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Troponin I (cTnI), the n-terminal creatine kinase-myocardial band (CK-MB), pro b-type natriuretic peptide (NT-proBNP), lactate dehydrogenase (LDH), myoglobin, creatinine (CREA) and the estimated glomerular filtration rate (eGFR)\u00a0were measured before (T0), immediately after (T1) and 3\u00a0days after the race (T2).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>The concentrations of cTnI, myoglobin, LDH, CK-MB and CREA significantly increased (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05), whereas eGRF decreased at T1 (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05). All the above parameters returned to baseline at T2, except for eGFR, which remained lower than that at T0 (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05). A positive association was observed between \u0394CK-MB (%) and the time spent in Zone 3 during the race (<jats:italic>R<\/jats:italic>\u2009=\u20090.686, <jats:italic>P<\/jats:italic>\u2009=\u20090.014). The \u0394myoglobin (%) was positively correlated with race time, race mean speed and time in Zone 3 (<jats:italic>R<\/jats:italic>\u2009=\u20090.574\u20130.862, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05). The \u2206CREA values were moderately correlated with the race mean HR<jats:sub>MAX<\/jats:sub> (%) and time spent in Zone 3 (%) (<jats:italic>R<\/jats:italic>\u2009=\u20090.514\u20130.610; <jats:italic>P<\/jats:italic>\u2009=\u20090.05). The \u2206eGRF values were moderately inversely correlated with the time spent in Zone 3 (%) (<jats:italic>R<\/jats:italic>\u2009=\u2009\u2009\u2013\u20090.627; <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion<\/jats:title>\n            <jats:p>Changes in cardiac, muscular and renal inflammatory markers in trained men with obesity are consistent with those described in the literature in normal-weight individuals. Finally, running parameters, such as running time, average running intensity and time in Zone 3 appear to be responsible for the changes in cardiac, muscular and renal function markers after long-distance running.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1007\/s00421-024-05697-8","type":"journal-article","created":{"date-parts":[[2025,1,9]],"date-time":"2025-01-09T10:05:28Z","timestamp":1736417128000},"page":"1485-1500","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["The influence of prolonged aerobic exercise on cardiac, muscular, and renal biomarkers in trained individuals with obesity"],"prefix":"10.1007","volume":"125","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9179-1618","authenticated-orcid":false,"given":"M.","family":"D\u2019Alleva","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. 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