{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T23:49:22Z","timestamp":1780789762067,"version":"3.54.1"},"reference-count":62,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,7,3]],"date-time":"2025-07-03T00:00:00Z","timestamp":1751500800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,7,3]],"date-time":"2025-07-03T00:00:00Z","timestamp":1751500800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"the Ministry of Education, Science, and Sport of the Republic of Lithuania","award":["No. S\u2011A\u2011UEI\u201123\u20132"],"award-info":[{"award-number":["No. S\u2011A\u2011UEI\u201123\u20132"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur J Appl Physiol"],"published-print":{"date-parts":[[2026,1]]},"DOI":"10.1007\/s00421-025-05861-8","type":"journal-article","created":{"date-parts":[[2025,7,3]],"date-time":"2025-07-03T08:06:50Z","timestamp":1751530010000},"page":"135-146","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Kinetics of cell-free DNA in response to exogenous and exertional heating in healthy young men"],"prefix":"10.1007","volume":"126","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6589-5843","authenticated-orcid":false,"given":"Ema","family":"Ju\u0161kevi\u010di\u016bt\u0117","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elmo W. I.","family":"Neuberger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nerijus","family":"Eimantas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katharina","family":"Hoeter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu\u2011Kai","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Perikles","family":"Simon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1369-7524","authenticated-orcid":false,"given":"Marius","family":"Brazaitis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,7,3]]},"reference":[{"key":"5861_CR1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0223470","author":"L Alghofaili","year":"2019","unstructured":"Alghofaili L, Almubarak H, Gassem K, Islam SS, Coskun S, Kaya N, Karakas B (2019) Cell-free DNA levels of twins and sibling pairs indicate individuality and possible use as a personalized biomarker. PLoS ONE. https:\/\/doi.org\/10.1371\/journal.pone.0223470","journal-title":"PLoS ONE"},{"issue":"2","key":"5861_CR2","doi-asserted-by":"publisher","first-page":"390","DOI":"10.1152\/japplphysiol.00780.2021","volume":"133","author":"SB Amin","year":"2022","unstructured":"Amin SB, Hansen AB, Mugele H, Simpson LL, Marume K, Moore JP, Cornwell WK, Lawley JS (2022) High-intensity exercise and passive hot water immersion cause similar postintervention changes in peripheral and cerebral shear. J Appl Physiol 133(2):390\u2013402. https:\/\/doi.org\/10.1152\/japplphysiol.00780.2021","journal-title":"J Appl Physiol"},{"issue":"7","key":"5861_CR3","doi-asserted-by":"publisher","first-page":"953","DOI":"10.1123\/ijspp.2017-0421","volume":"13","author":"MV Andreatta","year":"2018","unstructured":"Andreatta MV, Curty VM, Coutinho JVS, Santos M\u00c2A, Vassallo PF, de Sousa NF, Barauna VG (2018) Cell-free DNA as an earlier predictor of exercise-induced performance decrement related to muscle damage. Int J Sports Physiol Perform 13(7):953\u2013956. https:\/\/doi.org\/10.1123\/ijspp.2017-0421","journal-title":"Int J Sports Physiol Perform"},{"issue":"4","key":"5861_CR4","doi-asserted-by":"publisher","first-page":"695","DOI":"10.1007\/s00421-010-1532-5","volume":"110","author":"J Atamaniuk","year":"2010","unstructured":"Atamaniuk J, Vidotto C, Kinzlbauer M, Bachl N, Tiran B, Tschan H (2010) Cell-free plasma DNA and purine nucleotide degradation markers following weightlifting exercise. Eur J Appl Physiol 110(4):695\u2013701. https:\/\/doi.org\/10.1007\/s00421-010-1532-5","journal-title":"Eur J Appl Physiol"},{"issue":"2","key":"5861_CR5","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1007\/s11154-022-09758-1","volume":"24","author":"N Athanasiou","year":"2023","unstructured":"Athanasiou N, Bogdanis GC, Mastorakos G (2023) Endocrine responses of the stress system to different types of exercise. Rev Endocr Metab Disord 24(2):251\u2013266","journal-title":"Rev Endocr Metab Disord"},{"key":"5861_CR6","doi-asserted-by":"publisher","first-page":"625","DOI":"10.1007\/s40279-014-0296-1","volume":"45","author":"T Beiter","year":"2015","unstructured":"Beiter T, Fragasso A, Hartl D, Nie\u00df AM (2015) Neutrophil extracellular traps: a walk on the wild side of exercise immunology. Sports Med 45:625\u2013640","journal-title":"Sports Med"},{"issue":"48","key":"5861_CR7","doi-asserted-by":"publisher","first-page":"34943","DOI":"10.1074\/jbc.M113.486571","volume":"288","author":"S Belugin","year":"2013","unstructured":"Belugin S, Diogenes AR, Patil MJ, Ginsburg E, Henry MA, Akopian AN (2013) Mechanisms of transient signaling via short and long prolactin receptor isoforms in female and male sensory neurons. J Biol Chem 288(48):34943\u201334955. https:\/\/doi.org\/10.1074\/jbc.M113.486571","journal-title":"J Biol Chem"},{"issue":"4","key":"5861_CR8","doi-asserted-by":"publisher","first-page":"771","DOI":"10.1007\/s00421-010-1429-3","volume":"109","author":"M Brazaitis","year":"2010","unstructured":"Brazaitis M, Skurvydas A (2010) Heat acclimation does not reduce the impact of hyperthermia on central fatigue. Eur J Appl Physiol 109(4):771\u2013778. https:\/\/doi.org\/10.1007\/s00421-010-1429-3","journal-title":"Eur J Appl Physiol"},{"issue":"4","key":"5861_CR9","doi-asserted-by":"publisher","first-page":"325","DOI":"10.3109\/02656736.2015.1004135","volume":"31","author":"M Brazaitis","year":"2015","unstructured":"Brazaitis M, Eimantas N, Daniuseviciute L, Vitkauskiene A, Paulauskas H, Skurvydas A (2015) Two strategies for the acute response to cold exposure but one strategy for the response to heat stress. Int J Hyperth 31(4):325\u2013335. https:\/\/doi.org\/10.3109\/02656736.2015.1004135","journal-title":"Int J Hyperth"},{"issue":"1","key":"5861_CR10","doi-asserted-by":"publisher","first-page":"660","DOI":"10.1080\/02656736.2019.1627431","volume":"36","author":"M Brazaitis","year":"2019","unstructured":"Brazaitis M, Eimantas N, Baranauskiene N, Kilikeviciene S, Vitkauskiene A, Daniuseviciute L (2019) Effects of severe whole-body hyperthermia on ovarian hormone and extracellular Hsp72 responses in young adult women. Int J Hyperth 36(1):660\u2013665. https:\/\/doi.org\/10.1080\/02656736.2019.1627431","journal-title":"Int J Hyperth"},{"issue":"7","key":"5861_CR11","doi-asserted-by":"publisher","first-page":"565","DOI":"10.2165\/11631380-000000000-00000","volume":"42","author":"S Breitbach","year":"2012","unstructured":"Breitbach S, Tug S, Simon P (2012) Circulating cell-free DNA: An up-coming molecular marker in exercise physiology. Sports Med 42(7):565\u2013586. https:\/\/doi.org\/10.2165\/11631380-000000000-00000","journal-title":"Sports Med"},{"issue":"02","key":"5861_CR12","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1055\/s-2007-971895","volume":"19","author":"I Brenner","year":"1998","unstructured":"Brenner I, Shek PN, Zamecnik J, Shephard RJ (1998) Stress hormones and the immunological responses to heat and exercise. Int J Sports Med 19(02):130\u2013143","journal-title":"Int J Sports Med"},{"issue":"13","key":"5861_CR13","doi-asserted-by":"publisher","first-page":"2600","DOI":"10.1182\/blood-2012-02-409805","volume":"120","author":"ML Capitano","year":"2012","unstructured":"Capitano ML, Nemeth MJ, Mace TA, Salisbury-Ruf C, Segal BH, McCarthy PL, Repasky EA (2012) Elevating body temperature enhances hematopoiesis and neutrophil recovery after total body irradiation in an IL-1-, IL-17-, and G-CSF-dependent manner. Blood 120(13):2600\u20132609. https:\/\/doi.org\/10.1182\/blood-2012-02-409805","journal-title":"Blood"},{"issue":"5","key":"5861_CR14","doi-asserted-by":"publisher","first-page":"1731","DOI":"10.1152\/jappl.1998.84.5.1731","volume":"84","author":"SS Cheung","year":"1998","unstructured":"Cheung SS, McLellan TM (1998) Heat acclimation, aerobic fitness, and hydration effects on tolerance during uncompensable heat stress. J Appl Physiol 84(5):1731\u20131739","journal-title":"J Appl Physiol"},{"issue":"1","key":"5861_CR15","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1002\/cphy.c140015","volume":"5","author":"CG Crandall","year":"2015","unstructured":"Crandall CG, Wilson TE (2015) Human cardiovascular responses to passive heat stress. Compr Physiol 5(1):17\u201343. https:\/\/doi.org\/10.1002\/cphy.c140015","journal-title":"Compr Physiol"},{"issue":"10","key":"5861_CR16","doi-asserted-by":"publisher","first-page":"165823","DOI":"10.1016\/j.bbadis.2020.165823","volume":"1866","author":"D da Luz Scheffer","year":"2020","unstructured":"da Luz Scheffer D, Latini A (2020) Exercise-induced immune system response: anti-inflammatory status on peripheral and central organs. Biochim Biophys Acta 1866(10):165823","journal-title":"Biochim Biophys Acta"},{"issue":"3","key":"5861_CR17","first-page":"292","volume":"21","author":"K Dorshkind","year":"2000","unstructured":"Dorshkind K, Horseman ND (2000) The roles of prolactin, growth hormone, insulin-like growth factor-I, and thyroid hormones in lymphocyte development and function: insights from genetic models of hormone and hormone receptor deficiency. Endocr Rev 21(3):292\u2013312","journal-title":"Endocr Rev"},{"issue":"1","key":"5861_CR18","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1152\/physiolgenomics.00086.2020","volume":"53","author":"MH Drag","year":"2021","unstructured":"Drag MH, Kilpel\u00e4inen TO (2021) Cell-free DNA and RNA\u2014measurement and applications in clinical diagnostics with focus on metabolic disorders. Physiol Genomics 53(1):33\u201346","journal-title":"Physiol Genomics"},{"issue":"3","key":"5861_CR19","doi-asserted-by":"publisher","first-page":"292","DOI":"10.1080\/23328940.2017.1288688","volume":"4","author":"SH Faulkner","year":"2017","unstructured":"Faulkner SH, Jackson S, Fatania G, Leicht CA (2017) The effect of passive heating on heat shock protein 70 and interleukin-6: a possible treatment tool for metabolic diseases? Temperature 4(3):292\u2013304. https:\/\/doi.org\/10.1080\/23328940.2017.1288688","journal-title":"Temperature"},{"key":"5861_CR20","doi-asserted-by":"publisher","DOI":"10.1016\/j.xcrm.2023.101074","author":"O Fridlich","year":"2023","unstructured":"Fridlich O, Peretz A, Fox-Fisher I, Pyanzin S, Dadon Z, Shcolnik E, Sadeh R, Fialkoff G, Sharkia I, Moss J, Arpinati L, Nice S, Nogiec CD, Ahuno ST, Li R, Taborda E, Dunkelbarger S, Fridlender ZG, Polak P, Dor Y (2023) Elevated cfDNA after exercise is derived primarily from mature polymorphonuclear neutrophils, with a minor contribution of cardiomyocytes. Cell Rep Med. https:\/\/doi.org\/10.1016\/j.xcrm.2023.101074","journal-title":"Cell Rep Med"},{"issue":"2","key":"5861_CR21","doi-asserted-by":"publisher","first-page":"603","DOI":"10.1111\/j.1469-7793.2000.00603.x","volume":"524","author":"J Gonz\u00e1lez-Alonso","year":"2000","unstructured":"Gonz\u00e1lez-Alonso J, Quistorff B, Krustrup P, Bangsbo J, Saltin B (2000) Heat production in human skeletal muscle at the onset of intense dynamic exercise. J Physiol 524(2):603\u2013615","journal-title":"J Physiol"},{"issue":"1","key":"5861_CR22","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1016\/j.immuni.2019.06.025","volume":"51","author":"FR Greten","year":"2019","unstructured":"Greten FR, Grivennikov SI (2019) Inflammation and cancer: triggers, mechanisms, and consequences. Immunity 51(1):27\u201341","journal-title":"Immunity"},{"key":"5861_CR23","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1016\/j.coemr.2019.06.012","volume":"9","author":"AC Hackney","year":"2019","unstructured":"Hackney AC, Saeidi A (2019) The thyroid axis, prolactin, and exercise in humans. Curr Opin Endocr Metab Res 9:45\u201350","journal-title":"Curr Opin Endocr Metab Res"},{"key":"5861_CR24","doi-asserted-by":"publisher","DOI":"10.7717\/peerj.16072","author":"K Hoeter","year":"2023","unstructured":"Hoeter K, Neuberger E, Fischer S, Herbst M, Ju\u0161kevi\u010di\u016bt\u0117 E, Enders K, Rossmann H, Sprinzl MF, Simon P, Bodenstein M, Schaefer M (2023) Evidence for the utility of cfDNA plasma concentrations to predict disease severity in COVID-19: a retrospective pilot study. PeerJ. https:\/\/doi.org\/10.7717\/peerj.16072","journal-title":"PeerJ"},{"key":"5861_CR25","doi-asserted-by":"publisher","DOI":"10.1038\/s41398-018-0264-x","author":"EM Hummel","year":"2018","unstructured":"Hummel EM, Hessas E, M\u00fcller S, Beiter T, Fisch M, Eibl A, Wolf OT, Giebel B, Platen P, Kumsta R, Moser DA (2018) Cell-free DNA release under psychosocial and physical stress conditions. Transl Psychiatry. https:\/\/doi.org\/10.1038\/s41398-018-0264-x","journal-title":"Transl Psychiatry"},{"issue":"2","key":"5861_CR26","doi-asserted-by":"publisher","first-page":"184","DOI":"10.4085\/1062-6050-47.2.184","volume":"47","author":"M Iguchi","year":"2012","unstructured":"Iguchi M, Littmann AE, Chang SH, Wester LA, Knipper JS, Shields RK (2012) Heat stress and cardiovascular, hormonal, and heat shock proteins in humans. J Athl Train 47(2):184\u2013190","journal-title":"J Athl Train"},{"issue":"4","key":"5861_CR27","doi-asserted-by":"publisher","first-page":"1297","DOI":"10.1007\/s00421-023-05366-2","volume":"124","author":"E Ju\u0161kevi\u010di\u016bt\u0117","year":"2023","unstructured":"Ju\u0161kevi\u010di\u016bt\u0117 E, Neuberger E, Eimantas N, Venckunas T, Kamandulis S, Simon P, Brazaitis M (2023) Three-week sprint interval training (SIT) reduces cell-free DNA and low-frequency fatigue but does not induce VO2max improvement in older men. Eur J Appl Physiol 124(4):1297\u20131309. https:\/\/doi.org\/10.1007\/s00421-023-05366-2","journal-title":"Eur J Appl Physiol"},{"key":"5861_CR28","doi-asserted-by":"publisher","DOI":"10.1113\/EP091986","author":"E Ju\u0161kevi\u010di\u016bt\u0117","year":"2024","unstructured":"Ju\u0161kevi\u010di\u016bt\u0117 E, Neuberger E, Eimantas N, Heinkel K, Simon P, Brazaitis M (2024) Cell-free DNA kinetics in response to muscle-damaging exercise: a drop jump study. Exp Physiol. https:\/\/doi.org\/10.1113\/EP091986","journal-title":"Exp Physiol"},{"issue":"5","key":"5861_CR29","doi-asserted-by":"publisher","first-page":"1543","DOI":"10.1152\/japplphysiol.00253.2021","volume":"131","author":"BW Kaiser","year":"2021","unstructured":"Kaiser BW, Kruse KK, Gibson BM, Santisteban KJ, Larson EA, Wilkins BW, Jones AM, Halliwill JR, Minson CT (2021) The impact of elevated body core temperature on critical power as determined by a 3-min all-out test. J Appl Physiol 131(5):1543\u20131551. https:\/\/doi.org\/10.1152\/japplphysiol.00253.2021","journal-title":"J Appl Physiol"},{"issue":"6","key":"5861_CR30","doi-asserted-by":"publisher","first-page":"677","DOI":"10.1123\/ijspp.8.6.677","volume":"8","author":"LP Kilduff","year":"2013","unstructured":"Kilduff LP, Finn CV, Baker JS, Cook CJ, West DJ (2013) Preconditioning strategies to enhance physical performance on the day of competition. Int J Sports Physiol Perform 8(6):677\u2013681","journal-title":"Int J Sports Physiol Perform"},{"key":"5861_CR31","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1002\/wsbm.032","volume":"1","author":"SD Kobayashi","year":"2009","unstructured":"Kobayashi SD, Deleo FR (2009) Role of neutrophils in innate immunity: a systems biology-level approach. Inc Wires Syst Biol Med 1:309\u2013333. https:\/\/doi.org\/10.1002\/wsbm.032","journal-title":"Inc Wires Syst Biol Med"},{"issue":"4","key":"5861_CR33","doi-asserted-by":"publisher","first-page":"419","DOI":"10.1080\/10253890.2016.1203415","volume":"19","author":"O Krizanova","year":"2016","unstructured":"Krizanova O, Babula P, Pacak K (2016) Stress, catecholaminergic system and cancer. Stress 19(4):419\u2013428","journal-title":"Stress"},{"issue":"2\u20133","key":"5861_CR34","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1080\/10715762.2020.1726343","volume":"54","author":"J Kruk","year":"2020","unstructured":"Kruk J, Kotarska K, Aboul-Enein BH (2020) Physical exercise and catecholamines response: benefits and health risk: possible mechanisms. Free Radical Res 54(2\u20133):105\u2013125","journal-title":"Free Radical Res"},{"issue":"6","key":"5861_CR35","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1016\/j.mpaic.2014.03.013","volume":"15","author":"J Kuht","year":"2014","unstructured":"Kuht J, Farmery AD (2014) Body temperature and its regulation. Anaesth Intensive Care Med 15(6):273\u2013278","journal-title":"Anaesth Intensive Care Med"},{"key":"5861_CR36","doi-asserted-by":"publisher","first-page":"483","DOI":"10.3389\/fmolb.2022.895814","volume":"9","author":"Y Liu","year":"2022","unstructured":"Liu Y, Lyu Y, Wang H (2022) TRP channels as molecular targets to relieve endocrine-related diseases. Front Mol Biosci 9:483\u2013516","journal-title":"Front Mol Biosci"},{"issue":"6","key":"5861_CR37","doi-asserted-by":"publisher","first-page":"909","DOI":"10.1113\/expphysiol.2005.031294","volume":"90","author":"D Low","year":"2005","unstructured":"Low D, Purvis A, Reilly T, Cable NT (2005) The prolactin responses to active and passive heating in man. Exp Physiol 90(6):909\u2013917. https:\/\/doi.org\/10.1113\/expphysiol.2005.031294","journal-title":"Exp Physiol"},{"key":"5861_CR38","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1016\/j.ijpsycho.2021.10.005","volume":"170","author":"T McMorris","year":"2021","unstructured":"McMorris T (2021) The acute exercise-cognition interaction: from the catecholamines hypothesis to an interoception model. Int J Psychophysiol 170:75\u201388","journal-title":"Int J Psychophysiol"},{"issue":"2","key":"5861_CR39","doi-asserted-by":"publisher","first-page":"514","DOI":"10.1093\/infdis\/jiae252","volume":"230","author":"A Meier","year":"2024","unstructured":"Meier A, Sakoulas G, Nizet V, Ulloa ER (2024) Neutrophil extracellular traps: an emerging therapeutic target to improve infectious disease outcomes. J Infect Dis 230(2):514\u2013521. https:\/\/doi.org\/10.1093\/infdis\/jiae252","journal-title":"J Infect Dis"},{"issue":"6","key":"5861_CR40","doi-asserted-by":"publisher","first-page":"651","DOI":"10.1111\/j.1365-2265.1989.tb00271.x","volume":"30","author":"N M\u00f8ller","year":"1989","unstructured":"M\u00f8ller N, Beckwith R, Butler PC, Christensen NJ, \u00d8rskov H, Alberti KGMM (1989) Metabolic and hormonal responses to exogenous hyperthermia in man. Clin Endocrinol 30(6):651\u2013660","journal-title":"Clin Endocrinol"},{"key":"5861_CR41","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-07466-6","author":"J Moss","year":"2018","unstructured":"Moss J, Magenheim J, Neiman D, Zemmour H, Loyfer N, Korach A, Samet Y, Maoz M, Druid H, Arner P, Fu KY, Kiss E, Spalding KL, Landesberg G, Zick A, Grinshpun A, Shapiro AMJ, Grompe M, Wittenberg AD, Dor Y (2018) Comprehensive human cell-type methylation atlas reveals origins of circulating cell-free DNA in health and disease. Nat Commun. https:\/\/doi.org\/10.1038\/s41467-018-07466-6","journal-title":"Nat Commun"},{"issue":"4","key":"5861_CR42","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1515\/labmed-2022-0027","volume":"46","author":"EW Neuberger","year":"2022","unstructured":"Neuberger EW, Simon P (2022) Cell-free DNA in sports medicine: implications for clinical laboratory medicine. J Lab Med 46(4):295\u2013300","journal-title":"J Lab Med"},{"key":"5861_CR43","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-92826-4","author":"EWI Neuberger","year":"2021","unstructured":"Neuberger EWI, Brahmer A, Ehlert T, Kluge K, Philippi KFA, Boedecker SC, Weinmann-Menke J, Simon P (2021) Validating quantitative PCR assays for cfDNA detection without DNA extraction in exercising SLE patients. Sci Rep. https:\/\/doi.org\/10.1038\/s41598-021-92826-4","journal-title":"Sci Rep"},{"key":"5861_CR44","doi-asserted-by":"publisher","DOI":"10.3390\/genes12040522","author":"EWI Neuberger","year":"2021","unstructured":"Neuberger EWI, Hillen B, Mayr K, Simon P, Kr\u00e4mer-Albers EM, Brahmer A (2021) Kinetics and topology of dna associated with circulating extracellular vesicles released during exercise. Genes. https:\/\/doi.org\/10.3390\/genes12040522","journal-title":"Genes"},{"key":"5861_CR46","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2018.00135","volume":"5","author":"MA Nystoriak","year":"2018","unstructured":"Nystoriak MA, Bhatnagar A (2018) Cardiovascular effects and benefits of exercise. Front Cardiovasc Med 5:408204","journal-title":"Front Cardiovasc Med"},{"key":"5861_CR47","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1007\/978-4-431-55720-3_17","volume-title":"Musculoskeletal disease associated with diabetes mellitus","author":"K Okazaki","year":"2016","unstructured":"Okazaki K (2016) Body temperature regulation during exercise training. Musculoskeletal disease associated with diabetes mellitus. Springer, Japan, pp 253\u2013268"},{"issue":"5","key":"5861_CR48","doi-asserted-by":"publisher","first-page":"715","DOI":"10.1038\/s41416-019-0716-y","volume":"122","author":"A Otandault","year":"2020","unstructured":"Otandault A, Abraham JD, Al Amir Dache Z, Khalyfa A, Jariel-Encontre I, Forn\u00e9 T, Pr\u00e9vostel C, Chouaib S, Gozal D, Thierry AR (2020) Hypoxia differently modulates the release of mitochondrial and nuclear DNA. British J Cancer 122(5):715\u2013725. https:\/\/doi.org\/10.1038\/s41416-019-0716-y","journal-title":"British J Cancer"},{"issue":"2","key":"5861_CR49","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1038\/nri.2017.105","volume":"18","author":"V Papayannopoulos","year":"2018","unstructured":"Papayannopoulos V (2018) Neutrophil extracellular traps in immunity and disease. Nat Rev Immunol 18(2):134\u2013147. https:\/\/doi.org\/10.1038\/nri.2017.105","journal-title":"Nat Rev Immunol"},{"issue":"2","key":"5861_CR50","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1177\/107327481702400212","volume":"24","author":"Y Pasikhova","year":"2017","unstructured":"Pasikhova Y, Ludlow S, Baluch A (2017) Fever in patients with cancer. Cancer Control 24(2):193\u2013197. https:\/\/doi.org\/10.1177\/107327481702400212","journal-title":"Cancer Control"},{"issue":"6","key":"5861_CR51","doi-asserted-by":"publisher","first-page":"435","DOI":"10.1249\/00005768-198206000-00005","volume":"14","author":"SK Powers","year":"1982","unstructured":"Powers SK, Howley ET, Cox RONALD (1982) A differential catecholamine response during prolonged exercise and passive heating. Med Sci Sports Exerc 14(6):435\u2013439","journal-title":"Med Sci Sports Exerc"},{"issue":"3","key":"5861_CR52","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1080\/23328940.2017.1356427","volume":"4","author":"S Racinais","year":"2017","unstructured":"Racinais S, Cocking S, P\u00e9riard JD (2017) Sports and environmental temperature: from warming-up to heating-up. Temperature 4(3):227\u2013257","journal-title":"Temperature"},{"key":"5861_CR53","doi-asserted-by":"publisher","DOI":"10.1002\/wsbm.1458","author":"V Rungelrath","year":"2020","unstructured":"Rungelrath V, Kobayashi SD, DeLeo FR (2020) Neutrophils in innate immunity and systems biology-level approaches. Wiley Interdiscip Rev Syst Biol Med. https:\/\/doi.org\/10.1002\/wsbm.1458","journal-title":"Wiley Interdiscip Rev Syst Biol Med"},{"issue":"3","key":"5861_CR54","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1080\/0265673021000054621","volume":"19","author":"HS Sharma","year":"2003","unstructured":"Sharma HS, Hoopes PJ (2003) Hyperthermia induced pathophysiology of the central nervous system. Int J Hyperth 19(3):325\u2013354. https:\/\/doi.org\/10.1080\/0265673021000054621","journal-title":"Int J Hyperth"},{"key":"5861_CR55","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/j.neuroscience.2016.04.028","volume":"328","author":"JN Silva","year":"2016","unstructured":"Silva JN, Lucena EV, Silva TM, Damasceno RS, Takakura AC, Moreira TS (2016) Inhibition of the pontine K\u00f6lliker-Fuse nucleus reduces genioglossal activity elicited by stimulation of the retrotrapezoid chemoreceptor neurons. Neuroscience 328:9\u201321. https:\/\/doi.org\/10.1016\/j.neuroscience.2016.04.028","journal-title":"Neuroscience"},{"issue":"4","key":"5861_CR56","doi-asserted-by":"publisher","first-page":"1109","DOI":"10.1007\/s00421-023-05336-8","volume":"124","author":"Y Su","year":"2024","unstructured":"Su Y, Hoekstra SP, Leicht CA (2024) Hot water immersion is associated with higher thermal comfort than dry passive heating for a similar rise in rectal temperature and plasma interleukin-6 concentration. Eur J Appl Physiol 124(4):1109\u20131119. https:\/\/doi.org\/10.1007\/s00421-023-05336-8","journal-title":"Eur J Appl Physiol"},{"key":"5861_CR57","doi-asserted-by":"publisher","DOI":"10.3390\/antiox9050401","author":"K Suzuki","year":"2020","unstructured":"Suzuki K, Tominaga T, Ruhee RT, Ma S (2020) Characterization and modulation of systemic inflammatory response to exhaustive exercise in relation to oxidative stress. Antioxidants. https:\/\/doi.org\/10.3390\/antiox9050401","journal-title":"Antioxidants"},{"key":"5861_CR58","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0024385","author":"GD Syu","year":"2011","unstructured":"Syu GD, Chen HI, Jen CJ (2011) Severe exercise and exercise training exert opposite effects on human neutrophil apoptosis via altering the redox status. PLoS ONE. https:\/\/doi.org\/10.1371\/journal.pone.0024385","journal-title":"PLoS ONE"},{"key":"5861_CR59","first-page":"89","volume-title":"Diabetes and its complications","author":"R Takeda","year":"2018","unstructured":"Takeda R, Okazaki K (2018) Body temperature regulation during exercise and hyperthermia in diabetics. In: Ahmed RG (ed) Diabetes and its complications. InTech, Houston, p 89"},{"key":"5861_CR60","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtherbio.2021.103029","volume":"100","author":"Y Uchida","year":"2021","unstructured":"Uchida Y, Izumizaki M (2021) Effect of menstrual cycle and female hormones on TRP and TREK channels in modifying thermosensitivity and physiological functions in women. J Therm Biol 100:103029","journal-title":"J Therm Biol"},{"key":"5861_CR61","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1007\/978-1-4939-8973-7_14","volume":"1909","author":"LN Vittori","year":"2019","unstructured":"Vittori LN, Tarozzi A, Latessa PM (2019) Circulating cell-free DNA in physical activities. Methods Mol Biol 1909:183\u2013197. https:\/\/doi.org\/10.1007\/978-1-4939-8973-7_14","journal-title":"Methods Mol Biol"},{"key":"5861_CR62","doi-asserted-by":"publisher","DOI":"10.3390\/medicina59091665","author":"J Wang","year":"2023","unstructured":"Wang J, Solianik R, Eimantas N, Baranauskiene N, Brazaitis M (2023) Age-related difference in cognitive performance under severe whole-body hyperthermia parallels cortisol and physical strain responses. Medicina (Lithuania). https:\/\/doi.org\/10.3390\/medicina59091665","journal-title":"Medicina (Lithuania)"},{"issue":"4","key":"5861_CR63","doi-asserted-by":"publisher","first-page":"1251","DOI":"10.1152\/japplphysiol.00484.2007","volume":"103","author":"M Whitham","year":"2007","unstructured":"Whitham M, Laing SJ, Jackson A, Maassen N, Walsh NP (2007) Effect of exercise with and without a thermal clamp on the plasma heat shock protein 72 response. J Appl Physiol 103(4):1251\u20131256","journal-title":"J Appl Physiol"},{"key":"5861_CR64","doi-asserted-by":"publisher","first-page":"401","DOI":"10.2165\/00007256-200838050-00004","volume":"38","author":"H Zouhal","year":"2008","unstructured":"Zouhal H, Jacob C, Delamarche P, Gratas-Delamarche A (2008) Catecholamines and the effects of exercise, training and gender. Sports Med 38:401\u2013423","journal-title":"Sports Med"}],"container-title":["European Journal of Applied Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00421-025-05861-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00421-025-05861-8","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00421-025-05861-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T12:42:00Z","timestamp":1770381720000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00421-025-05861-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,3]]},"references-count":62,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["5861"],"URL":"https:\/\/doi.org\/10.1007\/s00421-025-05861-8","relation":{},"ISSN":["1439-6319","1439-6327"],"issn-type":[{"value":"1439-6319","type":"print"},{"value":"1439-6327","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7,3]]},"assertion":[{"value":"14 March 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 June 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 July 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors have no relevant financial or non-financial interests to disclose.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}