{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T15:22:35Z","timestamp":1786980155284,"version":"build-2736575974"},"reference-count":35,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2017,2,2]],"date-time":"2017-02-02T00:00:00Z","timestamp":1485993600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2017,2,2]],"date-time":"2017-02-02T00:00:00Z","timestamp":1485993600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"name":"Vice-Rectorate of Research and Science, at the Camilo Jose Cela University","award":["2014-0010"],"award-info":[{"award-number":["2014-0010"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur J Appl Physiol"],"published-print":{"date-parts":[[2017,3]]},"DOI":"10.1007\/s00421-017-3542-z","type":"journal-article","created":{"date-parts":[[2017,2,2]],"date-time":"2017-02-02T09:08:58Z","timestamp":1486026538000},"page":"409-416","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":48,"title":["ACTN3 genotype influences exercise-induced muscle damage during a marathon competition"],"prefix":"10.1007","volume":"117","author":[{"given":"Juan","family":"Del Coso","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marjorie","family":"Valero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan Jos\u00e9","family":"Salinero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beatriz","family":"Lara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Germ\u00e1n","family":"D\u00edaz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9sar","family":"Gallo-Salazar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diana","family":"Ruiz-Vicente","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco","family":"Areces","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos","family":"Puente","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan Carlos","family":"Carril","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ram\u00f3n","family":"Cacabelos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,2,2]]},"reference":[{"key":"3542_CR1","doi-asserted-by":"publisher","DOI":"10.1080\/15438627.2015.1076416","author":"P Abian","year":"2015","unstructured":"Abian P, Coso JD, Salinero JJ, Gallo-Salazar C, Areces F, Ruiz-Vicente D, Lara B, Soriano L, Munoz V, Lorenzo-Capella I, Abian-Vicen J (2015) Muscle damage produced during a simulated badminton match in competitive male players. Res Sports Med:1\u201314. doi:10.1080\/15438627.2015.1076416","journal-title":"Res Sports Med"},{"issue":"5","key":"3542_CR2","doi-asserted-by":"publisher","first-page":"1169","DOI":"10.1007\/s00726-014-1677-3","volume":"46","author":"F Areces","year":"2014","unstructured":"Areces F, Salinero JJ, Abian-Vicen J, Gonzalez-Millan C, Gallo-Salazar C, Ruiz-Vicente D, Lara B, Del Coso J (2014) A 7-day oral supplementation with branched-chain amino acids was ineffective to prevent muscle damage during a marathon. Amino Acids 46(5):1169\u20131176. doi:10.1007\/s00726-014-1677-3","journal-title":"Amino Acids"},{"issue":"6","key":"3542_CR3","doi-asserted-by":"publisher","first-page":"462","DOI":"10.2519\/jospt.2015.5863","volume":"45","author":"F Areces","year":"2015","unstructured":"Areces F, Salinero JJ, Abian-Vicen J, Gonzalez-Millan C, Ruiz-Vicente D, Lara B, Lledo M, Del Coso J (2015) The use of compression stockings during a marathon competition to reduce exercise-induced muscle damage: are they really useful? J Orthop Sports Phys Ther 45(6):462\u2013470. doi:10.2519\/jospt.2015.5863","journal-title":"J Orthop Sports Phys Ther"},{"issue":"3","key":"3542_CR4","doi-asserted-by":"publisher","first-page":"104","DOI":"10.2519\/jospt.2003.33.3.104","volume":"33","author":"RE Baxter","year":"2003","unstructured":"Baxter RE, Moore JH (2003) Diagnosis and treatment of acute exertional rhabdomyolysis. J Orthop Sports Phys Ther 33(3):104\u2013108. doi:10.2519\/jospt.2003.33.3.104","journal-title":"J Orthop Sports Phys Ther"},{"issue":"5","key":"3542_CR5","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1249\/00005768-198205000-00012","volume":"14","author":"GA Borg","year":"1982","unstructured":"Borg GA (1982) Psychophysical bases of perceived exertion. Med Sci Sports Exerc 14(5):377\u2013381","journal-title":"Med Sci Sports Exerc"},{"issue":"9","key":"3542_CR6","doi-asserted-by":"publisher","first-page":"870","DOI":"10.1080\/02640414.2013.865251","volume":"32","author":"A Chatzinikolaou","year":"2014","unstructured":"Chatzinikolaou A, Draganidis D, Avloniti A, Karipidis A, Jamurtas AZ, Skevaki CL, Tsoukas D, Sovatzidis A, Theodorou A, Kambas A, Papassotiriou I, Taxildaris K, Fatouros I (2014) The microcycle of inflammation and performance changes after a basketball match. J Sports Sci 32(9):870\u2013882. doi:10.1080\/02640414.2013.865251","journal-title":"J Sports Sci"},{"issue":"4\u20135","key":"3542_CR7","doi-asserted-by":"publisher","first-page":"361","DOI":"10.2165\/00007256-200737040-00022","volume":"37","author":"PM Clarkson","year":"2007","unstructured":"Clarkson PM (2007) Exertional rhabdomyolysis and acute renal failure in marathon runners. Sports Med (Auckland, NZ) 37(4\u20135):361\u2013363","journal-title":"Sports Med (Auckland, NZ)"},{"issue":"11 Suppl","key":"3542_CR8","doi-asserted-by":"publisher","first-page":"S52","DOI":"10.1097\/01.PHM.0000029772.45258.43","volume":"81","author":"PM Clarkson","year":"2002","unstructured":"Clarkson PM, Hubal MJ (2002) Exercise-induced muscle damage in humans. Am J Phys Med Rehabil 81(11 Suppl):S52\u2013S69. doi:10.1097\/01.PHM.0000029772.45258.43","journal-title":"Am J Phys Med Rehabil"},{"issue":"2","key":"3542_CR9","doi-asserted-by":"publisher","first-page":"564","DOI":"10.1152\/japplphysiol.00130.2005","volume":"99","author":"PM Clarkson","year":"2005","unstructured":"Clarkson PM, Hoffman EP, Zambraski E, Gordish-Dressman H, Kearns A, Hubal M, Harmon B, Devaney JM (2005) ACTN3 and MLCK genotype associations with exertional muscle damage. J Appl Physiol (1985) 99 (2):564\u2013569. doi:10.1152\/japplphysiol.00130.2005","journal-title":"J Appl Physiol"},{"key":"3542_CR10","volume-title":"Statistical power analysis for the behavioral sciences","author":"J Cohen","year":"1988","unstructured":"Cohen J (1988) Statistical power analysis for the behavioral sciences. Lawrence Erlbaum Associates, Hillsdale"},{"issue":"1","key":"3542_CR11","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1007\/s007260170062","volume":"20","author":"C Cuisinier","year":"2001","unstructured":"Cuisinier C, Ward RJ, Francaux M, Sturbois X, de Witte P (2001) Changes in plasma and urinary taurine and amino acids in runners immediately and 24h after a marathon. Amino Acids 20(1):13\u201323","journal-title":"Amino Acids"},{"issue":"8","key":"3542_CR12","doi-asserted-by":"publisher","first-page":"e43280","DOI":"10.1371\/journal.pone.0043280","volume":"7","author":"J Del Coso","year":"2012","unstructured":"Del Coso J, Gonzalez-Millan C, Salinero JJ, Abian-Vicen J, Soriano L, Garde S, Perez-Gonzalez B (2012) Muscle damage and its relationship with muscle fatigue during a half-iron triathlon. PloS one 7(8):e43280. doi:10.1371\/journal.pone.0043280","journal-title":"PloS one"},{"key":"3542_CR13","doi-asserted-by":"publisher","unstructured":"Del Coso J, Fernandez de Velasco D, Abian-Vicen J, Salinero JJ, Gonzalez-Millan C, Areces F, Ruiz D, Gallo C, Calleja-Gonzalez J, Perez-Gonzalez B (2013a) Running pace decrease during a marathon is positively related to blood markers of muscle damage. PloS one 8(2):e57602. doi:10.1371\/journal.pone.0057602","DOI":"10.1371\/journal.pone.0057602"},{"key":"3542_CR14","doi-asserted-by":"publisher","unstructured":"Del Coso J, Salinero JJ, Abian-Vicen J, Gonzalez-Millan C, Garde S, Vega P, Perez-Gonzalez B (2013b) Influence of body mass loss and myoglobinuria on the development of muscle fatigue after a marathon in a warm environment. Appl Physiol Nutr Metab 38(3):286\u2013291. doi:10.1139\/apnm-2012-0241","DOI":"10.1139\/apnm-2012-0241"},{"key":"3542_CR15","doi-asserted-by":"publisher","DOI":"10.1007\/s00421-016-3507-7","author":"J Del Coso","year":"2016","unstructured":"Del Coso J, Salinero JJ, Lara B, Gallo-Salazar C, Areces F, Puente C, Herrero D (2016) ACTN3 X-allele carriers had greater levels of muscle damage during a half-ironman. Eur J Appl Physiol. doi:10.1007\/s00421-016-3507-7","journal-title":"Eur J Appl Physiol"},{"issue":"8","key":"3542_CR16","doi-asserted-by":"publisher","first-page":"1997","DOI":"10.1007\/s00421-013-2622-y","volume":"113","author":"PA Deuster","year":"2013","unstructured":"Deuster PA, Contreras-Sesvold CL, O\u2019Connor FG, Campbell WW, Kenney K, Capacchione JF, Landau ME, Muldoon SM, Rushing EJ, Heled Y (2013) Genetic polymorphisms associated with exertional rhabdomyolysis. Eur J Appl Physiol 113(8):1997\u20132004. doi:10.1007\/s00421-013-2622-y","journal-title":"Eur J Appl Physiol"},{"issue":"Pt 13","key":"3542_CR17","doi-asserted-by":"publisher","first-page":"3063","DOI":"10.1113\/jphysiol.2011.207035","volume":"589","author":"N Eynon","year":"2011","unstructured":"Eynon N, Ruiz JR, Oliveira J, Duarte JA, Birk R, Lucia A (2011) Genes and elite athletes: a roadmap for future research. J Physiol 589(Pt 13):3063\u20133070. doi:10.1113\/jphysiol.2011.207035","journal-title":"J Physiol"},{"issue":"9","key":"3542_CR18","doi-asserted-by":"publisher","first-page":"803","DOI":"10.1007\/s40279-013-0059-4","volume":"43","author":"N Eynon","year":"2013","unstructured":"Eynon N, Hanson ED, Lucia A, Houweling PJ, Garton F, North KN, Bishop DJ (2013) Genes for elite power and sprint performance: ACTN3 leads the way. Sports Med (Auckland, NZ) 43(9):803\u2013817. doi:10.1007\/s40279-013-0059-4","journal-title":"Sports Med (Auckland, NZ)"},{"issue":"5","key":"3542_CR19","doi-asserted-by":"publisher","first-page":"521","DOI":"10.1249\/00005768-199205000-00005","volume":"24","author":"J Friden","year":"1992","unstructured":"Friden J, Lieber RL (1992) Structural and mechanical basis of exercise-induced muscle injury. Med Sci Sports Exerc 24(5):521\u2013530","journal-title":"Med Sci Sports Exerc"},{"issue":"2","key":"3542_CR20","doi-asserted-by":"publisher","first-page":"e1004862","DOI":"10.1371\/journal.pgen.1004862","volume":"11","author":"SI Head","year":"2015","unstructured":"Head SI, Chan S, Houweling PJ, Quinlan KG, Murphy R, Wagner S, Friedrich O, North KN (2015) Altered Ca2+ kinetics associated with alpha-actinin-3 deficiency may explain positive selection for ACTN3 null allele in human evolution. PLoS Genet 11(2):e1004862. doi:10.1371\/journal.pgen.1004862","journal-title":"PLoS Genet"},{"issue":"1","key":"3542_CR21","doi-asserted-by":"publisher","first-page":"e1004908","DOI":"10.1371\/journal.pgen.1004908","volume":"11","author":"N Ivarsson","year":"2015","unstructured":"Ivarsson N, Westerblad H (2015) alpha-Actinin-3: why gene loss is an evolutionary gain. PLoS Genet 11(1):e1004908. doi:10.1371\/journal.pgen.1004908","journal-title":"PLoS Genet"},{"issue":"1","key":"3542_CR22","doi-asserted-by":"publisher","first-page":"e54685","DOI":"10.1371\/journal.pone.0054685","volume":"8","author":"F Ma","year":"2013","unstructured":"Ma F, Yang Y, Li X, Zhou F, Gao C, Li M, Gao L (2013) The association of sport performance with ACE and ACTN3 genetic polymorphisms: a systematic review and meta-analysis. PloS one 8(1):e54685. doi:10.1371\/journal.pone.0054685","journal-title":"PloS one"},{"issue":"4","key":"3542_CR23","doi-asserted-by":"publisher","first-page":"384","DOI":"10.1375\/twin.11.4.384","volume":"11","author":"K North","year":"2008","unstructured":"North K (2008) Why is alpha-actinin-3 deficiency so common in the general population? The evolution of athletic performance. Twin Res Hum Genet 11(4):384\u2013394. doi:10.1375\/twin.11.4.384","journal-title":"Twin Res Hum Genet"},{"key":"3542_CR24","doi-asserted-by":"publisher","DOI":"10.1123\/ijspp.2015-0406","author":"CL Oxendale","year":"2015","unstructured":"Oxendale CL, Twist C, Daniels M, Highton J (2015) The Relationship Between Match-Play Characteristics of Elite Rugby League and Indirect Markers of Muscle Damage. Int J Sports Physiol Perform. doi:10.1123\/ijspp.2015-0406","journal-title":"Int J Sports Physiol Perform"},{"issue":"4","key":"3542_CR25","doi-asserted-by":"publisher","first-page":"1495","DOI":"10.1007\/s00421-011-2109-7","volume":"112","author":"EM Pimenta","year":"2012","unstructured":"Pimenta EM, Coelho DB, Cruz IR, Morandi RF, Veneroso CE, de Azambuja Pussieldi G, Carvalho MR, Silami-Garcia E, De Paz Fernandez JA (2012) The ACTN3 genotype in soccer players in response to acute eccentric training. Eur J Appl Physiol 112(4):1495\u20131503. doi:10.1007\/s00421-011-2109-7","journal-title":"Eur J Appl Physiol"},{"key":"3542_CR26","volume-title":"Visual analog scale and verbal pain intensity scale: from pain management: theory and practice","author":"R Portenoy","year":"1996","unstructured":"Portenoy R, Tanner R (1996) Visual analog scale and verbal pain intensity scale: from pain management: theory and practice. Oxford University Press, New York"},{"issue":"6","key":"3542_CR27","doi-asserted-by":"publisher","first-page":"e34","DOI":"10.1111\/j.1600-0838.2010.01134.x","volume":"21","author":"JR Ruiz","year":"2011","unstructured":"Ruiz JR, Fernandez del Valle M, Verde Z, Diez-Vega I, Santiago C, Yvert T, Rodriguez-Romo G, Gomez-Gallego F, Molina JJ, Lucia A (2011) ACTN3 R577X polymorphism does not influence explosive leg muscle power in elite volleyball players. Scand J Med Sci Sports 21(6):e34\u2013e41. doi:10.1111\/j.1600-0838.2010.01134.x","journal-title":"Scand J Med Sci Sports"},{"issue":"5","key":"3542_CR28","doi-asserted-by":"publisher","first-page":"771","DOI":"10.1111\/j.1600-0838.2009.01017.x","volume":"20","author":"C Santiago","year":"2010","unstructured":"Santiago C, Rodriguez-Romo G, Gomez-Gallego F, Gonzalez-Freire M, Yvert T, Verde Z, Naclerio F, Altmae S, Esteve-Lanao J, Ruiz JR, Lucia A (2010) Is there an association between ACTN3 R577X polymorphism and muscle power phenotypes in young, non-athletic adults? Scand J Med Sci Sports 20(5):771\u2013778. doi:10.1111\/j.1600-0838.2009.01017.x","journal-title":"Scand J Med Sci Sports"},{"issue":"12","key":"3542_CR29","doi-asserted-by":"publisher","first-page":"1697","DOI":"10.1097\/00005768-199912000-00002","volume":"31","author":"SP Sayers","year":"1999","unstructured":"Sayers SP, Clarkson PM, Rouzier PA, Kamen G (1999) Adverse events associated with eccentric exercise protocols: six case studies. Med Sci Sports Exerc 31(12):1697\u20131702","journal-title":"Med Sci Sports Exerc"},{"issue":"1","key":"3542_CR30","first-page":"280","volume":"110","author":"PF Skiba","year":"2011","unstructured":"Skiba PF, Jones AM (2011) Implications of the critical speed and slow component of Vo2 for the 2-hour marathon. J Appl Physiol (1985) 110 (1):280; (discussion 294)","journal-title":"J Appl Physiol"},{"issue":"10","key":"3542_CR31","doi-asserted-by":"publisher","first-page":"2783","DOI":"10.1519\/JSC.0b013e318241e174","volume":"26","author":"R Thorpe","year":"2012","unstructured":"Thorpe R, Sunderland C (2012) Muscle damage, endocrine, and immune marker response to a soccer match. J Strength Cond Res 26(10):2783\u20132790. doi:10.1519\/JSC.0b013e318241e174","journal-title":"J Strength Cond Res"},{"issue":"6","key":"3542_CR32","doi-asserted-by":"publisher","first-page":"1038","DOI":"10.1139\/h2012-087","volume":"37","author":"T Venckunas","year":"2012","unstructured":"Venckunas T, Skurvydas A, Brazaitis M, Kamandulis S, Snieckus A, Moran CN (2012) Human alpha-actinin-3 genotype association with exercise-induced muscle damage and the repeated-bout effect. Appl Physiol Nutr Metab 37(6):1038\u20131046. doi:10.1139\/h2012-087","journal-title":"Appl Physiol Nutr Metab"},{"issue":"1","key":"3542_CR33","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1152\/physiolgenomics.00173.2007","volume":"32","author":"B Vincent","year":"2007","unstructured":"Vincent B, De Bock K, Ramaekers M, Van den Eede E, Van Leemputte M, Hespel P, Thomis MA (2007) ACTN3 (R577X) genotype is associated with fiber type distribution. Physiol Genomics 32(1):58\u201363. doi:10.1152\/physiolgenomics.00173.2007","journal-title":"Physiol Genomics"},{"issue":"2","key":"3542_CR34","doi-asserted-by":"publisher","first-page":"564","DOI":"10.1152\/japplphysiol.01007.2009","volume":"109","author":"B Vincent","year":"2010","unstructured":"Vincent B, Windelinckx A, Nielens H, Ramaekers M, Van Leemputte M, Hespel P, Thomis MA (2010) Protective role of alpha-actinin-3 in the response to an acute eccentric exercise bout. J Appl Physiol (1985) 109 (2):564\u2013573. doi:10.1152\/japplphysiol.01007.2009","journal-title":"J Appl Physiol"},{"issue":"3","key":"3542_CR35","doi-asserted-by":"publisher","first-page":"627","DOI":"10.1086\/377590","volume":"73","author":"N Yang","year":"2003","unstructured":"Yang N, MacArthur DG, Gulbin JP, Hahn AG, Beggs AH, Easteal S, North K (2003) ACTN3 genotype is associated with human elite athletic performance. Am J Hum Genet 73(3):627\u2013631. doi:10.1086\/377590","journal-title":"Am J Hum Genet"}],"container-title":["European Journal of Applied Physiology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00421-017-3542-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00421-017-3542-z\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00421-017-3542-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,2,10]],"date-time":"2021-02-10T10:05:43Z","timestamp":1612951543000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00421-017-3542-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,2,2]]},"references-count":35,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2017,3]]}},"alternative-id":["3542"],"URL":"https:\/\/doi.org\/10.1007\/s00421-017-3542-z","relation":{},"ISSN":["1439-6319","1439-6327"],"issn-type":[{"value":"1439-6319","type":"print"},{"value":"1439-6327","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,2,2]]},"assertion":[{"value":"17 August 2016","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 January 2017","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 February 2017","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no conflict of interest derived from the outcomes of this study.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"The study was part of the DAMUS project supported by a Grant-in-aid from the Vice-Rectorate of Research and Science, at the Camilo Jose Cela University.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Financial support"}},{"value":"All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and\/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}]}}