{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,13]],"date-time":"2026-06-13T04:03:06Z","timestamp":1781323386093,"version":"3.54.1"},"reference-count":36,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2024,5,27]],"date-time":"2024-05-27T00:00:00Z","timestamp":1716768000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,5,27]],"date-time":"2024-05-27T00:00:00Z","timestamp":1716768000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur J Appl Physiol"],"published-print":{"date-parts":[[2024,10]]},"DOI":"10.1007\/s00421-024-05502-6","type":"journal-article","created":{"date-parts":[[2024,5,27]],"date-time":"2024-05-27T07:01:56Z","timestamp":1716793316000},"page":"3021-3029","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["The impact of uninterrupted sitting on central and peripheral cardiovascular function in pre-menopausal and post-menopausal women"],"prefix":"10.1007","volume":"124","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4242-1714","authenticated-orcid":false,"given":"Arsalan","family":"Moinuddin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6572-7874","authenticated-orcid":false,"given":"Keeron","family":"Stone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0847-2232","authenticated-orcid":false,"given":"Louise","family":"Turner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3125-9712","authenticated-orcid":false,"given":"Craig","family":"Paterson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicky","family":"Hall","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9656-856X","authenticated-orcid":false,"given":"Anne","family":"Daykin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8713-2457","authenticated-orcid":false,"given":"Sam","family":"Lucas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3704-6737","authenticated-orcid":false,"given":"James","family":"Faulkner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0376-0104","authenticated-orcid":false,"given":"Simon","family":"Fryer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,5,27]]},"reference":[{"issue":"2","key":"5502_CR1","doi-asserted-by":"publisher","first-page":"123","DOI":"10.7326\/M14-1651","volume":"162","author":"A Biswas","year":"2015","unstructured":"Biswas A, Oh PI, Faulkner GE, Bajaj RR, Silver MA, Mitchell MS et al (2015) Sedentary time and its association with risk for disease incidence, mortality, and hospitalization in adults a systematic review and meta-analysis. Ann Intern Med 162(2):123\u2013132","journal-title":"Ann Intern Med"},{"issue":"1","key":"5502_CR2","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/j.artres.2008.11.002","volume":"3","author":"P Boutouyrie","year":"2009","unstructured":"Boutouyrie P, Briet M, Collin C, Vermeersch S, Pannier B (2009) Assessment of pulse wave velocity. Artery Res 3(1):3\u20138","journal-title":"Artery Res"},{"key":"5502_CR3","unstructured":"BRFSS Prevalence and Trends Data. [cited 2023 Jun 5]. https:\/\/nccd.cdc.gov\/BRFSSPrevalence\/rdPage.aspx?rdReport=DPH_BRFSS.ExploreByTopic&irbLocationType=StatesAndMMSA&islClass=CLASS14&islTopic=TOPIC09&islYear=2019&rdRnd=33961126. Accessed 5 June 2023"},{"key":"5502_CR4","first-page":"2591","volume":"2014","author":"M Butlin","year":"2012","unstructured":"Butlin M, Qasem A, Avolio AP (2012) Estimation of central aortic pressure waveform features derived from the brachial cuff volume displacement waveform. Proc Annu Int Conf IEEE Eng Med Biol Soc EMBS 2014:2591\u20132594","journal-title":"Proc Annu Int Conf IEEE Eng Med Biol Soc EMBS"},{"key":"5502_CR5","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.119.013403","author":"YJ Chang","year":"2020","unstructured":"Chang YJ, Bellettiere J, Godbole S, Keshavarz S, Maestas JP, Unkart JT et al (2020) Total sitting time and sitting pattern in postmenopausal women differ by hispanic ethnicity and are associated with cardiometabolic risk biomarkers. J Am Heart Assoc. https:\/\/doi.org\/10.1161\/JAHA.119.013403","journal-title":"J Am Heart Assoc"},{"issue":"23","key":"5502_CR6","doi-asserted-by":"publisher","first-page":"2346","DOI":"10.1016\/j.jacc.2013.03.031","volume":"61","author":"AK Chomistek","year":"2013","unstructured":"Chomistek AK, Manson JE, Stefanick ML, Lu B, Sands-Lincoln M, Going SB et al (2013) Relationship of sedentary behavior and physical activity to incident cardiovascular disease: results from the women\u2019s health initiative. J Am Coll Cardiol 61(23):2346\u20132354","journal-title":"J Am Coll Cardiol"},{"key":"5502_CR7","first-page":"227","volume-title":"Statistical power analysis for the behavioral sciences","author":"J Cohen","year":"1988","unstructured":"Cohen J (1988) Statistical power analysis for the behavioral sciences, 2nd edn. Lawrence Erlbaum Associates, London, p 227","edition":"2"},{"issue":"2","key":"5502_CR8","doi-asserted-by":"publisher","first-page":"260","DOI":"10.1016\/j.amjcard.2018.10.014","volume":"123","author":"DP Credeur","year":"2019","unstructured":"Credeur DP, Miller SM, Jones R, Stoner L, Dolbow DR, Fryer SM et al (2019) Impact of prolonged sitting on peripheral and central vascular health. Am J Cardiol 123(2):260\u2013266. https:\/\/doi.org\/10.1016\/j.amjcard.2018.10.014","journal-title":"Am J Cardiol"},{"issue":"5","key":"5502_CR9","doi-asserted-by":"publisher","first-page":"976","DOI":"10.2337\/dc11-1931","volume":"35","author":"DW Dunstan","year":"2012","unstructured":"Dunstan DW, Kingwell BA, Larsen R, Healy GN, Cerin E, Hamilton MT et al (2012) Breaking up prolonged sitting reduces postprandial glucose and insulin responses. Diabetes Care 35(5):976\u2013983","journal-title":"Diabetes Care"},{"key":"5502_CR10","doi-asserted-by":"publisher","first-page":"781","DOI":"10.1152\/japplphysiol.00318.2019","volume":"127","author":"WS Evans","year":"2019","unstructured":"Evans WS, Stoner XL, Willey Q, Kelsch E, Credeur DP, Hanson ED (2019) Local exercise does not prevent the aortic stiffening response to acute prolonged sitting: a randomized crossover trial. J Appl Physiol 127:781\u2013787","journal-title":"J Appl Physiol"},{"issue":"2","key":"5502_CR11","doi-asserted-by":"publisher","first-page":"175","DOI":"10.3758\/BF03193146","volume":"39","author":"F Faul","year":"2007","unstructured":"Faul F, Erdfelder E, Albert-Georg Lang AB (2007) G*Power 3: a flexible statistical power analysis program for the social, behavior, and biomedical sciences. Behav Res Methods 39(2):175\u2013191","journal-title":"Behav Res Methods"},{"issue":"10","key":"5502_CR12","doi-asserted-by":"publisher","first-page":"1332","DOI":"10.1038\/s41440-021-00708-z","volume":"44","author":"S Fryer","year":"2021","unstructured":"Fryer S, Stone K, Paterson C, Brown M, Faulkner J, Lambrick D et al (2021) Central and peripheral arterial stiffness responses to uninterrupted prolonged sitting combined with a high-fat meal: a randomized controlled crossover trial. Hypertens Res 44(10):1332\u20131340","journal-title":"Hypertens Res"},{"key":"5502_CR13","doi-asserted-by":"publisher","first-page":"1107456","DOI":"10.3389\/fphys.2023.1107456","volume":"14","author":"S Fryer","year":"2023","unstructured":"Fryer S, Paterson C, Turner L, Moinuddin A, Faulkner J, Stoner L et al (2023) Localized activity attenuates the combined impact of a high fat meal and prolonged sitting on arterial stiffness: a randomized, controlled cross-over trial. Front Physiol 14:1107456","journal-title":"Front Physiol"},{"issue":"2","key":"5502_CR14","doi-asserted-by":"publisher","first-page":"H468","DOI":"10.1152\/ajpheart.00354.2020","volume":"319","author":"RJ Headid","year":"2020","unstructured":"Headid RJ, Pekas EJ, Wooden TK, Son WM, Layec G, Shin J et al (2020) Impacts of prolonged sitting with mild hypercapnia on vascular and autonomic function in healthy recreationally active adults. Am J Physiol - Hear Circ Physiol 319(2):H468\u2013H480","journal-title":"Am J Physiol - Hear Circ Physiol"},{"issue":"5","key":"5502_CR15","doi-asserted-by":"publisher","first-page":"590","DOI":"10.1093\/eurheartj\/ehq451","volume":"32","author":"GN Healy","year":"2011","unstructured":"Healy GN, Matthews CE, Dunstan DW, Winkler EAH, Owen N (2011) Sedentary time and cardio-metabolic biomarkers in US adults: NHANES 200306. Eur Heart J 32(5):590\u2013597","journal-title":"Eur Heart J"},{"issue":"6","key":"5502_CR16","doi-asserted-by":"publisher","first-page":"624","DOI":"10.1097\/GME.0000000000000116","volume":"21","author":"KL Hildreth","year":"2014","unstructured":"Hildreth KL, Kohrt WM, Moreau KL (2014) Oxidative stress contributes to large elastic arterial stiffening across the stages of the menopausal transition. Menopause 21(6):624\u2013632","journal-title":"Menopause"},{"key":"5502_CR17","unstructured":"Jamovi (2021) [cited 2023 Jun 3]. www.jamovi.org. Accessed 3 June 2023"},{"issue":"1","key":"5502_CR18","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1152\/japplphysiol.00030.2021","volume":"131","author":"E Kelsch","year":"2023","unstructured":"Kelsch E, Diana JC, Burnet K, Stone KJ, Stoner L, Hanson ED et al (2023) Arterial stiffness responses to prolonged sitting combined with a high-glycemic- index meal: a double-blind, randomized -cross-over trial. J Appl Physiol 131(1):229\u2013237","journal-title":"J Appl Physiol"},{"issue":"5","key":"5502_CR19","doi-asserted-by":"publisher","first-page":"1652","DOI":"10.1152\/japplphysiol.90549.2008","volume":"105","author":"GF Mitchell","year":"2008","unstructured":"Mitchell GF (2008) Effects of central arterial aging on the structure and function of the peripheral vasculature: implications for end-organ damage. J Appl Physiol 105(5):1652\u20131660","journal-title":"J Appl Physiol"},{"issue":"3","key":"5502_CR20","doi-asserted-by":"publisher","first-page":"890","DOI":"10.1152\/japplphysiol.00877.2006","volume":"102","author":"KL Moreau","year":"2007","unstructured":"Moreau KL, Depaulis AR, Gavin KM, Seals DR (2007) Oxidative stress contributes to chronic leg vasoconstriction in estrogen-deficient postmenopausal women. J Appl Physiol 102(3):890\u2013895","journal-title":"J Appl Physiol"},{"issue":"12","key":"5502_CR21","doi-asserted-by":"publisher","first-page":"4692","DOI":"10.1210\/jc.2012-2244","volume":"97","author":"KL Moreau","year":"2012","unstructured":"Moreau KL, Hildreth KL, Meditz AL, Deane KD, Kohrt WM (2012) Endothelial function is impaired across the stages of the menopause transition in healthy women. J Clin Endocrinol Metab 97(12):4692\u20134700","journal-title":"J Clin Endocrinol Metab"},{"issue":"1","key":"5502_CR22","first-page":"1","volume":"7","author":"MW O\u2019Brien","year":"2022","unstructured":"O\u2019Brien MW, Wu Y, Petterson JL, Frayne RJ, Kimmerly DS (2022) Ecological validity of prolonged sitting studies: how well do they represent real-life sedentary patterns? A pilot study. Transl J Am Coll Sport Med 7(1):1\u20133","journal-title":"Transl J Am Coll Sport Med"},{"issue":"3","key":"5502_CR23","doi-asserted-by":"publisher","first-page":"874","DOI":"10.1152\/japplphysiol.00799.2021","volume":"132","author":"SY Park","year":"2022","unstructured":"Park SY, Wooden TSK, Pekas EJ, Anderson CP, Yadav SK, Slivka DR et al (2022) Effects of passive and active leg movements to interrupt sitting in mild hypercapnia on cardiovascular function in healthy adults. J Appl Physiol 132(3):874\u2013887","journal-title":"J Appl Physiol"},{"key":"5502_CR24","doi-asserted-by":"publisher","first-page":"1929","DOI":"10.1007\/s40279-020-01325-5","volume":"50","author":"C Paterson","year":"2020","unstructured":"Paterson C, Fryer S, Zieff G, Stone K, Credeur DP, Barone Gibbs B et al (2020) The effects of acute exposure to prolonged sitting, with and without interruption, on vascular function among adults: a meta-analysis. Sports Med 50:1929\u20131942","journal-title":"Sports Med"},{"issue":"6","key":"5502_CR25","doi-asserted-by":"publisher","first-page":"1369","DOI":"10.1007\/s40279-021-01614-7","volume":"52","author":"C Paterson","year":"2022","unstructured":"Paterson C, Fryer S, Stone K, Zieff G, Turner L, Stoner L (2022) The effects of acute exposure to prolonged sitting, with and without interruption, on peripheral blood pressure among adults: a systematic review and meta-analysis. Sport Med 52(6):1369\u20131383. https:\/\/doi.org\/10.1007\/s40279-021-01614-7","journal-title":"Sport Med"},{"key":"5502_CR26","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00361.2023","author":"C Paterson","year":"2024","unstructured":"Paterson C, Stone K, Turner L, Moinuddin A, Stoner L, Fryer S (2024) The effect of cardiorespiratory fitness and habitual physical activity on cardiovascular responses to 2-hours of uninterrupted sitting. J Appl Physiol. https:\/\/doi.org\/10.1152\/japplphysiol.00361.2023","journal-title":"J Appl Physiol"},{"key":"5502_CR27","unstructured":"R Core Team (2020) R: a language and environment for statistical computing. www.R-project.org. Accessed 5 Apr 2023"},{"issue":"3","key":"5502_CR28","doi-asserted-by":"publisher","first-page":"746","DOI":"10.1210\/jc.2010-1746","volume":"96","author":"JF Randolph","year":"2011","unstructured":"Randolph JF, Zheng H, Sowers MFR, Crandall C, Crawford S, Gold EB et al (2011) Change in follicle- stimulating hormone and estradiol across the menopausal transition: effect of age at the final menstrual period. J Clin Endocrinol Metab 96(3):746\u2013754","journal-title":"J Clin Endocrinol Metab"},{"issue":"37","key":"5502_CR29","doi-asserted-by":"publisher","first-page":"2805","DOI":"10.1093\/eurheartj\/ehw632","volume":"38","author":"JE Sharman","year":"2017","unstructured":"Sharman JE, Avolio AP, Baulmann J, Benetos A, Blacher J, Blizzard CL et al (2017) Validation of non- invasive central blood pressure devices: ARTERY Society task force consensus statement on protocol standardization. Eur Heart J 38(37):2805\u20132812","journal-title":"Eur Heart J"},{"issue":"9","key":"5502_CR30","doi-asserted-by":"publisher","first-page":"1682","DOI":"10.1111\/jch.13954","volume":"22","author":"K Stamatelopoulos","year":"2020","unstructured":"Stamatelopoulos K, Ba NT, Armeni E, Paschou SA, Augoulea A, Kaparos G et al (2020) Physical activity is associated with lower arterial stiffness in normal-weight postmenopausal women. J Clin Hypertens (Greenwich) 22(9):1682\u20131690","journal-title":"J Clin Hypertens (Greenwich)"},{"key":"5502_CR31","doi-asserted-by":"publisher","first-page":"234","DOI":"10.1016\/j.atherosclerosis.2016.06.030","volume":"251","author":"KJ Stone","year":"2016","unstructured":"Stone KJ, Fryer SM, Ryan T, Stoner L (2016) The validity and reliability of continuous-wave near-infrared spectroscopy for the assessment of leg blood volume during an orthostatic challenge. Atherosclerosis 251:234\u2013239","journal-title":"Atherosclerosis"},{"key":"5502_CR32","doi-asserted-by":"publisher","first-page":"176","DOI":"10.1038\/s41440-017-0005-1","volume":"41","author":"L Stoner","year":"2018","unstructured":"Stoner L, Stone K, Hanson ED, Faulkner J, Fryer S, Credeur D (2018) Reliability of pulse waveform separation analysis responses to an orthostatic challenge. Hypertens Res 41:176\u2013182","journal-title":"Hypertens Res"},{"key":"5502_CR33","first-page":"8","volume":"17","author":"L Stoner","year":"2021","unstructured":"Stoner L, Barone Gibbs B, Meyer ML, Fryer S, Credeur D, Paterson C et al (2021) A primer on repeated sitting exposure and the cardiovascular system: considerations for study design, analysis, interpretation, and translation. Front Cardiovasc Med 17:8","journal-title":"Front Cardiovasc Med"},{"key":"5502_CR34","unstructured":"The North Americcan Menopause Society (2005) Menopause Health Questionnaire [Internet]. Clinical Practice Material. 2005 [cited 2022 Jun 2]. p 1\u20138. https:\/\/www.menopause.org\/publications\/clinical-practice-materials\/menopause-health-questionnaire. Accessed 2 June 2023"},{"issue":"30","key":"5502_CR35","doi-asserted-by":"publisher","first-page":"2534","DOI":"10.1093\/eurheartj\/ehz350","volume":"40","author":"DHJ Thijssen","year":"2019","unstructured":"Thijssen DHJ, Bruno RM, van Mil ACCM, Holder SM, Faita F, Greyling A, Zock PL, Taddei S, Deanfield JE, Luscher T, Green DJ, Ghiadoni L (2019) Expert consensus and evidence-based recommendations for the assessment of flow-mediated dilation in humans. Eur Heart J 40(30):2534\u20132547","journal-title":"Eur Heart J"},{"key":"5502_CR36","doi-asserted-by":"publisher","first-page":"1291","DOI":"10.1097\/gme.0b013e31821f81c2","volume":"18","author":"GA Woodard","year":"2011","unstructured":"Woodard GA, Mehta VG, MacKey RH, Tepper P, Kelsey SF, Newman AB et al (2011) C-reactive protein is associated with aortic stiffness in a cohort of African American and white women transitioning through menopause. Menopause 18:1291\u20131297","journal-title":"Menopause"}],"container-title":["European Journal of Applied Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00421-024-05502-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00421-024-05502-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00421-024-05502-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,11]],"date-time":"2024-10-11T00:02:56Z","timestamp":1728604976000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00421-024-05502-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5,27]]},"references-count":36,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2024,10]]}},"alternative-id":["5502"],"URL":"https:\/\/doi.org\/10.1007\/s00421-024-05502-6","relation":{},"ISSN":["1439-6319","1439-6327"],"issn-type":[{"value":"1439-6319","type":"print"},{"value":"1439-6327","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,5,27]]},"assertion":[{"value":"16 November 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 April 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 May 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}