{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T00:13:08Z","timestamp":1790727188129,"version":"4.1.0"},"reference-count":55,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2023,7,15]],"date-time":"2023-07-15T00:00:00Z","timestamp":1689379200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2023,7,15]],"date-time":"2023-07-15T00:00:00Z","timestamp":1689379200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Deutsche Sporthochschule K\u00f6ln (DSHS)"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur J Appl Physiol"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Purpose<\/jats:title>\n                <jats:p>Cytokines are released as part of an inflammatory reaction in response to strength exercise to initiate muscle repair and morphological adaptations. Whether hormonal fluctuations induced by the menstrual cycle or oral contraceptives affect inflammatory responses to strength exercise remains unknown. Therefore, we aimed to compare the response of cytokines after acute strength exercise in naturally menstruating women and oral contraceptive users.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>Naturally menstruating women (MC, <jats:italic>n<\/jats:italic>\u2009=\u200913, 24\u2009\u00b1\u20094\u00a0years, weekly strength training: 4.3\u2009\u00b1\u20091.7\u00a0h) and women using a monophasic combined pill (&gt;\u20099\u00a0months) (OC, <jats:italic>n<\/jats:italic>\u2009=\u20098, 22\u2009\u00b1\u20093\u00a0years, weekly strength training: 4.5\u2009\u00b1\u20091.9\u00a0h) were recruited. A one-repetition-maximum (1RM) test and strength exercise in the squat (4\u2009\u00d7\u200910 repetitions, 70%1RM) was performed in the early follicular phase or pill free interval. Concentrations of oestradiol, IL-1\u03b2, IL-1ra, IL-6, IL-8, and IL-10 were assessed before (pre), directly after (post) and 24\u00a0h after (post<jats:sub>24<\/jats:sub>) strength exercise.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>IL-1ra increased from pre to post (+\u200951.1\u2009\u00b1\u200959.4%, <jats:italic>p<\/jats:italic>\u2009=\u20090.189) and statistically decreased from post to post<jats:sub>24<\/jats:sub> (\u2013 20.5\u2009\u00b1\u200913.5%, <jats:italic>p<\/jats:italic>\u2009=\u20090.011) only in OC. Additionally, IL-1\u03b2 statistically decreased from post to post<jats:sub>24<\/jats:sub> (\u2013 39.6\u2009\u00b1\u200923.0%, <jats:italic>p<\/jats:italic>\u2009=\u20090.044) only in OC. There was an interaction effect for IL-1\u03b2 (<jats:italic>p<\/jats:italic>\u2009=\u20090.038) and concentrations were statistically decreased at post<jats:sub>24<\/jats:sub> in OC compared to MC (<jats:italic>p<\/jats:italic>\u2009=\u20090.05). IL-8 increased across both groups from post to post<jats:sub>24<\/jats:sub> (+\u200966.6\u2009\u00b1\u200996.3%, <jats:italic>p<\/jats:italic>\u2009=\u20090.004).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>We showed a differential regulation of IL-1\u03b2 and IL-1ra between OC users in the pill-free interval and naturally cycling women 24\u00a0h after strength exercise, while there was no effect on other cytokines. Whether this is associated with previously shown compromised morphological adaptations remains to be investigated.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00421-023-05275-4","type":"journal-article","created":{"date-parts":[[2023,7,15]],"date-time":"2023-07-15T18:01:18Z","timestamp":1689444078000},"page":"257-267","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Comparison of the cytokine responses to acute strength exercise between oral contraceptive users and naturally cycling women"],"prefix":"10.1007","volume":"124","author":[{"given":"Hannah L.","family":"Notbohm","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa","family":"Umlauff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wilhelm","family":"Bloch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9605-3489","authenticated-orcid":false,"given":"Moritz","family":"Schumann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,7,15]]},"reference":[{"issue":"1","key":"5275_CR1","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1016\/s0015-0282(02)03173-4","volume":"78","author":"L Auerbach","year":"2002","unstructured":"Auerbach L, Hafner T, Huber JC, Panzer S (2002) Influence of low-dose oral contraception on peripheral blood lymphocyte subsets at particular phases of the hormonal cycle. 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