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Correlations between sweat and blood have not been established for most constituents, with perhaps the exception of ethanol. With respect to sweat diagnostics, it is well accepted that elevated sweat sodium and chloride is a useful screening tool for cystic fibrosis. However, sweat electrolyte concentrations are not predictive of hydration status or sweating rate. Sweat metabolite concentrations are not a reliable biomarker for exercise intensity or other physiological stressors. To date, glucose, cytokine, and cortisol research is too limited to suggest that sweat is a useful surrogate for blood.<\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n Final sweat composition is not only influenced by extracellular solute concentrations, but also mechanisms of secretion and\/or reabsorption, sweat flow rate, byproducts of sweat gland metabolism, skin surface contamination, and sebum secretions, among other factors related to methodology. Future research that accounts for these confounding factors is needed to address the existing gaps in the literature.<\/jats:p>\n <\/jats:sec>","DOI":"10.1007\/s00421-020-04323-7","type":"journal-article","created":{"date-parts":[[2020,3,2]],"date-time":"2020-03-02T07:02:32Z","timestamp":1583132552000},"page":"719-752","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":353,"title":["Physiological mechanisms determining eccrine sweat composition"],"prefix":"10.1007","volume":"120","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6588-9424","authenticated-orcid":false,"given":"Lindsay B.","family":"Baker","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony S.","family":"Wolfe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,3,2]]},"reference":[{"key":"4323_CR1","doi-asserted-by":"crossref","first-page":"46","DOI":"10.3181\/00379727-74-17804","volume":"74","author":"WS Adams","year":"1950","unstructured":"Adams WS, Leslie A, Levin MH (1950) The dermal loss of iron. 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