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Unpleasant salty (1\u00a0M) and bitter (2\u00a0mM quinine) solutions were compared to water, sweetened water, and no solution, which functioned as control conditions. In a non-blinded randomized cross-over order, each solution was mouth rinsed (10\u00a0s) and ingested before perceptual responses, instantaneous heart rate (a marker of autonomic nervous system activation), quadricep corticomotor excitability (motor-evoked potential amplitude) and neuromuscular function during a maximal voluntary contraction (maximum voluntary force, resting twitch force, voluntary activation, 0\u201350\u00a0ms impulse, 0\u2013100 impulse, 100\u2013200\u00a0ms impulse) were measured.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Hedonic value (water: 47\u2009\u00b1\u20098%, sweet: 23\u2009\u00b1\u200917%, salt: 71\u2009\u00b1\u20098%, bitter: 80\u2009\u00b1\u200910%), taste intensity, unpleasantness and increases in heart rate (no solution: 14\u2009\u00b1\u20095\u00a0bpm, water: 18\u2009\u00b1\u20095\u00a0bpm, sweet: 20\u2009\u00b1\u20095\u00a0bpm, salt: 24\u2009\u00b1\u20097\u00a0bpm, bitter: 23\u2009\u00b1\u20096\u00a0bpm) were significantly higher in the salty and bitter conditions compared to control conditions. Nausea was low in all conditions (&lt;\u200915%) but was significantly higher in salty and bitter conditions compared to water (water: 3\u2009\u00b1\u20095%, sweet: 6\u2009\u00b1\u200913%, salt: 7\u2009\u00b1\u20099%, bitter: 14\u2009\u00b1\u200916%). There was no significant difference between conditions in neuromuscular function or corticomotor excitability variables.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>At rest, unpleasant tastes appear to have no influence on quadricep corticomotor excitability or neuromuscular function. These data question the mechanisms via which unpleasant tastes are proposed to influence exercise performance.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00421-023-05141-3","type":"journal-article","created":{"date-parts":[[2023,1,26]],"date-time":"2023-01-26T10:02:45Z","timestamp":1674727365000},"page":"1179-1189","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Mouth rinsing and ingesting salty or bitter solutions does not influence corticomotor excitability or neuromuscular function"],"prefix":"10.1007","volume":"123","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2274-2147","authenticated-orcid":false,"given":"Edward","family":"Gray","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rocco","family":"Cavaleri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason","family":"Siegler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,1,26]]},"reference":[{"issue":"9","key":"5141_CR1","doi-asserted-by":"publisher","first-page":"1810","DOI":"10.1249\/MSS.0000000000000973","volume":"48","author":"T Ataide-Silva","year":"2016","unstructured":"Ataide-Silva T, Ghiarone T, Bertuzzi R, Stathis CG, Leandro CG, Lima-Silva AE (2016) CHO mouth rinse ameliorates neuromuscular response with lower endogenous CHO stores. 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