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An affordable method could improve accessibility; however, there is a need to establish efficacy and safety prior to prescription as an alternative IRT method. This study aims to determine whether a novel isometric training band (ITB) can elicit cardiovascular (CV) responses (blood pressure [BP] and heart rate [HR]) comparable with those of established methods.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods<\/jats:title>\n            <jats:p>Fifteen normotensive adults (systolic [sBP]; 120\u2009\u00b1\u20093 mmHg, diastolic [dBP]; 71\u2009\u00b1\u20096 mmHg) completed a single 2-min isometric handgrip contraction (IHG) at 30% maximal voluntary contraction (MVC) followed by 2-min contractions for four individual ITB exercises at a self-determined intensity to replicate perceived exertion (CR-10) during IHG. A further 15 normotensive participants (sBP; 118\u2009\u00b1\u20096 mmHg, dBP; 68\u2009\u00b1\u20097 mmHg) completed bouts of IRT (IHG, 4\u2009\u00d7\u20092 min at 30% MVC; ITB, 4\u2009\u00d7\u20092 min at imposed CR-10 values [4\u20135]), with CV responses compared between bouts.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>No differences in BP responses were detected between IHG and each ITB exercise (<jats:italic>P<\/jats:italic>\u2009&gt;\u20090.05). CR-10 values and HRs were comparable between the individual IHG contraction and three ITB exercises (<jats:italic>P<\/jats:italic>\u2009&gt;\u20090.05). Between bouts, regulating contraction intensity through imposed CR-10 values resulted in comparable BP responses (<jats:italic>P<\/jats:italic>\u2009&gt;\u20090.05).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion<\/jats:title>\n            <jats:p>These findings suggest that a\u00a0novel ITB and associated protocol may serve as versatile, inclusive, and accessible alternative method for performing IRT.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1007\/s00421-025-05785-3","type":"journal-article","created":{"date-parts":[[2025,4,11]],"date-time":"2025-04-11T10:06:08Z","timestamp":1744365968000},"page":"2611-2623","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Validation of a novel multi-exercise approach to isometric resistance training in normotensive adults"],"prefix":"10.1007","volume":"125","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7369-016X","authenticated-orcid":false,"given":"Ben H.","family":"Wright","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4625-1927","authenticated-orcid":false,"given":"Peter G. 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