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Cardiac magnetic resonance (CMR) native T1\/T2 mapping is sensitive to the pathological increase of myocardial water content. Therefore, we evaluated exercise-induced acute myocardial changes in recreational cyclists by incorporating biomarkers, echocardiography and CMR.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Nineteen male recreational participants (age: 48\u2009\u00b1\u20095\u00a0years) cycled the \u2018L\u2019\u00e9tape du tour de France\u201d (EDT) 2021\u2019 (175\u00a0km, 3600 altimeters). One week before the race, a maximal graded cycling test was conducted to determine individual heart rate (HR) training zones. One day before and 3\u20136\u00a0h post-exercise 3\u00a0T CMR and echocardiography were performed to assess myocardial native T1\/T2 relaxation times and cardiac function, and blood samples were collected. All participants were asked to cycle 2\u00a0h around their anaerobic gas exchange threshold (HR zone 4).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Eighteen participants completed the EDT stage in 537\u2009\u00b1\u200958\u00a0min, including 154\u2009\u00b1\u200961\u00a0min of cycling time in HR zone 4. Post-race right ventricular (RV) dysfunction with reduced strain and increased volumes (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05) and borderline significant left ventricular global longitudinal strain reduction (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.05) were observed. Post-exercise cTnI (0.75\u2009\u00b1\u20095.1\u00a0ng\/l to 69.9\u2009\u00b1\u200941.6\u00a0ng\/l;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) and T1 relaxation times (1133\u2009\u00b1\u200948\u00a0ms to 1182\u2009\u00b1\u200946\u00a0ms,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) increased significantly with no significant change in T2 (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.474). cTnI release correlated with increase in T1 relaxation time (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.002;\n                      <jats:italic>r<\/jats:italic>\n                      \u2009=\u20090.703), post-race RV dysfunction (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05;\n                      <jats:italic>r<\/jats:italic>\n                      \u2009=\u20090.562) and longer cycling in HR zone 4 (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05;\n                      <jats:italic>r<\/jats:italic>\n                      \u2009=\u20090.607).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Strenuous exercise causes early post-race cTnI increase, increased T1 relaxation time and RV dysfunction in recreational cyclists, which showed interdependent correlation. The long-term clinical significance of these changes needs further investigation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial registration numbers and date<\/jats:title>\n                    <jats:p>NCT 04940650 06\/18\/2021. NCT 05138003 06\/18\/2021.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00421-023-05259-4","type":"journal-article","created":{"date-parts":[[2023,7,22]],"date-time":"2023-07-22T07:02:21Z","timestamp":1690009341000},"page":"2107-2117","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Exercise-induced myocardial T1 increase and right ventricular dysfunction in recreational cyclists: a CMR study"],"prefix":"10.1007","volume":"123","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9229-9489","authenticated-orcid":false,"given":"Olivier","family":"Ghekiere","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lieven","family":"Herbots","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin","family":"Peters","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baptiste Vande","family":"Berg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tom","family":"Dresselaers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wouter","family":"Franssen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernard","family":"Padovani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dorothee","family":"Ducreux","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emile","family":"Ferrari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alain","family":"Nchimi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie","family":"Demanez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruben","family":"De Bosscher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rik","family":"Willems","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hein","family":"Heidbuchel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andre","family":"La Gerche","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guido","family":"Claessen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Bogaert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bert O.","family":"Eijnde","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,7,22]]},"reference":[{"issue":"6","key":"5259_CR1","doi-asserted-by":"publisher","first-page":"1445","DOI":"10.1016\/j.jcmg.2019.12.020","volume":"13","author":"VL Aengevaeren","year":"2020","unstructured":"Aengevaeren VL, Froeling M, Hooijmans MT, Monte JR, van den Berg-Faay S, Hopman MTE, Strijkers GJ, Nederveen AJ, Bakermans AJ, Eijsvogels TMH (2020) Myocardial injury and compromised cardiomyocyte integrity following a marathon run. 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All authors disclose personal professional financial relationships with companies or manufacturers. All authors declare that the results of the study are presented clearly, honestly, and without fabrication, falsification, or inappropriate data manipulation.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interests"}}]}}