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We hypothesized that EIMD would increase muscle afferent sensitivity and, accordingly, increase blood pressure responses to exercise and PECO.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>Eleven male and nine female participants performed unilateral isometric knee extension at 30% of maximal voluntary contraction (MVC) for 3-min. A thigh cuff was rapidly inflated to 250\u00a0mmHg for two min PECO, followed by 3\u00a0min recovery. Heart rate and blood pressure were monitored beat-by-beat, with stroke volume and cardiac output estimated from the Modelflow algorithm. Measurements were taken before and 48\u00a0h after completing eccentric knee-extension contractions to induce muscle damage (EIMD).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>EIMD caused 21% decrease in MVC (baseline: 634.6\u2009\u00b1\u2009229.3 N, 48\u00a0h: 504.0\u2009\u00b1\u2009160 N), and a 17-fold increase in perceived soreness using a visual-analogue scale (0\u2013100\u00a0mm; VAS<jats:sub>SQ<\/jats:sub>) (both p\u2009&lt;\u20090.001). CV responses to exercise and PECO were not different between pre and post EIMD. However, mean arterial pressure (MAP) was higher during the recovery phase after EIMD (p\u2009&lt;\u20090.05). Significant associations were found between increases in MAP during exercise and VAS<jats:sub>SQ<\/jats:sub>, Rate of Perceived Exertion (RPE) and Pain after EIMD only (all p\u2009&lt;\u20090.05).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>The MAP correlations with muscle soreness, RPE and Pain during contractions of damaged muscles suggests that higher afferent activity was associated with higher MAP responses to exercise.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00421-023-05255-8","type":"journal-article","created":{"date-parts":[[2023,6,27]],"date-time":"2023-06-27T09:06:09Z","timestamp":1687856769000},"page":"2747-2754","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Effects of exercise induced muscle damage on cardiovascular responses to isometric muscle contractions and post-exercise circulatory occlusion"],"prefix":"10.1007","volume":"123","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4178-6965","authenticated-orcid":false,"given":"Fabio","family":"Zambolin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4968-5525","authenticated-orcid":false,"given":"Tiago","family":"Pe\u00e7anha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1816-2644","authenticated-orcid":false,"given":"Susan","family":"Pinner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2469-8787","authenticated-orcid":false,"given":"Massimo","family":"Venturelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3659-0773","authenticated-orcid":false,"given":"Jamie Stewart","family":"McPhee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,6,27]]},"reference":[{"issue":"4","key":"5255_CR1","doi-asserted-by":"publisher","first-page":"372","DOI":"10.1113\/jphysiol.1937.sp003485","volume":"89","author":"M Alam","year":"1937","unstructured":"Alam M, Smirk FH (1937) Observations in man upon a blood pressure raising reflex arising from the voluntary muscles. 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