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Although Sirtuin 1 (SIRT1) is well studied, no previous study has examined the relationship between circulating SIRT1 levels and antioxidant defense variables in master athletes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To compare and analyze the relationships between circulating levels of SIRT1 and variables related to antioxidant defense in master athletes (MA) and untrained middle-aged individuals (UMA).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Male MA (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200942; 51.62\u2009\u00b1\u20097.33 years; \u226510 years of training and competition in running) and UMA (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200915; 47.73\u2009\u00b1\u20098.52 years) were evaluated. Venous blood samples were collected for biochemical analyses of SIRT1, antioxidant enzymes, TBARS and F2-isoprostanes, 8-OHdG, and redox balance indexes.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      MA showed higher levels of SIRT1 (18.22\u2009\u00b1\u20094.53 vs. 6.08\u2009\u00b1\u20092.11 ng\/mL;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.0001), as well as of SOD, CAT, and GSH (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), indicating a more favorable antioxidant profile. After adjustment for body fat percentage, differences in SOD, CAT, GSH and TBARS, remained significant. SIRT1 was positively correlated with SOD (\n                      <jats:italic>r<\/jats:italic>\n                      \u2009=\u20090.279;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.031), CAT (\n                      <jats:italic>r<\/jats:italic>\n                      \u2009=\u20090.485;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), GSH (\n                      <jats:italic>r<\/jats:italic>\n                      \u2009=\u20090.476;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) and CAT\/8-OHdG (\n                      <jats:italic>r<\/jats:italic>\n                      \u2009=\u20090.430;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.032), and negatively correlated with TBARS (\n                      <jats:italic>r<\/jats:italic>\n                      \u2009=\u2009\u2212\u20090.518;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Master athletes exhibited higher circulating SIRT1 concentrations and a more favorable systemic redox profile than untrained individuals, with SIRT1 being associated with markers of antioxidant defense, lipid peroxidation, and redox balance.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00421-026-06369-5","type":"journal-article","created":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T11:10:43Z","timestamp":1789470643000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Association between sirtuin 1 and markers of oxidative stress in master athletes"],"prefix":"10.1007","author":[{"given":"Larissa Alves","family":"Maciel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patr\u00edcio Lopes","family":"de Ara\u00fajo Leite","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel","family":"da Silva Aguiar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caio Victor","family":"Sousa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodrigo Vanerson Passos","family":"Neves","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-2316-331X","authenticated-orcid":false,"given":"Jo\u00e3o Vitor Sena","family":"de Carvalho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcus Vin\u00edcius Alves","family":"Pereira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thiago","family":"dos Santos Rosa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rita Cristine Barboza","family":"Patricio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivo Vieira","family":"de Sousa Neto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Herbert Gustavo","family":"Sim\u00f5es","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,9,15]]},"reference":[{"key":"6369_CR1","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2018.00686","volume":"9","author":"LI Aftanas","year":"2019","unstructured":"Aftanas LI, Anisimenko MS, Berdyugina DA, Garanin AY, Maximov VN, Voevoda MI, Vyalova NM, Bokhan NA, Ivanova SA, Danilenko KV, Kovalenko SP (2019) SIRT1 allele frequencies in depressed patients of European descent in Russia. 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