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Participants were exposed to no light (CON); 10\u00a0J\u00a0cm2<\/jats:sup> (15\u00a0min) of UV-A light (UVA10) and 20\u00a0J\u00a0cm2<\/jats:sup> (30\u00a0min) of UV-A light (UVA20) in a randomized order. Plasma nitrite [NO2<\/jats:sub>\u2212<\/jats:sup>] and nitrate [NO3<\/jats:sub>\u2212<\/jats:sup>] concentrations, blood pressure (BP), and heart rate (HR) were recorded before, immediately after exposure and 30\u00a0min post-exposure. Whole body oxygen utilization ($${{\\dot{V}}}{\\rm O}_{2}$$<\/jats:tex-math>\n \n \n V<\/mml:mi>\n \u02d9<\/mml:mo>\n <\/mml:mover>\n \n O<\/mml:mi>\n 2<\/mml:mn>\n <\/mml:msub>\n <\/mml:mrow>\n <\/mml:math><\/jats:alternatives><\/jats:inline-formula>), resting metabolic rate (RMR) and skin temperature were recorded continuously.<\/jats:p>\n <\/jats:sec>\n Results<\/jats:title>\n None of the measured parameters changed significantly during CON (all P<\/jats:italic>\u2009>\u20090.05). $${{\\dot{V}}}{\\rm O}_{2}$$<\/jats:tex-math>\n \n \n V<\/mml:mi>\n \u02d9<\/mml:mo>\n <\/mml:mover>\n \n O<\/mml:mi>\n 2<\/mml:mn>\n <\/mml:msub>\n <\/mml:mrow>\n <\/mml:math><\/jats:alternatives><\/jats:inline-formula> and RMR were significantly reduced immediately after UVA10 (P<\/jats:italic>\u2009<\u20090.05) despite no change in plasma [NO2<\/jats:sub>\u2212<\/jats:sup>] (P<\/jats:italic>\u2009>\u20090.05). Immediately after exposure to UVA20, plasma [NO2<\/jats:sub>\u2212<\/jats:sup>] was higher (P<\/jats:italic>\u2009=\u20090.014) and $${{\\dot{V}}}{\\rm O}_{2}$$<\/jats:tex-math>\n \n \n V<\/mml:mi>\n \u02d9<\/mml:mo>\n <\/mml:mover>\n \n O<\/mml:mi>\n 2<\/mml:mn>\n <\/mml:msub>\n <\/mml:mrow>\n <\/mml:math><\/jats:alternatives><\/jats:inline-formula> and RMR tended to be lower compared to baseline (P<\/jats:italic>\u2009=\u20090.06). There were no differences in [NO2<\/jats:sub>\u2212<\/jats:sup>] or $${{\\dot{V}}}{\\rm O}_{2}$$<\/jats:tex-math>\n \n \n V<\/mml:mi>\n \u02d9<\/mml:mo>\n <\/mml:mover>\n \n O<\/mml:mi>\n 2<\/mml:mn>\n <\/mml:msub>\n <\/mml:mrow>\n <\/mml:math><\/jats:alternatives><\/jats:inline-formula> at the 30\u00a0min time point in any condition. UV-A exposure did not alter systolic BP, diastolic BP or MAP (all P<\/jats:italic>\u2009>\u20090.05). UV-A light did not alter plasma [NO3<\/jats:sub>\u2212<\/jats:sup>] at any time point (all P<\/jats:italic>\u2009>\u20090.05).<\/jats:p>\n <\/jats:sec>\n Conclusions<\/jats:title>\n This study demonstrates that a UV-A dose of 20 J cm2<\/jats:sup> is necessary to increase plasma [NO2<\/jats:sub>\u2212<\/jats:sup>] although a smaller dose is capable of reducing $${{\\dot{V}}}{\\rm O}_{2}$$<\/jats:tex-math>\n \n \n V<\/mml:mi>\n \u02d9<\/mml:mo>\n <\/mml:mover>\n \n O<\/mml:mi>\n 2<\/mml:mn>\n <\/mml:msub>\n <\/mml:mrow>\n <\/mml:math><\/jats:alternatives><\/jats:inline-formula> and RMR at rest. Exposure to UV-A did not significantly reduce BP in this cohort of healthy adults. These data suggest that exposure to sunlight has a meaningful acute impact on metabolic function.<\/jats:p>\n <\/jats:sec>","DOI":"10.1007\/s00421-018-3835-x","type":"journal-article","created":{"date-parts":[[2018,3,7]],"date-time":"2018-03-07T13:21:25Z","timestamp":1520428885000},"page":"1043-1052","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["The effects of two different doses of ultraviolet-A light exposure on nitric oxide metabolites and cardiorespiratory outcomes"],"prefix":"10.1007","volume":"118","author":[{"given":"Chris","family":"Monaghan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luke C.","family":"McIlvenna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luke","family":"Liddle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mia","family":"Burleigh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard B.","family":"Weller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernadette O.","family":"Fernandez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Feelisch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David J.","family":"Muggeridge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4808-1287","authenticated-orcid":false,"given":"Chris","family":"Easton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2018,3,7]]},"reference":[{"key":"3835_CR1","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1016\/j.niox.2009.01.002","volume":"20","author":"JD Allen","year":"2009","unstructured":"Allen JD, Miller EM, Schwark E et al (2009) Plasma nitrite response and arterial reactivity differentiate vascular health and performance. 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