{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T23:42:37Z","timestamp":1792798957823,"version":"4.5.0"},"reference-count":144,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2021,1,5]],"date-time":"2021-01-05T00:00:00Z","timestamp":1609804800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,1,5]],"date-time":"2021-01-05T00:00:00Z","timestamp":1609804800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100001807","name":"FAPESP","doi-asserted-by":"crossref","award":["2017\/15314-1"],"award-info":[{"award-number":["2017\/15314-1"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001807","name":"FAPESP","doi-asserted-by":"crossref","award":["2020\/02391-0"],"award-info":[{"award-number":["2020\/02391-0"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001807","name":"FAPESP","doi-asserted-by":"crossref","award":["2016\/50438-0"],"award-info":[{"award-number":["2016\/50438-0"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001807","name":"FAPESP","doi-asserted-by":"crossref","award":["2017\/13552-2"],"award-info":[{"award-number":["2017\/13552-2"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100002322","name":"CAPES","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100005640","name":"Faculdade de Medicina da Universidade de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2020.1.362.5.2"],"award-info":[{"award-number":["2020.1.362.5.2"]}],"id":[{"id":"10.13039\/501100005640","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur J Appl Physiol"],"published-print":{"date-parts":[[2021,3]]},"DOI":"10.1007\/s00421-020-04571-7","type":"journal-article","created":{"date-parts":[[2021,1,5]],"date-time":"2021-01-05T18:08:24Z","timestamp":1609870104000},"page":"749-769","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":58,"title":["Novel insights on caffeine supplementation, CYP1A2 genotype, physiological responses and exercise performance"],"prefix":"10.1007","volume":"121","author":[{"given":"Gabriel","family":"Barreto","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beatriz","family":"Grecco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pietro","family":"Merola","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caio Eduardo Gon\u00e7alves","family":"Reis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno","family":"Gualano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0995-9077","authenticated-orcid":false,"given":"Bryan","family":"Saunders","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,1,5]]},"reference":[{"issue":"10","key":"4571_CR1","doi-asserted-by":"publisher","first-page":"3102","DOI":"10.1002\/hbm.20732","volume":"30","author":"MA Addicott","year":"2009","unstructured":"Addicott MA, Yang LL, Peiffer AM, Burnett LR, Burdette JH, Chen MY, Hayasaka S, Kraft RA, Maldjian JA, Laurienti PJ (2009) The effect of daily caffeine use on cerebral blood flow: How much caffeine can we tolerate? Hum Brain Mapp 30(10):3102\u20133114. https:\/\/doi.org\/10.1002\/hbm.20732","journal-title":"Hum Brain Mapp"},{"issue":"1","key":"4571_CR2","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1089\/jcr.2015.0029","volume":"6","author":"HA Algrain","year":"2016","unstructured":"Algrain HA, Thomas RM, Carrillo AE, Ryan EJ, Kim C-H, Lettan RB, Ryan EJ (2016) The effects of a polymorphism in the cytochrome P450 CYP1A2 gene on performance enhancement with caffeine in recreational cyclists. J Caffeine Res 6(1):34\u201339","journal-title":"J Caffeine Res"},{"issue":"4","key":"4571_CR3","doi-asserted-by":"publisher","first-page":"453","DOI":"10.1249\/00005768-199404000-00009","volume":"26","author":"DE Anderson","year":"1994","unstructured":"Anderson DE, Hickey MS (1994) Effects of caffeine on the metabolic and catecholamine responses to exercise in 5 and 28 degrees C. Med Sci Sports Exerc 26(4):453\u2013458","journal-title":"Med Sci Sports Exerc"},{"issue":"1","key":"4571_CR4","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1186\/s12970-020-00360-x","volume":"17","author":"A Apostolidis","year":"2020","unstructured":"Apostolidis A, Mougios V, Smilios I, Frangous M, Hadjicharalambous M (2020) Caffeine supplementation is ergogenic in soccer players independent of cardiorespiratory or neuromuscular fitness levels. J Int Soc Sports Nutr 17(1):31. https:\/\/doi.org\/10.1186\/s12970-020-00360-x","journal-title":"J Int Soc Sports Nutr"},{"key":"4571_CR5","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1007\/978-3-642-13443-2_3","volume":"200","author":"MJ Arnaud","year":"2011","unstructured":"Arnaud MJ (2011) Pharmacokinetics and metabolism of natural methylxanthines in animal and man. Handb Exp Pharmacol 200:33\u201391. https:\/\/doi.org\/10.1007\/978-3-642-13443-2_3","journal-title":"Handb Exp Pharmacol"},{"issue":"1","key":"4571_CR6","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1519\/JSC.0b013e3181c1f88a","volume":"24","author":"TA Astorino","year":"2010","unstructured":"Astorino TA, Roberson DW (2010) Efficacy of acute caffeine ingestion for short-term high-intensity exercise performance: a systematic review. J Strength Cond Res 24(1):257\u2013265. https:\/\/doi.org\/10.1519\/JSC.0b013e3181c1f88a","journal-title":"J Strength Cond Res"},{"issue":"2","key":"4571_CR7","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1016\/j.nutres.2011.12.001","volume":"32","author":"TA Astorino","year":"2012","unstructured":"Astorino TA, Cottrell T, Lozano AT, Aburto-Pratt K, Duhon J (2012) Increases in cycling performance in response to caffeine ingestion are repeatable. Nutr Res 32(2):78\u201384. https:\/\/doi.org\/10.1016\/j.nutres.2011.12.001","journal-title":"Nutr Res"},{"issue":"6","key":"4571_CR8","doi-asserted-by":"publisher","first-page":"379","DOI":"10.1016\/j.pneurobio.2004.06.004","volume":"73","author":"R Basheer","year":"2004","unstructured":"Basheer R, Strecker RE, Thakkar MM, McCarley RW (2004) Adenosine and sleep-wake regulation. Prog Neurobiol 73(6):379\u2013396. https:\/\/doi.org\/10.1016\/j.pneurobio.2004.06.004","journal-title":"Prog Neurobiol"},{"key":"4571_CR9","doi-asserted-by":"publisher","first-page":"509","DOI":"10.1007\/978-3-642-13443-2_21","volume":"200","author":"MS Beaudoin","year":"2011","unstructured":"Beaudoin MS, Graham TE (2011) Methylxanthines and human health: epidemiological and experimental evidence. Handb Exp Pharmacol 200:509\u2013548. https:\/\/doi.org\/10.1007\/978-3-642-13443-2_21","journal-title":"Handb Exp Pharmacol"},{"issue":"19","key":"4571_CR10","doi-asserted-by":"publisher","first-page":"1920","DOI":"10.1080\/02640414.2016.1241421","volume":"35","author":"R Beaumont","year":"2017","unstructured":"Beaumont R, Cordery P, Funnell M, Mears S, James L, Watson P (2017) Chronic ingestion of a low dose of caffeine induces tolerance to the performance benefits of caffeine. J Sports Sci 35(19):1920\u20131927. https:\/\/doi.org\/10.1080\/02640414.2016.1241421","journal-title":"J Sports Sci"},{"issue":"12","key":"4571_CR11","doi-asserted-by":"publisher","first-page":"2159","DOI":"10.1249\/01.mss.0000233805.56315.a9","volume":"38","author":"CJ Beedie","year":"2006","unstructured":"Beedie CJ, Stuart EM, Coleman DA, Foad AJ (2006) Placebo effects of caffeine on cycling performance. Med Sci Sports Exerc 38(12):2159\u20132164. https:\/\/doi.org\/10.1249\/01.mss.0000233805.56315.a9","journal-title":"Med Sci Sports Exerc"},{"issue":"4","key":"4571_CR12","doi-asserted-by":"publisher","first-page":"1227","DOI":"10.1152\/japplphysiol.00187.2002","volume":"93","author":"DG Bell","year":"2002","unstructured":"Bell DG, McLellan TM (2002) Exercise endurance 1, 3, and 6 h after caffeine ingestion in caffeine users and nonusers. J Appl Physiol 93(4):1227\u20131234. https:\/\/doi.org\/10.1152\/japplphysiol.00187.2002","journal-title":"J Appl Physiol"},{"issue":"8","key":"4571_CR13","doi-asserted-by":"publisher","first-page":"1399","DOI":"10.1097\/00005768-200108000-00024","volume":"33","author":"DG Bell","year":"2001","unstructured":"Bell DG, Jacobs I, Ellerington K (2001) Effect of caffeine and ephedrine ingestion on anaerobic exercise performance. Med Sci Sports Exerc 33(8):1399\u20131403. https:\/\/doi.org\/10.1097\/00005768-200108000-00024","journal-title":"Med Sci Sports Exerc"},{"issue":"6","key":"4571_CR14","doi-asserted-by":"publisher","first-page":"684","DOI":"10.1016\/0009-9236(95)90025-X","volume":"58","author":"NL Benowitz","year":"1995","unstructured":"Benowitz NL, Jacob P 3rd, Mayan H, Denaro C (1995) Sympathomimetic effects of paraxanthine and caffeine in humans. Clin Pharmacol Ther 58(6):684\u2013691. https:\/\/doi.org\/10.1016\/0009-9236(95)90025-X","journal-title":"Clin Pharmacol Ther"},{"issue":"1","key":"4571_CR15","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1111\/j.1365-2125.1986.tb02883.x","volume":"22","author":"M Bruce","year":"1986","unstructured":"Bruce M, Scott N, Lader M, Marks V (1986) The psychopharmacological and electrophysiological effects of single doses of caffeine in healthy human subjects. Br J Clin Pharmacol 22(1):81\u201387. https:\/\/doi.org\/10.1111\/j.1365-2125.1986.tb02883.x","journal-title":"Br J Clin Pharmacol"},{"issue":"6","key":"4571_CR16","doi-asserted-by":"publisher","first-page":"1222","DOI":"10.1165\/rcmb.2011-0056OC","volume":"45","author":"L Calzetta","year":"2011","unstructured":"Calzetta L, Spina D, Cazzola M, Page CP, Facciolo F, Rendina EA, Matera MG (2011) Pharmacological characterization of adenosine receptors on isolated human bronchi. Am J Respir Cell Mol Biol 45(6):1222\u20131231. https:\/\/doi.org\/10.1165\/rcmb.2011-0056OC","journal-title":"Am J Respir Cell Mol Biol"},{"key":"4571_CR17","doi-asserted-by":"publisher","DOI":"10.1007\/s00421-020-04384-8","author":"AT Carswell","year":"2020","unstructured":"Carswell AT, Howland K, Martinez-Gonzalez B, Baron P, Davison G (2020) The effect of caffeine on cognitive performance is influenced by CYP1A2 but not ADORA2A genotype, yet neither genotype affects exercise performance in healthy adults. Eur J Appl Physiol. https:\/\/doi.org\/10.1007\/s00421-020-04384-8","journal-title":"Eur J Appl Physiol"},{"issue":"3","key":"4571_CR18","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1016\/j.toxlet.2004.12.005","volume":"156","author":"F Castorena-Torres","year":"2005","unstructured":"Castorena-Torres F, Mendoza-Cantu A, de Leon MB, Cisneros B, Zapata-Perez O, Lopez-Carrillo L, Salinas JE, Albores A (2005) CYP1A2 phenotype and genotype in a population from the carboniferous region of coahuila. Mex Toxicol Lett 156(3):331\u2013339. https:\/\/doi.org\/10.1016\/j.toxlet.2004.12.005","journal-title":"Mex Toxicol Lett"},{"issue":"12","key":"4571_CR19","doi-asserted-by":"publisher","first-page":"2791","DOI":"10.1038\/npp.2008.17","volume":"33","author":"E Childs","year":"2008","unstructured":"Childs E, Hohoff C, Deckert J, Xu K, Badner J, de Wit H (2008) Association between ADORA2A and DRD2 polymorphisms and caffeine-induced anxiety. Neuropsychopharmacol Off Publ Am Coll Neuropsychopharmacol 33(12):2791\u20132800. https:\/\/doi.org\/10.1038\/npp.2008.17","journal-title":"Neuropsychopharmacol Off Publ Am Coll Neuropsychopharmacol"},{"key":"4571_CR20","doi-asserted-by":"publisher","first-page":"240","DOI":"10.3389\/fphys.2017.00240","volume":"8","author":"PM Christensen","year":"2017","unstructured":"Christensen PM, Shirai Y, Ritz C, Nordsborg NB (2017) Caffeine and bicarbonate for speed. A meta-analysis of legal supplements potential for improving intense endurance exercise performance. Front Physiol 8:240. https:\/\/doi.org\/10.3389\/fphys.2017.00240","journal-title":"Front Physiol"},{"issue":"3\u20134","key":"4571_CR21","doi-asserted-by":"publisher","first-page":"358","DOI":"10.1007\/BF02425499","volume":"73","author":"BS Cohen","year":"1996","unstructured":"Cohen BS, Nelson AG, Prevost MC, Thompson GD, Marx BD, Morris GS (1996) Effects of caffeine ingestion on endurance racing in heat and humidity. Eur J Appl Physiol 73(3\u20134):358\u2013363. https:\/\/doi.org\/10.1007\/BF02425499","journal-title":"Eur J Appl Physiol"},{"issue":"5","key":"4571_CR22","doi-asserted-by":"publisher","first-page":"439","DOI":"10.1055\/s-2007-1024710","volume":"12","author":"K Collomp","year":"1991","unstructured":"Collomp K, Ahmaidi S, Audran M, Chanal JL, Prefaut C (1991) Effects of caffeine ingestion on performance and anaerobic metabolism during the Wingate Test. Int J Sports Med 12(5):439\u2013443. https:\/\/doi.org\/10.1055\/s-2007-1024710","journal-title":"Int J Sports Med"},{"issue":"3","key":"4571_CR23","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1089\/caf.2012.0019","volume":"2","author":"S Courtney","year":"2012","unstructured":"Courtney S, Klein AC, Martin M, Saunders MJ, Flohr JA, Bechtel MK, Dunham W, Hancock M, Womack CJ (2012) The effect of caffeine on performance in collegiate tennis players. J Caffeine Res 2(3):6. https:\/\/doi.org\/10.1089\/caf.2012.0019","journal-title":"J Caffeine Res"},{"issue":"1","key":"4571_CR24","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1007\/BF00734999","volume":"3","author":"JW Daly","year":"1983","unstructured":"Daly JW, Butts-Lamb P, Padgett W (1983) Subclasses of adenosine receptors in the central nervous system: interaction with caffeine and related methylxanthines. Cell Mol Neurobiol 3(1):69\u201380","journal-title":"Cell Mol Neurobiol"},{"issue":"2","key":"4571_CR25","doi-asserted-by":"publisher","first-page":"R399","DOI":"10.1152\/ajpregu.00386.2002","volume":"284","author":"JM Davis","year":"2003","unstructured":"Davis JM, Zhao Z, Stock HS, Mehl KA, Buggy J, Hand GA (2003) Central nervous system effects of caffeine and adenosine on fatigue. Am J Physiol Regul Integr Comp Physiol 284(2):R399-404. https:\/\/doi.org\/10.1152\/ajpregu.00386.2002","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"4571_CR26","doi-asserted-by":"publisher","DOI":"10.1519\/JSC.0000000000002966","author":"N Dittrich","year":"2019","unstructured":"Dittrich N, Serpa MC, Lemos EC, De Lucas RD, Guglielmo LGA (2019) Effects of caffeine chewing gum on exercise tolerance and neuromuscular responses in well-trained runners. J Strength Cond Res. https:\/\/doi.org\/10.1519\/JSC.0000000000002966","journal-title":"J Strength Cond Res"},{"issue":"7","key":"4571_CR27","doi-asserted-by":"publisher","first-page":"697","DOI":"10.1007\/s00228-010-0823-4","volume":"66","author":"N Djordjevic","year":"2010","unstructured":"Djordjevic N, Ghotbi R, Jankovic S, Aklillu E (2010) Induction of CYP1A2 by heavy coffee consumption is associated with the CYP1A2 -163C>A polymorphism. Eur J Clin Pharmacol 66(7):697\u2013703. https:\/\/doi.org\/10.1007\/s00228-010-0823-4","journal-title":"Eur J Clin Pharmacol"},{"issue":"1","key":"4571_CR28","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1123\/ijsnem.2013-0103","volume":"24","author":"TM Doering","year":"2014","unstructured":"Doering TM, Fell JW, Leveritt MD, Desbrow B, Shing CM (2014) The effect of a caffeinated mouth-rinse on endurance cycling time-trial performance. Int J Sport Nutr Exerc Metab 24(1):90\u201397. https:\/\/doi.org\/10.1123\/ijsnem.2013-0103","journal-title":"Int J Sport Nutr Exerc Metab"},{"issue":"2","key":"4571_CR29","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1111\/j.1600-0838.2005.00445.x","volume":"15","author":"M Doherty","year":"2005","unstructured":"Doherty M, Smith PM (2005) Effects of caffeine ingestion on rating of perceived exertion during and after exercise: a meta-analysis. Scand J Med Sci Sports 15(2):69\u201378. https:\/\/doi.org\/10.1111\/j.1600-0838.2005.00445.x","journal-title":"Scand J Med Sci Sports"},{"key":"4571_CR30","doi-asserted-by":"publisher","DOI":"10.1123\/ijsnem.2020-0083","author":"AM Ehlert","year":"2020","unstructured":"Ehlert AM, Twiddy HM, Wilson PB (2020) The effects of caffeine mouth rinsing on exercise performance: a systematic review. Int J Sport Nutr Exerc Metab. https:\/\/doi.org\/10.1123\/ijsnem.2020-0083","journal-title":"Int J Sport Nutr Exerc Metab"},{"issue":"1","key":"4571_CR31","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1007\/s12263-007-0043-4","volume":"2","author":"A El-Sohemy","year":"2007","unstructured":"El-Sohemy A, Cornelis MC, Kabagambe EK, Campos H (2007) Coffee, CYP1A2 genotype and risk of myocardial infarction. Genes Nutr 2(1):155\u2013156. https:\/\/doi.org\/10.1007\/s12263-007-0043-4","journal-title":"Genes Nutr"},{"issue":"4","key":"4571_CR32","doi-asserted-by":"publisher","first-page":"386","DOI":"10.1123\/ijsn.2.4.386","volume":"2","author":"HJ Engels","year":"1992","unstructured":"Engels HJ, Haymes EM (1992) Effects of caffeine ingestion on metabolic responses to prolonged walking in sedentary males. Int J Sport Nutr 2(4):386\u2013396. https:\/\/doi.org\/10.1123\/ijsn.2.4.386","journal-title":"Int J Sport Nutr"},{"issue":"11","key":"4571_CR33","doi-asserted-by":"publisher","first-page":"2335","DOI":"10.1249\/MSS.0000000000001043","volume":"48","author":"RH Fitts","year":"2016","unstructured":"Fitts RH (2016) The role of acidosis in fatigue: pro perspective. Med Sci Sports Exerc 48(11):2335\u20132338. https:\/\/doi.org\/10.1249\/MSS.0000000000001043","journal-title":"Med Sci Sports Exerc"},{"issue":"4","key":"4571_CR34","doi-asserted-by":"publisher","first-page":"443","DOI":"10.1016\/S0006-2952(00)00570-0","volume":"61","author":"BB Fredholm","year":"2001","unstructured":"Fredholm BB, Irenius E, Kull B, Schulte G (2001a) Comparison of the potency of adenosine as an agonist at human adenosine receptors expressed in Chinese hamster ovary cells. Biochem Pharmacol 61(4):443\u2013448","journal-title":"Biochem Pharmacol"},{"issue":"4","key":"4571_CR35","first-page":"527","volume":"53","author":"BB Fredholm","year":"2001","unstructured":"Fredholm BB, Ap IJ, Jacobson KA, Klotz KN, Linden J (2001b) International union of pharmacology. XXV. Nomenclature and classification of adenosine receptors. Pharmacol Rev 53(4):527\u2013552","journal-title":"Pharmacol Rev"},{"issue":"04","key":"4571_CR36","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1055\/s-2008-1025841","volume":"6","author":"G Gaesser","year":"1985","unstructured":"Gaesser G, Rich R (1985) Influence of caffeine on blood lactate response during incremental exercise. Int J Sports Med 6(04):207\u2013211","journal-title":"Int J Sports Med"},{"issue":"6","key":"4571_CR37","doi-asserted-by":"publisher","first-page":"1249","DOI":"10.1002\/cpt.1083","volume":"104","author":"M Gazzaz","year":"2018","unstructured":"Gazzaz M, Kinzig M, Schaeffeler E, Jubner M, Hsin CH, Li X, Taubert M, Trueck C, Iltgen-Breburda J, Kraus D, Queckenberg C, Stoffel M, Schwab M, Sorgel F, Fuhr U (2018) Drinking ethanol has few acute effects on CYP2C9, CYP2C19, NAT2, and P-Glycoprotein Activities but somewhat inhibits CYP1A2, CYP2D6, and Intestinal CYP3A: So What? Clin Pharmacol Ther 104(6):1249\u20131259. https:\/\/doi.org\/10.1002\/cpt.1083","journal-title":"Clin Pharmacol Ther"},{"issue":"2","key":"4571_CR38","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1089\/caff.2017.0028","volume":"8","author":"GE Giersch","year":"2018","unstructured":"Giersch GE, Boyett JC, Hargens TA, Luden ND, Saunders MJ, Daley H, Hughey CA, El-Sohemy A, Womack CJ (2018) The Effect of the CYP1A2\u2212 163 C> a polymorphism on caffeine metabolism and subsequent cycling performance. J Caffeine Adenosine Res 8(2):65\u201370","journal-title":"J Caffeine Adenosine Res"},{"key":"4571_CR39","doi-asserted-by":"publisher","DOI":"10.1139\/apnm-2020-0551","author":"M Glaister","year":"2020","unstructured":"Glaister M, Chopra K, Pereira De Sena A, Sternbach C, Morina L, Mavrommatis Y (2020) Caffeine, exercise physiology, and time-trial performance: no effect of ADORA2A or CYP1A2 genotypes<sup><\/sup>. Appl Physiol Nutr Metab. https:\/\/doi.org\/10.1139\/apnm-2020-0551","journal-title":"Appl Physiol Nutr Metab"},{"issue":"1","key":"4571_CR40","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1186\/1550-2783-7-5","volume":"7","author":"ER Goldstein","year":"2010","unstructured":"Goldstein ER, Ziegenfuss T, Kalman D, Kreider R, Campbell B, Wilborn C, Taylor L, Willoughby D, Stout J, Graves BS, Wildman R, Ivy JL, Spano M, Smith AE, Antonio J (2010) International society of sports nutrition position stand: caffeine and performance. J Int Soc Sports Nutr 7(1):5. https:\/\/doi.org\/10.1186\/1550-2783-7-5","journal-title":"J Int Soc Sports Nutr"},{"issue":"1","key":"4571_CR41","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1152\/japplphysiol.00260.2017","volume":"123","author":"LS Goncalves","year":"2017","unstructured":"Goncalves LS, Painelli VS, Yamaguchi G, Oliveira LF, Saunders B, da Silva RP, Maciel E, Artioli GG, Roschel H, Gualano B (2017) Dispelling the myth that habitual caffeine consumption influences the performance response to acute caffeine supplementation. J Appl Physiol 123(1):213\u2013220. https:\/\/doi.org\/10.1152\/japplphysiol.00260.2017","journal-title":"J Appl Physiol"},{"issue":"1","key":"4571_CR42","first-page":"93","volume":"16","author":"PS Goods","year":"2017","unstructured":"Goods PS, Landers G, Fulton S (2017) Caffeine ingestion improves repeated freestyle sprints in elite male swimmers. J Sports Sci Med 16(1):93\u201398","journal-title":"J Sports Sci Med"},{"issue":"7","key":"4571_CR43","doi-asserted-by":"publisher","first-page":"559","DOI":"10.1139\/y01-026","volume":"79","author":"TE Graham","year":"2001","unstructured":"Graham TE, Sathasivam P, Rowland M, Marko N, Greer F, Battram D (2001) Caffeine ingestion elevates plasma insulin response in humans during an oral glucose tolerance test. Can J Physiol Pharmacol 79(7):559\u2013565","journal-title":"Can J Physiol Pharmacol"},{"issue":"4","key":"4571_CR44","doi-asserted-by":"publisher","first-page":"1502","DOI":"10.1152\/jappl.1998.85.4.1502","volume":"85","author":"F Greer","year":"1998","unstructured":"Greer F, McLean C, Graham TE (1998) Caffeine, performance, and metabolism during repeated Wingate exercise tests. J Appl Physiol 85(4):1502\u20131508. https:\/\/doi.org\/10.1152\/jappl.1998.85.4.1502","journal-title":"J Appl Physiol"},{"issue":"2","key":"4571_CR45","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1080\/17461391.2017.1394371","volume":"18","author":"J Grgic","year":"2018","unstructured":"Grgic J (2018) Caffeine ingestion enhances Wingate performance: a meta-analysis. Eur J Sport Sci 18(2):219\u2013225. https:\/\/doi.org\/10.1080\/17461391.2017.1394371","journal-title":"Eur J Sport Sci"},{"key":"4571_CR46","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1186\/s12970-018-0216-0","volume":"15","author":"J Grgic","year":"2018","unstructured":"Grgic J, Trexler ET, Lazinica B, Pedisic Z (2018) Effects of caffeine intake on muscle strength and power: a systematic review and meta-analysis. J Int Soc Sports Nutr 15:11. https:\/\/doi.org\/10.1186\/s12970-018-0216-0","journal-title":"J Int Soc Sports Nutr"},{"key":"4571_CR47","doi-asserted-by":"publisher","DOI":"10.1136\/bjsports-2018-100278","author":"J Grgic","year":"2019","unstructured":"Grgic J, Grgic I, Pickering C, Schoenfeld BJ, Bishop DJ, Pedisic Z (2019a) Wake up and smell the coffee: caffeine supplementation and exercise performance-an umbrella review of 21 published meta-analyses. Br J Sports Med. https:\/\/doi.org\/10.1136\/bjsports-2018-100278","journal-title":"Br J Sports Med"},{"issue":"1","key":"4571_CR48","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1007\/s40279-018-0997-y","volume":"49","author":"J Grgic","year":"2019","unstructured":"Grgic J, Mikulic P, Schoenfeld BJ, Bishop DJ, Pedisic Z (2019b) The influence of caffeine supplementation on resistance exercise: a review. Sports Med 49(1):17\u201330. https:\/\/doi.org\/10.1007\/s40279-018-0997-y","journal-title":"Sports Med"},{"key":"4571_CR49","doi-asserted-by":"publisher","DOI":"10.3390\/nu12030741","author":"J Grgic","year":"2020","unstructured":"Grgic J, Pickering C, Bishop DJ, Del Coso J, Schoenfeld BJ, Tinsley GM, Pedisic Z (2020a) ADOR2A C allele carriers exhibit ergogenic responses to caffeine supplementation. Nutrients. https:\/\/doi.org\/10.3390\/nu12030741","journal-title":"Nutrients"},{"issue":"1","key":"4571_CR50","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1186\/s12970-020-00349-6","volume":"17","author":"J Grgic","year":"2020","unstructured":"Grgic J, Pickering C, Bishop DJ, Schoenfeld BJ, Mikulic P, Pedisic Z (2020b) CYP1A2 genotype and acute effects of caffeine on resistance exercise, jumping, and sprinting performance. J Int Soc Sports Nutr 17(1):21. https:\/\/doi.org\/10.1186\/s12970-020-00349-6","journal-title":"J Int Soc Sports Nutr"},{"issue":"2","key":"4571_CR51","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1097\/00008571-199204000-00004","volume":"2","author":"L Gu","year":"1992","unstructured":"Gu L, Gonzalez FJ, Kalow W, Tang BK (1992) Biotransformation of caffeine, paraxanthine, theobromine and theophylline by cDNA-expressed human CYP1A2 and CYP2E1. Pharmacogenetics 2(2):73\u201377. https:\/\/doi.org\/10.1097\/00008571-199204000-00004","journal-title":"Pharmacogenetics"},{"issue":"8","key":"4571_CR52","doi-asserted-by":"publisher","first-page":"1570","DOI":"10.1249\/mss.0000000000001596","volume":"50","author":"N Guest","year":"2018","unstructured":"Guest N, Corey P, Vescovi J, El-Sohemy A (2018) Caffeine, CYP1A2 genotype, and endurance performance in athletes. Med Sci Sports Exerc 50(8):1570\u20131578. https:\/\/doi.org\/10.1249\/mss.0000000000001596","journal-title":"Med Sci Sports Exerc"},{"key":"4571_CR53","doi-asserted-by":"publisher","first-page":"8","DOI":"10.3389\/fnut.2019.00008","volume":"6","author":"NS Guest","year":"2019","unstructured":"Guest NS, Horne J, Vanderhout SM, El-Sohemy A (2019) Sport nutrigenomics: personalized nutrition for athletic performance. Front Nutr 6:8. https:\/\/doi.org\/10.3389\/fnut.2019.00008","journal-title":"Front Nutr"},{"key":"4571_CR54","doi-asserted-by":"publisher","DOI":"10.1519\/JSC.0000000000003665","author":"NS Guest","year":"2020","unstructured":"Guest NS, Corey P, Tyrrell PN, El-Sohemy A (2020) Effect of caffeine on endurance performance in athletes may depend on HTR2A and CYP1A2 genotypes. J Strength Cond Res. https:\/\/doi.org\/10.1519\/JSC.0000000000003665","journal-title":"J Strength Cond Res"},{"issue":"5","key":"4571_CR55","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1016\/j.molmed.2015.02.009","volume":"21","author":"KT Hall","year":"2015","unstructured":"Hall KT, Loscalzo J, Kaptchuk TJ (2015) Genetics and the placebo effect: the placebome. Trends Mol Med 21(5):285\u2013294. https:\/\/doi.org\/10.1016\/j.molmed.2015.02.009","journal-title":"Trends Mol Med"},{"issue":"4","key":"4571_CR56","doi-asserted-by":"publisher","first-page":"E700","DOI":"10.1152\/ajpendo.1998.274.4.E700","volume":"274","author":"XX Han","year":"1998","unstructured":"Han XX, Bonen A (1998) Epinephrine translocates GLUT-4 but inhibits insulin-stimulated glucose transport in rat muscle. Am J Physiol 274(4):E700-707. https:\/\/doi.org\/10.1152\/ajpendo.1998.274.4.E700","journal-title":"Am J Physiol"},{"issue":"5","key":"4571_CR57","doi-asserted-by":"publisher","first-page":"540","DOI":"10.1046\/j.1365-2125.2002.01686.x","volume":"54","author":"XM Han","year":"2002","unstructured":"Han XM, Ouyang DS, Chen XP, Shu Y, Jiang CH, Tan ZR, Zhou HH (2002) Inducibility of CYP1A2 by omeprazole in vivo related to the genetic polymorphism of CYP1A2. Br J Clin Pharmacol 54(5):540\u2013543. https:\/\/doi.org\/10.1046\/j.1365-2125.2002.01686.x","journal-title":"Br J Clin Pharmacol"},{"issue":"8","key":"4571_CR58","doi-asserted-by":"publisher","first-page":"730","DOI":"10.1016\/j.amjmed.2012.12.023","volume":"126","author":"JP Higgins","year":"2013","unstructured":"Higgins JP, Babu KM (2013) Caffeine reduces myocardial blood flow during exercise. Am J Med 126(8):730\u2013738. https:\/\/doi.org\/10.1016\/j.amjmed.2012.12.023","journal-title":"Am J Med"},{"issue":"2919","key":"4571_CR59","doi-asserted-by":"publisher","first-page":"544","DOI":"10.1038\/116544a0","volume":"116","author":"AV Hill","year":"1925","unstructured":"Hill AV (1925) The physiological basis of athletic records1. Nature 116(2919):544\u2013548. https:\/\/doi.org\/10.1038\/116544a0","journal-title":"Nature"},{"issue":"4","key":"4571_CR60","doi-asserted-by":"publisher","first-page":"e59561","DOI":"10.1371\/journal.pone.0059561","volume":"8","author":"AB Hodgson","year":"2013","unstructured":"Hodgson AB, Randell RK, Jeukendrup AE (2013) The metabolic and performance effects of caffeine compared to coffee during endurance exercise. PLoS ONE 8(4):e59561. https:\/\/doi.org\/10.1371\/journal.pone.0059561","journal-title":"PLoS ONE"},{"issue":"4","key":"4571_CR61","doi-asserted-by":"publisher","first-page":"438","DOI":"10.1123\/ijsnem.12.4.438","volume":"12","author":"AM Hunter","year":"2002","unstructured":"Hunter AM, St Clair Gibson A, Collins M, Lambert M, Noakes TD (2002) Caffeine ingestion does not alter performance during a 100-km cycling time-trial performance. Int J Sport Nutr Exerc Metab 12(4):438\u2013452","journal-title":"Int J Sport Nutr Exerc Metab"},{"issue":"10","key":"4571_CR62","doi-asserted-by":"publisher","first-page":"2180","DOI":"10.1016\/j.pain.2014.08.029","volume":"155","author":"SK Jaaskelainen","year":"2014","unstructured":"Jaaskelainen SK, Lindholm P, Valmunen T, Pesonen U, Taiminen T, Virtanen A, Lamusuo S, Forssell H, Hagelberg N, Hietala J, Pertovaara A (2014) Variation in the dopamine D2 receptor gene plays a key role in human pain and its modulation by transcranial magnetic stimulation. Pain 155(10):2180\u20132187. https:\/\/doi.org\/10.1016\/j.pain.2014.08.029","journal-title":"Pain"},{"issue":"1","key":"4571_CR63","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1186\/s12970-019-0332-5","volume":"17","author":"P Jodra","year":"2020","unstructured":"Jodra P, Lago-Rodriguez A, Sanchez-Oliver AJ, Lopez-Samanes A, Perez-Lopez A, Veiga-Herreros P, San Juan AF, Dominguez R (2020) Effects of caffeine supplementation on physical performance and mood dimensions in elite and trained-recreational athletes. J Int Soc Sports Nutr 17(1):2. https:\/\/doi.org\/10.1186\/s12970-019-0332-5","journal-title":"J Int Soc Sports Nutr"},{"issue":"1\u20132","key":"4571_CR64","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1016\/S0378-5173(01)00958-9","volume":"234","author":"GH Kamimori","year":"2002","unstructured":"Kamimori GH, Karyekar CS, Otterstetter R, Cox DS, Balkin TJ, Belenky GL, Eddington ND (2002a) The rate of absorption and relative bioavailability of caffeine administered in chewing gum versus capsules to normal healthy volunteers. Int J Pharm 234(1\u20132):159\u2013167","journal-title":"Int J Pharm"},{"issue":"4","key":"4571_CR65","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1097\/01.CSMR.0000306510.57644.a7","volume":"5","author":"BD Keisler","year":"2006","unstructured":"Keisler BD, Armsey TD 2nd (2006) Caffeine as an ergogenic aid. Curr Sports Med Rep 5(4):215\u2013219","journal-title":"Curr Sports Med Rep"},{"issue":"3","key":"4571_CR66","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1089\/jcr.2012.0019","volume":"2","author":"CS Klein","year":"2012","unstructured":"Klein CS, Clawson A, Martin M, Saunders MJ, Flohr JA, Bechtel MK, Dunham W, Hancock M, Womack CJ (2012) The effect of caffeine on performance in collegiate tennis players. J Caffeine Res 2(3):111\u2013116","journal-title":"J Caffeine Res"},{"issue":"6","key":"4571_CR01","doi-asserted-by":"publisher","first-page":"760","DOI":"10.1038\/s41397-017-0011-3","volume":"18","author":"N Koonrungsesomboon","year":"2018","unstructured":"Koonrungsesomboon N, Khatsri R, Wongchompoo P, Teekachunhatean S (2018) The impact of genetic polymorphisms on CYP1A2 activity in humans: a systematic review and meta-analysis. Pharmacogenomics J 18(6):760\u2013768. https:\/\/doi.org\/10.1038\/s41397-017-0011-3","journal-title":"Pharmacogenomics J"},{"issue":"5","key":"4571_CR67","doi-asserted-by":"publisher","first-page":"543","DOI":"10.1007\/BF02285099","volume":"43","author":"JD Lane","year":"1992","unstructured":"Lane JD, Steege JF, Rupp SL, Kuhn CM (1992) Menstrual cycle effects on caffeine elimination in the human female. Eur J Clin Pharmacol 43(5):543\u2013546","journal-title":"Eur J Clin Pharmacol"},{"issue":"1","key":"4571_CR68","doi-asserted-by":"publisher","first-page":"e0210275","DOI":"10.1371\/journal.pone.0210275","volume":"14","author":"B Lara","year":"2019","unstructured":"Lara B, Ruiz-Moreno C, Salinero JJ, Del Coso J (2019) Time course of tolerance to the performance benefits of caffeine. PLoS ONE 14(1):e0210275. https:\/\/doi.org\/10.1371\/journal.pone.0210275","journal-title":"PLoS ONE"},{"issue":"6","key":"4571_CR69","doi-asserted-by":"publisher","first-page":"2525","DOI":"10.1007\/s00394-019-02100-7","volume":"59","author":"B Lara","year":"2020","unstructured":"Lara B, Gutierrez-Hellin J, Garcia-Bataller A, Rodriguez-Fernandez P, Romero-Moraleda B, Del Coso J (2020a) Ergogenic effects of caffeine on peak aerobic cycling power during the menstrual cycle. Eur J Nutr 59(6):2525\u20132534. https:\/\/doi.org\/10.1007\/s00394-019-02100-7","journal-title":"Eur J Nutr"},{"issue":"4","key":"4571_CR70","doi-asserted-by":"publisher","first-page":"745","DOI":"10.1111\/bcp.14175","volume":"86","author":"B Lara","year":"2020","unstructured":"Lara B, Gutierrez Hellin J, Ruiz-Moreno C, Romero-Moraleda B, Del Coso J (2020b) Acute caffeine intake increases performance in the 15-s Wingate test during the menstrual cycle. Br J Clin Pharmacol 86(4):745\u2013752. https:\/\/doi.org\/10.1111\/bcp.14175","journal-title":"Br J Clin Pharmacol"},{"issue":"1","key":"4571_CR71","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1016\/0091-3057(95)00066-6","volume":"52","author":"CE Lau","year":"1995","unstructured":"Lau CE, Falk JL (1995) Dose-dependent surmountability of locomotor activity in caffeine tolerance. Pharmacol Biochem Behav 52(1):139\u2013143. https:\/\/doi.org\/10.1016\/0091-3057(95)00066-6","journal-title":"Pharmacol Biochem Behav"},{"issue":"6","key":"4571_CR72","doi-asserted-by":"publisher","first-page":"2170","DOI":"10.1210\/jcem.85.6.6655","volume":"85","author":"D Laurent","year":"2000","unstructured":"Laurent D, Schneider KE, Prusaczyk WK, Franklin C, Vogel SM, Krssak M, Petersen KF, Goforth HW, Shulman GI (2000) Effects of caffeine on muscle glycogen utilization and the neuroendocrine axis during exercise. J Clin Endocrinol Metab 85(6):2170\u20132175. https:\/\/doi.org\/10.1210\/jcem.85.6.6655","journal-title":"J Clin Endocrinol Metab"},{"key":"4571_CR73","doi-asserted-by":"publisher","first-page":"740","DOI":"10.3389\/fnins.2019.00740","volume":"13","author":"M Lazarus","year":"2019","unstructured":"Lazarus M, Oishi Y, Bjorness TE, Greene RW (2019) Gating and the need for sleep: dissociable effects of adenosine A1 and A2A receptors. Front Neurosci 13:740. https:\/\/doi.org\/10.3389\/fnins.2019.00740","journal-title":"Front Neurosci"},{"issue":"11","key":"4571_CR74","doi-asserted-by":"publisher","first-page":"e0142078","DOI":"10.1371\/journal.pone.0142078","volume":"10","author":"JP Lopes-Silva","year":"2015","unstructured":"Lopes-Silva JP, Silva Santos JF, Branco BH, Abad CC, Oliveira LF, Loturco I, Franchini E (2015) Caffeine ingestion increases estimated glycolytic metabolism during taekwondo combat simulation but does not improve performance or parasympathetic reactivation. PLoS ONE 10(11):e0142078. https:\/\/doi.org\/10.1371\/journal.pone.0142078","journal-title":"PLoS ONE"},{"issue":"2","key":"4571_CR75","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1089\/jcr.2014.0035","volume":"5","author":"BD Loy","year":"2015","unstructured":"Loy BD, O\u2019Connor PJ, Lindheimer JB, Covert SF (2015) Caffeine is ergogenic for adenosine A2A receptor gene (ADORA2A) T allele homozygotes: a pilot study. J Caffeine Res 5(2):73\u201381","journal-title":"J Caffeine Res"},{"issue":"7\u20138","key":"4571_CR76","doi-asserted-by":"publisher","first-page":"535","DOI":"10.1080\/1040-830491379245","volume":"45","author":"F Magkos","year":"2005","unstructured":"Magkos F, Kavouras SA (2005) Caffeine use in sports, pharmacokinetics in man, and cellular mechanisms of action. Crit Rev Food Sci Nutr 45(7\u20138):535\u2013562. https:\/\/doi.org\/10.1080\/1040-830491379245","journal-title":"Crit Rev Food Sci Nutr"},{"issue":"19","key":"4571_CR77","doi-asserted-by":"publisher","first-page":"6059","DOI":"10.1016\/S0021-9258(19)44763-7","volume":"247","author":"TE Mansour","year":"1972","unstructured":"Mansour TE (1972) Phosphofructokinase activity in skeletal muscle extracts following administration of epinephrine. J Biol Chem 247(19):6059\u20136066","journal-title":"J Biol Chem"},{"key":"4571_CR78","doi-asserted-by":"publisher","DOI":"10.3390\/nu10060657","author":"AC Marques","year":"2018","unstructured":"Marques AC, Jesus AA, Giglio BM, Marini AC, Lobo PCB, Mota JF, Pimentel GD (2018) Acute caffeinated coffee consumption does not improve time trial performance in an 800-m run: a randomized, double-blind, crossover Placebo-Controlled Study. Nutrients. https:\/\/doi.org\/10.3390\/nu10060657","journal-title":"Nutrients"},{"key":"4571_CR79","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1016\/j.ejphar.2018.07.038","volume":"834","author":"IK Martikainen","year":"2018","unstructured":"Martikainen IK, Hagelberg N, Jaaskelainen SK, Hietala J, Pertovaara A (2018) Dopaminergic and serotonergic mechanisms in the modulation of pain: in vivo studies in human brain. Eur J Pharmacol 834:337\u2013345. https:\/\/doi.org\/10.1016\/j.ejphar.2018.07.038","journal-title":"Eur J Pharmacol"},{"issue":"7","key":"4571_CR80","doi-asserted-by":"publisher","first-page":"439","DOI":"10.1136\/bjsports-2018-099027","volume":"52","author":"RJ Maughan","year":"2018","unstructured":"Maughan RJ, Burke LM, Dvorak J, Larson-Meyer DE, Peeling P, Phillips SM, Rawson ES, Walsh NP, Garthe I, Geyer H, Meeusen R, van Loon LJC, Shirreffs SM, Spriet LL, Stuart M, Vernec A, Currell K, Ali VM, Budgett RG, Ljungqvist A, Mountjoy M, Pitsiladis YP, Soligard T, Erdener U, Engebretsen L (2018) IOC consensus statement: dietary supplements and the high-performance athlete. Br J Sports Med 52(7):439\u2013455. https:\/\/doi.org\/10.1136\/bjsports-2018-099027","journal-title":"Br J Sports Med"},{"key":"4571_CR81","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1186\/1550-2783-4-11","volume":"4","author":"SR McClaran","year":"2007","unstructured":"McClaran SR, Wetter TJ (2007) Low doses of caffeine reduce heart rate during submaximal cycle ergometry. J Int Soc Sports Nutr 4:11. https:\/\/doi.org\/10.1186\/1550-2783-4-11","journal-title":"J Int Soc Sports Nutr"},{"issue":"3","key":"4571_CR82","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1080\/02701367.1987.10605458","volume":"58","author":"L Mcnaughton","year":"1987","unstructured":"Mcnaughton L (1987) Two levels of caffeine ingestion on blood lactate and free fatty acid responses during incremental exercise. Res Q Exerc Sport 58(3):255\u2013259","journal-title":"Res Q Exerc Sport"},{"key":"4571_CR83","doi-asserted-by":"publisher","DOI":"10.3390\/nu11102313","author":"J Mielgo-Ayuso","year":"2019","unstructured":"Mielgo-Ayuso J, Marques-Jimenez D, Refoyo I, Del Coso J, Leon-Guereno P, Calleja-Gonzalez J (2019) Effect of caffeine supplementation on sports performance based on differences between sexes: a systematic review. Nutrients. https:\/\/doi.org\/10.3390\/nu11102313","journal-title":"Nutrients"},{"issue":"7","key":"4571_CR84","doi-asserted-by":"publisher","first-page":"2101","DOI":"10.3390\/nu12072101","volume":"12","author":"AP Morales","year":"2020","unstructured":"Morales AP, Sampaio-Jorge F, Barth T, Pierucci APTR, Ribeiro BG (2020) Caffeine supplementation for 4 days does not induce tolerance to the ergogenic effects promoted by acute intake on physiological, metabolic, and performance parameters of cyclists: a randomized, double-blind, crossover, Placebo-Controlled Study. Nutrients 12(7):2101","journal-title":"Nutrients"},{"issue":"8","key":"4571_CR85","doi-asserted-by":"publisher","first-page":"933","DOI":"10.3390\/genes11080933","volume":"11","author":"A Mu\u00f1oz","year":"2020","unstructured":"Mu\u00f1oz A, L\u00f3pez-Samanes \u00c1, Aguilar-Navarro M, Varillas-Delgado D, Rivilla-Garc\u00eda J, Moreno-P\u00e9rez V, Del Coso J (2020) Effects of CYP1A2 and ADORA2A genotypes on the ergogenic response to caffeine in professional handball players. Genes 11(8):933","journal-title":"Genes"},{"issue":"5","key":"4571_CR86","doi-asserted-by":"publisher","first-page":"e5665","DOI":"10.1371\/journal.pone.0005665","volume":"4","author":"M Namdar","year":"2009","unstructured":"Namdar M, Schepis T, Koepfli P, Gaemperli O, Siegrist PT, Grathwohl R, Valenta I, Delaloye R, Klainguti M, Wyss CA, Luscher TF, Kaufmann PA (2009) Caffeine impairs myocardial blood flow response to physical exercise in patients with coronary artery disease as well as in age-matched controls. PLoS ONE 4(5):e5665. https:\/\/doi.org\/10.1371\/journal.pone.0005665","journal-title":"PLoS ONE"},{"issue":"4","key":"4571_CR87","doi-asserted-by":"publisher","first-page":"563","DOI":"10.1016\/S0149-7634(98)00050-5","volume":"23","author":"A Nehlig","year":"1999","unstructured":"Nehlig A (1999) Are we dependent upon coffee and caffeine? A review on human and animal data. Neurosci Biobehav Rev 23(4):563\u2013576","journal-title":"Neurosci Biobehav Rev"},{"issue":"2","key":"4571_CR88","doi-asserted-by":"publisher","first-page":"384","DOI":"10.1124\/pr.117.014407","volume":"70","author":"A Nehlig","year":"2018","unstructured":"Nehlig A (2018) Interindividual differences in caffeine metabolism and factors driving caffeine consumption. Pharmacol Rev 70(2):384\u2013411. https:\/\/doi.org\/10.1124\/pr.117.014407","journal-title":"Pharmacol Rev"},{"issue":"2","key":"4571_CR89","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1016\/0165-0173(92)90012-b","volume":"17","author":"A Nehlig","year":"1992","unstructured":"Nehlig A, Daval JL, Debry G (1992) Caffeine and the central nervous system: mechanisms of action, biochemical, metabolic and psychostimulant effects. Brain Res Brain Res Rev 17(2):139\u2013170. https:\/\/doi.org\/10.1016\/0165-0173(92)90012-b","journal-title":"Brain Res Brain Res Rev"},{"key":"4571_CR90","doi-asserted-by":"publisher","DOI":"10.1111\/sms.13776","author":"M Norum","year":"2020","unstructured":"Norum M, Risvang LC, Bjornsen T, Dimitriou L, Ronning PO, Bjorgen M, Raastad T (2020) Caffeine increases strength and power performance in resistance-trained females during early follicular phase. Scand J Med Sci Sports. https:\/\/doi.org\/10.1111\/sms.13776","journal-title":"Scand J Med Sci Sports"},{"key":"4571_CR91","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1007\/978-1-4614-3903-5_2","volume-title":"Adenosine","author":"J Park","year":"2013","unstructured":"Park J, Gupta RS (2013) Adenosine metabolism, adenosine kinase, and evolution. In: Masino S, Boison D (eds) Adenosine. Springer, New York, pp 23\u201354"},{"issue":"6","key":"4571_CR92","doi-asserted-by":"publisher","first-page":"613","DOI":"10.1111\/sms.12501","volume":"26","author":"MW Pataky","year":"2016","unstructured":"Pataky MW, Womack CJ, Saunders MJ, Goffe JL, D\u2019Lugos AC, El-Sohemy A, Luden ND (2016) Caffeine and 3-km cycling performance: effects of mouth rinsing, genotype, and time of day. Scand J Med Sci Sports 26(6):613\u2013619. https:\/\/doi.org\/10.1111\/sms.12501","journal-title":"Scand J Med Sci Sports"},{"issue":"11","key":"4571_CR93","doi-asserted-by":"publisher","first-page":"3118","DOI":"10.1158\/1055-9965.EPI-09-0589","volume":"18","author":"S Peterson","year":"2009","unstructured":"Peterson S, Schwarz Y, Li SS, Li L, King IB, Chen C, Eaton DL, Potter JD, Lampe JW (2009) CYP1A2, GSTM1, and GSTT1 polymorphisms and diet effects on CYP1A2 activity in a crossover feeding trial. Cancer Epidemiol Biomark Prev Publ Am Assoc Cancer Res Cosponsored Am Soc Prev Oncol 18(11):3118\u20133125. https:\/\/doi.org\/10.1158\/1055-9965.EPI-09-0589","journal-title":"Cancer Epidemiol Biomark Prev Publ Am Assoc Cancer Res Cosponsored Am Soc Prev Oncol"},{"issue":"7","key":"4571_CR94","doi-asserted-by":"publisher","first-page":"1007","DOI":"10.1007\/s40279-019-01101-0","volume":"49","author":"C Pickering","year":"2019","unstructured":"Pickering C, Grgic J (2019) Caffeine and exercise: What Next? Sports Med 49(7):1007\u20131030. https:\/\/doi.org\/10.1007\/s40279-019-01101-0","journal-title":"Sports Med"},{"issue":"1","key":"4571_CR95","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1007\/s40279-017-0776-1","volume":"48","author":"C Pickering","year":"2018","unstructured":"Pickering C, Kiely J (2018) Are the current guidelines on caffeine use in sport optimal for everyone? Inter-individual variation in caffeine ergogenicity, and a move towards personalised sports nutrition. Sports Med 48(1):7\u201316. https:\/\/doi.org\/10.1007\/s40279-017-0776-1","journal-title":"Sports Med"},{"issue":"10","key":"4571_CR96","doi-asserted-by":"publisher","first-page":"528","DOI":"10.1016\/j.tips.2009.07.005","volume":"30","author":"R Polosa","year":"2009","unstructured":"Polosa R, Blackburn MR (2009) Adenosine receptors as targets for therapeutic intervention in asthma and chronic obstructive pulmonary disease. Trends Pharmacol Sci 30(10):528\u2013535. https:\/\/doi.org\/10.1016\/j.tips.2009.07.005","journal-title":"Trends Pharmacol Sci"},{"issue":"9","key":"4571_CR97","doi-asserted-by":"publisher","first-page":"1265","DOI":"10.1080\/00140138808966766","volume":"31","author":"DC Poole","year":"1988","unstructured":"Poole DC, Ward SA, Gardner GW, Whipp BJ (1988) Metabolic and respiratory profile of the upper limit for prolonged exercise in man. Ergonomics 31(9):1265\u20131279. https:\/\/doi.org\/10.1080\/00140138808966766","journal-title":"Ergonomics"},{"issue":"11","key":"4571_CR98","doi-asserted-by":"publisher","first-page":"2320","DOI":"10.1249\/MSS.0000000000000939","volume":"48","author":"DC Poole","year":"2016","unstructured":"Poole DC, Burnley M, Vanhatalo A, Rossiter HB, Jones AM (2016) Critical power: an important fatigue threshold in exercise physiology. Med Sci Sports Exerc 48(11):2320\u20132334. https:\/\/doi.org\/10.1249\/MSS.0000000000000939","journal-title":"Med Sci Sports Exerc"},{"key":"4571_CR99","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1007\/978-3-642-13443-2_12","volume-title":"Methylxanthines","author":"T Porkka-Heiskanen","year":"2011","unstructured":"Porkka-Heiskanen T (2011) Methylxanthines and sleep. In: Fredholm BB (ed) Methylxanthines. Springer, Berlin, pp 331\u2013348"},{"issue":"4","key":"4571_CR100","doi-asserted-by":"publisher","first-page":"e0195943","DOI":"10.1371\/journal.pone.0195943","volume":"13","author":"C Puente","year":"2018","unstructured":"Puente C, Abian-Vicen J, Del Coso J, Lara B, Salinero JJ (2018) The CYP1A2 -163C>A polymorphism does not alter the effects of caffeine on basketball performance. PLoS ONE 13(4):e0195943. https:\/\/doi.org\/10.1371\/journal.pone.0195943","journal-title":"PLoS ONE"},{"issue":"9","key":"4571_CR101","doi-asserted-by":"publisher","first-page":"1153","DOI":"10.1016\/s0026-0495(96)90016-5","volume":"45","author":"CA Raguso","year":"1996","unstructured":"Raguso CA, Coggan AR, Sidossis LS, Gastaldelli A, Wolfe RR (1996) Effect of theophylline on substrate metabolism during exercise. Metab Clin Exp 45(9):1153\u20131160. https:\/\/doi.org\/10.1016\/s0026-0495(96)90016-5","journal-title":"Metab Clin Exp"},{"issue":"1","key":"4571_CR102","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1007\/s11845-018-1780-7","volume":"188","author":"R Rahimi","year":"2019","unstructured":"Rahimi R (2019) The effect of CYP1A2 genotype on the ergogenic properties of caffeine during resistance exercise: a randomized, double-blind, placebo-controlled, crossover study. Ir J Med Sci 188(1):337\u2013345. https:\/\/doi.org\/10.1007\/s11845-018-1780-7","journal-title":"Ir J Med Sci"},{"issue":"3","key":"4571_CR103","doi-asserted-by":"publisher","first-page":"184","DOI":"10.1016\/j.jtcme.2018.01.001","volume":"9","author":"CEG Reis","year":"2019","unstructured":"Reis CEG, Dorea JG, da Costa THM (2019) Effects of coffee consumption on glucose metabolism: a systematic review of clinical trials. J tradit Complement Med 9(3):184\u2013191. https:\/\/doi.org\/10.1016\/j.jtcme.2018.01.001","journal-title":"J tradit Complement Med"},{"key":"4571_CR104","doi-asserted-by":"publisher","first-page":"413","DOI":"10.1007\/978-3-642-13443-2_16","volume":"200","author":"NP Riksen","year":"2011","unstructured":"Riksen NP, Smits P, Rongen GA (2011) The cardiovascular effects of methylxanthines. Handb Exp Pharmacol 200:413\u2013437. https:\/\/doi.org\/10.1007\/978-3-642-13443-2_16","journal-title":"Handb Exp Pharmacol"},{"issue":"12","key":"4571_CR105","doi-asserted-by":"publisher","first-page":"3089","DOI":"10.1007\/s00421-011-1945-9","volume":"111","author":"B Roelands","year":"2011","unstructured":"Roelands B, Buyse L, Pauwels F, Delbeke F, Deventer K, Meeusen R (2011) No effect of caffeine on exercise performance in high ambient temperature. Eur J Appl Physiol 111(12):3089\u20133095. https:\/\/doi.org\/10.1007\/s00421-011-1945-9","journal-title":"Eur J Appl Physiol"},{"key":"4571_CR106","doi-asserted-by":"publisher","DOI":"10.3390\/nu11112662","author":"B Romero-Moraleda","year":"2019","unstructured":"Romero-Moraleda B, Del Coso J, Gutierrez-Hellin J, Lara B (2019) The effect of caffeine on the velocity of half-squat exercise during the menstrual cycle: a randomized controlled trial. Nutrients. https:\/\/doi.org\/10.3390\/nu11112662","journal-title":"Nutrients"},{"key":"4571_CR107","doi-asserted-by":"publisher","DOI":"10.1007\/s00394-020-02393-z","author":"C Ruiz-Moreno","year":"2020","unstructured":"Ruiz-Moreno C, Gutierrez-Hellin J, Amaro-Gahete FJ, Gonzalez-Garcia J, Giraldez-Costas V, Perez-Garcia V, Del Coso J (2020a) Caffeine increases whole-body fat oxidation during 1 h of cycling at Fatmax. Eur J Nutr. https:\/\/doi.org\/10.1007\/s00394-020-02393-z","journal-title":"Eur J Nutr"},{"key":"4571_CR108","doi-asserted-by":"publisher","DOI":"10.1007\/s00394-019-02167-2","author":"C Ruiz-Moreno","year":"2020","unstructured":"Ruiz-Moreno C, Lara B, Salinero JJ, Brito de Souza D, Ordovas JM, Del Coso J (2020b) Time course of tolerance to adverse effects associated with the ingestion of a moderate dose of caffeine. Eur J Nutr. https:\/\/doi.org\/10.1007\/s00394-019-02167-2","journal-title":"Eur J Nutr"},{"issue":"1","key":"4571_CR109","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1519\/JSC.0b013e3182541d03","volume":"27","author":"EJ Ryan","year":"2013","unstructured":"Ryan EJ, Kim CH, Fickes EJ, Williamson M, Muller MD, Barkley JE, Gunstad J, Glickman EL (2013) Caffeine gum and cycling performance: a timing study. J Strength Cond Res 27(1):259\u2013264. https:\/\/doi.org\/10.1519\/JSC.0b013e3182541d03","journal-title":"J Strength Cond Res"},{"issue":"4","key":"4571_CR110","doi-asserted-by":"publisher","first-page":"445","DOI":"10.1046\/j.1365-2125.1999.00898.x","volume":"47","author":"C Sachse","year":"1999","unstructured":"Sachse C, Brockmoller J, Bauer S, Roots I (1999) Functional significance of a C\u2013>A polymorphism in intron 1 of the cytochrome P450 CYP1A2 gene tested with caffeine. Br J Clin Pharmacol 47(4):445\u2013449. https:\/\/doi.org\/10.1046\/j.1365-2125.1999.00898.x","journal-title":"Br J Clin Pharmacol"},{"key":"4571_CR111","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1016\/j.ejps.2015.01.011","volume":"70","author":"JF Sacramento","year":"2015","unstructured":"Sacramento JF, Ribeiro MJ, Yubero S, Melo BF, Obeso A, Guarino MP, Gonzalez C, Conde SV (2015) Disclosing caffeine action on insulin sensitivity: effects on rat skeletal muscle. Eur J Pharm Sci Off J Eur Feder Pharm Sci 70:107\u2013116. https:\/\/doi.org\/10.1016\/j.ejps.2015.01.011","journal-title":"Eur J Pharm Sci Off J Eur Feder Pharm Sci"},{"key":"4571_CR112","doi-asserted-by":"publisher","first-page":"493","DOI":"10.1007\/978-1-4614-3903-5_23","volume-title":"Adenosine","author":"JD Salamone","year":"2013","unstructured":"Salamone JD, Correa M, Randall PA, Nunes EJ, Pardo M, Lopez-Cruz L (2013) The role of adenosine in the ventral striatal circuits regulating behavioral activation and effort-related decision making: importance for normal and pathological aspects of motivation. In: Masino S, Boison D (eds) Adenosine. Springer, New York, pp 493\u2013512"},{"key":"4571_CR113","doi-asserted-by":"publisher","DOI":"10.3390\/nu9030269","author":"JJ Salinero","year":"2017","unstructured":"Salinero JJ, Lara B, Ruiz-Vicente D, Areces F, Puente-Torres C, Gallo-Salazar C, Pascual T, Del Coso J (2017) CYP1A2 genotype variations do not modify the benefits and drawbacks of caffeine during exercise: a pilot study. Nutrients. https:\/\/doi.org\/10.3390\/nu9030269","journal-title":"Nutrients"},{"issue":"2","key":"4571_CR114","doi-asserted-by":"publisher","first-page":"238","DOI":"10.1080\/15438627.2018.1552146","volume":"27","author":"JJ Salinero","year":"2019","unstructured":"Salinero JJ, Lara B, Del Coso J (2019) Effects of acute ingestion of caffeine on team sports performance: a systematic review and meta-analysis. Res Sports Med 27(2):238\u2013256. https:\/\/doi.org\/10.1080\/15438627.2018.1552146","journal-title":"Res Sports Med"},{"issue":"9","key":"4571_CR115","doi-asserted-by":"publisher","first-page":"e75399","DOI":"10.1371\/journal.pone.0075399","volume":"8","author":"A Santos Rde","year":"2013","unstructured":"Santos Rde A, Kiss MA, Silva-Cavalcante MD, Correia-Oliveira CR, Bertuzzi R, Bishop DJ, Lima-Silva AE (2013) Caffeine alters anaerobic distribution and pacing during a 4000-m cycling time trial. PLoS ONE 8(9):e75399. https:\/\/doi.org\/10.1371\/journal.pone.0075399","journal-title":"PLoS ONE"},{"issue":"11","key":"4571_CR116","doi-asserted-by":"publisher","first-page":"1240","DOI":"10.1111\/sms.12793","volume":"27","author":"B Saunders","year":"2017","unstructured":"Saunders B, de Oliveira LF, da Silva RP, de Salles PV, Goncalves LS, Yamaguchi G, Mutti T, Maciel E, Roschel H, Artioli GG, Gualano B (2017) Placebo in sports nutrition: a proof-of-principle study involving caffeine supplementation. Scand J Med Sci Sports 27(11):1240\u20131247. https:\/\/doi.org\/10.1111\/sms.12793","journal-title":"Scand J Med Sci Sports"},{"key":"4571_CR117","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1007\/978-1-4614-3903-5_17","volume-title":"Adenosine","author":"J Sawynok","year":"2013","unstructured":"Sawynok J (2013) Adenosine and pain. In: Masino S, Boison D (eds) Adenosine. Springer, New York, pp 343\u2013360"},{"key":"4571_CR118","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1007\/978-1-62703-758-7_3","volume":"1113","author":"E Seibert","year":"2014","unstructured":"Seibert E, Tracy TS (2014) Different enzyme kinetic models. Methods Mol Biol 1113:23\u201335. https:\/\/doi.org\/10.1007\/978-1-62703-758-7_3","journal-title":"Methods Mol Biol"},{"key":"4571_CR119","doi-asserted-by":"publisher","DOI":"10.3390\/nu10101528","author":"A Shabir","year":"2018","unstructured":"Shabir A, Hooton A, Tallis J, Higgins MF (2018) The influence of caffeine expectancies on sport, exercise, and cognitive performance. Nutrients. https:\/\/doi.org\/10.3390\/nu10101528","journal-title":"Nutrients"},{"issue":"12A","key":"4571_CR120","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1016\/S0002-9149(97)00256-7","volume":"79","author":"JC Shryock","year":"1997","unstructured":"Shryock JC, Belardinelli L (1997) Adenosine and adenosine receptors in the cardiovascular system: biochemistry, physiology, and pharmacology. Am J Cardiol 79(12A):2\u201310","journal-title":"Am J Cardiol"},{"issue":"8","key":"4571_CR121","doi-asserted-by":"publisher","first-page":"e72025","DOI":"10.1371\/journal.pone.0072025","volume":"8","author":"MD Silva-Cavalcante","year":"2013","unstructured":"Silva-Cavalcante MD, Correia-Oliveira CR, Santos RA, Lopes-Silva JP, Lima HM, Bertuzzi R, Duarte M, Bishop DJ, Lima-Silva AE (2013) Caffeine increases anaerobic work and restores cycling performance following a protocol designed to lower endogenous carbohydrate availability. PLoS ONE 8(8):e72025. https:\/\/doi.org\/10.1371\/journal.pone.0072025","journal-title":"PLoS ONE"},{"issue":"1","key":"4571_CR122","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1249\/MSS.0000000000001408","volume":"50","author":"R Silveira","year":"2018","unstructured":"Silveira R, Andrade-Souza VA, Arcoverde L, Tomazini F, Sansonio A, Bishop DJ, Bertuzzi R, Lima-Silva AE (2018) Caffeine increases work done above critical power, but not anaerobic work. Med Sci Sports Exerc 50(1):131\u2013140. https:\/\/doi.org\/10.1249\/MSS.0000000000001408","journal-title":"Med Sci Sports Exerc"},{"issue":"3","key":"4571_CR123","doi-asserted-by":"publisher","first-page":"571","DOI":"10.1249\/MSS.0b013e3181b6668b","volume":"42","author":"TL Skinner","year":"2010","unstructured":"Skinner TL, Jenkins DG, Coombes JS, Taaffe DR, Leveritt MD (2010) Dose response of caffeine on 2000-m rowing performance. Med Sci Sports Exerc 42(3):571\u2013576. https:\/\/doi.org\/10.1249\/MSS.0b013e3181b6668b","journal-title":"Med Sci Sports Exerc"},{"issue":"1","key":"4571_CR124","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1016\/j.jsams.2012.04.004","volume":"16","author":"TL Skinner","year":"2013","unstructured":"Skinner TL, Jenkins DG, Taaffe DR, Leveritt MD, Coombes JS (2013) Coinciding exercise with peak serum caffeine does not improve cycling performance. J Sci Med Sport 16(1):54\u201359. https:\/\/doi.org\/10.1016\/j.jsams.2012.04.004","journal-title":"J Sci Med Sport"},{"key":"4571_CR125","doi-asserted-by":"publisher","DOI":"10.3390\/nu10101352","author":"K Southward","year":"2018","unstructured":"Southward K, Rutherfurd-Markwick K, Badenhorst C, Ali A (2018a) The role of genetics in moderating the inter-individual differences in the ergogenicity of caffeine. Nutrients. https:\/\/doi.org\/10.3390\/nu10101352","journal-title":"Nutrients"},{"issue":"8","key":"4571_CR126","doi-asserted-by":"publisher","first-page":"1913","DOI":"10.1007\/s40279-018-0939-8","volume":"48","author":"K Southward","year":"2018","unstructured":"Southward K, Rutherfurd-Markwick KJ, Ali A (2018b) The effect of acute caffeine ingestion on endurance performance: a systematic review and meta-analysis. Sports Med 48(8):1913\u20131928. https:\/\/doi.org\/10.1007\/s40279-018-0939-8","journal-title":"Sports Med"},{"issue":"1","key":"4571_CR127","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1007\/s00394-016-1331-9","volume":"56","author":"DB Souza","year":"2017","unstructured":"Souza DB, Del Coso J, Casonatto J, Polito MD (2017) Acute effects of caffeine-containing energy drinks on physical performance: a systematic review and meta-analysis. Eur J Nutr 56(1):13\u201327. https:\/\/doi.org\/10.1007\/s00394-016-1331-9","journal-title":"Eur J Nutr"},{"key":"4571_CR128","doi-asserted-by":"publisher","DOI":"10.1111\/sms.13749","author":"H Spineli","year":"2020","unstructured":"Spineli H, Pinto MP, Dos Santos BP, Lima-Silva AE, Bertuzzi R, Gitai DLG, de Araujo GG (2020a) Caffeine improves various aspects of athletic performance in adolescents independent of their 163 C > A CYP1A2 genotypes. Scand J Med Sci Sports. https:\/\/doi.org\/10.1111\/sms.13749","journal-title":"Scand J Med Sci Sports"},{"key":"4571_CR129","doi-asserted-by":"publisher","DOI":"10.1111\/sms.13749","author":"H Spineli","year":"2020","unstructured":"Spineli H, Pinto MP, Dos Santos BP, Lima-Silva AE, Bertuzzi R, Gitai DLG, de Araujo GG (2020b) Caffeine improves various aspects of athletic performance in adolescents independent of their 163 C>A CYP1A2 genotypes. Scand J Med Sci Sports. https:\/\/doi.org\/10.1111\/sms.13749","journal-title":"Scand J Med Sci Sports"},{"issue":"6 Pt 1","key":"4571_CR130","doi-asserted-by":"publisher","first-page":"E891","DOI":"10.1152\/ajpendo.1992.262.6.E891","volume":"262","author":"LL Spriet","year":"1992","unstructured":"Spriet LL, MacLean DA, Dyck DJ, Hultman E, Cederblad G, Graham TE (1992) Caffeine ingestion and muscle metabolism during prolonged exercise in humans. Am J Physiol 262(6 Pt 1):E891-898. https:\/\/doi.org\/10.1152\/ajpendo.1992.262.6.E891","journal-title":"Am J Physiol"},{"issue":"2","key":"4571_CR131","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1016\/0278-6915(88)90107-x","volume":"26","author":"B Stavric","year":"1988","unstructured":"Stavric B, Klassen R, Watkinson B, Karpinski K, Stapley R, Fried P (1988) Variability in caffeine consumption from coffee and tea: possible significance for epidemiological studies. Food Chem Toxicol Int J Publish Br Industrial Biol Res Assoc 26(2):111\u2013118. https:\/\/doi.org\/10.1016\/0278-6915(88)90107-x","journal-title":"Food Chem Toxicol Int J Publish Br Industrial Biol Res Assoc"},{"key":"4571_CR132","doi-asserted-by":"publisher","DOI":"10.3390\/sports8040054","author":"JA Stein","year":"2020","unstructured":"Stein JA, Ramirez M, Heinrich KM (2020) Acute caffeine supplementation does not improve performance in trained crossfit((R)) athletes. Sports. https:\/\/doi.org\/10.3390\/sports8040054","journal-title":"Sports"},{"issue":"10","key":"4571_CR133","doi-asserted-by":"publisher","first-page":"4011","DOI":"10.1523\/JNEUROSCI.19-10-04011.1999","volume":"19","author":"P Svenningsson","year":"1999","unstructured":"Svenningsson P, Nomikos GG, Fredholm BB (1999) The stimulatory action and the development of tolerance to caffeine is associated with alterations in gene expression in specific brain regions. J Neurosci Official J Soc Neurosci 19(10):4011\u20134022","journal-title":"J Neurosci Official J Soc Neurosci"},{"issue":"15","key":"4571_CR134","doi-asserted-by":"publisher","first-page":"3703","DOI":"10.1111\/bph.13187","volume":"172","author":"J Tallis","year":"2015","unstructured":"Tallis J, Duncan MJ, James RS (2015) What can isolated skeletal muscle experiments tell us about the effects of caffeine on exercise performance? Br J Pharmacol 172(15):3703\u20133713. https:\/\/doi.org\/10.1111\/bph.13187","journal-title":"Br J Pharmacol"},{"issue":"5","key":"4571_CR135","doi-asserted-by":"publisher","first-page":"1719","DOI":"10.1152\/jappl.2000.89.5.1719","volume":"89","author":"M Tarnopolsky","year":"2000","unstructured":"Tarnopolsky M (2000) Cupido C (2000) Caffeine potentiates low frequency skeletal muscle force in habitual and nonhabitual caffeine consumers. J Appl Physiol 89(5):1719\u20131724. https:\/\/doi.org\/10.1152\/jappl.2000.89.5.1719","journal-title":"J Appl Physiol"},{"issue":"4","key":"4571_CR136","doi-asserted-by":"publisher","first-page":"418","DOI":"10.1249\/00005768-198908000-00013","volume":"21","author":"MA Tarnopolsky","year":"1989","unstructured":"Tarnopolsky MA, Atkinson SA, MacDougall JD, Sale DG, Sutton JR (1989) Physiological responses to caffeine during endurance running in habitual caffeine users. Med Sci Sports Exerc 21(4):418\u2013424","journal-title":"Med Sci Sports Exerc"},{"issue":"3","key":"4571_CR137","doi-asserted-by":"publisher","first-page":"520","DOI":"10.1249\/01.mss.0000191189.40436.73","volume":"38","author":"KR Turley","year":"2006","unstructured":"Turley KR, Gerst JW (2006) Effects of caffeine on physiological responses to exercise in young boys and girls. Med Sci Sports Exerc 38(3):520\u2013526. https:\/\/doi.org\/10.1249\/01.mss.0000191189.40436.73","journal-title":"Med Sci Sports Exerc"},{"issue":"2","key":"4571_CR138","doi-asserted-by":"publisher","first-page":"805","DOI":"10.1152\/jappl.1993.75.2.805","volume":"75","author":"MH Van Soeren","year":"1993","unstructured":"Van Soeren MH, Sathasivam P, Spriet LL, Graham TE (1993) Caffeine metabolism and epinephrine responses during exercise in users and nonusers. J Appl Physiol 75(2):805\u2013812. https:\/\/doi.org\/10.1152\/jappl.1993.75.2.805","journal-title":"J Appl Physiol"},{"key":"4571_CR139","doi-asserted-by":"publisher","DOI":"10.1123\/ijspp.2019-0098","author":"S Venier","year":"2019","unstructured":"Venier S, Grgic J, Mikulic P (2019) Acute enhancement of jump performance, muscle strength, and power in resistance-trained men after consumption of caffeinated chewing gum. Int J Sports Physiol Perform. https:\/\/doi.org\/10.1123\/ijspp.2019-0098","journal-title":"Int J Sports Physiol Perform"},{"issue":"4","key":"4571_CR140","doi-asserted-by":"publisher","first-page":"941","DOI":"10.1007\/s00421-019-04083-z","volume":"119","author":"G Vinetti","year":"2019","unstructured":"Vinetti G, Taboni A, Bruseghini P, Camelio S, D\u2019Elia M, Fagoni N, Moia C, Ferretti G (2019) Experimental validation of the 3-parameter critical power model in cycling. Eur J Appl Physiol 119(4):941\u2013949. https:\/\/doi.org\/10.1007\/s00421-019-04083-z","journal-title":"Eur J Appl Physiol"},{"issue":"7","key":"4571_CR141","doi-asserted-by":"publisher","first-page":"918","DOI":"10.1016\/0002-9149(84)90525-3","volume":"53","author":"TL Whitsett","year":"1984","unstructured":"Whitsett TL, Manion CV, Christensen HD (1984) Cardiovascular effects of coffee and caffeine. Am J Cardiol 53(7):918\u2013922","journal-title":"Am J Cardiol"},{"issue":"1","key":"4571_CR142","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1186\/1550-2783-9-7","volume":"9","author":"CJ Womack","year":"2012","unstructured":"Womack CJ, Saunders MJ, Bechtel MK, Bolton DJ, Martin M, Luden ND, Dunham W, Hancock M (2012) The influence of a CYP1A2 polymorphism on the ergogenic effects of caffeine. J Int Soc Sports Nutr 9(1):7. https:\/\/doi.org\/10.1186\/1550-2783-9-7","journal-title":"J Int Soc Sports Nutr"},{"key":"4571_CR143","doi-asserted-by":"publisher","first-page":"405071","DOI":"10.1155\/2014\/405071","volume":"2014","author":"J Xiao","year":"2014","unstructured":"Xiao J, Huang WH, Peng JB, Tan ZR, Ou-Yang DS, Hu DL, Zhang W, Chen Y (2014) Quercetin significantly inhibits the metabolism of caffeine, a substrate of cytochrome P450 1A2 unrelated to CYP1A2*1C (-2964G>A) and *1F (734C>A) gene polymorphisms. Biomed Res Int 2014:405071. https:\/\/doi.org\/10.1155\/2014\/405071","journal-title":"Biomed Res Int"}],"container-title":["European Journal of Applied Physiology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00421-020-04571-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00421-020-04571-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00421-020-04571-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,2,19]],"date-time":"2021-02-19T15:00:35Z","timestamp":1613746835000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00421-020-04571-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1,5]]},"references-count":144,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2021,3]]}},"alternative-id":["4571"],"URL":"https:\/\/doi.org\/10.1007\/s00421-020-04571-7","relation":{},"ISSN":["1439-6319","1439-6327"],"issn-type":[{"value":"1439-6319","type":"print"},{"value":"1439-6327","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,1,5]]},"assertion":[{"value":"21 August 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 November 2020","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 January 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"Bryan Saunders has received caffeine supplements free of charge from Farm\u00e1cia Anal\u00edtica (Rio de Janeiro, Brazil) for experimental investigations. Farm\u00e1cia Anal\u00edtica had no involvement in the manuscript.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}