{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T00:06:25Z","timestamp":1792713985885,"version":"4.5.0"},"reference-count":42,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2025,12,19]],"date-time":"2025-12-19T00:00:00Z","timestamp":1766102400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,12,19]],"date-time":"2025-12-19T00:00:00Z","timestamp":1766102400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100003787","name":"Natural Science Foundation of Hebei Province","doi-asserted-by":"publisher","award":["No. C2024205024"],"award-info":[{"award-number":["No. C2024205024"]}],"id":[{"id":"10.13039\/501100003787","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003481","name":"Hebei Normal University","doi-asserted-by":"publisher","award":["No. XCXZZBC 202553"],"award-info":[{"award-number":["No. XCXZZBC 202553"]}],"id":[{"id":"10.13039\/501100003481","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur J Appl Physiol"],"published-print":{"date-parts":[[2026,5]]},"DOI":"10.1007\/s00421-025-06097-2","type":"journal-article","created":{"date-parts":[[2025,12,19]],"date-time":"2025-12-19T05:23:28Z","timestamp":1766121808000},"page":"2813-2831","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Exogenous lactate infusion enhanced VMH neuroplasticity and visceral fat reduction via PGC-1\u03b1-ER\u03b1 pathway in female rats"],"prefix":"10.1007","volume":"126","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-9775-0214","authenticated-orcid":false,"given":"Shuai","family":"Tian","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaomin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinchan","family":"Du","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2113-7490","authenticated-orcid":false,"given":"Yang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,12,19]]},"reference":[{"issue":"2","key":"6097_CR1","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1002\/j.2040-4603.2019.tb00071.x","volume":"9","author":"GB Bernasochi","year":"2019","unstructured":"Bernasochi GB, Bell JR, Simpson ER, Delbridge L, Boon WC (2019) Impact of estrogens on the regulation of white, beige, and brown adipose tissue depots. Compr Physiol 9(2):457\u2013475","journal-title":"Compr Physiol"},{"issue":"5","key":"6097_CR2","doi-asserted-by":"publisher","first-page":"1229","DOI":"10.1113\/JP280955","volume":"600","author":"GA Brooks","year":"2022","unstructured":"Brooks GA, Arevalo JA, Osmond AD, Leija RG, Curl CC, Tovar AP (2022) Lactate in contemporary biology: a phoenix risen. J Physiol 600(5):1229\u20131251","journal-title":"J Physiol"},{"issue":"3","key":"6097_CR3","doi-asserted-by":"publisher","first-page":"529","DOI":"10.1152\/japplphysiol.00497.2022","volume":"134","author":"GA Brooks","year":"2023","unstructured":"Brooks GA, Osmond AD, Arevalo JA et al (2023) Lactate as a myokine and exerkine: drivers and signals of physiology and metabolism. J Appl Physiol (1985) 134(3):529\u2013548","journal-title":"J Appl Physiol (1985)"},{"key":"6097_CR4","doi-asserted-by":"publisher","DOI":"10.3389\/fnut.2022.800901","volume":"9","author":"M Cai","year":"2022","unstructured":"Cai M, Wang H, Song H et al (2022) Lactate is answerable for brain function and treating brain diseases: energy substrates and signal molecule. Front Nutr 9:800901","journal-title":"Front Nutr"},{"issue":"20","key":"6097_CR5","doi-asserted-by":"publisher","first-page":"4659","DOI":"10.1016\/j.cub.2021.08.016","volume":"31","author":"V Careau","year":"2021","unstructured":"Careau V, Halsey LG, Pontzer H et al (2021) Energy compensation and adiposity in humans. Curr Biol 31(20):4659-4666.e2","journal-title":"Curr Biol"},{"key":"6097_CR6","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2023.106207","volume":"184","author":"B Cauli","year":"2023","unstructured":"Cauli B, Dusart I, Li D (2023) Lactate as a determinant of neuronal excitability, neuroenergetics and beyond. Neurobiol Dis 184:106207","journal-title":"Neurobiol Dis"},{"key":"6097_CR7","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2022.839005","volume":"13","author":"P Chen","year":"2022","unstructured":"Chen P, Li B, Ou-Yang L (2022) Role of estrogen receptors in health and disease. Front Endocrinol (Lausanne) 13:839005","journal-title":"Front Endocrinol (Lausanne)"},{"issue":"2","key":"6097_CR8","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1007\/s13105-023-01004-9","volume":"80","author":"X Chen","year":"2024","unstructured":"Chen X, Li Y, Zhang J, Huang W, Su J, Zhang J (2024) Lactate coordinated with exercise promoted the browning of inguinal white adipose tissue. J Physiol Biochem 80(2):303\u2013315","journal-title":"J Physiol Biochem"},{"issue":"1","key":"6097_CR9","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1186\/s12944-024-02397-2","volume":"23","author":"B Cheng","year":"2024","unstructured":"Cheng B, Du J, Tian S, Zhang Z, Chen W, Liu Y (2024) High-intensity interval training or lactate administration combined with aerobic training enhances visceral fat loss while promoting VMH neuroplasticity in female rats. Lipids Health Dis 23(1):405","journal-title":"Lipids Health Dis"},{"issue":"24","key":"6097_CR10","doi-asserted-by":"publisher","first-page":"4685","DOI":"10.1038\/s41388-019-0756-z","volume":"38","author":"MJ Contreras-Z\u00e1rate","year":"2019","unstructured":"Contreras-Z\u00e1rate MJ, Day NL, Ormond DR et al (2019) Estradiol induces BDNF\/TrkB signaling in triple-negative breast cancer to promote brain metastases. Oncogene 38(24):4685\u20134699","journal-title":"Oncogene"},{"issue":"43","key":"6097_CR11","doi-asserted-by":"publisher","first-page":"35983","DOI":"10.1074\/jbc.M507339200","volume":"280","author":"TM D'Eon","year":"2005","unstructured":"D\u2019Eon TM, Souza SC, Aronovitz M, Obin MS, Fried SK, Greenberg AS (2005) Estrogen regulation of adiposity and fuel partitioning. Evidence of genomic and non-genomic regulation of lipogenic and oxidative pathways. J Biol Chem 280(43):35983\u201335991","journal-title":"J Biol Chem"},{"issue":"Suppl 1","key":"6097_CR12","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1111\/obr.12783","volume":"19","author":"\u00c9 Doucet","year":"2018","unstructured":"Doucet \u00c9, McInis K, Mahmoodianfard S (2018) Compensation in response to energy deficits induced by exercise or diet. Obes Rev 19(Suppl 1):36\u201346","journal-title":"Obes Rev"},{"issue":"11","key":"6097_CR13","doi-asserted-by":"publisher","first-page":"1143","DOI":"10.1161\/CIRCULATIONAHA.117.030501","volume":"137","author":"Y Gepner","year":"2018","unstructured":"Gepner Y, Shelef I, Schwarzfuchs D et al (2018) Effect of distinct lifestyle interventions on mobilization of fat storage pools: CENTRAL magnetic resonance imaging randomized controlled trial. Circulation 137(11):1143\u20131157","journal-title":"Circulation"},{"issue":"1","key":"6097_CR14","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1002\/oby.23308","volume":"30","author":"KD Hall","year":"2022","unstructured":"Hall KD (2022) Energy compensation and metabolic adaptation: \u201cthe Biggest Loser\u201d study reinterpreted. Obesity (Silver Spring) 30(1):11\u201313","journal-title":"Obesity (Silver Spring)"},{"key":"6097_CR15","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2021.685166","volume":"12","author":"MB Harris","year":"2021","unstructured":"Harris MB, Kuo CH (2021) Scientific challenges on theory of fat burning by exercise. Front Physiol 12:685166","journal-title":"Front Physiol"},{"key":"6097_CR16","doi-asserted-by":"publisher","first-page":"164","DOI":"10.1016\/j.ibneur.2021.10.001","volume":"11","author":"FQ He","year":"2021","unstructured":"He FQ, Fan MY, Hui YN et al (2021) Effects of treadmill exercise on anxiety-like behavior in association with changes in estrogen receptors ER\u03b1, ER\u03b2 and oxytocin of C57BL\/6J female mice. IBRO Neurosci Reports 11:164\u2013174","journal-title":"IBRO Neurosci Reports"},{"issue":"1","key":"6097_CR17","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1186\/s40798-025-00862-5","volume":"11","author":"S Huang","year":"2025","unstructured":"Huang S, Shangguan R, Chen S, Lai X, Han H, Sun J (2025) Mechanism of fatty lac metabolism and regulation by lactate during exercise in white adipose and skeletal muscle tissue: a review. Sports Med Open 11(1):76","journal-title":"Sports Med Open"},{"issue":"4","key":"6097_CR18","doi-asserted-by":"publisher","first-page":"450","DOI":"10.1080\/02701367.2018.1513633","volume":"89","author":"H Islam","year":"2018","unstructured":"Islam H, Townsend LK, Hazell TJ (2018) Excess Postexercise Oxygen Consumption and Fat Utilization Following Submaximal Continuous and Supramaximal Interval Running. Res Q Exerc Sport 89(4):450\u2013456","journal-title":"Res Q Exerc Sport"},{"issue":"12","key":"6097_CR19","doi-asserted-by":"publisher","first-page":"4556","DOI":"10.3390\/nu13124556","volume":"13","author":"SH Ko","year":"2021","unstructured":"Ko SH, Jung Y (2021) Energy metabolism changes and dysregulated lipid metabolism in postmenopausal women. Nutrients 13(12):4556","journal-title":"Nutrients"},{"issue":"2","key":"6097_CR20","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2024.e24421","volume":"10","author":"Z Lei","year":"2024","unstructured":"Lei Z, Mozaffaritabar S, Kawamura T et al (2024) The effects of long-term lactate and high-intensity interval training (HIIT) on brain neuroplasticity of aged mice. Heliyon 10(2):e24421","journal-title":"Heliyon"},{"issue":"22","key":"6097_CR21","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph20227082","volume":"20","author":"C Leite","year":"2023","unstructured":"Leite C, Zovico P, Rica RL et al (2023) Exercise-Induced Muscle Damage after a High-Intensity Interval Exercise Session: Systematic Review. Int J Environ Res Public Health 20(22):7082","journal-title":"Int J Environ Res Public Health"},{"key":"6097_CR22","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2020.535722","volume":"11","author":"Y Liu","year":"2020","unstructured":"Liu Y, Dong G, Zhao X, Huang Z, Li P, Zhang H (2020) Post-exercise effects and long-term training adaptations of hormone sensitive lipase lipolysis induced by high-intensity interval training in adipose tissue of mice. Front Physiol 11:535722","journal-title":"Front Physiol"},{"issue":"1","key":"6097_CR23","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1186\/s13098-022-00834-9","volume":"14","author":"Y Liu","year":"2022","unstructured":"Liu Y, Li Y, Cheng B et al (2022) Comparison of visceral fat lipolysis adaptation to high-intensity interval training in obesity-prone and obesity-resistant rats. Diabetol Metab Syndr 14(1):62","journal-title":"Diabetol Metab Syndr"},{"key":"6097_CR24","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2022.113808","volume":"156","author":"F Mahboobifard","year":"2022","unstructured":"Mahboobifard F, Pourgholami MH, Jorjani M et al (2022) Estrogen as a key regulator of energy homeostasis and metabolic health. Biomed Pharmacother 156:113808","journal-title":"Biomed Pharmacother"},{"key":"6097_CR25","doi-asserted-by":"crossref","unstructured":"Mandadzhiev N. The contemporary role of lactate in exercise physiology and exercise prescription - a review of the literature. Folia Med (Plovdiv). 2025. 67(1):","DOI":"10.3897\/folmed.67.e144693"},{"issue":"11","key":"6097_CR26","doi-asserted-by":"publisher","first-page":"1189","DOI":"10.1016\/j.numecd.2014.05.015","volume":"24","author":"MA Martinez-Gonzalez","year":"2014","unstructured":"Martinez-Gonzalez MA, Sayon-Orea C, Ruiz-Canela M, de la Fuente C, Gea A, Bes-Rastrollo M (2014) Yogurt consumption, weight change and risk of overweight\/obesity: the SUN cohort study. Nutr Metab Cardiovasc Dis 24(11):1189\u20131196","journal-title":"Nutr Metab Cardiovasc Dis"},{"issue":"3","key":"6097_CR27","doi-asserted-by":"publisher","first-page":"280","DOI":"10.1016\/j.nutres.2015.12.003","volume":"36","author":"L Metz","year":"2016","unstructured":"Metz L, Gerbaix M, Masgrau A et al (2016) Nutritional and exercise interventions variably affect estrogen receptor expression in the adipose tissue of male rats. Nutr Res 36(3):280\u2013289","journal-title":"Nutr Res"},{"issue":"4","key":"6097_CR28","doi-asserted-by":"publisher","first-page":"638","DOI":"10.1111\/sms.13610","volume":"30","author":"SC Moniz","year":"2020","unstructured":"Moniz SC, Islam H, Hazell TJ (2020) Mechanistic and methodological perspectives on the impact of intense interval training on post-exercise metabolism. Scand J Med Sci Sports 30(4):638\u2013651","journal-title":"Scand J Med Sci Sports"},{"issue":"2","key":"6097_CR29","doi-asserted-by":"publisher","first-page":"206","DOI":"10.1038\/ijo.2015.114","volume":"40","author":"E Morselli","year":"2016","unstructured":"Morselli E, Frank AP, Palmer BF, Rodriguez-Navas C, Criollo A, Clegg DJ (2016) A sexually dimorphic hypothalamic response to chronic high-fat diet consumption. Int J Obes (Lond) 40(2):206\u2013209","journal-title":"Int J Obes (Lond)"},{"issue":"4","key":"6097_CR30","doi-asserted-by":"publisher","DOI":"10.3390\/jcm9041136","volume":"9","author":"P M\u00fcller","year":"2020","unstructured":"M\u00fcller P, Duderstadt Y, Lessmann V, M\u00fcller NG (2020) Lactate and BDNF: key mediators of exercise induced neuroplasticity. J Clin Med 9(4):1136","journal-title":"J Clin Med"},{"issue":"11","key":"6097_CR31","doi-asserted-by":"publisher","first-page":"2189","DOI":"10.1016\/j.cmet.2021.08.013","volume":"33","author":"DL Palliyaguru","year":"2021","unstructured":"Palliyaguru DL, Shiroma EJ, Nam JK et al (2021) Fasting blood glucose as a predictor of mortality: lost in translation. Cell Metab 33(11):2189-2200.e3","journal-title":"Cell Metab"},{"issue":"1","key":"6097_CR32","first-page":"23","volume":"16","author":"F P\u00e9ronnet","year":"1991","unstructured":"P\u00e9ronnet F, Massicotte D (1991) Table of nonprotein respiratory quotient: an update. Can J Sport Sci 16(1):23\u201329","journal-title":"Can J Sport Sci"},{"issue":"3","key":"6097_CR33","doi-asserted-by":"publisher","first-page":"737","DOI":"10.1113\/JP279963","volume":"599","author":"DC Poole","year":"2021","unstructured":"Poole DC, Rossiter HB, Brooks GA, Gladden LB (2021) The anaerobic threshold: 50+ years of controversy. J Physiol 599(3):737\u2013767","journal-title":"J Physiol"},{"issue":"6","key":"6097_CR34","doi-asserted-by":"publisher","first-page":"468","DOI":"10.1016\/j.numecd.2015.11.012","volume":"26","author":"S Santiago","year":"2016","unstructured":"Santiago S, Say\u00f3n-Orea C, Babio N et al (2016) Yogurt consumption and abdominal obesity reversion in the PREDIMED study. Nutr Metab Cardiovasc Dis 26(6):468\u2013475","journal-title":"Nutr Metab Cardiovasc Dis"},{"issue":"2","key":"6097_CR35","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1093\/ajh\/hpu191","volume":"28","author":"JE Sharman","year":"2015","unstructured":"Sharman JE, La Gerche A, Coombes JS (2015) Exercise and cardiovascular risk in patients with hypertension. Am J Hypertens 28(2):147\u2013158","journal-title":"Am J Hypertens"},{"key":"6097_CR36","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2022.898139","volume":"13","author":"VC Torres Irizarry","year":"2022","unstructured":"Torres Irizarry VC, Jiang Y, He Y, Xu P (2022) Hypothalamic estrogen signaling and adipose tissue metabolism in energy homeostasis. Front Endocrinol (Lausanne) 13:898139","journal-title":"Front Endocrinol (Lausanne)"},{"issue":"8","key":"6097_CR37","doi-asserted-by":"publisher","first-page":"664","DOI":"10.1111\/obr.12406","volume":"17","author":"RJ Verheggen","year":"2016","unstructured":"Verheggen RJ, Maessen MF, Green DJ, Hermus AR, Hopman MT, Thijssen DH (2016) A systematic review and meta-analysis on the effects of exercise training versus hypocaloric diet: distinct effects on body weight and visceral adipose tissue. Obes Rev 17(8):664\u2013690","journal-title":"Obes Rev"},{"issue":"1","key":"6097_CR38","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1186\/s12944-025-02533-6","volume":"24","author":"J Wang","year":"2025","unstructured":"Wang J, Tian S, Du J, Du S, Chen W, Liu Y (2025) The hypothalamic estrogen receptor \u03b1 pathway is involved in high-intensity interval training-induced visceral fat loss in premenopausal rats. Lipids Health Dis 24(1):118","journal-title":"Lipids Health Dis"},{"issue":"17","key":"6097_CR39","doi-asserted-by":"publisher","DOI":"10.3390\/ijms241713398","volume":"24","author":"A Wu","year":"2023","unstructured":"Wu A, Lee D, Xiong WC (2023) Lactate metabolism, signaling, and function in brain development, synaptic plasticity, angiogenesis, and neurodegenerative diseases. Int J Mol Sci 24(17):13398","journal-title":"Int J Mol Sci"},{"issue":"50","key":"6097_CR40","doi-asserted-by":"publisher","first-page":"14841","DOI":"10.1021\/acs.jafc.0c05899","volume":"68","author":"Z Yao","year":"2020","unstructured":"Yao Z, Yan Y, Zheng X et al (2020) Dietary lactate supplementation protects against obesity by promoting adipose browning in mice. J Agric Food Chem 68(50):14841\u201314849","journal-title":"J Agric Food Chem"},{"issue":"1","key":"6097_CR41","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1111\/sms.13803","volume":"31","author":"H Zhang","year":"2021","unstructured":"Zhang H, Tong TK, Kong Z, Shi Q, Liu Y, Nie J (2021) Exercise training-induced visceral fat loss in obese women: the role of training intensity and modality. Scand J Med Sci Sports 31(1):30\u201343","journal-title":"Scand J Med Sci Sports"},{"key":"6097_CR42","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2025.1598419","volume":"16","author":"X Zhu","year":"2025","unstructured":"Zhu X, Chen W, Pinho RA, Thirupathi A (2025) Lactate-induced metabolic signaling is the potential mechanism for reshaping the brain function - role of physical exercise. Front Endocrinol (Lausanne) 16:1598419","journal-title":"Front Endocrinol (Lausanne)"}],"container-title":["European Journal of Applied Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00421-025-06097-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00421-025-06097-2","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00421-025-06097-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T10:02:36Z","timestamp":1780567356000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00421-025-06097-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,19]]},"references-count":42,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,5]]}},"alternative-id":["6097"],"URL":"https:\/\/doi.org\/10.1007\/s00421-025-06097-2","relation":{},"ISSN":["1439-6319","1439-6327"],"issn-type":[{"value":"1439-6319","type":"print"},{"value":"1439-6327","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,19]]},"assertion":[{"value":"13 August 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 December 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 December 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare that there is no conflict of interest regarding the publication of this article.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"All experimental protocols in this study were approved by the Ethics Committee of Hebei Normal University (Approval No. LLSC2024070). The 3R principles (Replacement, Reduction, Refinement) were applied at the experimental design stage and the relevant regulations of the National Institute of Health Guide for the Care and Use of Laboratory Animals (1996 revised edition, NIH Publication No. 80-23) were implemented during experiment execution.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}}]}}