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Changes in oxyhemoglobin (O\n                      <jats:sub>2<\/jats:sub>\n                      Hb), deoxyhemoglobin (HHb), total hemoglobin (tHB), and tissue saturation index (TSI%) using near-infrared spectroscopy were assessed in the vastus lateralis (leg) and biceps brachii (arm) muscles as well as the brain prefrontal cortex. Vastus lateralis blood flow (Q\u0307\n                      <jats:sub>VL<\/jats:sub>\n                      ) was calculated from whole-body oxygen consumption (V\u0307O\n                      <jats:sub>2<\/jats:sub>\n                      ) and HHb values. We analyzed between-group differences at absolute workloads and relative to V\u0307O\n                      <jats:sub>2peak<\/jats:sub>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      No significant between-group differences emerged in leg or arm oxygenation. Q\u0307\n                      <jats:sub>VL<\/jats:sub>\n                      was lower in FM at 50% (0.066 [0.022] vs. 0.080 [0.028] a.u.), 75% (0.082 [0.020] vs. 0.106 [0.039] a.u.), and 100% (0.091 [0.036] vs. 0.111 [0.041] a.u.) of V\u0307O\n                      <jats:sub>2peak<\/jats:sub>\n                      , but similar at submaximal absolute workloads. Cerebral HHb values were higher in FM at 75 (1.09 [2.23] vs. \u22120.18 [1.38] \u03bcM) and 100 W (2.20 [2.96] vs. 0.06 [1.92] \u03bcM) but not at relative workloads. Cerebral TSI%, O\n                      <jats:sub>2<\/jats:sub>\n                      Hb and tHb were not significantly different between groups.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      Leg oxygenation or peak exercise cerebral deoxygenation in FM do not differ from controls. Q\u0307\n                      <jats:sub>VL<\/jats:sub>\n                      was lower at peak exercise in FM. These results present evidence that exercise intolerance in FM may rely on other mechanisms than muscle oxygenation.\n                    <\/jats:p>\n                    <jats:p>\n                      <jats:italic>Trial registration<\/jats:italic>\n                      ClinicalTrials.gov, NCT03300635. Registered 3 October 2017\u2014retrospectively registered.\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"https:\/\/clinicaltrials.gov\/ct2\/show\/NCT03300635\" ext-link-type=\"uri\">https:\/\/clinicaltrials.gov\/ct2\/show\/NCT03300635<\/jats:ext-link>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00421-025-06013-8","type":"journal-article","created":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T13:26:39Z","timestamp":1760016399000},"page":"1723-1735","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Muscle and cerebral oxygenation during exercise in fibromyalgia: a near-infrared spectroscopy study"],"prefix":"10.1007","volume":"126","clinical-trial-number":[{"clinical-trial-number":"nct03300635","registry":"10.18810\/clinical-trials-gov"}],"author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4428-1401","authenticated-orcid":false,"given":"Taneli","family":"Lehto","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8314-1439","authenticated-orcid":false,"given":"Teemu","family":"Zetterman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9051-0949","authenticated-orcid":false,"given":"Dominique","family":"Gagnon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-8191-5880","authenticated-orcid":false,"given":"Ritva","family":"Markkula","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7023-2235","authenticated-orcid":false,"given":"Jari","family":"Arokoski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4899-605X","authenticated-orcid":false,"given":"Eija","family":"Kalso","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4733-8784","authenticated-orcid":false,"given":"Juha E.","family":"Peltonen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,10,9]]},"reference":[{"key":"6013_CR1","doi-asserted-by":"publisher","first-page":"1360","DOI":"10.1152\/japplphysiol.00166.2018","volume":"126","author":"TJ Barstow","year":"2019","unstructured":"Barstow TJ (2019) Understanding near infrared spectroscopy and its application to skeletal muscle research. 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