{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T12:03:11Z","timestamp":1787313791817,"version":"build-2736575974"},"reference-count":93,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2022,6,18]],"date-time":"2022-06-18T00:00:00Z","timestamp":1655510400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2022,6,18]],"date-time":"2022-06-18T00:00:00Z","timestamp":1655510400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004586","name":"Funda\u00e7\u00e3o Carlos Chagas Filho de Amparo \u00e0 Pesquisa do Estado do Rio de Janeiro","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004586","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur J Appl Physiol"],"published-print":{"date-parts":[[2022,9]]},"DOI":"10.1007\/s00421-022-04978-4","type":"journal-article","created":{"date-parts":[[2022,6,18]],"date-time":"2022-06-18T05:02:53Z","timestamp":1655528573000},"page":"2005-2018","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Orthostatic intolerance: a handicap of aging or physical deconditioning?"],"prefix":"10.1007","volume":"122","author":[{"given":"Gabriel Dias","family":"Rodrigues","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonas L\u00edrio","family":"Gurgel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio Claudio Lucas","family":"da Nobrega","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9589-4294","authenticated-orcid":false,"given":"Pedro Paulo da Silva","family":"Soares","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,6,18]]},"reference":[{"key":"4978_CR1","doi-asserted-by":"publisher","first-page":"875","DOI":"10.1016\/j.brs.2017.05.006","volume":"10","author":"D Antonino","year":"2017","unstructured":"Antonino D, Teixeira AL, Maia-Lopes PM, Souza MC, Sabino-Carvalho JL, Murray AR, Deuchars J, Vianna LC (2017) Non-invasive vagus nerve stimulation acutely improves spontaneous cardiac baroreflex sensitivity in healthy young men: a randomized placebo-controlled trial. Brain Stimul 10:875\u2013881","journal-title":"Brain Stimul"},{"key":"4978_CR2","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1007\/s004210100473","volume":"86","author":"P Arbeille","year":"2001","unstructured":"Arbeille P, Fomina G, Roumy J, Alferova I, Tobal N, Herault S (2001) Adaptation of the left heart, cerebral and femoral arteries, and jugular and femoral veins during short- and long-term head-down tilt and spaceflights. Eur J Appl Physiol 86:157\u2013168","journal-title":"Eur J Appl Physiol"},{"key":"4978_CR3","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1016\/j.neucli.2020.01.006","volume":"50","author":"H Baharlouei","year":"2020","unstructured":"Baharlouei H, Saba MA, Yazdi MJS, Jaberzadeh S (2020) The effect of transcranial direct current stimulation on balance in healthy young and older adults: A systematic review of the literature. Clin Neurophysiol 50:119\u2013131","journal-title":"Clin Neurophysiol"},{"issue":"4","key":"4978_CR4","doi-asserted-by":"publisher","first-page":"453","DOI":"10.1080\/0361073X.2010.507433","volume":"36","author":"AB Baker","year":"2010","unstructured":"Baker AB, Tang YQ (2010) Aging performance for masters records in athletics, swimming, rowing, cycling, triathlon, and weightlifting. Exp Aging Res 36(4):453\u2013477","journal-title":"Exp Aging Res"},{"issue":"1","key":"4978_CR5","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1080\/03610730303706","volume":"29","author":"AB Baker","year":"2003","unstructured":"Baker AB, Tang YQ, Turner MJ (2003) Percentage decline in masters super athlete track and field performance with aging. Exp Aging Res 29(1):47\u201365","journal-title":"Exp Aging Res"},{"key":"4978_CR6","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1186\/1472-6793-4-6","volume":"4","author":"AP Blaber","year":"2004","unstructured":"Blaber AP, Bondar RL, Kassam MS (2004) Heart rate variability and short duration spaceflight: relationship to post-flight orthostatic intolerance. BMC Physiol 4:6","journal-title":"BMC Physiol"},{"key":"4978_CR7","first-page":"634","volume":"27","author":"I Braz","year":"2017","unstructured":"Braz I, Fluck D, Lip G et al (2017) Impact of aerobic fitness on cerebral blood flow and cerebral vascular responsiveness to CO2 in young and older men. Am J Physiol Heart Circ Physiol 27:634\u2013642","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"4978_CR8","doi-asserted-by":"publisher","first-page":"4836","DOI":"10.18632\/aging.102074","volume":"11","author":"B Bretherton","year":"2019","unstructured":"Bretherton B, Atkinson L, Murray A, Clancy J, Deuchars S, Deuchars J (2019) Effects of Transcutaneous Vagus Nerve Stimulation in Individuals Aged 55 Years or above: Potential Benefits of Daily Stimulation. Aging (albany NY) 11:4836\u20134857. https:\/\/doi.org\/10.18632\/aging.102074","journal-title":"Aging (albany NY)"},{"key":"4978_CR9","doi-asserted-by":"publisher","first-page":"588","DOI":"10.1111\/joa.13122","volume":"236","author":"MF Butt","year":"2020","unstructured":"Butt MF, Albusoda A, Farmer AD, Aziz Q (2020) The anatomical basis for transcutaneous auricular vagus nerve stimulation. J Anat 236:588\u2013611","journal-title":"J Anat"},{"key":"4978_CR10","doi-asserted-by":"publisher","first-page":"102893","DOI":"10.1016\/j.autneu.2021.102893","volume":"236","author":"A Carandina","year":"2021","unstructured":"Carandina A, Rodrigues GD, Franscesco P, Filtz A, Bellocchi FL, Carugo MN, Tobaldini E (2021) Effects of transcutaneous auricular vagus nerve stimulation on cardiovascular autonomic control in health and disease. Auton Neurosci 236:102893","journal-title":"Auton Neurosci"},{"issue":"12","key":"4978_CR11","doi-asserted-by":"publisher","first-page":"2895","DOI":"10.1161\/01.STR.31.12.2895","volume":"31","author":"BJ Carey","year":"2000","unstructured":"Carey BJ, Eames PJ, Blake MJ, Panerai RB, Potter JF (2000) Dynamic cerebral autoregulation is unaffected by aging. Stroke 31(12):2895\u20132900","journal-title":"Stroke"},{"key":"4978_CR12","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1007\/s10286-019-00598-9","volume":"29","author":"WP Cheshire","year":"2019","unstructured":"Cheshire WP, Goldstein DS (2019) Autonomic uprising: the tilt table test in autonomic medicine. Clin Auton Res 29:215\u2013230","journal-title":"Clin Auton Res"},{"key":"4978_CR13","doi-asserted-by":"publisher","first-page":"871","DOI":"10.1016\/j.brs.2014.07.031","volume":"7","author":"JA Clancy","year":"2014","unstructured":"Clancy JA, Mary DA, Witte KK, Greenwood JP, Deuchars SA, Deuchars J (2014) Non-invasive vagus nerve stimulation in healthy humans reduces sympathetic nerve activity. Brain Stimul 7:871\u2013877. https:\/\/doi.org\/10.1016\/j.brs.2014.07.031","journal-title":"Brain Stimul"},{"issue":"4","key":"4978_CR14","doi-asserted-by":"publisher","first-page":"267","DOI":"10.2174\/1389201054553716","volume":"6","author":"G Clement","year":"2005","unstructured":"Clement G, Reschke M, Wood S (2005) Neurovestibular and Sensorimotor studies in Space and Earth benefits. Curr Pharm Biotechnol 6(4):267\u2013283","journal-title":"Curr Pharm Biotechnol"},{"key":"4978_CR15","first-page":"1","volume":"9","author":"VA Convertino","year":"2002","unstructured":"Convertino VA (2002) Mechanisms of microgravity induced orthostatic intolerance: implications for effective countermeasures. J Gravit Physiol 9:1\u201313","journal-title":"J Gravit Physiol"},{"issue":"6","key":"4978_CR16","doi-asserted-by":"publisher","first-page":"846","DOI":"10.4187\/respcare.01018","volume":"56","author":"V Convertino","year":"2011","unstructured":"Convertino V, Ryan K, Rickards C, Glorsky S, Idris A, Yannopoulos D, Metzger A, Lurie K (2011) Optimizing the respiratory pump: harnessing inspiratory resistance to treat systemic hypotension. Respir Care 56(6):846\u2013857","journal-title":"Respir Care"},{"issue":"2","key":"4978_CR17","doi-asserted-by":"publisher","first-page":"764","DOI":"10.1152\/japplphysiol.00438.2002","volume":"94","author":"AJ Donato","year":"2003","unstructured":"Donato AJ, Tench K, Glueck DH, Seals DR, Eskurza I, Tanaka H (2003) Declines in physiological functional capacity with age: A longitudinal study in peak swimming performance. J Appl Physiol 94(2):764\u2013769","journal-title":"J Appl Physiol"},{"issue":"6","key":"4978_CR18","doi-asserted-by":"publisher","first-page":"1159","DOI":"10.1249\/MSS.0000000000000532","volume":"47","author":"A Duarte","year":"2015","unstructured":"Duarte A, Soares PP, Pescatello L, Farinatti P (2015) Aerobic training improves vagal reactivation regardless of resting vagal control. Med Sci Sports Exerc 47(6):1159\u20131167","journal-title":"Med Sci Sports Exerc"},{"issue":"1","key":"4978_CR19","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1016\/0197-4580(84)90083-6","volume":"5","author":"RE Dustman","year":"1984","unstructured":"Dustman RE, Ruhling RO, Russell EM, Shearer DE, Bonekat HW, Shigeoka JW et al (1984) Aerobic exercise training and improved neuropsychological function of older individuals. Neurobiol Aging 5(1):35\u201342","journal-title":"Neurobiol Aging"},{"key":"4978_CR20","doi-asserted-by":"publisher","first-page":"474","DOI":"10.1111\/jgs.14563","volume":"65","author":"C Finucane","year":"2017","unstructured":"Finucane C, O\u2019Connell MD, Donoghue O, Richardson K, Savva GM, Kenny RA (2017) Impaired orthostatic blood pressure recovery is associated with unexplained and injurious falls. J Am Geriatr Soc 65:474\u2013482","journal-title":"J Am Geriatr Soc"},{"key":"4978_CR21","first-page":"3521","volume":"8","author":"A Garg","year":"2014","unstructured":"Garg A, Xu D, Bruner M, Blaber A (2014a) Alteration in cardiovascular and postural control relationship in non-fainting elderly individuals. Annu Int Conf IEEE Eng Med Biol Soc IEEE Eng Med Biol Soc Annu Int Conf [internet] 8:3521\u20133524","journal-title":"Annu Int Conf IEEE Eng Med Biol Soc IEEE Eng Med Biol Soc Annu Int Conf [internet]"},{"key":"4978_CR22","first-page":"H259","volume":"307","author":"A Garg","year":"2014","unstructured":"Garg A, Xu D, Laurin A, Blaber A (2014b) Physiological interdependence of the cardiovascular and postural control systems under orthostatic stress. Am J Physiol 307:H259\u2013H264","journal-title":"Am J Physiol"},{"key":"4978_CR23","doi-asserted-by":"publisher","first-page":"803","DOI":"10.3389\/fphys.2017.00803","volume":"8","author":"N Goswami","year":"2017","unstructured":"Goswami N, Blaber AP, Hinghofer-Szalkay H, Montani J-P (2017) Orthostatic intolerance in older persons: etiology and countermeasures. Front Physiol 8:803","journal-title":"Front Physiol"},{"key":"4978_CR24","doi-asserted-by":"crossref","unstructured":"Guirguis-Blake J, Michael Y, Perdue L, Coppola E, Beil T, Thompson J (2018) Interventions to Prevent Falls in Community-Dwelling Older Adults\u202f: a systematic review for the U.S. Preventive Services Task Force. Evid Synth No 159 [Internet]; AHRQ Public (159): Rockville, MD: Agency for HEalthcare Research and","DOI":"10.1001\/jama.2017.21962"},{"key":"4978_CR25","doi-asserted-by":"publisher","first-page":"431","DOI":"10.1161\/01.RES.11.3.431","volume":"11","author":"AC Guyton","year":"1962","unstructured":"Guyton AC, Douglas BH, Langston JB, Richardson TQ (1962) Instantaneous increase in mean circulatory pressure and cardiac output at onset of muscular activity. Circ Res 11:431\u2013441","journal-title":"Circ Res"},{"issue":"152","key":"4978_CR26","first-page":"161","volume":"32","author":"SD Harridge","year":"2017","unstructured":"Harridge SD, Lazarus NR (2017) Physical Activity, Aging, and Physiological Function. Physiology 32(152):161","journal-title":"Physiology"},{"key":"4978_CR27","doi-asserted-by":"publisher","first-page":"384","DOI":"10.1007\/s004210050058","volume":"81","author":"S Herault","year":"2000","unstructured":"Herault S, Fomina G, Alferova I, Kotovskaya A, Poliakov V, Arbeille P (2000) Cardiac, arterial and venous adaptation to weightlessness during 6-month Mir spaceflights with and with- out thigh cuffs (bracelets). Eur J Appl Physiol 81:384\u2013390","journal-title":"Eur J Appl Physiol"},{"key":"4978_CR28","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1007\/s00221-002-1040-x","volume":"144","author":"PW Hodges","year":"2002","unstructured":"Hodges PW, Gurfinkel VS, Brumagne S, Smith TC, Cordo PC (2002) Coexistence of stability and mobility in postural control: evidence from postural compensation for respiration. Exp Brain Res 144:293\u2013302","journal-title":"Exp Brain Res"},{"issue":"suppl_2","key":"4978_CR29","doi-asserted-by":"publisher","first-page":"ii7","DOI":"10.1093\/ageing\/afl077","volume":"35","author":"FB Horak","year":"2006","unstructured":"Horak FB (2006) Postural orientation and equilibrium: what do we need to know about neural control of balance to prevent falls? Age Ageing [internet] 35(suppl_2):ii7\u2013ii11","journal-title":"Age Ageing [internet]"},{"key":"4978_CR30","doi-asserted-by":"publisher","first-page":"325","DOI":"10.3389\/fnhum.2016.00325","volume":"10","author":"Y Inukai","year":"2016","unstructured":"Inukai Y, Saito K, Sasaki R, Kotan S, Nakagawa M, Onishi H (2016) Influence of transcranial direct current stimulation to thecerebellum on standing posture control. Front Hum Neurosci 10:325","journal-title":"Front Hum Neurosci"},{"issue":"19","key":"4978_CR31","doi-asserted-by":"publisher","first-page":"1781","DOI":"10.1001\/archinternmed.2009.312","volume":"169","author":"AS Jackson","year":"2009","unstructured":"Jackson AS, Sui X, H\u00e9bert JR, Church TS, Blair SN (2009) Role of lifestyle and aging on the longitudinal change in cardiorespiratory fitness. Arch Intern Med 169(19):1781\u20131787","journal-title":"Arch Intern Med"},{"issue":"7","key":"4978_CR32","doi-asserted-by":"publisher","first-page":"1085","DOI":"10.1017\/S0007114511003886","volume":"107","author":"AS Jackson","year":"2012","unstructured":"Jackson AS, Janssen I, Sui X, Church TS, Blair SN (2012) Longitudinal changes in body composition associated with healthy ageing: men, aged 20\u201396 years. Br J Nutr [internet] 107(7):1085\u20131091","journal-title":"Br J Nutr [internet]"},{"issue":"10","key":"4978_CR33","doi-asserted-by":"publisher","first-page":"1339","DOI":"10.1007\/s00702-007-0657-0","volume":"114","author":"JV Jacobs","year":"2007","unstructured":"Jacobs JV, Horak FB (2007) Cortical control of postural responses. J Neural Transm 114(10):1339\u20131348","journal-title":"J Neural Transm"},{"key":"4978_CR34","doi-asserted-by":"publisher","first-page":"e57949","DOI":"10.1371\/journal.pone.0057949","volume":"8","author":"L Janssens","year":"2013","unstructured":"Janssens L, Brumagne S, McConnell AK et al (2013) Proprioceptive changes impair balance control in individuals with chronic obstructive pulmonary disease. PLoS ONE 8:e57949","journal-title":"PLoS ONE"},{"key":"4978_CR35","doi-asserted-by":"publisher","first-page":"H489","DOI":"10.1152\/ajpheart.00427.2011","volume":"302","author":"SM Jeong","year":"2012","unstructured":"Jeong SM, Shibata S, Levine BD, Zhang R (2012) Exercise plus volume loading prevents orthostatic intolerance but not reduction in cerebral blood flow velocity after bed rest. Am J Physiol Heart Circ Physiol 302:H489\u2013H497","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"4978_CR36","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1152\/japplphysiol.00710.2013","volume":"116","author":"S-M Jeong","year":"2014","unstructured":"Jeong S-M, Hwang G-S, Kim S-O, Levine BD, Zhang R (2014) Dynamic cerebral autoregulation after bed rest: effects of volume loading and exercise countermeasures. J Appl Physiol 116:24\u201331 (First published October 24, 2013)","journal-title":"J Appl Physiol"},{"issue":"June","key":"4978_CR37","doi-asserted-by":"publisher","DOI":"10.1016\/j.exger.2019.110643","volume":"124","author":"DS Kehler","year":"2019","unstructured":"Kehler DS, Theou O, Rockwood K (2019) Bed rest and accelerated aging in relation to the musculoskeletal and cardiovascular systems and frailty biomarkers: a review. Exp Gerontol [internet] 124(June):110643","journal-title":"Exp Gerontol [internet]"},{"key":"4978_CR38","doi-asserted-by":"publisher","first-page":"344","DOI":"10.1016\/j.neurobiolaging.2009.02.019","volume":"32","author":"YS Kim","year":"2011","unstructured":"Kim YS, Bogert LW, Immink RV et al (2011) Effects of aging on the cerebrovascular orthostatic response. Neurobiol Aging 32:344\u2013353","journal-title":"Neurobiol Aging"},{"key":"4978_CR39","doi-asserted-by":"publisher","first-page":"234","DOI":"10.1161\/01.CIR.90.1.234","volume":"90","author":"BA Kingwell","year":"1994","unstructured":"Kingwell BA, Thompson JM, Kaye DM, McPherson GA, Jennings GL, Esler MD (1994) Heart rate spectral analysis, cardiac norepinephrine spillover, and muscle sympathetic nerve activity during human sympathetic nervous activation and failure. Circulation 90:234\u2013240","journal-title":"Circulation"},{"issue":"2","key":"4978_CR40","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1111\/j.1532-5415.2009.02681.x","volume":"58","author":"A Koster","year":"2010","unstructured":"Koster A, Visser M, Simonsick EM, Yu B, Allison DB, Newman AB et al (2010) Association between fitness and changes in body composition and muscle strength. J Am Geriatr Soc 58(2):219\u2013226","journal-title":"J Am Geriatr Soc"},{"issue":"6","key":"4978_CR41","doi-asserted-by":"publisher","first-page":"2333","DOI":"10.1152\/japplphysiol.00444.2003","volume":"96","author":"T Laitinen","year":"2004","unstructured":"Laitinen T, Niskanen L, Geelen G, L\u00e4nsimies E, Hartikainen J (2004) Age dependency of cardiovascular autonomic responses to head-up tilt in healthy subjects. J Appl Physiol 96(6):2333\u20132340","journal-title":"J Appl Physiol"},{"issue":"2","key":"4978_CR42","doi-asserted-by":"publisher","first-page":"152","DOI":"10.1152\/physiol.00029.2016","volume":"32","author":"NR Lazarus","year":"2017","unstructured":"Lazarus NR (2017) Physical activity, aging, and physiological function. Physiology 32(2):152\u2013161","journal-title":"Physiology"},{"issue":"8","key":"4978_CR43","doi-asserted-by":"publisher","first-page":"1897","DOI":"10.1161\/01.STR.31.8.1897","volume":"31","author":"LA Lipsitz","year":"2000","unstructured":"Lipsitz LA, Mukai S, Hamner J, Gagnon M, Babikian V (2000) Dynamic regulation of middle cerebral artery blood flow velocity in aging and hypertension. Stroke 31(8):1897\u20131903","journal-title":"Stroke"},{"issue":"3","key":"4978_CR44","doi-asserted-by":"publisher","first-page":"698","DOI":"10.1161\/HYPERTENSIONAHA.109.146290","volume":"55","author":"S Lucas","year":"2010","unstructured":"Lucas S, Tzeng YC, Galvin SD, Thomas KN, Ogoh S, Ainslie P (2010) Influence of changes in blood pressure on cerebral perfusion and oxygenation. Hypertension 55(3):698\u2013705","journal-title":"Hypertension"},{"key":"4978_CR45","doi-asserted-by":"publisher","first-page":"504","DOI":"10.1007\/s11065-009-9119-9","volume":"19","author":"C Lustig","year":"2009","unstructured":"Lustig C, Shah P, Seidler R, Reuter-Lorenz PA (2009) Aging, training, and the brain: A review and future directions. Neuropsychol Rev 19:504\u2013522","journal-title":"Neuropsychol Rev"},{"issue":"April","key":"4978_CR46","first-page":"1","volume":"15","author":"TR Macaulay","year":"2021","unstructured":"Macaulay TR, Peters BT, Wood SJ, Cl\u00e9ment GR, Oddsson L, Bloomberg JJ (2021) developing proprioceptive countermeasures to mitigate postural and locomotor control deficits after long-duration spaceflight. Front Syst Neurosci 15(April):1\u201314","journal-title":"Front Syst Neurosci"},{"issue":"Pt B","key":"4978_CR47","first-page":"330","volume":"74","author":"E Makovac","year":"2016","unstructured":"Makovac E, Thayer JF, Ottaviani C (2016) A meta-analysis of non-invasive brainstimulation and autonomic functioning: implications for brain-heart path-ways to cardiovascular disease. Neurosci Biobehav Rev 74(Pt B):330\u2013341","journal-title":"Neurosci Biobehav Rev"},{"key":"4978_CR48","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1016\/j.archger.2016.10.002","volume":"68","author":"EA Marques","year":"2017","unstructured":"Marques EA, Figueiredo P, Harris TB et al (2017) Are resistance and aerobic exercise training equally effective at improving knee muscle strength and balance in older women? Arch Gerontol Geriatr 68:106\u2013112. https:\/\/doi.org\/10.1016\/j.archger.2016.10.002","journal-title":"Arch Gerontol Geriatr"},{"key":"4978_CR49","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1093\/gerona\/gln025","volume":"64","author":"JM McGavock","year":"2009","unstructured":"McGavock JM, Hastings JL, Snell PG, McGuire DK, Pacini EL, Levine BD, Mitchell JH (2009) A forty-year follow-up of the Dallas Bed Rest and Training study: the effect of age on the cardiovascular response to exercise in men. J Gerontol A Biol Sci Med Sci 64:293\u2013299","journal-title":"J Gerontol A Biol Sci Med Sci"},{"issue":"3","key":"4978_CR50","doi-asserted-by":"publisher","first-page":"567","DOI":"10.1007\/s10522-016-9641-0","volume":"17","author":"JS McPhee","year":"2016","unstructured":"McPhee JS, French DP, Jackson D, Nazroo J, Pendleton N, Degens H (2016) Physical activity in older age: perspectives for healthy ageing and frailty. Biogerontology 17(3):567\u2013580","journal-title":"Biogerontology"},{"key":"4978_CR51","doi-asserted-by":"publisher","first-page":"1615","DOI":"10.1161\/01.STR.31.7.1615","volume":"31","author":"D Mehagnoul-schipper","year":"2000","unstructured":"Mehagnoul-schipper D, Vloet L, Colier W, Hoefnagels W, Jansen W (2000) Cerebral oxygenation declines in healthy elderly subjects in response to assuming the upright position. Stroke 31:1615\u20131620","journal-title":"Stroke"},{"issue":"2","key":"4978_CR52","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1016\/j.hrthm.2006.10.011","volume":"4","author":"D Melby","year":"2007","unstructured":"Melby D, Lu F, Sakaguchi S, Zook M, Benditt D (2007a) Increased impedance to inspiration ameliorates hemodynamic changes associated with movement to upright posture in orthostatic hypotension: a randomized blinded pilot study. Heart Rhythm 4(2):128\u2013135","journal-title":"Heart Rhythm"},{"issue":"3 Pt 2","key":"4978_CR53","first-page":"5","volume":"118","author":"D Melby","year":"2007","unstructured":"Melby D, Lu F, Sakaguchi S, Zook M, Benditt D (2007b) Physiological principles of vestibular function on earth and in space. Otolaryngol Head Neck Surg 118(3 Pt 2):5\u201315","journal-title":"Otolaryngol Head Neck Surg"},{"key":"4978_CR54","doi-asserted-by":"publisher","first-page":"1293","DOI":"10.1161\/CIRCULATIONAHA.119.041046","volume":"140","author":"JH Mitchell","year":"2019","unstructured":"Mitchell JH, Levine BD, McGuire DK (2019) The Dallas bed rest and training study; revisited after 50 years. Circulation 140:1293\u20131295","journal-title":"Circulation"},{"key":"4978_CR55","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1111\/j.1469-7793.2000.00263.x","volume":"529","author":"KD Monahan","year":"2000","unstructured":"Monahan KD, Dinenno FA, Tanaka H et al (2000) Regular aerobic exercise modulates age-associated declines in cardiovagal baroreflex sensistivity in healthy men. J Physiol 529:263\u2013271","journal-title":"J Physiol"},{"key":"4978_CR56","first-page":"131","volume":"49","author":"N Montero-Fernandez","year":"2013","unstructured":"Montero-Fernandez N, Serra-Rexach JA (2013) Role of exercis e on sarcopen ia in the elderly. Eur JPhys Rehabil Med 49:131\u2013143","journal-title":"Eur JPhys Rehabil Med"},{"key":"4978_CR57","first-page":"9","volume":"5","author":"A Morrison","year":"2013","unstructured":"Morrison A, Fan T, Sen SS, Weisenfluh L (2013) Epidemiology of falls and osteoporotic fractures a syst. Clin Outcomes Res. 5:9\u201318","journal-title":"Clin Outcomes Res."},{"issue":"18","key":"4978_CR58","doi-asserted-by":"publisher","first-page":"1213","DOI":"10.1136\/bjsports-2012-091658","volume":"49","author":"AH Okano","year":"2013","unstructured":"Okano AH, Fontes EB, Montenegro RA, Farinatti PdTV, Cyrino ES, Li LM et al (2013) Brain stimulation modulates the autonomic nervous system, rating of perceived exertion and performance during maximal exercise. Br J Sports Med 49(18):1213\u20131218","journal-title":"Br J Sports Med"},{"issue":"1","key":"4978_CR59","doi-asserted-by":"publisher","first-page":"R243","DOI":"10.1152\/ajpregu.00087.2007","volume":"293","author":"C Rickards","year":"2007","unstructured":"Rickards C, Ryan K, Cooke W, Lurie K, Convertino V (2007) Inspiratory resistance delays the reporting of symptoms with central hypovolemia: association with cerebral blood flow. Am J Physiol Regul Integr Comp Physiol 293(1):R243\u2013R250","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"issue":"6","key":"4978_CR60","doi-asserted-by":"publisher","first-page":"557","DOI":"10.3357\/ASEM.2149.2008","volume":"79","author":"C Rickards","year":"2008","unstructured":"Rickards C, Cohen K, Bergeron L, Burton L, Khatri P, Lee C, Ryan K, Cooke W, Doerr D, Lurie K, Convertino V (2008) Inspiratory resistance, cerebral blood flow velocity, and symptoms of acute hypotension. Aviat Space Environ Med 79(6):557\u2013564","journal-title":"Aviat Space Environ Med"},{"key":"4978_CR61","doi-asserted-by":"publisher","first-page":"692","DOI":"10.1111\/ggi.13231","volume":"18","author":"GD Rodrigues","year":"2018","unstructured":"Rodrigues GD, Gurgel JL, Gon\u00e7alves TR, Porto F, Soares PPDS (2018a) Influence of breathing patterns and orthostatic stress on postural control in older adults. Geriatr Gerontol Int 18:692\u2013697","journal-title":"Geriatr Gerontol Int"},{"issue":"6","key":"4978_CR62","doi-asserted-by":"publisher","first-page":"1143","DOI":"10.1007\/s00421-018-3844-9","volume":"118","author":"GD Rodrigues","year":"2018","unstructured":"Rodrigues GD, Gurgel JL, Gon\u00e7alves TR, Soares PPS (2018b) Inspiratory muscle training improves physical performance and cardiac autonomic modulation in older women. Eur J Appl Physiol 118(6):1143\u20131152","journal-title":"Eur J Appl Physiol"},{"key":"4978_CR63","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1016\/j.ejim.2019.06.003","volume":"66","author":"GD Rodrigues","year":"2019","unstructured":"Rodrigues GD, Tobaldini E, Bellocchi C, Santaniello A, Caronni M, Severino A, Froldi M, Beretta L, Soares PPS, Montano N (2019) Cardiac autonomic modulation at rest and during orthostatic stress among different systemic sclerosis subsets. Eur J Intern Med 66:75\u201380","journal-title":"Eur J Intern Med"},{"key":"4978_CR64","doi-asserted-by":"publisher","first-page":"1033","DOI":"10.1016\/j.resp.2020.103384","volume":"275","author":"G Rodrigues","year":"2020","unstructured":"Rodrigues G, Gurgel J, Galdino I, da N\u00f3brega AC, Soares PP (2020a) Respiratory pump contributions in cerebrovascular and postural control responses during orthostatic stress in older women. Respir Physiol Neurobiol 275:1033\u20131084","journal-title":"Respir Physiol Neurobiol"},{"issue":"10","key":"4978_CR65","doi-asserted-by":"publisher","first-page":"2171","DOI":"10.1007\/s00421-020-04441-2","volume":"120","author":"GD Rodrigues","year":"2020","unstructured":"Rodrigues GD, Gurgel J, Galdino I, Nobrega AC, Soares P (2020b) Inspiratory muscle training improves cerebrovascular and postural control responses during orthostatic stress in older women. Eur J Appl Physiol 120(10):2171\u20132181","journal-title":"Eur J Appl Physiol"},{"key":"4978_CR66","doi-asserted-by":"publisher","first-page":"103505","DOI":"10.1016\/j.resp.2020.103505","volume":"281","author":"GD Rodrigues","year":"2020","unstructured":"Rodrigues GD, Gurgel JL, Soares PPS (2020c) Inspiratory muscles contributions to postural control in healthy older women. Respir Physiol Neurobiol 281:103505","journal-title":"Respir Physiol Neurobiol"},{"issue":"3","key":"4978_CR67","doi-asserted-by":"publisher","first-page":"e20201677","DOI":"10.1590\/0001-3765202120201677","volume":"93","author":"GD Rodrigues","year":"2021","unstructured":"Rodrigues GD, Gurgel JL, Gon\u00e7alves TR, Soares PPDS (2021a) The Physical Capacity of Rowing Athletes Cannot Reverse the Influence of Age on Heart Rate Variability during Orthostatic Stress. An Acad Bras Cienc 93(3):e20201677","journal-title":"An Acad Bras Cienc"},{"issue":"150","key":"4978_CR68","doi-asserted-by":"publisher","first-page":"111357","DOI":"10.1016\/j.exger.2021.111357","volume":"15","author":"GD Rodrigues","year":"2021","unstructured":"Rodrigues GD, Dal Lago P, Soares PPS (2021b) Time-dependent effects of inspiratory muscle training and detraining on cardiac autonomic control in older women. Exp Gerontol 15(150):111357","journal-title":"Exp Gerontol"},{"key":"4978_CR69","doi-asserted-by":"publisher","first-page":"103672","DOI":"10.1016\/j.resp.2021.103672","volume":"290","author":"GD Rodrigues","year":"2021","unstructured":"Rodrigues GD, Dal Lago P, Soares PPS (2021c) Inspiratory muscle training improves breathing pattern and sympatho-vagal balance but not spontaneous baroreflex sensitivity in older women. Respir Physiol Neurobiol 290:103672","journal-title":"Respir Physiol Neurobiol"},{"key":"4978_CR70","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1007\/s10286-019-00647-3","volume":"30","author":"NI Saedon","year":"2020","unstructured":"Saedon NI, Frith J, Goh CH et al (2020) Orthostatic blood pressure changes and physic, functional and cognitive performance; the MEL0R study. Clin Auton Res 30:129\u20131378","journal-title":"Clin Auton Res"},{"issue":"Suppl 5","key":"4978_CR71","first-page":"VIII","volume":"38","author":"B Saltin","year":"1968","unstructured":"Saltin B, Blomqvist G, Mitchell JH, Johnson RL Jr, Wildenthal K, Chapman CB (1968) Response to exercise after bed rest and after training. Circulation 38(Suppl 5):VIII-VII78","journal-title":"Circulation"},{"key":"4978_CR72","doi-asserted-by":"publisher","first-page":"488","DOI":"10.1038\/jhh.2014.119","volume":"29","author":"WB Santos","year":"2014","unstructured":"Santos WB, Matoso JM, Maltez M et al (2014) Spectral analyses of systolic blood pressure and heart rate variability and their association with cognitive performance in elderly hypertensive subjects. J Hum Hypertens 29:488\u2013494","journal-title":"J Hum Hypertens"},{"key":"4978_CR73","doi-asserted-by":"publisher","first-page":"721","DOI":"10.1016\/j.neubiorev.2009.10.005","volume":"34","author":"RD Seidler","year":"2010","unstructured":"Seidler RD, Bernard JA, Burutolu TB, Fling BW, Gordon MT, Gwin JT, Kwak Y, Lipps DB (2010) Motor control and aging: links to age-related brain structural, functional, and biochemical effects. Neurosci Biobehav Rev 34:721\u2013733","journal-title":"Neurosci Biobehav Rev"},{"issue":"1","key":"4978_CR74","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1037\/0882-7974.7.1.15","volume":"7","author":"KA Shay","year":"1992","unstructured":"Shay KA, Roth DL (1992) Association between aerobic fitness and visuospatial performance in healthy older adults. Psychol Aging 7(1):15\u201324","journal-title":"Psychol Aging"},{"issue":"24","key":"4978_CR75","doi-asserted-by":"publisher","first-page":"1750","DOI":"10.1136\/bjsports-2016-096547","volume":"51","author":"C Sherrington","year":"2017","unstructured":"Sherrington C, Michaleff ZA, Fairhall N, Paul SS, Tiedemann A, Whitney J et al (2017) Exercise to prevent falls in older adults: an updated systematic review and meta-analysis. Br J Sports Med 51(24):1750\u20131758","journal-title":"Br J Sports Med"},{"issue":"1","key":"4978_CR76","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1093\/ageing\/afh028","volume":"33","author":"VS Stel","year":"2004","unstructured":"Stel VS, Smit JH, Pluijm SMF, Lips P (2004) Consequences of falling in older men and women and risk factors for health service use and functional decline. Age Ageing 33(1):58\u201365","journal-title":"Age Ageing"},{"key":"4978_CR77","doi-asserted-by":"publisher","first-page":"595","DOI":"10.1111\/jnc.14234","volume":"144","author":"T Tarumi","year":"2018","unstructured":"Tarumi T, Zhang R (2018) Cerebral blood flow in normal aging adults: cardiovascular determinants, clinical implications, and aerobic fitness. J Neurochem 144:595\u2013608","journal-title":"J Neurochem"},{"key":"4978_CR78","doi-asserted-by":"publisher","first-page":"1177","DOI":"10.1002\/jmri.24090","volume":"38","author":"BP Thomas","year":"2003","unstructured":"Thomas BP, Yezhuvath US, Tseng BY, Liu P, Levine BD, Zhang R, Lu H (2003) Life-long aerobic exercise preserved baseline cerebral blood flow but reduced vascular reactivity to CO2. J Magn Reson Imaging 38:1177\u20131183","journal-title":"J Magn Reson Imaging"},{"key":"4978_CR79","doi-asserted-by":"publisher","first-page":"e16218","DOI":"10.1097\/MD.0000000000016218","volume":"98","author":"E Thomas","year":"2019","unstructured":"Thomas E, Battaglia G, Patti A et al (2019) Physical activity programs for balance and fall prevention in elderly: a systematic review. Medicine (baltimore) 98:e16218","journal-title":"Medicine (baltimore)"},{"key":"4978_CR80","doi-asserted-by":"publisher","first-page":"496","DOI":"10.3390\/jcm8040496","volume":"8","author":"E Tobaldini","year":"2019","unstructured":"Tobaldini E, Toschi-Dias E, Appratto de Souza L, Rabello Casali K, Vicenzi M, Sandrone G, Cogliati C, La Rovere MT, Pinna GD, Montano N (2019) Cardiac and peripheral autonomic responses to orthostatic stress during transcutaneous vagus nerve stimulation in healthy subjects. JCM 8:496","journal-title":"JCM"},{"key":"4978_CR81","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1007\/s10286-019-00664-2","volume":"30","author":"DJL Van Twist","year":"2020","unstructured":"Van Twist DJL, Mostard GJM, Sipers WMWH (2020) Delayed recovery from initial orthostatic hypotension: an expression of frailty in the elderly. Clin Autom Res 30:105\u2013106","journal-title":"Clin Autom Res"},{"issue":"7","key":"4978_CR82","first-page":"1","volume":"27","author":"A Verma","year":"2017","unstructured":"Verma A, Garg A, Xu D, Bruner M, Fazel-rezai R, Blaber A, Tavakolian K (2017) Skeletal muscle pump drives control of cardiovascular and postural systems. Sci Rep 27(7):1\u20138","journal-title":"Sci Rep"},{"key":"4978_CR83","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1159\/000252852","volume":"56","author":"J Vernikos","year":"2010","unstructured":"Vernikos J, Schneider VS (2010) Space, gravity and the physiology of aging: parallel or convergent disciplines? A mini-review. Gerontology 56:157\u2013166","journal-title":"Gerontology"},{"key":"4978_CR84","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/230791","volume":"2014","author":"S Viboolvorakul","year":"2014","unstructured":"Viboolvorakul S, Patumraj S (2014) Exercise training could improve age-related changes in cerebral blood flow and capillary vascularity through the upregulation of VEGF and eNOS. Biomed Res Int 2014:230791","journal-title":"Biomed Res Int"},{"key":"4978_CR85","doi-asserted-by":"publisher","first-page":"368","DOI":"10.1212\/01.wnl.0000341271.90478.8e","volume":"72","author":"A Viswanathan","year":"2009","unstructured":"Viswanathan A, Rocca WA, Tzourio C (2009) Vascular risk factors and dementia: how to move forward? Neurology 72:368\u2013374","journal-title":"Neurology"},{"key":"4978_CR86","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1016\/j.trci.2017.04.001","volume":"3","author":"MJ Wheeler","year":"2017","unstructured":"Wheeler MJ, Dempsey PC, Grace MS, Ellis KA, Gardiner PA, Green DJ, Dunstan DW (2017) Sedentary behavior as a risk factor for cognitive decline? A focus on the influence of glycemic control in brain health. Alzheimers Dement (NY) 3:291\u2013300","journal-title":"Alzheimers Dement (NY)"},{"key":"4978_CR87","doi-asserted-by":"publisher","first-page":"1049","DOI":"10.1152\/japplphysiol.00001.2019","volume":"126","author":"MJ Wheeler","year":"2019","unstructured":"Wheeler MJ, Dunstan DW, Smith B et al (2019) Morning exercise mitigates the impact of prolonged sitting on cerebral blood flow inolder adults. J Appl Physiol 126:1049\u20131055","journal-title":"J Appl Physiol"},{"key":"4978_CR88","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1212\/01.WNL.0000149519.47454.F2","volume":"64","author":"RA Whitmer","year":"2005","unstructured":"Whitmer RA, Sidney S, Selby J, Johnston SC, Yaffe K (2005) Midlife cardiovascular risk factors and risk of dementia in late life. Neurology 64:277\u2013281","journal-title":"Neurology"},{"key":"4978_CR89","doi-asserted-by":"publisher","first-page":"1565","DOI":"10.1001\/jama.2009.460","volume":"301","author":"RA Whitmer","year":"2009","unstructured":"Whitmer RA, Karter AJ, Yaffe K, Quesenberry CP Jr, Selby JV (2009) Hypoglycemic episodes and risk of dementia in older patients with type 2 diabetes mellitus. JAMA 301:1565\u20131572","journal-title":"JAMA"},{"issue":"4","key":"4978_CR90","doi-asserted-by":"publisher","first-page":"728","DOI":"10.1249\/MSS.0000000000001153","volume":"49","author":"D Xu","year":"2017","unstructured":"Xu D, Wang H, Chen S, Ross S et al (2017) Aerobic exercise training improves orthostatic tolerance in aging humans. Med Sci Sports Exerc 49(4):728\u2013735","journal-title":"Med Sci Sports Exerc"},{"issue":"1","key":"4978_CR91","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-019-56847-4","volume":"10","author":"D Xu","year":"2020","unstructured":"Xu D, Tremblay MF, Verma AK, Tavakolian K, Goswami N, Blaber AP (2020) Cardio-postural interactions and muscle-pump baroreflex are severely impacted by 60-day bedrest immobilization. Sci Rep 10(1):1\u201313","journal-title":"Sci Rep"},{"key":"4978_CR92","doi-asserted-by":"publisher","first-page":"648","DOI":"10.1016\/j.cyto.2011.09.004","volume":"56","author":"CB Yang","year":"2011","unstructured":"Yang CB, Wang YC, Gao Y, Geng J, Wu YH, Zhang Y, Shi F, Sun XQ (2011) Artificial gravity with ergometric exercise preserves the cardiac, but not cerebrovascular, functions during 4 days of head-down bed rest. Cytokine 56:648\u2013655","journal-title":"Cytokine"},{"key":"4978_CR93","doi-asserted-by":"publisher","first-page":"110679","DOI":"10.1016\/j.exger.2019.110679","volume":"125","author":"ZZ Zlatar","year":"2019","unstructured":"Zlatar ZZ, Hays CC, Mestre Z et al (2019) Dose-dependent asso- ciation of accelerometer-measured physical activity and sedentary time with brain perfusion in aging. Exp Gerontol 125:110679","journal-title":"Exp Gerontol"}],"container-title":["European Journal of Applied Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00421-022-04978-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00421-022-04978-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00421-022-04978-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,11,13]],"date-time":"2022-11-13T21:19:30Z","timestamp":1668374370000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00421-022-04978-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6,18]]},"references-count":93,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2022,9]]}},"alternative-id":["4978"],"URL":"https:\/\/doi.org\/10.1007\/s00421-022-04978-4","relation":{},"ISSN":["1439-6319","1439-6327"],"issn-type":[{"value":"1439-6319","type":"print"},{"value":"1439-6327","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,6,18]]},"assertion":[{"value":"6 February 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 May 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 June 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}