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This is concerning, because ultramarathon participation is growing, but previous work on cardiovascular health among ultramarathon runners is equivocal. Prior work has not examined this population\u2019s age-related differences in prognostic cardiovascular health metrics.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>Measure brachial and central BP and arterial stiffness (carotid-to-femoral pulse wave velocity [cfPWV]) among ultramarathon runners.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We measured supine BP and cfPWV (SphygmoCor-XCEL) among 71 athletes (16 female\/55 male; body mass index: 22.6\u2009\u00b1\u20091.8\u00a0kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      ) 1\u20133 days before they competed in the 161-km Western States Endurance Run. We present data as mean\u2009\u00b1\u2009SD. We analyzed the relation between age and central BP, brachial BP, and cfPWV with nonlinear (quadratic) regression.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      There was a significant curvilinear relation between age (46\u2009\u00b1\u200910; range 26\u201369\u00a0years) and central (116\u2009\u00b1\u20098\u00a0mmHg, R\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u20090.18,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.02) but not brachial (129\u2009\u00b1\u20099\u00a0mmHg, R\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u20090.06,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.11) systolic BP. There was a significant relation between age and central (79\u2009\u00b1\u20097\u00a0mmHg,\n                      <jats:italic>R<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u20090.24,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001) and brachial (78\u2009\u00b1\u20097\u00a0mmHg,\n                      <jats:italic>R<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u20090.23,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001) diastolic BP. There was a significant (R\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u20090.31,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.02) curvilinear relation between age and cfPWV (6.5\u2009\u00b1\u20091.0m\/s). Average brachial systolic BP differed by +\u00a01.4\u00a0mmHg\/decade, and 86% of athletes had a cfPWV below age-predicted (mean difference: \u2212\u00a00.9\u2009\u00b1\u20091.0\u00a0m\/s).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>These are among the first data to characterize central BP and arterial stiffness across a wide age range of ultramarathon runners. Further work is needed to determine the longitudinal changes associated with training for and competing in ultramarathons.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00421-025-05924-w","type":"journal-article","created":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T18:50:58Z","timestamp":1753901458000},"page":"529-539","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Central blood pressure and arterial stiffness among ultramarathon runners across the lifespan"],"prefix":"10.1007","volume":"126","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-8573-5955","authenticated-orcid":false,"given":"Joseph D.","family":"Vondrasek","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1097-9980","authenticated-orcid":false,"given":"Soolim","family":"Jeong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3413-1773","authenticated-orcid":false,"given":"Omar B.","family":"El-Kurd","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6825-5622","authenticated-orcid":false,"given":"Braxton A.","family":"Linder","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8213-638X","authenticated-orcid":false,"given":"Nina L.","family":"Stute","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3062-5584","authenticated-orcid":false,"given":"Christin","family":"Domeier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-9660-043X","authenticated-orcid":false,"given":"Thomas G.","family":"Bissen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2709-548X","authenticated-orcid":false,"given":"James R.","family":"Bagley","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8250-3952","authenticated-orcid":false,"given":"Austin T.","family":"Robinson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8047-4411","authenticated-orcid":false,"given":"Matthew C.","family":"Babcock","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8929-4903","authenticated-orcid":false,"given":"Gregory J.","family":"Grosicki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7840-0643","authenticated-orcid":false,"given":"Joseph C.","family":"Watso","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,7,30]]},"reference":[{"key":"5924_CR1","doi-asserted-by":"publisher","DOI":"10.1161\/jaha.117.005974","author":"S Ahmadi-Abhari","year":"2017","unstructured":"Ahmadi-Abhari S, Sabia S, Shipley MJ, Kivim\u00e4ki M, Singh-Manoux A, Tabak A, McEniery C, Wilkinson IB, Brunner EJ (2017) Physical activity, sedentary behaviour, and long-term changes in aortic stiffness: the whitehall II study. 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