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Eight healthy, recreationally active males ingested 800\u00a0mg Ibuprofen or a placebo\u2009~\u20091\u00a0h prior to performing fixed RPE cycling for 60\u00a0min in 35\u00a0\u00b0C and 60% relative humidity at an intensity of hard to very hard (RPE\u2009=\u200916) with intermittent maximal (RPE\u2009=\u200920) sprints every 10\u00a0min. Power output (PO), core and mean skin temperatures (<jats:italic>T<\/jats:italic><jats:sub>c<\/jats:sub>, <jats:italic>T<\/jats:italic><jats:sub>sk<\/jats:sub>), respectively, and heart rate (HR) were measured continuously. Electroencephalography (EEG) recordings at the frontal (Fz), motor (Cz) and Parietal (Pz) areas (90\u00a0s) were collected every 5\u00a0min. IL-6, soluble glycoprotein receptor (sgp130) and IL-6 receptor (R) were collected at pre-, 30\u00a0min and immediately post-exercise. Mean PO, HR, <jats:italic>T<\/jats:italic><jats:sub>c<\/jats:sub> and <jats:italic>T<\/jats:italic><jats:sub>sk<\/jats:sub>, and RPE were not different between trials (<jats:italic>P<\/jats:italic>\u2009\u2265\u20090.33). At end-exercise, the change in IL-6, sgp130 and sIL-6R was not different between trials (<jats:italic>P<\/jats:italic>\u2009\u2265\u20090.12). The increase in <jats:italic>\u03b1<\/jats:italic> and <jats:italic>\u03b2<\/jats:italic> activity did not differ in any cortices between trials (<jats:italic>P<\/jats:italic>\u2009\u2265\u20090.07); however, there was a significant reduction in <jats:italic>\u03b1<\/jats:italic>\/<jats:italic>\u03b2<\/jats:italic> activity in the Ibuprofen compared to placebo trials at all sites (<jats:italic>P<\/jats:italic>\u2009\u2264\u20090.05). Ingesting a maximal, over-the-counter dose of Ibuprofen prior to exercise in the heat does not attenuate the release of IL-6, nor improve performance, but may influence cortical activity evidenced by a greater reduction in <jats:italic>\u03b1<\/jats:italic>\/<jats:italic>\u03b2<\/jats:italic> activity.<\/jats:p>","DOI":"10.1007\/s00421-024-05452-z","type":"journal-article","created":{"date-parts":[[2024,3,6]],"date-time":"2024-03-06T11:03:00Z","timestamp":1709722980000},"page":"2303-2313","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Acute ingestion of Ibuprofen does not influence the release of IL-6 or improve self-paced exercise in the heat despite altering cortical activity"],"prefix":"10.1007","volume":"124","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2634-7120","authenticated-orcid":false,"given":"Nicole T.","family":"Vargas","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline V.","family":"Robertson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank E.","family":"Marino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,3,6]]},"reference":[{"key":"5452_CR1","doi-asserted-by":"publisher","first-page":"709","DOI":"10.1016\/j.clinph.2009.02.005","volume":"120","author":"C Babiloni","year":"2009","unstructured":"Babiloni C et al (2009) Ibuprofen treatment modifies cortical sources of EEG rhythms in mild Alzheimer\u2019s disease. 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