{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,2]],"date-time":"2025-07-02T16:23:16Z","timestamp":1751473396082,"version":"3.37.3"},"reference-count":40,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2020,8,28]],"date-time":"2020-08-28T00:00:00Z","timestamp":1598572800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2020,8,28]],"date-time":"2020-08-28T00:00:00Z","timestamp":1598572800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"National Health and Medical Research Council Australia","award":["1080914"],"award-info":[{"award-number":["1080914"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur J Appl Physiol"],"published-print":{"date-parts":[[2020,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n<jats:title>Purpose<\/jats:title>\n<jats:p>Animal studies have shown that endothelial denudation abolishes vasodilation in response to increased shear stress. Interestingly, shear-mediated dilation has been reported to be reduced, but not abolished, in coronary artery disease (CAD) patients following catheterization. However, it is not known whether this resulted from a priori endothelial dysfunction in this diseased population. In this study, we evaluated shear-mediated dilation following catheterization in healthy young men.<\/jats:p>\n<\/jats:sec><jats:sec>\n<jats:title>Methods<\/jats:title>\n<jats:p>Twenty-six (age: 24.4\u2009\u00b1\u20093.8\u00a0years, BMI: 24.3\u2009\u00b1\u20092.8\u00a0kg\u00a0m<jats:sup>\u22122<\/jats:sup>, <jats:italic>V<\/jats:italic>O<jats:sub>2peak<\/jats:sub>: 50.5\u2009\u00b1\u20098.8\u00a0ml\/kg\/min) healthy males underwent unilateral transradial catheterization. Shear-mediated dilation of both radial arteries was measured using flow-mediated dilation (FMD) pre-, and 7\u00a0days post-catheterization.<\/jats:p>\n<\/jats:sec><jats:sec>\n<jats:title>Results<\/jats:title>\n<jats:p>FMD was reduced in the catheterized arm [9.3\u2009\u00b1\u20094.1% to 4.3\u2009\u00b1\u20094.1% (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001)] post-catheterization, whereas no change was observed in the control arm [8.4\u2009\u00b1\u20093.8% to 7.3\u2009\u00b1\u20093.8% (<jats:italic>P<\/jats:italic>\u2009=\u20090.168)]. FMD was completely abolished in the catheterized arm in five participants. Baseline diameter (<jats:italic>P<\/jats:italic>\u2009=\u20090.001) and peak diameter during FMD (<jats:italic>P<\/jats:italic>\u2009=\u20090.035) were increased in the catheterized arm 7\u00a0days post-catheterization (baseline: 2.3\u2009\u00b1\u20090.3 to 2.6\u2009\u00b1\u20090.2\u00a0mm, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001, peak: 2.5\u2009\u00b1\u20090.3 to 2.7\u2009\u00b1\u20090.3\u00a0mm, <jats:italic>P<\/jats:italic>\u2009=\u20090.001), with no change in the control arm (baseline: 2.3\u2009\u00b1\u20090.3 to 2.3\u2009\u00b1\u20090.3\u00a0mm, <jats:italic>P<\/jats:italic>\u2009=\u20090.288, peak: 2.5\u2009\u00b1\u20090.3 to 2.5\u2009\u00b1\u20090.3\u00a0mm, <jats:italic>P<\/jats:italic>\u2009=\u20090.608).<\/jats:p>\n<\/jats:sec><jats:sec>\n<jats:title>Conclusion<\/jats:title>\n<jats:p>This is the first study in young healthy individuals with intact a priori endothelial function to provide evidence of impaired shear-mediated dilation following catheterization. When combined with earlier studies in CAD patients, our data suggest the catheterization impairs artery function in humans.<\/jats:p>\n<\/jats:sec>","DOI":"10.1007\/s00421-020-04473-8","type":"journal-article","created":{"date-parts":[[2020,8,28]],"date-time":"2020-08-28T05:02:39Z","timestamp":1598590959000},"page":"2525-2532","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Impact of catheterization on shear-mediated arterial dilation in healthy young men"],"prefix":"10.1007","volume":"120","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8226-0724","authenticated-orcid":false,"given":"Andrea","family":"Tryfonos","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1671-8714","authenticated-orcid":false,"given":"Matthew","family":"Cocks","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Debar","family":"Rasoul","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph","family":"Mills","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3226-2921","authenticated-orcid":false,"given":"Daniel J.","family":"Green","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5958-267X","authenticated-orcid":false,"given":"Ellen A.","family":"Dawson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2020,8,28]]},"reference":[{"issue":"6","key":"4473_CR1","doi-asserted-by":"publisher","first-page":"481","DOI":"10.2165\/11531950-000000000-00000","volume":"40","author":"A Alkarmi","year":"2010","unstructured":"Alkarmi A, Thijssen DH, Albouaini K, Cable NT, Wright DJ, Green DJ, Dawson EA (2010) Arterial prehabilitation: can exercise induce changes in artery size and function that decrease complications of catheterization? 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