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The physiological low microvascular permeability may be impaired by conditions causing damage to the interstitial matrix macromolecular assembly leading to alveolar edema and haemorrhage. These conditions include hypoxia, cyclic alveolar unfolding\/folding during hyperventilation putting a tensile stress on septa, intensity and duration of exercise as well as inter-individual proneness to develop lung edema.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Data from exercising humans showed inter-individual differences in the dispersion of the lung ventilation\/perfusion ratio and increase in oxygen alveolar-capillary gradient. More recent data in humans support the hypothesis that greater vasoconstriction, pulmonary hypertension and slower kinetics of alveolar-capillary O2 equilibration relate with greater proneness to develop lung edema due higher inborn microvascular permeability possibly reflecting the morpho-functional features of the air\u2013blood barrier.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00421-022-05066-3","type":"journal-article","created":{"date-parts":[[2022,10,20]],"date-time":"2022-10-20T09:03:57Z","timestamp":1666256637000},"page":"1-24","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["A century of exercise physiology: lung fluid balance during and following exercise"],"prefix":"10.1007","volume":"123","author":[{"given":"Giuseppe","family":"Miserocchi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6288-0475","authenticated-orcid":false,"given":"Egidio","family":"Beretta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,10,20]]},"reference":[{"key":"5066_CR1","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1016\/j.hrtlng.2022.01.009","volume":"52","author":"A Adar","year":"2022","unstructured":"Adar A, Can EY, Elma Y, Ferah MA, Kececi M, Muderrisoglu H, Akbay E, Ak\u0131nc\u0131 S, Coner A, Haberal C, Cakan F, Onalan O (2022) A new and simple parameter for diagnosis pulmonary edema: Expiratory air humidity. 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