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Driving performance was assessed using a fixed-base motor vehicle simulator. Oxygenation in the frontal cortex was measured using functional near-infrared spectroscopy.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Speed limit exceedances were greater during the poikilocapnic than normoxic, hypercapnic, and isocapnic conditions (mean exceedances: 8, 4, 5, and 7, respectively; all <jats:italic>p<\/jats:italic>\u2009\u2264\u20090.05 vs poikilocapnic hypoxia). Vehicle speed was greater in the poikilocapnic than normoxic and hypercapnic conditions (mean difference: 0.35\u00a0km h<jats:sup>\u22121<\/jats:sup> and 0.67\u00a0km h<jats:sup>\u22121<\/jats:sup>, respectively). All hypoxic conditions similarly decreased cerebral oxyhaemoglobin and increased deoxyhaemoglobin, compared to normoxic baseline, while total hemoglobin remained unchanged.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>These findings demonstrate that supplemental CO<jats:sub>2<\/jats:sub> can confer a neuroprotective effect by offsetting impairments in complex psychomotor task performance evoked by severe poikilocapnic hypoxia; however, differences in performance are unlikely to be linked to measurable differences in cerebral oxygenation.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00421-023-05151-1","type":"journal-article","created":{"date-parts":[[2023,3,23]],"date-time":"2023-03-23T05:02:49Z","timestamp":1679547769000},"page":"1583-1593","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Carbon dioxide protects simulated driving performance during severe hypoxia"],"prefix":"10.1007","volume":"123","author":[{"given":"Peter Michael","family":"Bloomfield","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hayden","family":"Green","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James P.","family":"Fisher","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1023-839X","authenticated-orcid":false,"given":"Nicholas","family":"Gant","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2023,3,23]]},"reference":[{"issue":"1","key":"5151_CR1","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1152\/japplphysiol.01385.2003","volume":"97","author":"PN Ainslie","year":"2004","unstructured":"Ainslie PN, Poulin MJ (2004) Ventilatory, cerebrovascular, and cardiovascular interactions in acute hypoxia: regulation by carbon dioxide. 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