{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T03:42:05Z","timestamp":1788579725338,"version":"build-2803163510"},"reference-count":59,"publisher":"Springer Science and Business Media LLC","issue":"12","license":[{"start":{"date-parts":[[2025,6,21]],"date-time":"2025-06-21T00:00:00Z","timestamp":1750464000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,6,21]],"date-time":"2025-06-21T00:00:00Z","timestamp":1750464000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/100009388","name":"Jazan University","doi-asserted-by":"publisher","award":["GSSRD-25"],"award-info":[{"award-number":["GSSRD-25"]}],"id":[{"id":"10.13039\/100009388","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur J Appl Physiol"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1007\/s00421-025-05850-x","type":"journal-article","created":{"date-parts":[[2025,6,21]],"date-time":"2025-06-21T10:20:27Z","timestamp":1750501227000},"page":"3619-3630","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Acute sodium bicarbonate supplementation reduces the increase in markers of acute kidney injury during physical work in the heat"],"prefix":"10.1007","volume":"125","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-8730-9986","authenticated-orcid":false,"given":"Abdulaziz A.","family":"Masoud","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zidong","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael R.","family":"Deyhle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason","family":"Siegler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Specht","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zachary J.","family":"McKenna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Mermier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabiano","family":"Amorim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,6,21]]},"reference":[{"issue":"4","key":"5850_CR1","doi-asserted-by":"publisher","first-page":"42","DOI":"10.5114\/hm.2018.77323","volume":"19","author":"PF Aguiar","year":"2018","unstructured":"Aguiar PF, Moriarty TA, Baracho WA, De Paula F, Sampaio PFM, Ottone VO,   Amorim FT (2018) The accuracy of two equations for predicting maximal oxygen uptake on individualized ramp protocol. Hum Mov 19(4):42\u201348","journal-title":"Hum Mov"},{"key":"5850_CR2","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/1745-6673-3-4","volume":"3","author":"GP Bates","year":"2008","unstructured":"Bates GP, Miller VS (2008) Sweat Rate and Sodium Loss during Work in the Heat. J Occup Med Toxicol 3:1\u20136","journal-title":"J Occup Med Toxicol"},{"issue":"4","key":"5850_CR3","doi-asserted-by":"publisher","first-page":"435","DOI":"10.2215\/CJN.0000000000000119","volume":"18","author":"B Beynon-Cobb","year":"2023","unstructured":"Beynon-Cobb B, Louca P, Hoorn EJ, Menni C, Padmanabhan S (2023) Effect of sodium bicarbonate on systolic blood pressure in CKD: a systematic review and meta-analysis. Clin J Am Soc Nephrol 18(4):435\u2013445","journal-title":"Clin J Am Soc Nephrol"},{"key":"5850_CR4","doi-asserted-by":"crossref","unstructured":"Borg GA (1982) Psychophysical bases of perceived exertion. Med Science Sports Exer 14(5):377\u2013381.","DOI":"10.1249\/00005768-198205000-00012"},{"issue":"1","key":"5850_CR5","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1038\/s41572-021-00334-6","volume":"8","author":"A Bouchama","year":"2022","unstructured":"Bouchama A, Abuyassin B, Lehe C, Laitano O, Jay O, O\u2019Connor FG, Leon LR (2022) Classic and exertional heatstroke. Nat Rev Dis Primers 8(1):8","journal-title":"Nat Rev Dis Primers"},{"issue":"3","key":"5850_CR6","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1123\/ijsnem.21.3.189","volume":"21","author":"AJ Carr","year":"2011","unstructured":"Carr AJ, Slater GJ, Gore CJ, Dawson B, Burke LM (2011) Effect of sodium bicarbonate on [HCO3\u2212], pH, and gastrointestinal symptoms. Int J Sport Nutr Exerc Metab 21(3):189\u2013194","journal-title":"Int J Sport Nutr Exerc Metab"},{"issue":"3","key":"5850_CR7","doi-asserted-by":"publisher","first-page":"R189","DOI":"10.1152\/ajpregu.00351.2018","volume":"316","author":"CL Chapman","year":"2019","unstructured":"Chapman CL, Johnson BD, Sackett JR, Parker MD, Schlader ZJ (2019) Soft drink consumption during and following exercise in the heat elevates biomarkers of acute kidney injury. Am J Physiol-Regul Integr Comp Physiol 316(3):R189\u2013R198","journal-title":"Am J Physiol-Regul Integr Comp Physiol"},{"issue":"4","key":"5850_CR8","doi-asserted-by":"publisher","first-page":"715","DOI":"10.1152\/japplphysiol.00787.2019","volume":"128","author":"CL Chapman","year":"2020","unstructured":"Chapman CL, Johnson BD, Vargas NT, Hostler D, Parker MD, Schlader ZJ (2020) Both hyperthermia and dehydration during physical work in the heat contribute to the risk of acute kidney injury. J Appl Physiol 128(4):715\u2013728","journal-title":"J Appl Physiol"},{"issue":"2","key":"5850_CR9","doi-asserted-by":"publisher","first-page":"R141","DOI":"10.1152\/ajpregu.00103.2021","volume":"321","author":"CL Chapman","year":"2021","unstructured":"Chapman CL, Hess HW, Lucas RAI, Glaser J, Saran R, Bragg-Gresham J, Wegman DH, Hansson E, Minson CT, Schlader ZJ (2021) Occupational heat exposure and the risk of chronic kidney disease of nontraditional origin in the United States. Am J Physiol-Regul, Integr Comp Physiol 321(2):R141\u2013R151","journal-title":"Am J Physiol-Regul, Integr Comp Physiol"},{"key":"5850_CR10","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/1471-2369-15-55","volume":"15","author":"W Chen","year":"2014","unstructured":"Chen W, Abramowitz MK (2014) Metabolic acidosis and the progression of chronic kidney disease. BMC Nephrol 15:1\u20138","journal-title":"BMC Nephrol"},{"key":"5850_CR11","unstructured":"Coco A, Jacklitsch B, Williams J, Kim JH, Musolin K, Turner N (2016) Criteria for a recommended standard: Occupational exposure to heat and hot environments (NIOSH Publication No. 2016-106). Department of Health and Human Services, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health. Retrieved from https:\/\/www.elcosh.org\/record\/document\/3998\/d001392.pdf"},{"issue":"8","key":"5850_CR12","doi-asserted-by":"publisher","first-page":"1381","DOI":"10.1249\/01.MSS.0000078924.61453.FB","volume":"35","author":"CL Craig","year":"2003","unstructured":"Craig CL, Marshall AL, Sj\u00f6str\u00f6m M, Bauman AE, Booth ML, Ainsworth BE, Michael Pratt ULF, Ekelund AY, Sallis JF (2003) International physical activity questionnaire: 12-country reliability and validity. Med Sci Sports Exerc 35(8):1381\u20131395","journal-title":"Med Sci Sports Exerc"},{"issue":"2","key":"5850_CR13","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1152\/jappl.1974.37.2.247","volume":"37","author":"DB Dill","year":"1974","unstructured":"Dill DB, Costill DL (1974) Calculation of percentage changes in volumes of blood, plasma, and red cells in dehydration. J Appl Physiol 37(2):247\u2013248","journal-title":"J Appl Physiol"},{"issue":"12","key":"5850_CR14","doi-asserted-by":"publisher","first-page":"683","DOI":"10.1038\/nrneph.2014.198","volume":"10","author":"ZH Endre","year":"2014","unstructured":"Endre ZH, Pickering JW (2014) Cell cycle arrest biomarkers win race for AKI diagnosis. Nat Rev Nephrol 10(12):683\u2013685","journal-title":"Nat Rev Nephrol"},{"issue":"6","key":"5850_CR15","doi-asserted-by":"publisher","first-page":"2827","DOI":"10.1152\/jappl.1994.77.6.2827","volume":"77","author":"MA Febbraio","year":"1994","unstructured":"Febbraio MA, Snow RJ, Stathis CG, Hargreaves M, Carey MF (1994) Effect of heat stress on muscle energy metabolism during exercise. J Appl Physiol 77(6):2827\u20132831","journal-title":"J Appl Physiol"},{"issue":"4","key":"5850_CR16","doi-asserted-by":"publisher","first-page":"685","DOI":"10.1113\/expphysiol.1996.sp003969","volume":"81","author":"MA Febbraio","year":"1996","unstructured":"Febbraio MA, Snow RJ, Stathis CG, Hargreaves M, Carey MF (1996) Blunting the rise in body temperature reduces muscle glycogenolysis during exercise in humans. Expe Physiol: Transl Integr 81(4):685\u2013693","journal-title":"Expe Physiol: Transl Integr"},{"issue":"1","key":"5850_CR17","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1007\/BF00999931","volume":"34","author":"WJ Fink","year":"1975","unstructured":"Fink WJ, Costill DL, Van Handel PJ (1975) leg muscle metabolism during exercise in the heat and cold. Eur J Appl Physiol 34(1):183\u2013190","journal-title":"Eur J Appl Physiol"},{"issue":"12","key":"5850_CR18","doi-asserted-by":"publisher","first-page":"e521","DOI":"10.1016\/S2542-5196(18)30237-7","volume":"2","author":"AD Flouris","year":"2018","unstructured":"Flouris AD, Dinas PC, Ioannou LG, Nybo L, Havenith G, Kenny GP, Kjellstrom T (2018) Workers\u2019 health and productivity under occupational heat strain: a systematic review and meta-analysis. Lancet Planet Health 2(12):e521\u2013e531","journal-title":"Lancet Planet Health"},{"key":"5850_CR19","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1016\/j.lfs.2016.01.007","volume":"146","author":"PA Fonseca Magalh\u00e3es","year":"2016","unstructured":"Fonseca Magalh\u00e3es PA, de Brito TS, Freire RS, da Silva MT, dos Santos AA, Vale ML, de Menezes DB, Costa Martins AM, Lib\u00f3rio AB (2016) Metabolic acidosis aggravates experimental acute kidney injury. Life Sci 146:58\u201365","journal-title":"Life Sci"},{"issue":"3","key":"5850_CR20","doi-asserted-by":"publisher","first-page":"733","DOI":"10.1152\/jappl.1984.57.3.733","volume":"57","author":"RALPH Francesconi","year":"1984","unstructured":"Francesconi RALPH, Hubbard ROGER (1984) Exercise in the Heat: effects of saline or bicarbonate infusion. J Appl Physiol 57(3):733\u2013738","journal-title":"J Appl Physiol"},{"key":"5850_CR21","doi-asserted-by":"publisher","first-page":"746","DOI":"10.1016\/j.envres.2015.07.007","volume":"142","author":"R Garc\u00eda-Trabanino","year":"2015","unstructured":"Garc\u00eda-Trabanino R, Jarqu\u00edn E, Wesseling C, Johnson RJ, Gonz\u00e1lez-Quiroz M, Weiss I, Glaser J, Vindell JJ, Stockfelt L, Roncal C (2015) Heat Stress, dehydration, and kidney function in sugarcane cutters in El salvador\u2013a cross-shift study of workers at risk of mesoamerican nephropathy. Environ Res 142:746\u2013755","journal-title":"Environ Res"},{"issue":"4","key":"5850_CR22","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1123\/ijsnem.2018-0215","volume":"29","author":"SK Gaskell","year":"2019","unstructured":"Gaskell SK, Snipe RMJ, Costa RJS (2019) Test\u2013retest reliability of a modified visual analog scale assessment tool for determining incidence and severity of gastrointestinal symptoms in response to exercise stress. Int J Sport Nutr Exerc Metab 29(4):411\u2013419","journal-title":"Int J Sport Nutr Exerc Metab"},{"issue":"8","key":"5850_CR23","doi-asserted-by":"publisher","first-page":"1472","DOI":"10.2215\/CJN.13841215","volume":"11","author":"J Glaser","year":"2016","unstructured":"Glaser J, Lemery J, Rajagopalan B, Diaz HF, Garc\u00eda-Trabanino R, Taduri G, Madero M, Amarasinghe M, Abraham G, Anutrakulchai S (2016) Climate change and the emergent epidemic of CKD from heat stress in rural communities: the case for heat stress nephropathy. Clin J Am Soc Nephrol 11(8):1472\u20131483","journal-title":"Clin J Am Soc Nephrol"},{"issue":"12","key":"5850_CR24","doi-asserted-by":"publisher","first-page":"1856","DOI":"10.1080\/17461391.2021.1998644","volume":"22","author":"LA Gough","year":"2022","unstructured":"Gough LA, Williams JJ, Newbury JW, Gurton WH (2022) The effects of sodium bicarbonate supplementation at individual time-to-peak blood bicarbonate on 4-km cycling time trial performance in the heat. Eur J Sport Sci 22(12):1856\u20131864","journal-title":"Eur J Sport Sci"},{"issue":"1","key":"5850_CR25","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1186\/s12970-021-00458-w","volume":"18","author":"J Grgic","year":"2021","unstructured":"Grgic J, Pedisic Z, Saunders B, Artioli GG, Schoenfeld BJ, McKenna MJ, Bishop DJ, Kreider RB, Stout JR, Kalman DS (2021) International society of sports nutrition position stand: sodium bicarbonate and exercise performance. J Int Soc Sports Nutr 18(1):61","journal-title":"J Int Soc Sports Nutr"},{"issue":"2","key":"5850_CR26","first-page":"271","volume":"18","author":"M Hadzic","year":"2019","unstructured":"Hadzic M, Eckstein ML, Schugardt M (2019) The impact of sodium bicarbonate on performance in response to exercise duration in athletes: a systematic review. J Sports Sci Med 18(2):271","journal-title":"J Sports Sci Med"},{"issue":"4","key":"5850_CR27","doi-asserted-by":"publisher","first-page":"1126","DOI":"10.1152\/jappl.1997.82.4.1126","volume":"82","author":"CW Ho","year":"1997","unstructured":"Ho CW, Beard JL, Farrell PA, Minson CT, Kenney WL (1997) Age, fitness, and regional blood flow during exercise in the heat. J Appl Physiol 82(4):1126\u20131135","journal-title":"J Appl Physiol"},{"issue":"11","key":"5850_CR28","doi-asserted-by":"publisher","first-page":"2437","DOI":"10.1007\/s00421-022-05030-1","volume":"122","author":"J Houck","year":"2022","unstructured":"Houck J, McKenna Z, Fennel Z, Ducharme J, Wells A, Mermier C, Deyhle M, Laitano O, Specht J, Amorim F (2022) The effect of interval and continuous work on markers of acute kidney injury in a hot environment. Eur J Appl Physiol 122(11):2437\u20132450","journal-title":"Eur J Appl Physiol"},{"issue":"5","key":"5850_CR30","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1080\/00913847.1985.11708790","volume":"13","author":"AS Jackson","year":"1985","unstructured":"Jackson AS, Pollock ML (1985) Practical assessment of body composition. Phys Sportsmed 13(5):76\u201390","journal-title":"Phys Sportsmed"},{"issue":"19","key":"5850_CR31","doi-asserted-by":"publisher","first-page":"1843","DOI":"10.1056\/NEJMra1813869","volume":"380","author":"RJ Johnson","year":"2019","unstructured":"Johnson RJ, Wesseling C, Newman LS (2019) Chronic kidney disease of unknown cause in agricultural communities. N Engl J Med 380(19):1843\u20131852","journal-title":"N Engl J Med"},{"issue":"6","key":"5850_CR32","doi-asserted-by":"publisher","first-page":"F813","DOI":"10.1152\/ajprenal.00091.2013","volume":"305","author":"NA Junglee","year":"2013","unstructured":"Junglee NA, Di Felice U, Dolci A, Fortes MB, Jibani MM, Lemmey AB, Walsh NP, Macdonald JH (2013) Exercising in a hot environment with muscle damage: effects on acute kidney injury biomarkers and kidney function. Am J Physiol-Renal Physiol 305(6):F813\u2013F820","journal-title":"Am J Physiol-Renal Physiol"},{"issue":"3","key":"5850_CR33","doi-asserted-by":"publisher","first-page":"723","DOI":"10.1161\/HYPERTENSIONAHA.119.13932","volume":"75","author":"SP Juraschek","year":"2020","unstructured":"Juraschek SP, Miller III ER, Chang AR, Anderson CAM, Hall JE, Appel LJ (2020) Effects of sodium reduction on energy, metabolism, weight, thirst, and urine volume: results from the DASH (Dietary Approaches to Stop Hypertension)-sodium trial. Hypertension 75(3):723\u2013729","journal-title":"Hypertension"},{"key":"5850_CR34","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/cc12503","volume":"17","author":"K Kashani","year":"2013","unstructured":"Kashani K, Al-Khafaji A, Ardiles T, Artigas A, Bagshaw SM, Bell M, Bihorac A, Birkhahn R, Cely CM, Chawla LS (2013) Discovery and validation of cell cycle arrest biomarkers in human acute kidney injury. Crit Care 17:1\u201312","journal-title":"Crit Care"},{"key":"5850_CR35","doi-asserted-by":"crossref","unstructured":"Katagiri A, N Fujii, K Dobashi, YF Lai, B Tsuji, Nishiyasu T (2023) Sodium Bicarbonate Reduces Ventilation without Altering Core Temperature Threshold or Sensitivity of Hyperthermia-Induced Hyperventilation in Exercising Humans. Am J Physiol-Regul Integr Comp Physiol 325(1):R69\u2013R80","DOI":"10.1152\/ajpregu.00282.2022"},{"key":"5850_CR36","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1146\/annurev-publhealth-032315-021740","volume":"37","author":"T Kjellstrom","year":"2016","unstructured":"Kjellstrom T, Briggs D, Freyberg C, Lemke B, Otto M, Hyatt O (2016) Heat, human performance, and occupational health: a key issue for the assessment of global climate change impacts. Annu Rev Public Health 37:97\u2013112","journal-title":"Annu Rev Public Health"},{"issue":"5","key":"5850_CR37","doi-asserted-by":"publisher","first-page":"1239","DOI":"10.1007\/s00421-022-04919-1","volume":"122","author":"Z Li","year":"2022","unstructured":"Li Z, McKenna Z, Fennel Z, Nava RC, Wells A, Ducharme J, Houck J, Morana K, Mermier C, Kuennen M (2022) The combined effects of exercise-induced muscle damage and heat stress on acute kidney stress and heat strain during subsequent endurance exercise. Eur J Appl Physiol 122(5):1239\u20131248","journal-title":"Eur J Appl Physiol"},{"issue":"5","key":"5850_CR38","first-page":"598","volume":"31","author":"Y Lin","year":"2019","unstructured":"Lin Y, Zhang Y, Jiacheng Wu (2019) Preventive oral rehydration salts iii could protect intestinal function in rats with exertional heatstroke. Zhonghua Wei Zhong Bing Ji Jiu Yi Xue 31(5):598\u2013602","journal-title":"Zhonghua Wei Zhong Bing Ji Jiu Yi Xue"},{"key":"5850_CR39","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/2046-7648-4-S1-A23","volume":"4","author":"RAI Lucas","year":"2015","unstructured":"Lucas RAI, Bodin T, Garc\u00eda-Trabanino R, Wesseling C, Glaser J, Weiss I, Jarquin E, Jakobsson K, Wegman DH (2015) Heat stress and workload associated with sugarcane cutting-an excessively strenuous occupation! Extreme Physiol Med 4:1\u20132","journal-title":"Extreme Physiol Med"},{"issue":"3","key":"5850_CR40","doi-asserted-by":"publisher","first-page":"F499","DOI":"10.1152\/ajprenal.00350.2023","volume":"326","author":"A Masoud","year":"2024","unstructured":"Masoud A, McKenna ZJ, Li Z, Deyhle MR, Mermier CM, Schlader ZJ, Amorim FT (2024) Strategies to mitigate acute kidney injury risk during physical work in the heat. Am J Physiol-Renal Physiol 326(3):F499-510","journal-title":"Am J Physiol-Renal Physiol"},{"issue":"3","key":"5850_CR41","doi-asserted-by":"publisher","first-page":"431","DOI":"10.1080\/10803548.2016.1251137","volume":"23","author":"A Mazlomi","year":"2017","unstructured":"Mazlomi A, Golbabaei F, Dehghan SF, Abbasinia M, Khani SM, Ansari M, Hosseini M (2017) The influence of occupational heat exposure on cognitive performance and blood level of stress hormones: a field study report. Int J Occup Saf Ergon 23(3):431\u2013439","journal-title":"Int J Occup Saf Ergon"},{"issue":"6","key":"5850_CR42","doi-asserted-by":"publisher","first-page":"1431","DOI":"10.1152\/japplphysiol.00555.2023","volume":"135","author":"ZJ McKenna","year":"2023","unstructured":"McKenna ZJ, Nava RC, Magalh\u00e3es C, Magalh\u00e3es F, de Castro C, Moreira M, Shibuya E, da Cunha I, Maia PA, Roscani RC, Rocha-Vieira E (2023) A comprehensive evaluation of heat stress and heat strain in a sample of sugarcane cutters in Brazil. J Appl Physiol 135(6):1431\u20131439","journal-title":"J Appl Physiol"},{"issue":"48","key":"5850_CR43","doi-asserted-by":"publisher","first-page":"31731","DOI":"10.1074\/jbc.273.48.31731","volume":"273","author":"KP Moore","year":"1998","unstructured":"Moore KP, Holt SG, Patel RP, Svistunenko DA, Zackert W, Goodier D, Reeder BJ, Clozel M, Anand R, Cooper CE (1998) A causative role for redox cycling of myoglobin and its inhibition by alkalinization in the pathogenesis and treatment of rhabdomyolysis-induced renal failure. J Biol Chem 273(48):31731\u201331737","journal-title":"J Biol Chem"},{"issue":"2","key":"5850_CR44","doi-asserted-by":"publisher","first-page":"667","DOI":"10.1172\/JCI112020","volume":"76","author":"KA Nath","year":"1985","unstructured":"Nath KA, Hostetter MK, Hostetter TH (1985) Pathophysiology of chronic tubulo-interstitial disease in Rats interactions of dietary acid load, ammonia, and complement component C3. J Clin Investig 76(2):667\u2013675","journal-title":"J Clin Investig"},{"issue":"7","key":"5850_CR45","doi-asserted-by":"publisher","first-page":"1975","DOI":"10.1519\/JSC.0b013e3182576f3d","volume":"26","author":"DJ Peart","year":"2012","unstructured":"Peart DJ, Siegler JC, Vince RV (2012) Practical recommendations for coaches and athletes: a meta-analysis of sodium bicarbonate use for athletic performance. J Strength Cond Res 26(7):1975\u20131983","journal-title":"J Strength Cond Res"},{"issue":"8","key":"5850_CR46","doi-asserted-by":"publisher","first-page":"1745","DOI":"10.1249\/MSS.0000000000001254","volume":"49","author":"ZJ Schlader","year":"2017","unstructured":"Schlader ZJ, Chapman CL, Sarker S, Russo L, Rideout TC, Parker MD, Johnson BD, Hostler D (2017) Firefighter work duration influences the extent of acute kidney injury. Med Sci Sports Exerc 49(8):1745\u20131753","journal-title":"Med Sci Sports Exerc"},{"issue":"2","key":"5850_CR47","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1681\/ASN.2006080882","volume":"18","author":"KM Schmidt-Ott","year":"2007","unstructured":"Schmidt-Ott KM, Mori K, Li JY, Kalandadze A, Cohen DJ, Devarajan P, Barasch J (2007) Dual action of neutrophil gelatinase-associated lipocalin. J Am Soc Nephrol 18(2):407\u2013413","journal-title":"J Am Soc Nephrol"},{"issue":"3","key":"5850_CR48","doi-asserted-by":"publisher","first-page":"556","DOI":"10.1111\/apha.12764","volume":"219","author":"EV Schrezenmeier","year":"2017","unstructured":"Schrezenmeier EV, Barasch J, Budde K, Westhoff T, Schmidt-Ott KM (2017) Biomarkers in acute kidney injury-pathophysiological basis and clinical performance. Acta Physiol 219(3):556\u2013574","journal-title":"Acta Physiol"},{"issue":"9","key":"5850_CR49","doi-asserted-by":"publisher","first-page":"2551","DOI":"10.1519\/JSC.0b013e3181aeb154","volume":"24","author":"JC Siegler","year":"2010","unstructured":"Siegler JC, Midgley AW, Polman RCJ, Lever R (2010) Effects of various sodium bicarbonate loading protocols on the time-dependent extracellular buffering profile. J Strength Cond Res 24(9):2551\u20132557","journal-title":"J Strength Cond Res"},{"key":"5850_CR50","first-page":"233","volume-title":"Techniques for Measuring Body Composition","author":"WE Siri","year":"1961","unstructured":"Siri WE (1961) Body Composition from Fluid and Density: Analysis of Methods. In: Brozek J, Herschel A (eds) Techniques for Measuring Body Composition. National Academy of Sciences, National Research Council, Washington, DC, pp 233\u2013244"},{"issue":"2","key":"5850_CR51","doi-asserted-by":"publisher","first-page":"481","DOI":"10.1113\/jphysiol.2005.086801","volume":"566","author":"D Street","year":"2005","unstructured":"Street D, Nielsen J-J, Bangsbo J, Juel C (2005) Metabolic alkalosis reduces exercise-induced acidosis and potassium accumulation in human skeletal muscle interstitium. J Physiol 566(2):481\u2013489","journal-title":"J Physiol"},{"issue":"1","key":"5850_CR52","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1186\/s12882-021-02385-z","volume":"22","author":"N Tangri","year":"2021","unstructured":"Tangri N, Reaven NL, Funk SE, Ferguson TW, Collister D, Mathur V (2021) Metabolic acidosis is associated with increased risk of adverse kidney outcomes and mortality in patients with non-dialysis dependent chronic kidney disease: an observational cohort study. BMC Nephrol 22(1):185","journal-title":"BMC Nephrol"},{"issue":"5","key":"5850_CR53","doi-asserted-by":"publisher","first-page":"486","DOI":"10.1038\/ki.2010.165","volume":"78","author":"SS Waikar","year":"2010","unstructured":"Waikar SS, Sabbisetti VS, Bonventre JV (2010) Normalization of urinary biomarkers to creatinine during changes in glomerular filtration rate. Kidney Int 78(5):486\u2013494","journal-title":"Kidney Int"},{"issue":"2","key":"5850_CR54","doi-asserted-by":"publisher","first-page":"e71","DOI":"10.1016\/j.jemermed.2023.04.012","volume":"65","author":"G Wardi","year":"2023","unstructured":"Wardi G, Holgren S, Gupta A, Sobel J, Birch A, Pearce A, Malhotra A, Tainter C (2023) A review of bicarbonate use in common clinical scenarios. J Emerg Med 65(2):e71-e80","journal-title":"J Emerg Med"},{"issue":"11","key":"5850_CR55","doi-asserted-by":"publisher","first-page":"1927","DOI":"10.2105\/AJPH.2013.301594","volume":"103","author":"C Wesseling","year":"2013","unstructured":"Wesseling C, Crowe J, Hogstedt C, Jakobsson K, Lucas R, Wegman DH (2013) The epidemic of chronic kidney disease of unknown etiology in mesoamerica: a call for interdisciplinary research and action. Am J Public Health 103(11):1927\u20131930","journal-title":"Am J Public Health"},{"issue":"12","key":"5850_CR56","doi-asserted-by":"publisher","first-page":"e011034","DOI":"10.1136\/bmjopen-2016-011034","volume":"6","author":"C Wesseling","year":"2016","unstructured":"Wesseling C, Arag\u00f3n A, Gonz\u00e1lez M, Weiss I, Glaser J, Rivard CJ, Roncal-Jim\u00e9nez C, Correa-Rotter R, Johnson RJ (2016) Heat stress, Hydration and uric acid: a cross-sectional study in workers of three occupations in a hotspot of mesoamerican nephropathy in nicaragua. BMJ Open 6(12):e011034","journal-title":"BMJ Open"},{"key":"5850_CR57","first-page":"132","volume":"77","author":"JA Wojtczak-Jaroszowa","year":"1986","unstructured":"Wojtczak-Jaroszowa JA, Jarosz D (1986) Health complaints sicknesses and accidents of workers employed in high environmental temperatures. Can J Publ Health= Revue Canadienne de Sante Publique 77:132\u201335","journal-title":"Can J Publ Health= Revue Canadienne de Sante Publique"},{"key":"5850_CR29","unstructured":"World Health Organization. (2016). International expert consultation on chronic kidney disease of unknown etiology (pp. 1\u201348). World Health Organization. Retrieved from   https:\/\/apps.who.int\/iris\/bitstream\/handle\/10665\/255137\/Reportexpertconsultationonckdu.pdf?sequence=1"},{"issue":"5\u20136","key":"5850_CR58","doi-asserted-by":"publisher","first-page":"442","DOI":"10.1016\/0013-9351(69)90015-2","volume":"2","author":"CH Wyndham","year":"1969","unstructured":"Wyndham CH (1969) Adaptation to heat and cold. Environ Res 2(5\u20136):442\u2013469","journal-title":"Environ Res"},{"issue":"5","key":"5850_CR59","doi-asserted-by":"publisher","first-page":"1645","DOI":"10.1519\/JSC.0b013e318181febe","volume":"22","author":"M Zabala","year":"2008","unstructured":"Zabala M, Requena B, S\u00e1nchez-Mu\u00f1oz C, Gonz\u00e1lez-Badillo JJ, Garc\u00eda I, \u00d6\u00f6pik V, P\u00e4\u00e4suke M (2008) Effects of sodium bicarbonate ingestion on performance and perceptual responses in a laboratory-simulated BMX cycling qualification series. J Strength Cond Res 22(5):1645\u20131653","journal-title":"J Strength Cond Res"}],"container-title":["European Journal of Applied Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00421-025-05850-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00421-025-05850-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00421-025-05850-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,4]],"date-time":"2025-12-04T17:02:24Z","timestamp":1764867744000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00421-025-05850-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,21]]},"references-count":59,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["5850"],"URL":"https:\/\/doi.org\/10.1007\/s00421-025-05850-x","relation":{},"ISSN":["1439-6319","1439-6327"],"issn-type":[{"value":"1439-6319","type":"print"},{"value":"1439-6327","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6,21]]},"assertion":[{"value":"3 December 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 June 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 June 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declaration"}},{"value":"The authors declare no conflicts of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest."}}]}}