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Therefore, the aim of this study was to investigate the changes in gait variability and fatigability in distance runners over a 10-km running race.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods<\/jats:title>\n            <jats:p>For this aim, 12 runners (36.5\u2009\u00b1\u20095.4 y) completed a simulated 10-km running race. Throughout the trial, heart rate (HR) and rate perceived exertion (RPE, CR-10) were analyzed. In addition, kinematic\/kinetic measurements: contact time (CT), flight time (FT), step length (SL), stride time (ST) leg (k<jats:sub>vert<\/jats:sub>) and vertical (k<jats:sub>leg<\/jats:sub>) stiffness, were recorded. Gait variability including phase coordination index (PCI) was calculated for each 2-km segment.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>HR increased (from 88.46\u2009\u00b1\u20095.84 to 93.87\u2009\u00b1\u20096.48\u00a0%HR<jats:sub>MAX<\/jats:sub>, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05) as well as RPE (6.58\u2009\u00b1\u20090.47\u20138.96\u2009\u00b1\u20090.40 a.u., <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001) as the distance increased. Conversely, no differences between running segments for the kinematic\/kinetic data (CT\u2013FT\u2013SL\u2013ST\u2013k<jats:sub>vert<\/jats:sub>\u2013k<jats:sub>leg<\/jats:sub>) were observed over five 2\u00a0km. However, there was increase (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05) in gait variability (PCI), over the course of the running race. Furthermore, the determination coefficient (<jats:italic>R<\/jats:italic>\n              <jats:sup>2<\/jats:sup>) was found as strong and very strong when compared five (0\u201310\u00a0km) and four (4\u201310\u00a0km) running segments between HR\u2013RPE and PCI (<jats:italic>R<\/jats:italic>\n              <jats:sup>2<\/jats:sup>\u2009=\u20090.623\u20130.845).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion<\/jats:title>\n            <jats:p>These results suggest that the gait variability is one mechanical determinant in assessing the neuromuscular output when the fatigability increases during a running race.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1007\/s00421-025-05780-8","type":"journal-article","created":{"date-parts":[[2025,4,21]],"date-time":"2025-04-21T03:42:57Z","timestamp":1745206977000},"page":"2529-2535","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Gait variability and fatigability during a simulated 10-km running race in trained runners"],"prefix":"10.1007","volume":"125","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4254-3105","authenticated-orcid":false,"given":"Johnny","family":"Padulo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6984-9323","authenticated-orcid":false,"given":"Marta","family":"Borrelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Antiglio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4420-2611","authenticated-orcid":false,"given":"Fabio","family":"Esposito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,4,21]]},"reference":[{"key":"5780_CR1","doi-asserted-by":"publisher","first-page":"239","DOI":"10.2165\/00007256-200838030-00004","volume":"38","author":"CR Abbiss","year":"2008","unstructured":"Abbiss CR, Laursen PB (2008) Describing and understanding pacing strategies during athletic competition. 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