"2011","unstructured":"Girard O, Racinais S, Micallef J-P, Millet GP (2011) Spinal modulations accompany peripheral fatigue during prolonged tennis playing. Scand J Med Sci Sports 21(3):455\u2013464","journal-title":"Scand J Med Sci Sports"},{"issue":"6","key":"2883_CR14","doi-asserted-by":"crossref","first-page":"2323","DOI":"10.1007\/s00421-011-2205-8","volume":"112","author":"O Girard","year":"2012","unstructured":"Girard O, Millet GP, Micallef J-P, Racinais O (2012) Alteration in neuromuscular function after a 5\u00a0km running time trial. Eur J Appl Physiol 112(6):2323\u20132330","journal-title":"Eur J Appl Physiol"},{"issue":"1","key":"2883_CR15","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1113\/jphysiol.2007.142158","volume":"586","author":"J Gonzalez-Alonso","year":"2008","unstructured":"Gonzalez-Alonso J, Crandall CG, Johnson JM (2008) The cardiovascular challenge of exercising in the heat. J Physiol 586(1):45\u201353","journal-title":"J Physiol"},{"issue":"11","key":"2883_CR16","doi-asserted-by":"crossref","first-page":"2767","DOI":"10.1113\/jphysiol.2012.228890","volume":"590","author":"S Goodall","year":"2012","unstructured":"Goodall S, Gonz\u00e1lez-Alonso J, Ali L, Ross EZ, Romer LM (2012) Supraspinal fatigue after normoxic and hypoxic exercise in humans. J Physiol 590(11):2767\u20132782","journal-title":"J Physiol"},{"key":"2883_CR17","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1016\/j.neuroscience.2012.10.058","volume":"231","author":"M Gruet","year":"2013","unstructured":"Gruet M, Temesi J, Rupp T, Levy P, Millet GY, Verges S (2013) Stimulation of the motor cortex and corticospinal tract to assess human muscle fatigue. Neuroscience 231:384\u2013399","journal-title":"Neuroscience"},{"issue":"2","key":"2883_CR18","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1007\/BF00846037","volume":"60","author":"TM McLellan","year":"1990","unstructured":"McLellan TM, Kavanagh MF, Jacobs I (1990) The effect of hypoxia on performance during 30\u00a0s or 45\u00a0s of supramaximal exercise. Eur J Appl Physiol Occup Physiol 60(2):155\u2013161","journal-title":"Eur J Appl Physiol Occup Physiol"},{"key":"2883_CR19","doi-asserted-by":"crossref","first-page":"e17059","DOI":"10.1371\/journal.pone.0017059","volume":"22","author":"GY Millet","year":"2011","unstructured":"Millet GY, Tomazin K, Verges S, Vincent C, Bonnefoy R, Boisson RC, Gergel\u00e9 L, F\u00e9asson L, Martin V (2011) Neuromuscular consequences of an extreme mountain ultra-marathon. PLoS One 22:e17059","journal-title":"PLoS One"},{"key":"2883_CR20","doi-asserted-by":"crossref","unstructured":"Mitchell JB, Rogers MM, Basset JT, Hubing KA (2013) Fatigue during high-intensity endurance exercise: the interaction between metabolic factors and thermal stress. J Strength Cond Res (in press)","DOI":"10.1519\/JSC.0000000000000319"},{"issue":"5\u20136","key":"2883_CR21","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1007\/s00421-004-1063-z","volume":"91","author":"S Morrison","year":"2004","unstructured":"Morrison S, Sleivert GG, Cheung SS (2004) Passive hyperthermia reduces voluntary activation and isometric force production. Eur J Appl Physiol 91(5\u20136):729\u2013736","journal-title":"Eur J Appl Physiol"},{"issue":"5","key":"2883_CR22","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1152\/japplphysiol.00910.2007","volume":"104","author":"L Nybo","year":"2008","unstructured":"Nybo L (2008) Hyperthermia and fatigue. J Appl Physiol 104(5):871\u2013878","journal-title":"J Appl Physiol"},{"issue":"3","key":"2883_CR23","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1152\/jappl.2001.91.3.1055","volume":"91","author":"L Nybo","year":"2001","unstructured":"Nybo L, Nielsen B (2001) Hyperthermia and central fatigue during prolonged exercise in humans. J Appl Physiol 91(3):1055\u20131060","journal-title":"J Appl Physiol"},{"issue":"2","key":"2883_CR24","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1113\/expphysiol.2010.054213","volume":"96","author":"JD P\u00e9riard","year":"2011","unstructured":"P\u00e9riard JD, Cramer MN, Chapman PG, Caillaud C, Thompson MW (2011) Cardiovascular strain impairs prolonged self-paced exercise in the heat. Exp Physiol 96(2):134\u2013144","journal-title":"Exp Physiol"},{"issue":"2","key":"2883_CR25","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1089\/ham.2008.1093","volume":"10","author":"S Perrey","year":"2009","unstructured":"Perrey S, Rupp T (2009) Altitude-induced changes in muscle contractile properties. High Alt Med Biol 10(2):175\u2013182","journal-title":"High Alt Med Biol"},{"issue":"6","key":"2883_CR26","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1007\/s00421-010-1445-3","volume":"109","author":"S Perrey","year":"2010","unstructured":"Perrey S, Racinais S, Saimouaa K, Girard O (2010) Neural and muscular adjustments following repeated running sprints. Eur J Appl Physiol 109(6):1027\u20131036","journal-title":"Eur J Appl Physiol"},{"issue":"6","key":"2883_CR27","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1111\/j.1469-8986.2012.01360.x","volume":"49","author":"S Racinais","year":"2012","unstructured":"Racinais S, Girard O (2012) Neuromuscular failure is unlikely to explain the early exercise cessation in hot ambient conditions. Psychophysiology 49(6):853\u2013865","journal-title":"Psychophysiology"},{"issue":"S3","key":"2883_CR28","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1600-0838.2010.01204.x","volume":"20","author":"S Racinais","year":"2010","unstructured":"Racinais S, Oksa J (2010) Temperature and neuromuscular function. Scand J Med Sci Sports 20(S3):1\u201318","journal-title":"Scand J Med Sci Sports"},{"issue":"1","key":"2883_CR29","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1152\/jn.00903.2006","volume":"97","author":"S Racinais","year":"2007","unstructured":"Racinais S, Girard O, Micallef J-P, Perrey S (2007) Failed excitability of spinal motoneurons induced by prolonged running exercise. J Neurophysiol 97(1):596\u2013603","journal-title":"J Neurophysiol"},{"issue":"19","key":"2883_CR30","doi-asserted-by":"crossref","first-page":"4751","DOI":"10.1113\/jphysiol.2008.157420","volume":"586","author":"S Racinais","year":"2008","unstructured":"Racinais S, Gaoua N, Grantham J (2008) Hyperthermia impairs short-term memory and peripheral motor drive transmission. J Physiol 586(19):4751\u20134762","journal-title":"J Physiol"},{"issue":"4","key":"2883_CR31","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1097\/WNP.0b013e31829ddcf1","volume":"30","author":"S Racinais","year":"2013","unstructured":"Racinais S, Maffiuletti NA, Girard O (2013) M-wave, H- and V-reflex recruitment curves during maximal voluntary contraction. J Clin Neurophysiol 30(4):415\u2013421","journal-title":"J Clin Neurophysiol"},{"issue":"11","key":"2883_CR32","doi-asserted-by":"crossref","first-page":"1985","DOI":"10.1113\/jphysiol.2009.186767","volume":"588","author":"P Rasmussen","year":"2010","unstructured":"Rasmussen P, Nielsen J, Overgaard M, Krogh-Madsen R, Gjedde A, Secher NH, Petersen NC (2010) Reduced muscle activation during exercise related to brain oxygenation and metabolism in humans. J Physiol 588(11):1985\u20131995","journal-title":"J Physiol"},{"key":"2883_CR33","doi-asserted-by":"crossref","first-page":"R598","DOI":"10.1152\/ajpregu.00269.2006","volume":"292","author":"LM Romer","year":"2007","unstructured":"Romer LM, Haverkamp HC, Amann M, Lovering AT, Pegelow DF, Dempsey JA (2007) Effect of acute severe hypoxia on peripheral fatigue and endurance capacity in healthy humans. Am J Physiol Regul Integr Comp Physiol 292:R598\u2013R606","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"issue":"1","key":"2883_CR34","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1055\/s-2006-924142","volume":"28","author":"T Rowland","year":"2007","unstructured":"Rowland T, Garrison A, Pober D (2007) Determinants of endurance exercise capacity in the heat in prepubertal boys. Int J Sports Med 28(1):26\u201332","journal-title":"Int J Sports Med"},{"issue":"5","key":"2883_CR35","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1002\/mus.21512","volume":"41","author":"T Rupp","year":"2010","unstructured":"Rupp T, Girard O, Perrey S (2010) Redetermination of the optimal intensity modifies resting H-reflex recovery after a sustained moderate-intensity muscle contraction. Muscle Nerve 41(5):642\u2013650","journal-title":"Muscle Nerve"},{"issue":"4","key":"2883_CR36","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.1152\/japplphysiol.00945.2005","volume":"100","author":"MM Thomas","year":"2006","unstructured":"Thomas MM, Cheung SS, Elder GC, Sleivert GC (2006) Voluntary muscle activation is impaired by core temperature rather than local muscle temperature. J Appl Physiol 100(4):1361\u20131369","journal-title":"J Appl Physiol"},{"key":"2883_CR37","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1186\/1465-9921-11-109","volume":"11","author":"S Verges","year":"2010","unstructured":"Verges S, Bachasson D, Wuyam B (2010) Effect of acute hypoxia on respiratory muscle fatigue in healthy humans. Respir Res 11:109","journal-title":"Respir Res"}],"container-title":["European Journal of Applied Physiology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00421-014-2883-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00421-014-2883-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00421-014-2883-0","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,8,18]],"date-time":"2020-08-18T01:51:34Z","timestamp":1597715494000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00421-014-2883-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,4,19]]},"references-count":37,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2014,7]]}},"alternative-id":["2883"],"URL":"https:\/\/doi.org\/10.1007\/s00421-014-2883-0","relation":{},"ISSN":["1439-6319","1439-6327"],"issn-type":[{"value":"1439-6319","type":"print"},{"value":"1439-6327","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,4,19]]}}}