{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T18:55:41Z","timestamp":1762541741808},"reference-count":43,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2008,8,7]],"date-time":"2008-08-07T00:00:00Z","timestamp":1218067200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Langenbecks Arch Surg"],"published-print":{"date-parts":[[2009,3]]},"DOI":"10.1007\/s00423-008-0395-2","type":"journal-article","created":{"date-parts":[[2008,8,6]],"date-time":"2008-08-06T03:12:25Z","timestamp":1217992345000},"page":"303-311","source":"Crossref","is-referenced-by-count":23,"title":["Direct hemoperfusion with polymyxin-B-immobilized fiber columns improves septic hypotension and reduces inflammatory mediators in septic patients with colorectal perforation"],"prefix":"10.1007","volume":"394","author":[{"given":"Tomoharu","family":"Shimizu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuyoshi","family":"Hanasawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koichi","family":"Sato","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masahiko","family":"Umeki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nobuhiko","family":"Koga","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tatsushi","family":"Naganuma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seiji","family":"Sato","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomonori","family":"Shimonishi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshiaki","family":"Ikeda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naoto","family":"Matsuno","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satoshi","family":"Ono","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hitoshi","family":"Saitoh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koshi","family":"Satoh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshimasa","family":"Otani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshihiro","family":"Endo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yutaka","family":"Eguchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tohru","family":"Tani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"PMX treatment study group","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2008,8,7]]},"reference":[{"key":"395_CR1","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1097\/00024382-199808000-00001","volume":"10","author":"AE Baue","year":"1998","unstructured":"Baue AE, Durham R, Faist E (1998) Systemic inflammatory response syndrome (SIRS), multiple organ dysfunction syndrome (MODS), multiple organ failure (MOF): are we winning the battle? Shock 10:79\u201389 doi: 10.1097\/00024382-199808000-00001","journal-title":"Shock"},{"key":"395_CR2","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1007\/s00423-007-0160-y","volume":"393","author":"M Hynninen","year":"2008","unstructured":"Hynninen M, Wennervirta J, Leppaniemi A et al (2008) Organ dysfunction and long term outcome in secondary peritonitis. Langenbecks Arch Surg 393:81\u201386 doi: 10.1007\/s00423-007-0160-y","journal-title":"Langenbecks Arch Surg"},{"key":"395_CR3","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1007\/s004230050090","volume":"383","author":"MH Schoenberg","year":"1998","unstructured":"Schoenberg MH, Weiss M, Radermacher P (1998) Outcome of patients with sepsis and septic shock after ICU treatment. Langenbecks Arch Surg 383:44\u201348 doi: 10.1007\/s004230050090","journal-title":"Langenbecks Arch Surg"},{"key":"395_CR4","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1186\/cc1828","volume":"7","author":"B Beutler","year":"2003","unstructured":"Beutler B (2003) Science review: key inflammatory and stress pathways in critical illness\u2014the central role of the toll-like receptors. Crit Care 7:39\u201346 doi: 10.1186\/cc1828","journal-title":"Crit Care"},{"key":"395_CR5","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1007\/s00423-007-0168-3","volume":"392","author":"P Jacob","year":"2007","unstructured":"Jacob P, Mueller MH, Hahn J et al (2007) Alterations of neuropeptides in the human gut during peritonitis. Langenbecks Arch Surg 392:267\u2013271 doi: 10.1007\/s00423-007-0168-3","journal-title":"Langenbecks Arch Surg"},{"key":"395_CR6","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1007\/s00423-001-0261-y","volume":"386","author":"K Kamei","year":"2002","unstructured":"Kamei K, Nimura Y, Nagino M et al (2002) Surgical stress reduces mortality from endotoxin shock. Langenbecks Arch Surg 386:512\u2013517 doi: 10.1007\/s00423-001-0261-y","journal-title":"Langenbecks Arch Surg"},{"key":"395_CR7","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1097\/00003246-199404000-00009","volume":"22","author":"MN Marra","year":"1994","unstructured":"Marra MN, Thornton MB, Snable JL et al (1994) Endotoxin-binding and -neutralizing properties of recombinant bactericidal\/permeability-increasing protein and monoclonal antibodies HA-1A and E5. Crit Care Med 22:559\u2013565 doi: 10.1097\/00003246-199404000-00009","journal-title":"Crit Care Med"},{"key":"395_CR8","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/j.transci.2006.06.006","volume":"35","author":"T Shimizu","year":"2006","unstructured":"Shimizu T, Endo Y, Tsuchihashi H et al (2006) Endotoxin apheresis for sepsis. Transfus Apheresis Sci 35:271\u2013282 doi: 10.1016\/j.transci.2006.06.006","journal-title":"Transfus Apheresis Sci"},{"key":"395_CR9","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1016\/0002-9610(94)90126-0","volume":"167","author":"H Aoki","year":"1994","unstructured":"Aoki H, Kodama M, Tani T et al (1994) Treatment of sepsis by extracorporeal elimination of endotoxin using polymyxin B-immobilized fiber. Am J Surg 167:412\u2013417 doi: 10.1016\/0002-9610(94)90126-0","journal-title":"Am J Surg"},{"key":"395_CR10","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1046\/j.1526-0968.2003.00006.x","volume":"7","author":"T Sato","year":"2003","unstructured":"Sato T, Shoji H, Koga N (2003) Endotoxin adsorption by polymyxin B immobilized fiber column in patients with systemic inflammatory response syndrome: the Japanese experience. Ther Apher Dial 7:252\u2013258 doi: 10.1046\/j.1526-0968.2003.00006.x","journal-title":"Ther Apher Dial"},{"key":"395_CR11","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1097\/01.shk.0000159930.87737.8a","volume":"23","author":"JL Vincent","year":"2005","unstructured":"Vincent JL, Laterre PF, Cohen J et al (2005) A pilot-controlled study of a polymyxin B-immobilized hemoperfusion cartridge in patients with severe sepsis secondary to intra-abdominal infection. Shock 23:400\u2013405 doi: 10.1097\/01.shk.0000159930.87737.8a","journal-title":"Shock"},{"key":"395_CR12","doi-asserted-by":"crossref","first-page":"R47","DOI":"10.1186\/cc5780","volume":"11","author":"DN Cruz","year":"2007","unstructured":"Cruz DN, Perazella MA, Bellomo R et al (2007) Effectiveness of polymyxin B-immobilized fiber column in sepsis: a systematic review. Crit Care 11:R47 doi: 10.1186\/cc5780","journal-title":"Crit Care"},{"key":"395_CR13","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.amjsurg.2003.12.067","volume":"188","author":"S Ono","year":"2004","unstructured":"Ono S, Tsujimoto H, Matsumoto A et al (2004) Modulation of human leukocyte antigen-DR on monocytes and CD16 on granulocytes in patients with septic shock using hemoperfusion with polymyxin B-immobilized fiber. Am J Surg 188:150\u2013156 doi: 10.1016\/j.amjsurg.2003.12.067","journal-title":"Am J Surg"},{"key":"395_CR14","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1111\/j.1744-9987.2006.00340.x","volume":"10","author":"M Kojika","year":"2006","unstructured":"Kojika M, Sato N, Yaegashi Y et al (2006) Endotoxin adsorption therapy for septic shock using polymyxin B-immobilized fibers (PMX): evaluation by high-sensitivity endotoxin assay and measurement of the cytokine production capacity. Ther Apher Dial 10:12\u201318 doi: 10.1111\/j.1744-9987.2006.00340.x","journal-title":"Ther Apher Dial"},{"key":"395_CR15","doi-asserted-by":"crossref","unstructured":"Anonymous (1992) American College of Chest Physicians\/Society of Critical Care Medicine Consensus Conference: definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. Crit Care Med 20:864\u2013874","DOI":"10.1097\/00003246-199206000-00025"},{"key":"395_CR16","doi-asserted-by":"crossref","first-page":"1368","DOI":"10.1056\/NEJMoa010307","volume":"345","author":"E Rivers","year":"2001","unstructured":"Rivers E, Nguyen B, Havstad S et al (2001) Early goal-directed therapy in the treatment of severe sepsis and septic shock. N Engl J Med 345:1368\u20131377 doi: 10.1056\/NEJMoa010307","journal-title":"N Engl J Med"},{"key":"395_CR17","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1097\/01.CCM.0000057403.73299.A6","volume":"31","author":"RP Dellinger","year":"2003","unstructured":"Dellinger RP (2003) Cardiovascular management of septic shock. Crit Care Med 31:946\u2013955 doi: 10.1097\/01.CCM.0000057403.73299.A6","journal-title":"Crit Care Med"},{"key":"395_CR18","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1097\/01.CCM.0000117317.18092.E4","volume":"32","author":"RP Dellinger","year":"2004","unstructured":"Dellinger RP, Carlet JM, Masur H et al (2004) Surviving Sepsis Campaign guidelines for management of severe sepsis and septic shock. Crit Care Med 32:858\u2013873 doi: 10.1097\/01.CCM.0000117317.18092.E4","journal-title":"Crit Care Med"},{"key":"395_CR19","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1007\/BF01709751","volume":"22","author":"JL Vincent","year":"1996","unstructured":"Vincent JL, Moreno R, Takala J et al (1996) The SOFA (Sepsis-related Organ Failure Assessment) score to describe organ dysfunction\/failure. On behalf of the Working Group on Sepsis-Related Problems of the European Society of Intensive Care Medicine. Intensive Care Med 22:707\u2013710 doi: 10.1007\/BF01709751","journal-title":"Intensive Care Med"},{"key":"395_CR20","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1111\/j.1526-0968.2004.00167.x","volume":"8","author":"T Ikeda","year":"2004","unstructured":"Ikeda T, Ikeda K, Nagura M et al (2004) Clinical evaluation of PMX-DHP for hypercytokinemia caused by septic multiple organ failure. Ther Apher Dial 8:293\u2013298 doi: 10.1111\/j.1526-0968.2004.00167.x","journal-title":"Ther Apher Dial"},{"key":"395_CR21","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1097\/00024382-200116010-00011","volume":"16","author":"T Shimizu","year":"2001","unstructured":"Shimizu T, Tani T, Hanasawa K et al (2001) The role of bacterial translocation on neutrophil activation during hemorrhagic shock in rats. Shock 16:59\u201363","journal-title":"Shock"},{"key":"395_CR22","doi-asserted-by":"crossref","first-page":"3228","DOI":"10.3748\/wjg.v13.i23.3228","volume":"13","author":"A Horiuchi","year":"2007","unstructured":"Horiuchi A, Watanabe Y, Doi T et al (2007) Evaluation of prognostic factors and scoring system in colonic perforation. World J Gastroenterol 13:3228\u20133231","journal-title":"World J Gastroenterol"},{"key":"395_CR23","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.suronc.2006.09.001","volume":"15","author":"MA Anwar","year":"2006","unstructured":"Anwar MA, D\u2019Souza F, Coulter R et al (2006) Outcome of acutely perforated colorectal cancers: experience of a single district general hospital. Surg Oncol 15:91\u201396 doi: 10.1016\/j.suronc.2006.09.001","journal-title":"Surg Oncol"},{"key":"395_CR24","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1111\/j.1463-1318.2006.00993.x","volume":"8","author":"TE Pavlidis","year":"2006","unstructured":"Pavlidis TE, Marakis G, Ballas K et al (2006) Safety of bowel resection for colorectal surgical emergency in the elderly. Colorectal Dis 8:657\u2013662 doi: 10.1111\/j.1463-1318.2006.00993.x","journal-title":"Colorectal Dis"},{"key":"395_CR25","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1002\/bjs.5326","volume":"93","author":"S Biondo","year":"2006","unstructured":"Biondo S, Ramos E, Fraccalvieri D et al (2006) Comparative study of left colonic Peritonitis Severity Score and Mannheim Peritonitis Index. Br J Surg 93:616\u2013622 doi: 10.1002\/bjs.5326","journal-title":"Br J Surg"},{"key":"395_CR26","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1159\/000046966","volume":"19","author":"H Nemoto","year":"2001","unstructured":"Nemoto H, Nakamoto H, Okada H et al (2001) Newly developed immobilized polymyxin B fibers improve the survival of patients with sepsis. Blood Purif 19:361\u2013368 doi: 10.1159\/000046966","journal-title":"Blood Purif"},{"key":"395_CR27","first-page":"323","volume":"168","author":"K Hanasawa","year":"1989","unstructured":"Hanasawa K, Tani T, Kodama M (1989) New approach to endotoxic and septic shock by means of polymyxin B immobilized fiber. Surg Gynecol Obstet 168:323\u2013331","journal-title":"Surg Gynecol Obstet"},{"key":"395_CR28","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1097\/00002480-199801000-00012","volume":"44","author":"BL Jaber","year":"1998","unstructured":"Jaber BL, Barrett TW, Cendoroglo NM et al (1998) Endotoxin removal by polymyxin-B immobilized polystyrene-derivative fibers during in vitro hemoperfusion of 10% human plasma. ASAIO J 44:54\u201361 doi: 10.1097\/00002480-199801000-00012","journal-title":"ASAIO J"},{"key":"395_CR29","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1203\/01.PDR.0000169995.25333.F7","volume":"58","author":"MH Hussein","year":"2005","unstructured":"Hussein MH, Kato T, Sugiura T et al (2005) Effect of hemoperfusion using polymyxin B-immobilized fiber on IL-6, HMGB-1, and IFN gamma in a neonatal sepsis model. Pediatr Res 58:309\u2013314 doi: 10.1203\/01.PDR.0000169995.25333.F7","journal-title":"Pediatr Res"},{"issue":"Suppl 1","key":"395_CR30","doi-asserted-by":"crossref","first-page":"S51","DOI":"10.1007\/s001340051119","volume":"26","author":"J Cohen","year":"2000","unstructured":"Cohen J (2000) The detection and interpretation of endotoxaemia. Intensive Care Med 26(Suppl 1):S51\u2013S56 doi: 10.1007\/s001340051119","journal-title":"Intensive Care Med"},{"key":"395_CR31","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/j.ab.2007.09.018","volume":"373","author":"T Obata","year":"2008","unstructured":"Obata T, Nomura M, Kase Y et al (2008) Early detection of the Limulus amebocyte lysate reaction evoked by endotoxins. Anal Biochem 373:281\u2013286 doi: 10.1016\/j.ab.2007.09.018","journal-title":"Anal Biochem"},{"key":"395_CR32","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1186\/cc1522","volume":"6","author":"JC Marshall","year":"2002","unstructured":"Marshall JC, Walker PM, Foster DM et al (2002) Measurement of endotoxin activity in critically ill patients using whole blood neutrophil dependent chemiluminescence. Crit Care 6:342\u2013348 doi: 10.1186\/cc1522","journal-title":"Crit Care"},{"key":"395_CR33","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1159\/000070696","volume":"21","author":"T Shimizu","year":"2003","unstructured":"Shimizu T, Hanasawa K, Tani T et al (2003) Changes in circulating levels of calcitonin gene-related peptide and nitric oxide metabolites in septic patients during direct hemoperfusion with polymyxin B-immobilized fiber. Blood Purif 21:237\u2013243 doi: 10.1159\/000070696","journal-title":"Blood Purif"},{"key":"395_CR34","doi-asserted-by":"crossref","first-page":"1038","DOI":"10.1046\/j.1525-1594.1998.06086.x","volume":"22","author":"T Tani","year":"1998","unstructured":"Tani T, Hanasawa K, Endo Y et al (1998) Therapeutic apheresis for septic patients with organ dysfunction: hemoperfusion using a polymyxin B immobilized column. Artif Organs 22:1038\u20131044 doi: 10.1046\/j.1525-1594.1998.06086.x","journal-title":"Artif Organs"},{"key":"395_CR35","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/0167-0115(96)00080-8","volume":"65","author":"F Arnalich","year":"1996","unstructured":"Arnalich F, Hernanz A, Jimenez M et al (1996) Relationship between circulating levels of calcitonin gene-related peptide, nitric oxide metabolites and hemodynamic changes in human septic shock. Regul Pept 65:115\u2013121 doi: 10.1016\/0167-0115(96)00080-8","journal-title":"Regul Pept"},{"key":"395_CR36","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1097\/01.shk.0000129338.99410.5d","volume":"22","author":"A Sakamoto","year":"2004","unstructured":"Sakamoto A, Matsumura J, Mii S et al (2004) A prostaglandin E2 receptor subtype EP4 agonist attenuates cardiovascular depression in endotoxin shock by inhibiting inflammatory cytokines and nitric oxide production. Shock 22:76\u201381 doi: 10.1097\/01.shk.0000129338.99410.5d","journal-title":"Shock"},{"key":"395_CR37","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1007\/s004230050195","volume":"384","author":"GA Wanner","year":"1999","unstructured":"Wanner GA, Stockle V, Bauer M et al (1999) Differential gene expression of CINC, NOS II, and ICAM-1 in endotoxemic liver cells by rG-CSF. Langenbecks Arch Surg 384:216\u2013221 doi: 10.1007\/s004230050195","journal-title":"Langenbecks Arch Surg"},{"key":"395_CR38","doi-asserted-by":"crossref","first-page":"1838","DOI":"10.1007\/s00134-004-2357-7","volume":"30","author":"T Nakamura","year":"2004","unstructured":"Nakamura T, Kawagoe Y, Matsuda T et al (2004) Effect of polymyxin B-immobilized fiber on bone resorption in patients with sepsis. Intensive Care Med 30:1838\u20131841 doi: 10.1007\/s00134-004-2357-7","journal-title":"Intensive Care Med"},{"key":"395_CR39","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/S0014-5793(00)01313-2","volume":"470","author":"Y Wang","year":"2000","unstructured":"Wang Y, Liu Y, Sarker KP et al (2000) Polymyxin B binds to anandamide and inhibits its cytotoxic effect. FEBS Lett 470:151\u2013155 doi: 10.1016\/S0014-5793(00)01313-2","journal-title":"FEBS Lett"},{"key":"395_CR40","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1006\/jsre.2001.6227","volume":"100","author":"H Tsuzuki","year":"2001","unstructured":"Tsuzuki H, Tani T, Ueyama H et al (2001) Lipopolysaccharide: neutralization by polymyxin B shuts down the signaling pathway of nuclear factor kappaB in peripheral blood mononuclear cells, even during activation. J Surg Res 100:127\u2013134 doi: 10.1006\/jsre.2001.6227","journal-title":"J Surg Res"},{"key":"395_CR41","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1046\/j.1526-0968.2002.00416.x","volume":"6","author":"H Suzuki","year":"2002","unstructured":"Suzuki H, Nemoto H, Nakamoto H et al (2002) Continuous hemodiafiltration with polymyxin-B immobilized fiber is effective in patients with sepsis syndrome and acute renal failure. Ther Apher 6:234\u2013240 doi: 10.1046\/j.1526-0968.2002.00416.x","journal-title":"Ther Apher"},{"key":"395_CR42","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1007\/s00540-005-0366-5","volume":"20","author":"S Kohro","year":"2006","unstructured":"Kohro S, Imaizumi H, Yamakage M et al (2006) Anandamide absorption by direct hemoperfusion with polymyxin B-immobilized fiber improves the prognosis and organ failure assessment score in patients with sepsis. J Anesth 20:11\u201316 doi: 10.1007\/s00540-005-0366-5","journal-title":"J Anesth"},{"key":"395_CR43","doi-asserted-by":"crossref","first-page":"2629","DOI":"10.1097\/01.CCM.0000187010.14426.CC","volume":"33","author":"Y Kadoi","year":"2005","unstructured":"Kadoi Y, Hinohara H, Kunimoto F et al (2005) Cannabinoid antagonist AM 281 reduces mortality rate and neurologic dysfunction after cecal ligation and puncture in rats. Crit Care Med 33:2629\u20132636 doi: 10.1097\/01.CCM.0000187010.14426.CC","journal-title":"Crit Care Med"}],"container-title":["Langenbeck's Archives of Surgery"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00423-008-0395-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00423-008-0395-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00423-008-0395-2","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,28]],"date-time":"2019-05-28T16:51:30Z","timestamp":1559062290000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00423-008-0395-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,8,7]]},"references-count":43,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2009,3]]}},"alternative-id":["395"],"URL":"https:\/\/doi.org\/10.1007\/s00423-008-0395-2","relation":{},"ISSN":["1435-2443","1435-2451"],"issn-type":[{"type":"print","value":"1435-2443"},{"type":"electronic","value":"1435-2451"}],"subject":[],"published":{"date-parts":[[2008,8,7]]}}}