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We measured beat-by-beat R-to-R interval (RRi) and mean arterial pressure (MAP). Mean RRi and MAP values defined the operating point (OP) before (PRE-ss) and in the second phase (\u03c62) of apnoea. Baroreflex sensitivity (BRS, ms\u00b7mmHg<jats:sup>\u22121<\/jats:sup>) was calculated with the sequence method.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>In PRE-ss, BRS was (median [IQR]): at rest, 20.3 [10.0\u201328.6] in air and 18.8 [13.8\u201325.2] in O<jats:sub>2<\/jats:sub>; at exercise 9.2[8.4\u201313.2] in air and 10.1[8.4\u201313.6] in O<jats:sub>2<\/jats:sub>. In \u03c61, during MAP decrease, BRS was lower than in PRE-ss at rest (6.6 [5.3\u201311.4] in air and 7.7 [4.9\u201314.3] in O<jats:sub>2<\/jats:sub>, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). At exercise, BRS in \u03c61 was 6.4 [3.9\u201313.1] in air and 6.7 [4.1\u20139.5] in O<jats:sub>2<\/jats:sub>. After attainment of minimum MAP (MAPmin), baroreflex resetting started. After attainment of minimum RRi, baroreflex sequences reappeared. In \u03c62, BRS at rest was 12.1 [9.6\u201316.2] in air, 12.9 [9.2\u201315.8] in O<jats:sub>2<\/jats:sub>. At exercise (no \u03c62 in air), it was 7.9 [5.4\u201310.7] in O<jats:sub>2<\/jats:sub>. In \u03c62, OP acts at higher MAP values.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>In apnoea \u03c61, there is a sudden correction of MAP fall via baroreflex. The lower BRS in the earliest \u03c61 suggests a possible parasympathetic mechanism underpinning this reduction. After MAPmin, baroreflex resets, displacing its OP at higher MAP level; thus, resetting may not be due to central command. After resetting, restoration of BRS suggests re-establishment of vagal drive.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00421-020-04544-w","type":"journal-article","created":{"date-parts":[[2020,11,5]],"date-time":"2020-11-05T09:02:46Z","timestamp":1604566966000},"page":"539-547","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Baroreflex responses during dry resting and exercise apnoeas in air and pure oxygen"],"prefix":"10.1007","volume":"121","author":[{"given":"Anna","family":"Taboni","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Vinetti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timoth\u00e9e","family":"Fontolliet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriele Simone","family":"Grasso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enrico","family":"Tam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Moia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guido","family":"Ferretti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7312-8174","authenticated-orcid":false,"given":"Nazzareno","family":"Fagoni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,11,5]]},"reference":[{"key":"4544_CR1","doi-asserted-by":"publisher","first-page":"673","DOI":"10.1139\/apnm-2012-0396","volume":"38","author":"A Adami","year":"2013","unstructured":"Adami A, Pizzinelli P, Bringard A et al (2013) Cardiovascular re-adjustments and baroreflex response during clinical reambulation procedure at the end of 35-day bed rest in humans. 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Approval was granted by the Commission Cantonale d\u2019\u00c9thique de la Recherche, Canton de Gen\u00e8ve, CH (Date 11th July 2018\u2013No. 2018-00913).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"All subjects gave their written informed consent after having received a detailed description of the methods and experimental procedures of the study.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"Informed consent was obtained from all participants included in the study.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The datasets generated and analysed during the current study are available from the corresponding author on reasonable request. Code availability: not applicable.","order":6,"name":"Ethics","group":{"name":"EthicsHeading","label":"Availability of data and material"}}]}}