{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T22:40:00Z","timestamp":1791499200437,"version":"4.3.4"},"reference-count":63,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2025,6,7]],"date-time":"2025-06-07T00:00:00Z","timestamp":1749254400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,6,7]],"date-time":"2025-06-07T00:00:00Z","timestamp":1749254400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Spanish Ministry of Science, Innovation and Universities","award":["PGC2018-097388-B-I00-MCI\/AEI\/FEDER"],"award-info":[{"award-number":["PGC2018-097388-B-I00-MCI\/AEI\/FEDER"]}]},{"name":"Spanish Ministry of Science, Innovation and Universities","award":["UE"],"award-info":[{"award-number":["UE"]}]},{"name":"FEDER\/Junta de Andaluc\u00eda-Ministry of Economic Transformation, Industry, Knowledge and Universities","award":["B-CTS-374-UGR20"],"award-info":[{"award-number":["B-CTS-374-UGR20"]}]},{"name":"FEDER\/Junta de Andaluc\u00eda-Ministry of Economic Transformation, Industry, Knowledge and Universities","award":["C-SEJ-015-UGR23"],"award-info":[{"award-number":["C-SEJ-015-UGR23"]}]},{"name":"Pre-competitive Research Projects Program for Young Researchers","award":["PPJIB2023-050"],"award-info":[{"award-number":["PPJIB2023-050"]}]},{"DOI":"10.13039\/501100006393","name":"Universidad de Granada","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100006393","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur J Appl Physiol"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:sec>\n            <jats:title>Purpose<\/jats:title>\n            <jats:p>To determine the effect of intermittent terrestrial hypobaric hypoxia (HH) exposure on stress and inflammatory biomarkers following a resistance training (R<jats:sub>T<\/jats:sub>) program.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods<\/jats:title>\n            <jats:p>Twenty trained males completed an 8-week R<jats:sub>T<\/jats:sub> program (3 sessions\/week) under HH (2320\u00a0m asl) or normoxia (N, 690\u00a0m asl). Before and after the R<jats:sub>T<\/jats:sub>, circulating stress biomarkers (calcium, inorganic phosphate, creatine kinase [CK], total antioxidant capacity [TAC]), inflammation (tumour necrosis factor-alpha [TNF-\u03b1]), interleukin 10 (IL-10), vascular endothelial growth factor and heat shock protein 70 (HSP70) were analyzed by immunology multiplex assay and ELISA. Moreover, maximal strength to back squat (1RM-SQ) and squat jump (SJ) performance were measured.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>The results revealed that, compared with N, the HH group exhibited a large increase in 1RM-SQ and SJ (all ES\u2009&gt;\u20090.99; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.041) outcomes. IL-10 and TNF-\u03b1 levels increased in HH more and faster than N (all ES\u2009&gt;\u20091.35; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.003), returning to baseline following the R<jats:sub>T<\/jats:sub>. Circulating HSP70 revealed\u00a0a similar trend, although remaining elevated in HH after the program (all ES\u2009&gt;\u20091.106; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.029). HSP70 in HH explained\u2009~\u200944% of TNF-\u03b1 variance (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). In addition, the R<jats:sub>T<\/jats:sub> program in HH induced greater decreases in TAC and CK than N (all ES\u2009&lt;\u2009\u2212 0.95; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p>Findings highlight the potential role of moderate altitude in long-term R<jats:sub>T<\/jats:sub> for inducing greater stress while maintaining the inflammatory balance, crucial for muscle adaptations in young males. Consequently, HH condition revealed an additional benefit in the contractile and explosive muscle strength development.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1007\/s00421-025-05842-x","type":"journal-article","created":{"date-parts":[[2025,6,7]],"date-time":"2025-06-07T15:04:35Z","timestamp":1749308675000},"page":"3311-3321","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["New insights into the integrative effects of resistance training at moderate altitude on systemic inflammation"],"prefix":"10.1007","volume":"125","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9503-4286","authenticated-orcid":false,"given":"S.","family":"P\u00e9rez-Regalado","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0543-4823","authenticated-orcid":false,"given":"J.","family":"Leon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0847-7378","authenticated-orcid":false,"given":"P.","family":"Padial","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5154-8602","authenticated-orcid":false,"given":"C.","family":"Benavente","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1881-4566","authenticated-orcid":false,"given":"F.","family":"Almeida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0083-0138","authenticated-orcid":false,"given":"J.","family":"Bonitch-Gongora","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3933-6041","authenticated-orcid":false,"given":"B.","family":"Feriche","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,6,7]]},"reference":[{"issue":"6","key":"5842_CR1","doi-asserted-by":"publisher","first-page":"R2156","DOI":"10.1152\/ajpregu.2000.279.6.R2156","volume":"279","author":"G Alloatti","year":"2000","unstructured":"Alloatti G et al (2000) Role of NO and PAF in the impairment of skeletal muscle contractility induced by TNF-\u03b1. Am J Physiol-Regul Integr Comparat Physiol 279(6):R2156\u2013R2163","journal-title":"Am J Physiol-Regul Integr Comparat Physiol"},{"issue":"1","key":"5842_CR2","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.jesf.2013.12.001","volume":"12","author":"K Azizbeigi","year":"2014","unstructured":"Azizbeigi K et al (2014) Antioxidant enzymes and oxidative stress adaptation to exercise training: comparison of endurance, resistance, and concurrent training in untrained males. J Exerc Sci Fit 12(1):1\u20136","journal-title":"J Exerc Sci Fit"},{"issue":"19","key":"5842_CR3","doi-asserted-by":"publisher","first-page":"7580","DOI":"10.3390\/s22197580","volume":"22","author":"A Bargees","year":"2022","unstructured":"Bargees A, Al-Shuhail AA (2022) First arrival picking of zero-phase seismic data by hilbert envelope empirical half window (HEEH) Method. Sensors 22(19):7580","journal-title":"Sensors"},{"key":"5842_CR4","doi-asserted-by":"publisher","DOI":"10.1080\/02640414.2024.2425536","author":"C Benavente","year":"2024","unstructured":"Benavente C, Feriche B (2024) The influence of specific resistance training methodological prescription variables on strength development under hypoxic conditions: a systematic review and meta-analysis. J Sports Sci. https:\/\/doi.org\/10.1080\/02640414.2024.2425536","journal-title":"J Sports Sci"},{"issue":"8","key":"5842_CR5","doi-asserted-by":"publisher","first-page":"4233","DOI":"10.3390\/ijerph18084233","volume":"18","author":"C Benavente","year":"2021","unstructured":"Benavente C et al (2021) Hormonal and inflammatory responses to hypertrophy-oriented resistance training at acute moderate altitude. Int J Environ Res Public Health 18(8):4233","journal-title":"Int J Environ Res Public Health"},{"issue":"1","key":"5842_CR6","doi-asserted-by":"publisher","first-page":"3676","DOI":"10.1038\/s41598-023-30808-4","volume":"13","author":"C Benavente","year":"2023","unstructured":"Benavente C et al (2023) Efficacy of resistance training in hypoxia on muscle hypertrophy and strength development: a systematic review with meta-analysis. Sci Rep 13(1):3676","journal-title":"Sci Rep"},{"key":"5842_CR7","doi-asserted-by":"publisher","first-page":"1221","DOI":"10.1007\/s00424-024-02978-1","volume":"476","author":"C Benavente","year":"2024","unstructured":"Benavente C et al (2024) Strength and muscle mass development after a resistance-training period at terrestrial and normobaric intermittent hypoxia. Pfl\u00fcgers Archiv-Eur J Physiol. 476:1221\u20131233","journal-title":"Pfl\u00fcgers Archiv-Eur J Physiol."},{"issue":"11","key":"5842_CR8","doi-asserted-by":"publisher","first-page":"770","DOI":"10.1136\/bjsports-2012-091296","volume":"46","author":"MF Bergeron","year":"2012","unstructured":"Bergeron MF et al (2012) International Olympic Committee consensus statement on thermoregulatory and altitude challenges for high-level athletes. Br J Sports Med 46(11):770\u2013779","journal-title":"Br J Sports Med"},{"key":"5842_CR9","doi-asserted-by":"publisher","first-page":"95","DOI":"10.3389\/fimmu.2012.00095","volume":"3","author":"TJ Borges","year":"2012","unstructured":"Borges TJ et al (2012) The anti-inflammatory mechanisms of Hsp70. Front Immunol 3:95","journal-title":"Front Immunol"},{"key":"5842_CR10","doi-asserted-by":"publisher","first-page":"1032450","DOI":"10.3389\/fphys.2022.1032450","volume":"13","author":"Z Bouredji","year":"2022","unstructured":"Bouredji Z, Argaw A, Frenette J (2022) The inflammatory response, a mixed blessing for muscle homeostasis and plasticity. Front Physiol 13:1032450","journal-title":"Front Physiol"},{"key":"5842_CR11","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2022.104718","volume":"138","author":"J Burtscher","year":"2022","unstructured":"Burtscher J et al (2022) The interplay of hypoxic and mental stress: Implications for anxiety and depressive disorders. Neurosci Biobehav Rev 138:104718","journal-title":"Neurosci Biobehav Rev"},{"issue":"4","key":"5842_CR12","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3892\/mmr.2021.12327","volume":"24","author":"J Cao","year":"2021","unstructured":"Cao J et al (2021) Heat shock protein 70 attenuates hypoxia-induced apoptosis of pulmonary microvascular endothelial cells isolated from neonatal rats. Mol Med Rep 24(4):1\u201312","journal-title":"Mol Med Rep"},{"issue":"5","key":"5842_CR13","doi-asserted-by":"publisher","first-page":"1389","DOI":"10.1519\/JSC.0b013e3181d1d318","volume":"24","author":"A Chatzinikolaou","year":"2010","unstructured":"Chatzinikolaou A et al (2010) Time course of changes in performance and inflammatory responses after acute plyometric exercise. J Strength Cond Res 24(5):1389\u20131398","journal-title":"J Strength Cond Res"},{"key":"5842_CR14","unstructured":"Cohen J (1988) Statistical power analysis for the behavioral sciences. New York, NY: Roudledge Academic. Computing R Foundation for Statistical Computing, Vienna, Austria"},{"key":"5842_CR15","doi-asserted-by":"publisher","first-page":"350","DOI":"10.1007\/s11914-020-00596-1","volume":"18","author":"SM Cornish","year":"2020","unstructured":"Cornish SM, Chilibeck PD, Candow DG (2020) Potential importance of immune system response to exercise on aging muscle and bone. Curr Osteoporos Rep 18:350\u2013356","journal-title":"Curr Osteoporos Rep"},{"key":"5842_CR16","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1007\/s40477-020-00486-3","volume":"23","author":"SJ Dankel","year":"2020","unstructured":"Dankel SJ, Razzano BM (2020) The impact of acute and chronic resistance exercise on muscle stiffness: a systematic review and meta-analysis. J Ultrasound 23:473\u2013480","journal-title":"J Ultrasound"},{"issue":"1","key":"5842_CR17","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1186\/s13102-022-00397-2","volume":"14","author":"S Docherty","year":"2022","unstructured":"Docherty S et al (2022) The effect of exercise on cytokines: implications for musculoskeletal health: a narrative review. BMC Sports Sci Med Rehabil 14(1):5","journal-title":"BMC Sports Sci Med Rehabil"},{"key":"5842_CR18","doi-asserted-by":"publisher","first-page":"379","DOI":"10.3389\/fphys.2013.00379","volume":"4","author":"DM D'Souza","year":"2013","unstructured":"D\u2019Souza DM, Al-Sajee D, Hawke TJ (2013) Diabetic myopathy: impact of diabetes mellitus on skeletal muscle progenitor cells. Front Physiol 4:379","journal-title":"Front Physiol"},{"key":"5842_CR19","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/1476-9255-11-19","volume":"11","author":"E Ferat-Osorio","year":"2014","unstructured":"Ferat-Osorio E et al (2014) Heat shock protein 70 down-regulates the production of toll-like receptor-induced pro-inflammatory cytokines by a heat shock factor-1\/constitutive heat shock element-binding factor-dependent mechanism. J Inflamm 11:1\u201312","journal-title":"J Inflamm"},{"issue":"1","key":"5842_CR20","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s40798-017-0078-z","volume":"3","author":"B Feriche","year":"2017","unstructured":"Feriche B et al (2017) Resistance training using different hypoxic training strategies: a basis for hypertrophy and muscle power development. Sports Med-Open 3(1):1\u201314","journal-title":"Sports Med-Open"},{"issue":"8","key":"5842_CR21","doi-asserted-by":"publisher","first-page":"1083","DOI":"10.1080\/17461391.2019.1691270","volume":"20","author":"B Feriche","year":"2020","unstructured":"Feriche B et al (2020) Altitude-induced effects on muscular metabolic stress and hypertrophy-related factors after a resistance training session. Eur J Sport Sci 20(8):1083\u20131092","journal-title":"Eur J Sport Sci"},{"key":"5842_CR22","doi-asserted-by":"publisher","first-page":"511","DOI":"10.1007\/s00421-017-3548-6","volume":"117","author":"LN Forti","year":"2017","unstructured":"Forti LN et al (2017) Effects of resistance training at different loads on inflammatory markers in young adults. Eur J Appl Physiol 117:511\u2013519","journal-title":"Eur J Appl Physiol"},{"issue":"12","key":"5842_CR23","doi-asserted-by":"publisher","first-page":"3607","DOI":"10.1007\/s11999-012-2456-7","volume":"470","author":"SP Frey","year":"2012","unstructured":"Frey SP et al (2012) VEGF improves skeletal muscle regeneration after acute trauma and reconstruction of the limb in a rabbit model. Clin Orthop Related Res 470(12):3607\u20133614","journal-title":"Clin Orthop Related Res"},{"issue":"10","key":"5842_CR24","doi-asserted-by":"publisher","first-page":"1059","DOI":"10.1093\/gerona\/61.10.1059","volume":"61","author":"BH Goodpaster","year":"2006","unstructured":"Goodpaster BH et al (2006) The loss of skeletal muscle strength, mass, and quality in older adults: the health, aging and body composition study. J Gerontol A Biol Sci Med Sci 61(10):1059\u20131064","journal-title":"J Gerontol A Biol Sci Med Sci"},{"issue":"6","key":"5842_CR25","doi-asserted-by":"publisher","first-page":"484","DOI":"10.1007\/s004210050541","volume":"79","author":"HC Gunga","year":"1999","unstructured":"Gunga HC et al (1999) Vascular endothelial growth factor in exercising humans under different environmental conditions. Eur J Appl Physiol Occup Physiol 79(6):484\u2013490","journal-title":"Eur J Appl Physiol Occup Physiol"},{"issue":"3","key":"5842_CR26","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1379\/CSC-265.1","volume":"12","author":"S Guo","year":"2007","unstructured":"Guo S et al (2007) Heat shock protein 70 regulates cellular redox status by modulating glutathione-related enzyme activities. Cell Stress Chaperones 12(3):245","journal-title":"Cell Stress Chaperones"},{"issue":"2","key":"5842_CR27","doi-asserted-by":"publisher","first-page":"298","DOI":"10.1002\/ijc.23906","volume":"124","author":"WJ Huang","year":"2009","unstructured":"Huang WJ et al (2009) Transcriptional upregulation of HSP70-2 by HIF-1 in cancer cells in response to hypoxia. Int J Cancer 124(2):298\u2013305","journal-title":"Int J Cancer"},{"key":"5842_CR28","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2016.00502","author":"MW Inness","year":"2016","unstructured":"Inness MW et al (2016) Heavy resistance training in hypoxia enhances 1RM squat performance. Front Physiol. https:\/\/doi.org\/10.3389\/fphys.2016.00502","journal-title":"Front Physiol"},{"issue":"9","key":"5842_CR29","doi-asserted-by":"publisher","first-page":"1686","DOI":"10.3390\/antiox11091686","volume":"11","author":"Y Ji","year":"2022","unstructured":"Ji Y et al (2022) Inflammation: roles in skeletal muscle atrophy. Antioxidants 11(9):1686","journal-title":"Antioxidants"},{"key":"5842_CR30","doi-asserted-by":"crossref","unstructured":"Juandi D et al. (2021) The effectiveness of dynamic geometry software applications in learning mathematics: A meta-analysis study","DOI":"10.3991\/ijim.v15i02.18853"},{"issue":"1","key":"5842_CR31","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s40798-023-00584-6","volume":"9","author":"M Khalafi","year":"2023","unstructured":"Khalafi M et al (2023a) Impact of exercise in hypoxia on inflammatory cytokines in adults: a systematic review and meta-analysis. Sports Med-Open 9(1):1\u201314","journal-title":"Sports Med-Open"},{"key":"5842_CR32","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2023.156303","volume":"169","author":"M Khalafi","year":"2023","unstructured":"Khalafi M et al (2023b) Influence of different modes of exercise training on inflammatory markers in older adults with and without chronic diseases: a systematic review and meta-analysis. Cytokine 169:156303","journal-title":"Cytokine"},{"issue":"4","key":"5842_CR33","doi-asserted-by":"publisher","first-page":"331","DOI":"10.4239\/wjd.v12.i4.331","volume":"12","author":"S-W Kim","year":"2021","unstructured":"Kim S-W et al (2021) Exercise intervention under hypoxic condition as a new therapeutic paradigm for type 2 diabetes mellitus: a narrative review. World J Diabetes 12(4):331","journal-title":"World J Diabetes"},{"issue":"4","key":"5842_CR34","doi-asserted-by":"publisher","first-page":"916","DOI":"10.1152\/japplphysiol.01052.2018","volume":"126","author":"K Kr\u00fcger","year":"2019","unstructured":"Kr\u00fcger K, Reichel T, Zeilinger C (2019) Role of heat shock proteins 70\/90 in exercise physiology and exercise immunology and their diagnostic potential in sports. J Appl Physiol 126(4):916\u2013927","journal-title":"J Appl Physiol"},{"key":"5842_CR35","doi-asserted-by":"publisher","DOI":"10.1016\/j.exger.2023.112177","volume":"177","author":"HE Kunz","year":"2023","unstructured":"Kunz HE, Lanza IR (2023) Age-associated inflammation and implications for skeletal muscle responses to exercise. Exp Gerontol 177:112177","journal-title":"Exp Gerontol"},{"issue":"11","key":"5842_CR36","doi-asserted-by":"publisher","first-page":"2077","DOI":"10.1249\/MSS.0b013e3182625928","volume":"44","author":"KA Larkin","year":"2012","unstructured":"Larkin KA et al (2012) Blood flow restriction enhances post\u2013resistance exercise angiogenic gene expression. Med Sci Sports Exerc 44(11):2077","journal-title":"Med Sci Sports Exerc"},{"issue":"1","key":"5842_CR37","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1152\/jappl.1999.86.1.101","volume":"86","author":"Y Liu","year":"1999","unstructured":"Liu Y et al (1999) Human skeletal muscle HSP70 response to training in highly trained rowers. J Appl Physiol 86(1):101\u2013104","journal-title":"J Appl Physiol"},{"issue":"6","key":"5842_CR38","doi-asserted-by":"publisher","first-page":"3651","DOI":"10.1074\/jbc.M109.068577","volume":"285","author":"W Luo","year":"2010","unstructured":"Luo W et al (2010) Hsp70 and CHIP selectively mediate ubiquitination and degradation of hypoxia-inducible factor (HIF)-1\u03b1 but Not HIF-2\u03b1 2. J Biol Chem 285(6):3651\u20133663","journal-title":"J Biol Chem"},{"issue":"6","key":"5842_CR39","doi-asserted-by":"publisher","first-page":"1601","DOI":"10.3390\/biomedicines11061601","volume":"11","author":"M Maga","year":"2023","unstructured":"Maga M et al (2023) Impact of blood-flow-restricted training on arterial functions and angiogenesis\u2014a systematic review with meta-analysis. Biomedicines 11(6):1601","journal-title":"Biomedicines"},{"issue":"10","key":"5842_CR40","doi-asserted-by":"publisher","first-page":"2119","DOI":"10.1007\/s00421-023-05195-3","volume":"123","author":"G M\u00e1rquez","year":"2023","unstructured":"M\u00e1rquez G et al (2023) Altitude-induced effects on neuromuscular, metabolic and perceptual responses before, during and after a high-intensity resistance training session. Eur J Appl Physiol 123(10):2119\u20132129","journal-title":"Eur J Appl Physiol"},{"key":"5842_CR41","doi-asserted-by":"publisher","first-page":"1245","DOI":"10.1007\/s40279-021-01430-z","volume":"51","author":"J Marshall","year":"2021","unstructured":"Marshall J et al (2021) Optimal training sequences to develop lower body force, velocity, power, and jump height: a systematic review with meta-analysis. Sports Med 51:1245\u20131271","journal-title":"Sports Med"},{"issue":"1","key":"5842_CR42","doi-asserted-by":"publisher","first-page":"36","DOI":"10.3390\/biomedicines9010036","volume":"9","author":"S Methenitis","year":"2021","unstructured":"Methenitis S et al (2021) Can exercise-induced muscle damage be a good model for the investigation of the anti-inflammatory properties of diet in humans? Biomedicines 9(1):36","journal-title":"Biomedicines"},{"issue":"10","key":"5842_CR43","doi-asserted-by":"publisher","first-page":"B359","DOI":"10.1093\/gerona\/57.10.B359","volume":"57","author":"EJ Metter","year":"2002","unstructured":"Metter EJ et al (2002) Skeletal muscle strength as a predictor of all-cause mortality in healthy men. J Gerontol A Biol Sci Med Sci 57(10):B359\u2013B365","journal-title":"J Gerontol A Biol Sci Med Sci"},{"key":"5842_CR44","doi-asserted-by":"crossref","unstructured":"Nanakorn N, Chuechan S (2022) Impaired oxidative stress in Thalassemia-Hemoglobin E traits after acute exhaustive exercise. Sport Sci Health 18:789\u2013797","DOI":"10.1007\/s11332-021-00857-1"},{"issue":"5","key":"5842_CR45","doi-asserted-by":"publisher","first-page":"1050","DOI":"10.1139\/H08-069","volume":"33","author":"EG Noble","year":"2008","unstructured":"Noble EG, Milne KJ, Melling CJ (2008) Heat shock proteins and exercise: a primer. Appl Physiol Nutr Metab 33(5):1050\u20131075","journal-title":"Appl Physiol Nutr Metab"},{"issue":"1","key":"5842_CR46","doi-asserted-by":"publisher","first-page":"5","DOI":"10.7600\/jpfsm.1.5","volume":"1","author":"H Ohno","year":"2012","unstructured":"Ohno H et al (2012) Effect of exercise on HIF-1 and VEGF signaling. J Phys Fitness Sports Med 1(1):5\u201316","journal-title":"J Phys Fitness Sports Med"},{"key":"5842_CR47","doi-asserted-by":"publisher","DOI":"10.1007\/s00424-023-02868-y","author":"S P\u00e9rez-Regalado","year":"2023","unstructured":"P\u00e9rez-Regalado S et al (2023) Effect of a resistance exercise at acute moderate altitude on muscle health biomarkers. Pfl\u00fcgers Archiv-Eur J Physiol. https:\/\/doi.org\/10.1007\/s00424-023-02868-y","journal-title":"Pfl\u00fcgers Archiv-Eur J Physiol"},{"issue":"21","key":"5842_CR48","doi-asserted-by":"publisher","first-page":"11418","DOI":"10.3390\/ijms252111418","volume":"25","author":"S P\u00e9rez-Regalado","year":"2024","unstructured":"P\u00e9rez-Regalado S et al (2024) Exploring the impact of resistance training at moderate altitude on metabolic cytokines in humans: implications for adipose tissue dynamics. Int J Mol Sci 25(21):11418","journal-title":"Int J Mol Sci"},{"key":"5842_CR49","doi-asserted-by":"publisher","first-page":"1384","DOI":"10.3389\/fphys.2019.01384","volume":"10","author":"L Petrigna","year":"2019","unstructured":"Petrigna L et al (2019) A review of countermovement and squat jump testing methods in the context of public health examination in adolescence: reliability and feasibility of current testing procedures. Front Physiol 10:1384","journal-title":"Front Physiol"},{"key":"5842_CR50","unstructured":"Team R.D.C. (2010) R: A language and environment for statistical computing. (No Title)"},{"key":"5842_CR51","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2020.582258","volume":"11","author":"PS Rogeri","year":"2020","unstructured":"Rogeri PS et al (2020) Crosstalk between skeletal muscle and immune system: which roles do IL-6 and glutamine play? Front Physiol 11:582258","journal-title":"Front Physiol"},{"issue":"5","key":"5842_CR52","doi-asserted-by":"publisher","DOI":"10.15252\/embr.201847388","volume":"20","author":"P Sadiku","year":"2019","unstructured":"Sadiku P, Walmsley SR (2019) Hypoxia and the regulation of myeloid cell metabolic imprinting: consequences for the inflammatory response. EMBO Rep 20(5):e47388","journal-title":"EMBO Rep"},{"issue":"10","key":"5842_CR53","doi-asserted-by":"publisher","first-page":"1126","DOI":"10.1038\/sj.cdd.4401276","volume":"10","author":"G Schett","year":"2003","unstructured":"Schett G et al (2003) TNF\u03b1 mediates susceptibility to heat-induced apoptosis by protein phosphatase-mediated inhibition of the HSF1\/hsp70 stress response. Cell Death Differ 10(10):1126\u20131136","journal-title":"Cell Death Differ"},{"key":"5842_CR54","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1016\/j.cyto.2016.11.005","volume":"90","author":"MM Shamsi","year":"2017","unstructured":"Shamsi MM et al (2017) Combined effect of aerobic interval training and selenium nanoparticles on expression of IL-15 and IL-10\/TNF-\u03b1 ratio in skeletal muscle of 4T1 breast cancer mice with cachexia. Cytokine 90:100\u2013108","journal-title":"Cytokine"},{"issue":"1","key":"5842_CR55","doi-asserted-by":"publisher","first-page":"10961","DOI":"10.1038\/s41598-018-28942-5","volume":"8","author":"AF Siqueira","year":"2018","unstructured":"Siqueira AF et al (2018) Multiple cold-water immersions attenuate muscle damage but not alter systemic inflammation and muscle function recovery: a parallel randomized controlled trial. Sci Rep 8(1):10961","journal-title":"Sci Rep"},{"key":"5842_CR56","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1016\/j.neurobiolaging.2023.12.004","volume":"135","author":"BX Song","year":"2023","unstructured":"Song BX et al (2023) The effect of exercise on blood concentrations of angiogenesis markers in older adults: a systematic review and meta-analysis. Neurobiol Aging 135:15\u201325","journal-title":"Neurobiol Aging"},{"issue":"4","key":"5842_CR57","first-page":"726","volume":"58","author":"R Sotler","year":"2019","unstructured":"Sotler R et al (2019) Prooxidant activities of antioxidants and their impact on health. Acta Clin Croat 58(4):726\u2013736","journal-title":"Acta Clin Croat"},{"issue":"4","key":"5842_CR58","doi-asserted-by":"publisher","first-page":"102","DOI":"10.3390\/jfmk7040102","volume":"7","author":"MH Stone","year":"2022","unstructured":"Stone MH et al (2022) Training specificity for athletes: Emphasis on strength-power training: a narrative review. J Funct Morphol Kinesiol 7(4):102","journal-title":"J Funct Morphol Kinesiol"},{"issue":"3","key":"5842_CR59","doi-asserted-by":"publisher","first-page":"904","DOI":"10.70252\/ECQJ8204","volume":"12","author":"RA Tibana","year":"2019","unstructured":"Tibana RA et al (2019) Time-course of changes in physiological, psychological, and performance markers following a functional-fitness competition. Int J Exerc Sci 12(3):904","journal-title":"Int J Exerc Sci"},{"issue":"9","key":"5842_CR60","doi-asserted-by":"publisher","first-page":"1207","DOI":"10.1038\/sj.ijo.0801373","volume":"24","author":"S Tsukui","year":"2000","unstructured":"Tsukui S et al (2000) Moderate-intensity regular exercise decreases serum tumor necrosis factor-\u03b1 and HbA1c levels in healthy women. Int J Obes 24(9):1207\u20131211","journal-title":"Int J Obes"},{"issue":"10","key":"5842_CR61","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0007332","volume":"4","author":"B van de Sluis","year":"2009","unstructured":"van de Sluis B et al (2009) COMMD1 promotes pVHL and O2-independent proteolysis of HIF-1\u03b1 via HSP90\/70. PLoS ONE 4(10):e7332","journal-title":"PLoS ONE"},{"issue":"12","key":"5842_CR62","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0051747","volume":"7","author":"J Wachstein","year":"2012","unstructured":"Wachstein J et al (2012) HSP70 enhances immunosuppressive function of CD4+ CD25+ FoxP3+ T regulatory cells and cytotoxicity in CD4+ CD25\u2212 T cells. PLoS ONE 7(12):e51747","journal-title":"PLoS ONE"},{"issue":"23","key":"5842_CR63","doi-asserted-by":"publisher","first-page":"15491","DOI":"10.3390\/ijerph192315491","volume":"19","author":"H Zhao","year":"2022","unstructured":"Zhao H et al (2022) The effect of resistance training on the rehabilitation of elderly patients with sarcopenia: a meta-analysis. Int J Environ Res Public Health 19(23):15491","journal-title":"Int J Environ Res Public Health"}],"container-title":["European Journal of Applied Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00421-025-05842-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00421-025-05842-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00421-025-05842-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T06:02:52Z","timestamp":1760508172000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00421-025-05842-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,7]]},"references-count":63,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2025,11]]}},"alternative-id":["5842"],"URL":"https:\/\/doi.org\/10.1007\/s00421-025-05842-x","relation":{},"ISSN":["1439-6319","1439-6327"],"issn-type":[{"value":"1439-6319","type":"print"},{"value":"1439-6327","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6,7]]},"assertion":[{"value":"13 March 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 May 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 June 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"No conflicts of interest, financial or otherwise, are declared by the authors.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"The study was conducted according to the guidelines of the Declaration of Helsinki and approved by the Institutional Review Board (protocol code 10\/18 and date of approval 06\/11\/2018).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Written informed consent was received from all participants involved in the study.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Participant consent"}}]}}