{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T19:12:50Z","timestamp":1792782770868,"version":"4.5.0"},"reference-count":42,"publisher":"Springer Science and Business Media LLC","license":[{"start":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T00:00:00Z","timestamp":1790553600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T00:00:00Z","timestamp":1790553600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"Sakarya Uygulamal\u0131 Bilimler \u00dcniversitesi","award":["218-2024"],"award-info":[{"award-number":["218-2024"]}],"id":[{"id":"https:\/\/ror.org\/01shwhq58","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur J Appl Physiol"],"DOI":"10.1007\/s00421-026-06453-w","type":"journal-article","created":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T15:03:19Z","timestamp":1790607799000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Acute circulating cartilage-related biomarker responses differ between walking and cycling in healthy young men"],"prefix":"10.1007","author":[{"given":"O\u011fuzhan Bahad\u0131r","family":"Demir","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7616-3330","authenticated-orcid":false,"given":"Hamza Malik","family":"Okuyan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tu\u011fba","family":"G\u00f6kbel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Birg\u00fcl","family":"Dingirdan Gultekinler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,9,28]]},"reference":[{"key":"6453_CR1","volume":"2011","author":"DL Bader","year":"2011","unstructured":"Bader DL, Salter DM, Chowdhury TT (2011) Biomechanical influence of cartilage homeostasis in health and disease. Arthritis (N Y) 2011:979032","journal-title":"Arthritis (N Y)"},{"issue":"1","key":"6453_CR2","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1016\/S1440-2440(99)80182-0","volume":"2","author":"A Bauman","year":"1999","unstructured":"Bauman A, Owen N (1999) Physical activity of adult Australians: epidemiological evidence and potential strategies for health gain. J Sci Med Sport 2(1):30\u201341","journal-title":"J Sci Med Sport"},{"issue":"2","key":"6453_CR3","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1177\/19476035241258170","volume":"16","author":"JJ Bjerre-Bastos","year":"2025","unstructured":"Bjerre-Bastos JJ et al (2025) The impact of weight-bearing exercise, non-weight-bearing exercise, and cardiovascular stress on biochemical markers of cartilage turnover in patients with mild to moderate knee osteoarthritis - a sequential, cross-over, clinical study. Cartilage 16(2):159\u2013168","journal-title":"Cartilage"},{"issue":"1","key":"6453_CR4","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1002\/1529-0131(199901)42:1<39::AID-ANR5>3.0.CO;2-Y","volume":"42","author":"JF Bleasel","year":"1999","unstructured":"Bleasel JF et al (1999) Changes in serum cartilage marker levels indicate altered cartilage metabolism in families with the osteoarthritis-related type II collagen gene COL2A1 mutation. Arthritis Rheum 42(1):39\u201345","journal-title":"Arthritis Rheum"},{"issue":"9","key":"6453_CR5","doi-asserted-by":"publisher","first-page":"5789","DOI":"10.4049\/jimmunol.174.9.5789","volume":"174","author":"M Bokarewa","year":"2005","unstructured":"Bokarewa M et al (2005) Resistin, an adipokine with potent proinflammatory properties. J Immunol 174(9):5789\u20135795","journal-title":"J Immunol"},{"key":"6453_CR6","first-page":"487","volume":"47","author":"JA Buckwalter","year":"1998","unstructured":"Buckwalter JA, Mankin HJ (1998) Articular cartilage: degeneration and osteoarthritis, repair, regeneration, and transplantation. Instr Course Lect 47:487\u2013504","journal-title":"Instr Course Lect"},{"key":"6453_CR7","doi-asserted-by":"publisher","first-page":"529","DOI":"10.2741\/1817","volume":"11","author":"PS Burrage","year":"2006","unstructured":"Burrage PS, Mix KS, Brinckerhoff CE (2006) Matrix metalloproteinases: role in arthritis. Front Biosci 11:529\u2013543","journal-title":"Front Biosci"},{"issue":"3","key":"6453_CR8","doi-asserted-by":"publisher","first-page":"612","DOI":"10.1002\/jor.23250","volume":"35","author":"NM Cattano","year":"2017","unstructured":"Cattano NM et al (2017) Physical activity levels and quality of life relate to collagen turnover and inflammation changes after running. J Orthop Res 35(3):612\u2013617","journal-title":"J Orthop Res"},{"issue":"1","key":"6453_CR9","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1016\/j.knee.2012.06.001","volume":"20","author":"O Celik","year":"2013","unstructured":"Celik O et al (2013) Serum cartilage oligomeric matrix protein accumulation decreases significantly after 12 weeks of running but not swimming and cycling training - a randomised controlled trial. Knee 20(1):19\u201325","journal-title":"Knee"},{"issue":"1","key":"6453_CR10","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1186\/s40798-023-00602-7","volume":"9","author":"SL Coburn","year":"2023","unstructured":"Coburn SL et al (2023) Immediate and delayed effects of joint loading activities on knee and hip cartilage: a systematic review and meta-analysis. Sports Med Open 9(1):56","journal-title":"Sports Med Open"},{"issue":"3","key":"6453_CR11","doi-asserted-by":"publisher","first-page":"541","DOI":"10.1016\/j.jbiomech.2012.09.013","volume":"46","author":"JL Coleman","year":"2013","unstructured":"Coleman JL et al (2013) Diurnal variations in articular cartilage thickness and strain in the human knee. J Biomech 46(3):541\u2013547","journal-title":"J Biomech"},{"key":"6453_CR12","volume":"2011","author":"J Conde","year":"2011","unstructured":"Conde J et al (2011) Adipokines and osteoarthritis: novel molecules involved in the pathogenesis and progression of disease. Arthritis (Hoboken) 2011:203901","journal-title":"Arthritis (Hoboken)"},{"issue":"6","key":"6453_CR13","doi-asserted-by":"publisher","first-page":"1127","DOI":"10.1007\/s00330-011-2057-y","volume":"21","author":"S Cotofana","year":"2011","unstructured":"Cotofana S et al (2011) In vivo measures of cartilage deformation: patterns in healthy and osteoarthritic female knees using 3T MR imaging. Eur Radiol 21(6):1127\u20131135","journal-title":"Eur Radiol"},{"issue":"10","key":"6453_CR14","doi-asserted-by":"publisher","first-page":"2248","DOI":"10.1002\/jor.25268","volume":"40","author":"HC Davis-Wilson","year":"2022","unstructured":"Davis-Wilson HC et al (2022) Fewer daily steps are associated with greater cartilage oligomeric matrix protein response to loading post-ACL reconstruction. J Orthop Res 40(10):2248\u20132257","journal-title":"J Orthop Res"},{"issue":"1","key":"6453_CR15","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-022-10310-z","volume":"12","author":"M Dreiner","year":"2022","unstructured":"Dreiner M et al (2022) Relationship between different serum cartilage biomarkers in the acute response to running and jumping in healthy male individuals. Sci Rep 12(1):6434","journal-title":"Sci Rep"},{"issue":"4","key":"6453_CR16","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1111\/j.1469-7580.2006.00546.x","volume":"208","author":"F Eckstein","year":"2006","unstructured":"Eckstein F, Hudelmaier M, Putz R (2006) The effects of exercise on human articular cartilage. J Anat 208(4):491\u2013512","journal-title":"J Anat"},{"key":"6453_CR17","first-page":"49","volume":"27","author":"DR Eyre","year":"1991","unstructured":"Eyre DR, Wu JJ, Woods PE (1991) The cartilage collagens: structural and metabolic studies. J Rheumatol Suppl 27:49\u201351","journal-title":"J Rheumatol Suppl"},{"issue":"19","key":"6453_CR18","doi-asserted-by":"publisher","first-page":"19502","DOI":"10.1074\/jbc.M400437200","volume":"279","author":"JB Fitzgerald","year":"2004","unstructured":"Fitzgerald JB et al (2004) Mechanical compression of cartilage explants induces multiple time-dependent gene expression patterns and involves intracellular calcium and cyclic AMP. J Biol Chem 279(19):19502\u201319511","journal-title":"J Biol Chem"},{"key":"6453_CR19","doi-asserted-by":"publisher","first-page":"921399","DOI":"10.3389\/fnut.2022.921399","volume":"9","author":"J Gao","year":"2022","unstructured":"Gao J et al (2022) Resistin as a systemic inflammation-related biomarker for sarcopenia in patients with chronic obstructive pulmonary disease. Front Nutr 9:921399","journal-title":"Front Nutr"},{"key":"6453_CR21","doi-asserted-by":"crossref","unstructured":"Guilak F et al (2018) Osteoarthritis as a disease of the cartilage pericellular matrix. Matrix Biol 71\u201372: 40\u201350","DOI":"10.1016\/j.matbio.2018.05.008"},{"issue":"2","key":"6453_CR22","first-page":"172","volume":"53","author":"JS Johansen","year":"2006","unstructured":"Johansen JS (2006) Studies on serum YKL-40 as a biomarker in diseases with inflammation, tissue remodelling, fibroses and cancer. Dan Med Bull 53(2):172\u2013209","journal-title":"Dan Med Bull"},{"issue":"12","key":"6453_CR23","doi-asserted-by":"publisher","first-page":"2116","DOI":"10.1136\/annrheumdis-2013-203620","volume":"73","author":"HJ Kerkhof","year":"2014","unstructured":"Kerkhof HJ et al (2014) Prediction model for knee osteoarthritis incidence, including clinical, genetic and biochemical risk factors. Ann Rheum Dis 73(12):2116\u20132121","journal-title":"Ann Rheum Dis"},{"issue":"10","key":"6453_CR24","doi-asserted-by":"publisher","first-page":"1227","DOI":"10.1016\/j.imbio.2013.04.010","volume":"218","author":"B Kornblit","year":"2013","unstructured":"Kornblit B et al (2013) Plasma YKL-40 and CHI3L1 in systemic inflammation and sepsis-experience from two prospective cohorts. Immunobiology 218(10):1227\u20131234","journal-title":"Immunobiology"},{"issue":"12","key":"6453_CR25","doi-asserted-by":"publisher","first-page":"2316","DOI":"10.3760\/cma.j.issn.0366-6999.20131991","volume":"127","author":"L Lu","year":"2014","unstructured":"Lu L, Wang Y (2014) Effects of exercises on knee cartilage volume in young healthy adults: a randomized controlled trial. Chin Med J (Engl) 127(12):2316\u20132321","journal-title":"Chin Med J (Engl)"},{"issue":"3","key":"6453_CR26","doi-asserted-by":"publisher","first-page":"651","DOI":"10.1007\/s00421-010-1529-0","volume":"110","author":"A Niehoff","year":"2010","unstructured":"Niehoff A et al (2010) Different mechanical loading protocols influence serum cartilage oligomeric matrix protein levels in young healthy humans. Eur J Appl Physiol 110(3):651\u2013657","journal-title":"Eur J Appl Physiol"},{"issue":"8","key":"6453_CR27","doi-asserted-by":"publisher","first-page":"1003","DOI":"10.1016\/j.joca.2011.04.012","volume":"19","author":"A Niehoff","year":"2011","unstructured":"Niehoff A et al (2011) Deformational behaviour of knee cartilage and changes in serum cartilage oligomeric matrix protein (COMP) after running and drop landing. Osteoarthritis Cartilage 19(8):1003\u201310","journal-title":"Osteoarthritis Cartilage"},{"key":"6453_CR28","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1002\/ajpa.20155","volume":"Suppl 39","author":"OM Pearson","year":"2004","unstructured":"Pearson OM, Lieberman DE (2004) The aging of Wolff\u2019s \u201claw\u201d: ontogeny and responses to mechanical loading in cortical bone. Am J Phys Anthropol Suppl 39:63\u201399","journal-title":"Am J Phys Anthropol"},{"issue":"10","key":"6453_CR29","doi-asserted-by":"publisher","first-page":"2288","DOI":"10.1002\/jor.23534","volume":"35","author":"B Pietrosimone","year":"2017","unstructured":"Pietrosimone B et al (2017) Biochemical markers of cartilage metabolism are associated with walking biomechanics 6-months following anterior cruciate ligament reconstruction. J Orthop Res 35(10):2288\u20132297","journal-title":"J Orthop Res"},{"issue":"12","key":"6453_CR30","doi-asserted-by":"publisher","first-page":"702","DOI":"10.11622\/smedj.2013245","volume":"54","author":"D Pruksakorn","year":"2013","unstructured":"Pruksakorn D et al (2013) Changes in the serum cartilage biomarker levels of healthy adults in response to an uphill walk. Singap Med J 54(12):702\u2013708","journal-title":"Singap Med J"},{"issue":"2","key":"6453_CR31","doi-asserted-by":"publisher","first-page":"87","DOI":"10.3109\/03009742.2015.1060259","volume":"45","author":"AS Siebuhr","year":"2016","unstructured":"Siebuhr AS et al (2016) Inflammation (or synovitis)-driven osteoarthritis: an opportunity for personalizing prognosis and treatment? Scand J Rheumatol 45(2):87\u201398","journal-title":"Scand J Rheumatol"},{"issue":"4","key":"6453_CR32","doi-asserted-by":"publisher","first-page":"1092","DOI":"10.1016\/j.bbrc.2005.06.202","volume":"334","author":"N Silswal","year":"2005","unstructured":"Silswal N et al (2005) Human resistin stimulates the pro-inflammatory cytokines TNF-alpha and IL-12 in macrophages by NF-kappaB-dependent pathway. Biochem Biophys Res Commun 334(4):1092\u20131101","journal-title":"Biochem Biophys Res Commun"},{"issue":"5","key":"6453_CR33","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1093\/rheumatology\/38.5.407","volume":"38","author":"A So","year":"1999","unstructured":"So A et al (1999) Serum MMP-3 in rheumatoid arthritis: correlation with systemic inflammation but not with erosive status. Rheumatology (Oxford) 38(5):407\u2013410","journal-title":"Rheumatology (Oxford)"},{"issue":"5","key":"6453_CR34","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1002\/jcla.21876","volume":"30","author":"YZ Song","year":"2016","unstructured":"Song YZ et al (2016) Possible involvement of serum and synovial fluid resistin in knee osteoarthritis: cartilage damage, clinical, and radiological links. J Clin Lab Anal 30(5):437\u2013443","journal-title":"J Clin Lab Anal"},{"issue":"6","key":"6453_CR35","doi-asserted-by":"publisher","first-page":"511","DOI":"10.2519\/jospt.2012.3975","volume":"42","author":"RB Souza","year":"2012","unstructured":"Souza RB et al (2012) Effects of unloading on knee articular cartilage T1rho and T2 magnetic resonance imaging relaxation times: a case series. J Orthop Sports Phys Ther 42(6):511\u2013520","journal-title":"J Orthop Sports Phys Ther"},{"issue":"5","key":"6453_CR37","doi-asserted-by":"publisher","first-page":"694","DOI":"10.1136\/ard.2004.022434","volume":"64","author":"I Tchetverikov","year":"2005","unstructured":"Tchetverikov I et al (2005) MMP protein and activity levels in synovial fluid from patients with joint injury, inflammatory arthritis, and osteoarthritis. Ann Rheum Dis 64(5):694\u2013698","journal-title":"Ann Rheum Dis"},{"issue":"10","key":"6453_CR38","doi-asserted-by":"publisher","first-page":"901","DOI":"10.1093\/rheumatology\/33.10.901","volume":"33","author":"JP Urban","year":"1994","unstructured":"Urban JP (1994) The chondrocyte: a cell under pressure. Br J Rheumatol 33(10):901\u2013908","journal-title":"Br J Rheumatol"},{"issue":"1","key":"6453_CR39","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1136\/annrheumdis-2011-201177","volume":"72","author":"WE van Spil","year":"2013","unstructured":"van Spil WE, Drossaers-Bakker KW, Lafeber FP (2013) Associations of CTX-II with biochemical markers of bone turnover raise questions on its tissue origin: data from CHECK, a cohort study of early osteoarthritis. Ann Rheum Dis 72(1):29\u201336","journal-title":"Ann Rheum Dis"},{"issue":"5","key":"6453_CR40","doi-asserted-by":"publisher","first-page":"1271","DOI":"10.1113\/JP275451","volume":"597","author":"TL Vincent","year":"2019","unstructured":"Vincent TL, Wann AKT (2019) Mechanoadaptation: articular cartilage through thick and thin. J Physiol 597(5):1271\u20131281","journal-title":"J Physiol"},{"issue":"4","key":"6453_CR41","first-page":"351","volume":"110","author":"B Volck","year":"1998","unstructured":"Volck B et al (1998) YKL-40, a mammalian member of the chitinase family, is a matrix protein of specific granules in human neutrophils. Proc Assoc Am Physicians 110(4):351\u2013360","journal-title":"Proc Assoc Am Physicians"},{"issue":"10","key":"6453_CR42","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0110481","volume":"9","author":"K Vuolteenaho","year":"2014","unstructured":"Vuolteenaho K et al (2014) Running a marathon induces changes in adipokine levels and in markers of cartilage degradation\u2013novel role for resistin. PLoS One 9(10):e110481","journal-title":"PLoS One"},{"issue":"7","key":"6453_CR43","doi-asserted-by":"publisher","first-page":"1993","DOI":"10.1002\/art.27473","volume":"62","author":"Z Zhang","year":"2010","unstructured":"Zhang Z et al (2010) Resistin induces expression of proinflammatory cytokines and chemokines in human articular chondrocytes via transcription and messenger RNA stabilization. Arthritis Rheum 62(7):1993\u20132003","journal-title":"Arthritis Rheum"},{"issue":"4","key":"6453_CR44","doi-asserted-by":"publisher","first-page":"1165","DOI":"10.1007\/s00264-009-0747-8","volume":"33","author":"S Zivanovic","year":"2009","unstructured":"Zivanovic S et al (2009) Human cartilage glycoprotein 39\u2013biomarker of joint damage in knee osteoarthritis. Int Orthop 33(4):1165\u20131170","journal-title":"Int Orthop"}],"container-title":["European Journal of Applied Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00421-026-06453-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00421-026-06453-w","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00421-026-06453-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T03:55:16Z","timestamp":1790654116000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00421-026-06453-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,28]]},"references-count":42,"alternative-id":["6453"],"URL":"https:\/\/doi.org\/10.1007\/s00421-026-06453-w","relation":{},"ISSN":["1439-6319","1439-6327"],"issn-type":[{"value":"1439-6319","type":"print"},{"value":"1439-6327","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,28]]},"assertion":[{"value":"6 May 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 September 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 September 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors have no relevant financial or non-financial interests to disclose.","order":1,"name":"Ethics","label":"Conflict of interest","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The Clinical Research Ethics Committee of Kocaeli University granted approval for the research (Approval Number: KU GOKAEK-2024\/13.11). The study was registered on the ClinicalTrials.gov platform (Clinical Trials ID: NCT06757699). All individuals granted informed consent before their participation in the study. Moreover, our research complied with the Declaration of Helsinki and the principles of Good Clinical Practices, as well as standard operating processes that guarantee adherence to all relevant legal obligations.","order":2,"name":"Ethics","label":"Ethical approval","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":3,"name":"Ethics","label":"Consent to publish","group":{"name":"EthicsHeading","label":"Declarations"}}]}}