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Growth hormone (GH), insulin-like growth factor-I (IGF-I), cortisol, testosterone, IL-6, and TNF-\u03b1 were analyzed in serum samples. Biological maturation was assessed according to the stages of the Tanner scale.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>There was a significant time-by-group interaction in IGF-I response (<jats:italic>p<\/jats:italic>\u2009=\u20090.044; \u03b7<jats:sup>2<\/jats:sup>\u2009=\u20090.209) and testosterone (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001; \u03b7<jats:sup>2<\/jats:sup>\u2009=\u20090.508), indicating a greater change in the pubertal group compared to the prepubertal group. Both groups significantly increased post-exercise GH levels (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). Only the prepuberal group significantly increased levels of IL-6 at all post-exercise time points (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). Both groups showed a significant (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05) increase in TNF-\u03b1 levels compared to resting levels.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion<\/jats:title>\n            <jats:p>These data suggest that acute testosterone and IGF-I response following resistance training differ between trained prepubertal and pubertal male children. Moderate-intensity resistance training performed to failure may thus have different effects in trained prepubertal and pubertal male children, which should be considered when giving training advice.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Trial registration<\/jats:title>\n            <jats:p>Clinical trials number: NCT05022992.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1007\/s00421-024-05603-2","type":"journal-article","created":{"date-parts":[[2024,9,11]],"date-time":"2024-09-11T11:09:18Z","timestamp":1726052958000},"page":"381-392","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Hormonal and inflammatory responses in prepubertal vs. pubertal male children following an acute free-weight resistance training session"],"prefix":"10.1007","volume":"125","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6488-0663","authenticated-orcid":false,"given":"Daniel","family":"Jansson","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6010-351X","authenticated-orcid":false,"given":"Elena","family":"Lundberg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3414-5481","authenticated-orcid":false,"given":"Anna-Clara","family":"Rullander","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0726-7029","authenticated-orcid":false,"given":"Magnus","family":"Domell\u00f6f","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2339-6381","authenticated-orcid":false,"given":"Ann-Sofie","family":"Lindberg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7116-565X","authenticated-orcid":false,"given":"Helena","family":"Andersson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8191-6659","authenticated-orcid":false,"given":"Apostolos","family":"Theos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,9,11]]},"reference":[{"key":"5603_CR1","doi-asserted-by":"publisher","first-page":"410","DOI":"10.1055\/s-2003-41171","volume":"24","author":"JP Ahtiainen","year":"2003","unstructured":"Ahtiainen JP, Pakarinen A, Kraemer WJ, H\u00e4kkinen K (2003) Acute hormonal and neuromuscular responses and recovery to forced vs maximum repetitions multiple resistance exercises. 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