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At baseline and each day up to 4\u00a0days RVFD, knee extensors maximum voluntary isometric force (MVIC), serum creatine kinase (CK) concentration, quadriceps swelling, and soreness were assessed. The early (0\u201350\u00a0ms) and late (100\u2013200\u00a0ms) phase of the RVFD, as well as the force developed at 50 and 200\u00a0ms, were also determined.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>MVIC showed moderate decrements (p\u2009&lt;\u20090.05) and recovered after 4\u00a0days (p\u2009&gt;\u20090.05). Force at 50\u00a0ms and the early phase were not impaired (p\u2009&gt;\u20090.05). Conversely, force at 200\u00a0ms and the late phase showed moderate decrements (p\u2009&lt;\u20090.05) and recovered after 3 and 4\u00a0days, respectively (p\u2009&gt;\u20090.05). CK concentration, quadriceps swelling, and soreness increased (p\u2009&lt;\u20090.05) were overall fully resolved after 4\u00a0days (p\u2009&gt;\u20090.05).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>Downhill running affected the knee extensors RVFD late but not early phase. The RVFD late phase may be used as an additional marker of muscle damage in trail running.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00421-023-05412-z","type":"journal-article","created":{"date-parts":[[2024,1,10]],"date-time":"2024-01-10T04:22:54Z","timestamp":1704860574000},"page":"1875-1883","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Downhill running increases markers of muscle damage and impairs the maximal voluntary force production as well as the late phase of the rate of voluntary force development"],"prefix":"10.1007","volume":"124","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7523-9102","authenticated-orcid":false,"given":"Giuseppe","family":"Coratella","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9385-6972","authenticated-orcid":false,"given":"Giorgio","family":"Varesco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7479-1189","authenticated-orcid":false,"given":"Vianney","family":"Rozand","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin","family":"Cuinet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0337-975X","authenticated-orcid":false,"given":"Veronica","family":"Sansoni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8365-985X","authenticated-orcid":false,"given":"Giovanni","family":"Lombardi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2580-4470","authenticated-orcid":false,"given":"Gianluca","family":"Vernillo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9486-3090","authenticated-orcid":false,"given":"Laurent","family":"Mourot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,1,10]]},"reference":[{"issue":"4","key":"5412_CR1","doi-asserted-by":"publisher","first-page":"1318","DOI":"10.1152\/japplphysiol.00283.2002","volume":"93","author":"P Aagaard","year":"2002","unstructured":"Aagaard P, Simonsen EB, Andersen JL, Magnusson P, Dyhre-Poulsen P (2002) Increased rate of force development and neural drive of human skeletal muscle following resistance training. 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