{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T07:11:21Z","timestamp":1761894681632},"reference-count":32,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2008,3,15]],"date-time":"2008-03-15T00:00:00Z","timestamp":1205539200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Langenbecks Arch Surg"],"published-print":{"date-parts":[[2009,3]]},"DOI":"10.1007\/s00423-008-0296-4","type":"journal-article","created":{"date-parts":[[2008,3,14]],"date-time":"2008-03-14T07:19:12Z","timestamp":1205479152000},"page":"249-253","source":"Crossref","is-referenced-by-count":24,"title":["Liver metastasis as an initial recurrence has no impact on the survival of patients with resectable pancreatic adenocarcinoma"],"prefix":"10.1007","volume":"394","author":[{"given":"Masaji","family":"Tani","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manabu","family":"Kawai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Motoki","family":"Miyazawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seiko","family":"Hirono","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinomi","family":"Ina","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryohei","family":"Nishioka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoichi","family":"Fujita","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuhisa","family":"Uchiyama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroki","family":"Yamaue","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2008,3,15]]},"reference":[{"key":"296_CR1","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1097\/00006676-200404000-00002","volume":"28","author":"S Matsuno","year":"2004","unstructured":"Matsuno S, Egawa S, Fukuyama S, Motoi F, Sunamura M, Isaji S, Imaizumi T, Okada S, Kato H, Suda K, Nakao A, Hiraoka T, Hosotani R, Takeda K (2004) Pancreatic cancer registry in Japan. Pancreas 28:219\u2013230","journal-title":"Pancreas"},{"key":"296_CR2","doi-asserted-by":"crossref","first-page":"106","DOI":"10.3322\/canjclin.56.2.106","volume":"56","author":"A Jemal","year":"2006","unstructured":"Jemal A, Siegel R, Ward E, Murray T, Xu J, Smigel C, Thun MJ (2006) Cancer statistics, 2006. CA Cancer J Clin 56:106\u2013130","journal-title":"CA Cancer J Clin"},{"key":"296_CR3","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1136\/gut.2004.047191","volume":"54","author":"M Carpelan-Holmstr\u00f6m","year":"2005","unstructured":"Carpelan-Holmstr\u00f6m M, Nordling S, Pukkala E, Sankila R, L\u00fcttges J, Kl\u00f6ppel G, Haglund C (2005) Does anyone survive pancreatic ductal adenocarcinoma? A nationwide study re-evaluating the data of the Finnish Cancer Registry. Gut 54:385\u2013387","journal-title":"Gut"},{"key":"296_CR4","volume-title":"The Japanese classification of pancreatic cancer","author":"Japan Pancreas Society","year":"2003","unstructured":"Japan Pancreas Society (2003) The Japanese classification of pancreatic cancer, 2nd edn. Kanehara, Tokyo","edition":"2"},{"key":"296_CR5","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1016\/j.surg.2004.04.030","volume":"136","author":"M Imamura","year":"2004","unstructured":"Imamura M, Doi R, Imaizumi T, Funakoshi A, Wakasugi H, Sunamura M, Ogata Y, Hishinuma S, Asano T, Aikou T, Hosotani R, Maetani S (2004) A randomized multicenter trial comparing resection and radiochemotherapy for resectable locally invasive pancreatic cancer. Surgery 136:1003\u20131011","journal-title":"Surgery"},{"key":"296_CR6","doi-asserted-by":"crossref","first-page":"1370","DOI":"10.1002\/bjs.1800841010","volume":"84","author":"JP Neoptolemos","year":"1997","unstructured":"Neoptolemos JP, Russell RCG, Bramhall S, Theis B (1997) Low mortality following resection for pancreatic and periampullary tumours in 1,026 patients: UK survey of specialist pancreatic units. Br J Surg 84:1370\u20131376","journal-title":"Br J Surg"},{"key":"296_CR7","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1097\/00000658-199709000-00004","volume":"226","author":"CJ Yeo","year":"1997","unstructured":"Yeo CJ, Cameron JL, Sohn TA, Lillemoe KD, Pitt HA, Talamini MA, Hruban RH, Ord SE, Sauter PK, Coleman J, Zahurak ML, Grochow LB, Abrams RA (1997) Six hundred fifty consecutive pancreaticoduodenectomies in the 1990s: pathology, complications, and outcomes. Ann Surg 226:248\u2013257","journal-title":"Ann Surg"},{"key":"296_CR8","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/01.sla.0000218077.14035.a6","volume":"244","author":"M Kawai","year":"2006","unstructured":"Kawai M, Tani M, Terasawa H, Ina S, Hirono S, Nishioka R, Miyazawa M, Uchiyama K, Yamaue H (2006) Early removal of prophylactic drains reduces the risk of intra-abdominal infections in patients with pancreatic head resection: prospective study for 104 consecutive patients. Ann Surg 244:1\u20137","journal-title":"Ann Surg"},{"key":"296_CR9","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1097\/00000658-199810000-00007","volume":"228","author":"S Pedrazzoli","year":"1998","unstructured":"Pedrazzoli S, DiCarlo V, Dionigi R, Mosca F, Pederzoli P, Pasquali C, Kl\u00f6ppel G, Dhaene K, Michelassi F, Lymphadenectomy Study Group (1998) Standard versus extended lymphadenectomy associated with pancreatoduodenectomy in the surgical treatment of adenocarcinoma of head of the pancreas: a multicenter, prospective, randomized study. Ann Surg 228:508\u2013517","journal-title":"Ann Surg"},{"key":"296_CR10","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1002\/bjs.4484","volume":"91","author":"M Wagner","year":"2004","unstructured":"Wagner M, Redaelli C, Lietz M, Seiler C, Friess H, B\u00fcchler MW (2004) Curative resection in the single most important factor determining outcome in patients with pancreatic adenocarcinoma. Br J Surg 91:586\u2013594","journal-title":"Br J Surg"},{"key":"296_CR11","doi-asserted-by":"crossref","first-page":"888","DOI":"10.1007\/s002689900594","volume":"23","author":"JD Roder","year":"1999","unstructured":"Roder JD, Thorban S, Pantel K, Siewert JR (1999) Micrometastases in bone marrow: prognostic indicators for pancreatic cancer. World J Surg 23:888\u2013891","journal-title":"World J Surg"},{"key":"296_CR12","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1159\/000055896","volume":"2","author":"I Vogel","year":"2002","unstructured":"Vogel I, Kalthoff H, Henne-Bruns D, Kremer B (2002) Detection and prognostic impact of disseminated tumor cells in pancreatic carcinoma. Pancreatology 2:79\u201388","journal-title":"Pancreatology"},{"key":"296_CR13","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1097\/00000658-199905000-00003","volume":"229","author":"CJ Yeo","year":"1999","unstructured":"Yeo CJ, Cameron JL, Sohn TA, Coleman JA, Sauter PK, Hruban RH, Pitt HA, Lillemoe KD (1999) Pancreaticoduodenectomy with or without extended retroperitoneal lymphadenectomy for periampullary adenocarcinoma. Comparison of morbidity and mortality and short-term outcome. Ann Surg 229:613\u2013624","journal-title":"Ann Surg"},{"key":"296_CR14","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1002\/1097-0142(19900701)66:1<56::AID-CNCR2820660112>3.0.CO;2-6","volume":"66","author":"J Griffin","year":"1990","unstructured":"Griffin J, Smalley S, Jewell W, Paradelo J, Reymond R, Hassanein R, Evans RG (1990) Patterns of failure after curative resection of pancreatic carcinoma. Cancer 66:56\u201361","journal-title":"Cancer"},{"key":"296_CR15","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/j.jamcollsurg.2006.05.289","volume":"203","author":"K Shimada","year":"2006","unstructured":"Shimada K, Sakamoto Y, Sano T, Kosuge T (2006) The role of paraaortic lymph node involvement on early recurrence and survival after macroscopic curative resection with extended lymphadenectomy for pancreatic carcinoma. J Am Coll Surg 203:345\u2013352","journal-title":"J Am Coll Surg"},{"key":"296_CR16","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1007\/s002689900215","volume":"21","author":"C Sperti","year":"1997","unstructured":"Sperti C, Pasquali C, Piccoli A, Pedrazzoli S (1997) Recurrence after resectoin for ductal adenocarcinoma of the pancreas. World J Surg 21:195\u2013200","journal-title":"World J Surg"},{"key":"296_CR17","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1016\/S0039-6060(97)90128-8","volume":"122","author":"F Mosca","year":"1997","unstructured":"Mosca F, Giulianotti P, Balestracci T, Candio G, Pietrabissa A, Sbrana F, Rossi G (1997) Long-term survival in pancreatic cancer: pylorus-preserving versus whipple pancreatoduodenectomy. Surgery 122:553\u2013566","journal-title":"Surgery"},{"key":"296_CR18","doi-asserted-by":"crossref","first-page":"2118","DOI":"10.1002\/1097-0142(19931001)72:7<2118::AID-CNCR2820720710>3.0.CO;2-4","volume":"72","author":"M Kayahara","year":"1993","unstructured":"Kayahara M, Nagakawa T, Ueno K, Ohta T, Takeda T, Miyazaki I (1993) An evaluation of radical resection for pancreatic cancer based on the mode of recurrence as determined by autopsy and diagnostic imaging. Cancer 72:2118\u20132123","journal-title":"Cancer"},{"key":"296_CR19","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1097\/00000658-199705000-00018","volume":"225","author":"CJ Yeo","year":"1997","unstructured":"Yeo CJ, Abrams RA, Grochow LB, Sohn TA, Ord SE, Hruban RH, Zahurak ML, Dooley WC, Coleman J, Sauter PK, Pitt HA, Lillemoe KD, Cameron JL (1997) Pancreaticoduodenectomy for pancreatic adenocarcinoma: postoperative adjuvant chemoradiation improves survival a prospective, single-institution experience. Ann Surg 225:621\u2013636","journal-title":"Ann Surg"},{"key":"296_CR20","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1016\/j.jamcollsurg.2004.01.008","volume":"198","author":"SP Cleary","year":"2004","unstructured":"Cleary SP, Gryfe R, Guindi M, Greig P, Smith L, Mackenzie R, Strasberg S, Hanna S, Taylor B, Langer B, Gallinger S (2004) Prognostic factors in resected pancreatic adenocarcinoma: analysis of actual 5-year survivors. J Am Coll Surg 198:722\u2013731","journal-title":"J Am Coll Surg"},{"key":"296_CR21","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1016\/j.gassur.2006.08.018","volume":"10","author":"JM Winter","year":"2006","unstructured":"Winter JM, Cameron JL, Campbell KA, Arnold MA, Chang DC, Coleman J, Hodgin MB, Sauter PK, Hruban RH, Riall TS, Schulick RD, Choti MA, Lillemoe KD, Yeo CJ (2006) 1423 pancreaticoduodenectomies for pancreatic cancer: a single-institution experience. J Gastrointest Surg 10:1199\u20131211","journal-title":"J Gastrointest Surg"},{"key":"296_CR22","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1016\/j.gassur.2005.09.016","volume":"10","author":"S Hishinuma","year":"2006","unstructured":"Hishinuma S, Ogata Y, Tomikawa M, Ozawa I, Hirabayashi K, Igarashi S (2006) Patterns of recurrence after curative resection of pancreatic cancer, based on autopsy findings. J Gastrointest Surg 10:511\u2013518","journal-title":"J Gastrointest Surg"},{"key":"296_CR23","doi-asserted-by":"crossref","first-page":"1258","DOI":"10.1016\/0277-5379(91)90093-S","volume":"27","author":"H Yamaue","year":"1991","unstructured":"Yamaue H, Tanimura H, Tsunoda T, Tani M (1991) Chemosensitivity testing with highly purified fresh human tumor cells with the MTT assay. Eur J Cancer 27:1258\u20131263","journal-title":"Eur J Cancer"},{"key":"296_CR24","doi-asserted-by":"crossref","first-page":"1200","DOI":"10.1056\/NEJMoa032295","volume":"350","author":"JP Neoptolemos","year":"2004","unstructured":"Neoptolemos JP, Stocken DD, Friess H, Bassi C, Dunn JA, Hickey H, Beger H, Fernandez-Cruz L, Dervenis C, Lacaine F, Falconi M, Pederzoli P, Pap A, Spooner D, Kerr DI, B\u00fcchler MW (2004) A randomized trial of chemoradiotherapy and chemotherapy after resection of pancreatic cancer. N Engl J Med 350:1200\u20131210","journal-title":"N Engl J Med"},{"key":"296_CR25","first-page":"721","volume":"211","author":"CJ Yeo","year":"1995","unstructured":"Yeo CJ, Cameron JL, Lillemoe KD, Sitzmann JV, Hruban RH, Zahurak ML, Goodman SN, Doolev WC, Coleman J, Pitt H (1995) Pancreaticoduodenectomy for cancer of the head of the pancreas: 201 patients. Ann Surg 211:721\u2013723","journal-title":"Ann Surg"},{"key":"296_CR26","doi-asserted-by":"crossref","first-page":"2006","DOI":"10.1002\/1097-0142(19870615)59:12<2006::AID-CNCR2820591206>3.0.CO;2-B","volume":"59","author":"Gastrointestinal Tumor Study Group","year":"1987","unstructured":"Gastrointestinal Tumor Study Group (1987) Further evidence of effective adjuvant combined radiation and chemotherapy following curative resection of pancreatic cancer. Cancer 59:2006\u20132010","journal-title":"Cancer"},{"key":"296_CR27","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1007\/s002689900604","volume":"23","author":"HG Beger","year":"1999","unstructured":"Beger HG, Gansauge F, B\u00fcchler MW, Link KH (1999) Intra-arterial adjuvant chemotherapy after pancreaicoduodenectomy for pancreatic cancer: significant reduction in occurrence of liver metastasis. World J Surg 23:946\u2013949","journal-title":"World J Surg"},{"key":"296_CR28","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1002\/jso.20440","volume":"93","author":"M Tani","year":"2006","unstructured":"Tani M, Kawai M, Terasawa H, Ina S, Hirono S, Uchiyama K, Yamaue H (2006) Does postoperative chemotherapy have a survival benefit for patients with pancreatic cancer? J Surg Oncol 93:485\u2013490","journal-title":"J Surg Oncol"},{"key":"296_CR29","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1097\/00006676-200211000-00008","volume":"25","author":"H Yamaue","year":"2002","unstructured":"Yamaue H, Tani M, Onishi H, Kinoshita H, Nakamori M, Yokoyama S, Uchiyama K (2002) Locoregional chemotherapy for patients with pancreatic cancer intra-arterial adjuvant chemotherapy after pancreatectomy with portal vein resection. Pancreas 25:366\u2013372","journal-title":"Pancreas"},{"key":"296_CR30","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/S0002-9610(05)80167-9","volume":"168","author":"O Ishikawa","year":"1994","unstructured":"Ishikawa O, Ohigashi H, Sasaki Y (1994) Liver perfusion chemotherapy via both the hepatic artery and portal vein to prevent hepatic metastasis after extended pancreatectomy for adenocarcinoma of the pancreas. Am J Surg 168:361\u2013364","journal-title":"Am J Surg"},{"key":"296_CR31","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1001\/jama.297.3.267","volume":"297","author":"H Oettle","year":"2007","unstructured":"Oettle H, Post S, Neuhaus P, Gellert K, Langrehr J, Ridwelski K, Schramm H, Fahlke J, Zuelke C, Burkart C, Gutberlet K, Kettner E, Schmalenberg H, Weigang-Koehler K, Bechstein WO, Niedergethmann M, Schmidt-Wolf I, Roll L, Doerken B, Riess H (2007) Adjuvant chemotherapy with gemcitabine vs observation in patients undergoing curative-intent resection of pancreatic cancer: a randomized controlled trial. JAMA 297:267\u2013277","journal-title":"JAMA"},{"key":"296_CR32","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1245\/ASO.2004.03.040","volume":"11","author":"MO Meyers","year":"2004","unstructured":"Meyers MO, Meszoely IM, Hoffman JP, Watson JC, Ross E, Eisenberg BL (2004) Is reporting of recurrence data important in pancreatic cancer. Ann Surg Oncol 11:304\u2013309","journal-title":"Ann Surg Oncol"}],"container-title":["Langenbeck's Archives of Surgery"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00423-008-0296-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00423-008-0296-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00423-008-0296-4","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,28]],"date-time":"2019-05-28T20:37:02Z","timestamp":1559075822000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00423-008-0296-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,3,15]]},"references-count":32,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2009,3]]}},"alternative-id":["296"],"URL":"https:\/\/doi.org\/10.1007\/s00423-008-0296-4","relation":{},"ISSN":["1435-2443","1435-2451"],"issn-type":[{"value":"1435-2443","type":"print"},{"value":"1435-2451","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,3,15]]}}}