{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T04:12:29Z","timestamp":1771647149087,"version":"3.50.1"},"reference-count":49,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2008,8,9]],"date-time":"2008-08-09T00:00:00Z","timestamp":1218240000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Langenbecks Arch Surg"],"published-print":{"date-parts":[[2009,3]]},"DOI":"10.1007\/s00423-008-0401-8","type":"journal-article","created":{"date-parts":[[2008,8,8]],"date-time":"2008-08-08T12:09:48Z","timestamp":1218197388000},"page":"363-369","source":"Crossref","is-referenced-by-count":2,"title":["Caerulein or taurocholate induced enzymatic and histologic alterations in the isolated perfused rat pancreas"],"prefix":"10.1007","volume":"394","author":[{"given":"R.","family":"Mantke","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Schubert","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"R\u00f6cken","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I.","family":"Paege","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W.","family":"Halangk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Peters","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Lippert","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H-U.","family":"Schulz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2008,8,9]]},"reference":[{"key":"401_CR1","first-page":"348","volume":"28","author":"HC Fehmann","year":"1990","unstructured":"Fehmann HC, Goke R, Goke B, Arnold R (1990) Carbachol priming increases glucose- and glucagon-like peptide-1 (7\u201336)amide-, but not arginine-induced insulin secretion from the isolated perfused rat pancreas. Z Gastroenterol 28:348\u2013352","journal-title":"Z Gastroenterol"},{"key":"401_CR2","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1152\/ajplegacy.1963.205.4.638","volume":"205","author":"GM Grodsky","year":"1963","unstructured":"Grodsky GM, Batts AA, Bennett LL, Vcella C, Williams NB, Smith DF (1963) Effects of carbohydrates on secretion of insulin from isolated rat pancreas. Am J Physiol 205:638\u2013644","journal-title":"Am J Physiol"},{"key":"401_CR3","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1007\/BF02801324","volume":"7","author":"V Leclercq-Meyer","year":"1997","unstructured":"Leclercq-Meyer V, Ladriere L, Fuhlendorff J, Malaisse WJ (1997) Stimulation of insulin and somatostatin release by two meglitinide analogs. Endocrine 7:311\u2013317 doi: 10.1007\/BF02801324","journal-title":"Endocrine"},{"key":"401_CR4","doi-asserted-by":"crossref","first-page":"1364","DOI":"10.1210\/endo-114-4-1364","volume":"114","author":"MR MacAdams","year":"1984","unstructured":"MacAdams MR, Pek SB, Lands WE (1984) The effect of flurbiprofen, a potent inhibitor of prostaglandin synthesis, on insulin and glucagon release from isolated rat pancreas. Endocrinology 114:1364\u20131370","journal-title":"Endocrinology"},{"key":"401_CR5","first-page":"280","volume":"28","author":"R Schmid","year":"1990","unstructured":"Schmid R, Schusdziarra V, Aulehner R, Weigert N, Classen M (1990) Comparison of GLP-1 (7\u201336amide) and GIP on release of somatostatin-like immunoreactivity and insulin from the isolated rat pancreas. Z Gastroenterol 28:280\u2013284","journal-title":"Z Gastroenterol"},{"key":"401_CR6","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1111\/j.1365-2362.2006.01723.x","volume":"36","author":"R Flaishon","year":"2006","unstructured":"Flaishon R, Szold O, Weinbroum AA (2006) Acute lung injury following pancreas ischaemia\u2013reperfusion: role of xanthine oxidase. Eur J Clin Investig 36:831\u2013837 doi: 10.1111\/j.1365-2362.2006.01723.x","journal-title":"Eur J Clin Investig"},{"key":"401_CR7","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1097\/00006676-199503000-00001","volume":"10","author":"Y Kihara","year":"1995","unstructured":"Kihara Y, Otsuki M (1995) Different inhibitory effects of the newly developed CCK receptor antagonists FK480 and KSG-504 on pancreatic exocrine and endocrine secretion in the isolated perfused rat pancreas. Pancreas 10:109\u2013117 doi: 10.1097\/00006676-199503000-00001","journal-title":"Pancreas"},{"key":"401_CR8","doi-asserted-by":"crossref","first-page":"1916","DOI":"10.1016\/0016-5085(92)91452-A","volume":"103","author":"W Kimura","year":"1992","unstructured":"Kimura W, Meyer F, Hess D, Kirchner T, Fischbach W, Mossner J (1992) Comparison of different treatment modalities in experimental pancreatitis in rats. Gastroenterology 103:1916\u20131924","journal-title":"Gastroenterology"},{"key":"401_CR9","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1007\/BF02803766","volume":"20","author":"W Kimura","year":"1996","unstructured":"Kimura W, Mossner J (1996) Role of hypertriglyceridemia in the pathogenesis of experimental acute pancreatitis in rats. Int J Pancreatol 20:177\u2013184 doi: 10.1007\/BF02803766","journal-title":"Int J Pancreatol"},{"key":"401_CR10","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1056\/NEJM198501173120305","volume":"312","author":"JM McCord","year":"1985","unstructured":"McCord JM (1985) Oxygen-derived free radicals in postischemic tissue injury. N Engl J Med 312:159\u2013163","journal-title":"N Engl J Med"},{"key":"401_CR11","first-page":"2402","volume":"46","author":"JM McCord","year":"1987","unstructured":"McCord JM (1987) Oxygen-derived radicals: a link between reperfusion injury and inflammation. Fed Proc 46:2402\u20132406","journal-title":"Fed Proc"},{"key":"401_CR12","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1007\/BF02785915","volume":"21","author":"C McKay","year":"1997","unstructured":"McKay C, Baxter J, Imrie C (1997) A randomized, controlled trial of octreotide in the management of patients with acute pancreatitis. Int J Pancreatol 21:13\u201319","journal-title":"Int J Pancreatol"},{"key":"401_CR13","doi-asserted-by":"crossref","first-page":"G685","DOI":"10.1152\/ajpcell.1991.261.3.C506","volume":"261","author":"JH Sweiry","year":"1991","unstructured":"Sweiry JH, Mann GE (1991) Pancreatic microvascular permeability in caerulein-induced acute pancreatitis. Am J Physiol 261:G685\u2013G692","journal-title":"Am J Physiol"},{"key":"401_CR14","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1007\/s00423-002-0297-7","volume":"387","author":"R Mantke","year":"2002","unstructured":"Mantke R, Rocken C, Schubert D, Pross M, Sokolowski A, Halangk W et al (2002) Enzymatic and histological alterations in the isolated perfused rat pancreas under conditions of oxidative stress. Langenbeck\u2019s Arch Surg 387:170\u2013176 doi: 10.1007\/s00423-002-0297-7","journal-title":"Langenbeck\u2019s Arch Surg"},{"key":"401_CR15","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1016\/S0344-0338(89)80143-8","volume":"184","author":"H Spormann","year":"1989","unstructured":"Spormann H, Sokolowski A, Letko G (1989) Effect of temporary ischemia upon development and histological patterns of acute pancreatitis in the rat. Pathol Res Pract 184:507\u2013513","journal-title":"Pathol Res Pract"},{"key":"401_CR16","first-page":"515","volume":"109","author":"JA Clemens","year":"1991","unstructured":"Clemens JA, Olson J, Cameron JL (1991) Cerulein-induced pancreatitis in the ex vivo isolated perfused canine pancreas. Surgery 109:515\u2013522","journal-title":"Surgery"},{"key":"401_CR17","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1007\/BF02805225","volume":"19","author":"W Kimura","year":"1996","unstructured":"Kimura W, Okubo K, Han I, Kanai S, Matsushita A, Muto T et al (1996) Effects of pancreatic duct ligation and aging on acute taurocholate-induced pancreatitis. Experiments in the perfused pancreas in rats. Int J Pancreatol 19:117\u2013127","journal-title":"Int J Pancreatol"},{"key":"401_CR18","first-page":"G207","volume":"267","author":"KY Lee","year":"1994","unstructured":"Lee KY, Lee YL, Kim CD, Chang TM, Chey WY (1994) Mechanism of action of insulin on pancreatic exocrine secretion in perfused rat pancreas. Am J Physiol 267:G207\u2013G212","journal-title":"Am J Physiol"},{"key":"401_CR19","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1055\/s-2001-19151","volume":"126","author":"R Mantke","year":"2001","unstructured":"Mantke R, Schubert D, Pross M, Kahl S, Sokolowski A, Halangk W et al (2001) The isolated perfused rat pancreas\u2014an experimental model for investigation the early events in the pathogenesis of acute pancreatitis. Zentralbl Chir 126:929\u2013933 doi: 10.1055\/s-2001-19151","journal-title":"Zentralbl Chir"},{"key":"401_CR20","doi-asserted-by":"crossref","first-page":"C506","DOI":"10.1152\/ajpcell.1991.261.3.C506","volume":"261","author":"JH Sweiry","year":"1991","unstructured":"Sweiry JH, Munoz M, Mann GE (1991) Cis-inhibition and trans-stimulation of cationic amino acid transport in the perfused rat pancreas. Am J Physiol 261:C506\u2013C514","journal-title":"Am J Physiol"},{"key":"401_CR21","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/S0925-4439(99)00021-6","volume":"1454","author":"JH Sweiry","year":"1999","unstructured":"Sweiry JH, Shibuya I, Asada N, Niwa K, Doolabh K, Habara Y et al (1999) Acute oxidative stress modulates secretion and repetitive Ca2+ spiking in rat exocrine pancreas. Biochim Biophys Acta 1454:19\u201330","journal-title":"Biochim Biophys Acta"},{"key":"401_CR22","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1007\/BF02787500","volume":"23","author":"A Brunelli","year":"1998","unstructured":"Brunelli A, Scutti G (1998) An ultrastructural study to investigate the effect of allopurinol on cerulein-induced damage to pancreatic acinar cells in rat. Int J Pancreatol 23:25\u201329","journal-title":"Int J Pancreatol"},{"key":"401_CR23","doi-asserted-by":"crossref","first-page":"1192","DOI":"10.1016\/0016-5085(85)90029-0","volume":"88","author":"C Niederau","year":"1985","unstructured":"Niederau C, Ferrell LD, Grendell JH (1985) Caerulein-induced acute necrotizing pancreatitis in mice: protective effects of proglumide, benzotript, and secretin. Gastroenterology 88:1192\u20131204","journal-title":"Gastroenterology"},{"key":"401_CR24","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1097\/00006676-199207000-00011","volume":"7","author":"C Niederau","year":"1992","unstructured":"Niederau C, Niederau M, Borchard F, Ude K, Luthen R, Strohmeyer G et al (1992) Effects of antioxidants and free radical scavengers in three different models of acute pancreatitis. Pancreas 7:486\u2013496","journal-title":"Pancreas"},{"key":"401_CR25","doi-asserted-by":"crossref","first-page":"2257","DOI":"10.1023\/A:1026656720868","volume":"44","author":"W Qi","year":"1999","unstructured":"Qi W, Tan DX, Reiter RJ, Kim SJ, Manchester LC, Cabrera J et al (1999) Melatonin reduces lipid peroxidation and tissue edema in cerulein-induced acute pancreatitis in rats. Dig Dis Sci 44:2257\u20132262 doi: 10.1023\/A:1026656720868","journal-title":"Dig Dis Sci"},{"key":"401_CR26","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1097\/00006676-199608000-00009","volume":"13","author":"ZH Wang","year":"1996","unstructured":"Wang ZH, Iguchi H, Ohshio G, Imamura T, Okada N, Tanaka T et al (1996) Increased pancreatic metallothionein and glutathione levels: protecting against cerulein- and taurocholate-induced acute pancreatitis in rats. Pancreas 13:173\u2013183 doi: 10.1097\/00006676-199608000-00009","journal-title":"Pancreas"},{"key":"401_CR27","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/0167-4889(93)90042-N","volume":"1177","author":"ST Bhat","year":"1993","unstructured":"Bhat ST, Vinayek R, Jensen RT, Gardner JD (1993) A newly recognized action of cholecystokinin on pancreatic acini-release of lactate dehydrogenase. Biochim Biophys Acta 1177:208\u2013214 doi: 10.1016\/0167-4889(93)90042-N","journal-title":"Biochim Biophys Acta"},{"key":"401_CR28","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1007\/BF02924641","volume":"12","author":"T Manabe","year":"1992","unstructured":"Manabe T, Hirano T, Imanishi K, Ando K, Yotsumoto F, Tobe T (1992) Protective effect of nafamostat mesilate on cellular and lysosomal fragility of acinar cells in rat cerulein pancreatitis. Int J Pancreatol 12:167\u2013172","journal-title":"Int J Pancreatol"},{"key":"401_CR29","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1097\/00006676-199808000-00004","volume":"17","author":"B Rau","year":"1998","unstructured":"Rau B, Cebulla M, Uhl W, Schoenberg MH, Beger HG (1998) The clinical value of human pancreas-specific protein procarboxypeptidase B as an indicator of necrosis in acute pancreatitis: comparison to CRP and LDH. Pancreas 17:134\u2013139 doi: 10.1097\/00006676-199808000-00004","journal-title":"Pancreas"},{"key":"401_CR30","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1097\/00006676-199403000-00017","volume":"9","author":"S Takano","year":"1994","unstructured":"Takano S, Kimura T, Kawabuchi M, Yamaguchi H, Kinjo M, Nawata H (1994) Ultrastructural study of the effects of stress on the pancreas in rats. Pancreas 9:249\u2013257 doi: 10.1097\/00006676-199403000-00017","journal-title":"Pancreas"},{"key":"401_CR31","doi-asserted-by":"crossref","first-page":"20","DOI":"10.3109\/00365528509092209","volume":"112","author":"HF Kern","year":"1985","unstructured":"Kern HF, Adler G, Scheele GA (1985) Structural and biochemical characterization of maximal and supramaximal hormonal stimulation of rat exocrine pancreas. Scand J Gastroenterol Suppl 112:20\u201329","journal-title":"Scand J Gastroenterol Suppl"},{"key":"401_CR32","doi-asserted-by":"crossref","first-page":"G713","DOI":"10.1152\/ajpgi.00519.2004","volume":"289","author":"G Perides","year":"2005","unstructured":"Perides G, Sharma A, Gopal A, Tao X, Dwyer K, Ligon B et al (2005) Secretin differentially sensitizes rat pancreatic acini to the effects of supramaximal stimulation with caerulein. Am J Physiol Gastrointest Liver Physiol 289:G713\u2013G721","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"issue":"4","key":"401_CR33","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1136\/gut.47.4.539","volume":"47","author":"JW Chen","year":"2000","unstructured":"Chen JW, Thomas A, Woods CM, Schloithe AC, Toouli J, Saccone GT (2000) Sphincter of Oddi dysfunction produces acute pancreatitis in the possum. Gut 47(4):539\u2013545","journal-title":"Gut"},{"issue":"3","key":"401_CR34","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1038\/sj.bjp.0703343","volume":"130","author":"EF Grady","year":"2000","unstructured":"Grady EF, Yoshimi SK, Maa J, Valeroso D, Vartanian RK, Rahim S, Kim EH, Gerard C, Gerard N, Bunnett NW, Kirkwood KS (2000) Substance P mediates inflammatory oedema in acute pancreatitis via activation of the neurokinin-1 receptor in rats and mice. Br J Pharmacol 130(3):505\u2013512","journal-title":"Br J Pharmacol"},{"key":"401_CR35","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1016\/S0344-0338(89)80013-5","volume":"185","author":"H Spormann","year":"1989","unstructured":"Spormann H, Sokolowski A, Letko G (1989) Experimental acute pancreatitis\u2014a quantification of dynamics at enzymic and histomorphologic levels. Pathol Res Pract 185:358\u2013362","journal-title":"Pathol Res Pract"},{"key":"401_CR36","doi-asserted-by":"crossref","first-page":"411","DOI":"10.3109\/00365528009181493","volume":"15","author":"HJ Aho","year":"1980","unstructured":"Aho HJ, Koskensalo SM, Nevalainen TJ (1980) Experimental pancreatitis in the rat. Sodium taurocholate-induced acute haemorrhagic pancreatitis. Scand J Gastroenterol 15:411\u2013416","journal-title":"Scand J Gastroenterol"},{"key":"401_CR37","doi-asserted-by":"crossref","first-page":"417","DOI":"10.3109\/00365528009181494","volume":"15","author":"HJ Aho","year":"1980","unstructured":"Aho HJ, Nevalainen TJ (1980) Experimental pancreatitis in the rat. Ultrastructure of sodium taurocholate-induced pancreatic lesions. Scand J Gastroenterol 15:417\u2013424","journal-title":"Scand J Gastroenterol"},{"key":"401_CR38","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1097\/00006676-198810000-00009","volume":"3","author":"PJ Blind","year":"1988","unstructured":"Blind PJ, Marklund SL, Stenling R, Dahlgren ST (1988) Parenteral superoxide dismutase plus catalase diminishes pancreatic edema in sodium taurocholate-induced pancreatitis in the rat. Pancreas 3:563\u2013567 doi: 10.1097\/00006676-198810000-00009","journal-title":"Pancreas"},{"key":"401_CR39","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1097\/00006676-200101000-00004","volume":"22","author":"Y Wang","year":"2001","unstructured":"Wang Y, Naruse S, Kitagawa M, Ishiguro H, Nakae Y, Hayakawa T (2001) Urinary excretion of trypsinogen activation peptide (TAP) in taurocholate-induced pancreatitis in rats. Pancreas 22:24\u201327 doi: 10.1097\/00006676-200101000-00004","journal-title":"Pancreas"},{"key":"401_CR40","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1097\/00006676-199710000-00012","volume":"15","author":"T Arendt","year":"1997","unstructured":"Arendt T, Wendt M, Olszewski M, Falkenhagen U, Stoffregen C, Folsch UR (1997) Cerulein-induced acute pancreatitis in rats\u2014does bacterial translocation occur via a transperitoneal pathway? Pancreas 15:291\u2013296 doi: 10.1097\/00006676-199710000-00012","journal-title":"Pancreas"},{"key":"401_CR41","first-page":"155","volume":"47","author":"M Dobosz","year":"1999","unstructured":"Dobosz M, Wajda Z, Hac S, Mysliwska J, Bryl E, Mionskowska L et al (1999) Nitric oxide, heparin and procaine treatment in experimental ceruleine-induced acute pancreatitis in rats. Arch Immunol Ther Exp (Warsz) 47:155\u2013160","journal-title":"Arch Immunol Ther Exp (Warsz)"},{"key":"401_CR42","doi-asserted-by":"crossref","first-page":"1256","DOI":"10.1002\/bjs.1800771119","volume":"77","author":"DB Gough","year":"1990","unstructured":"Gough DB, Boyle B, Joyce WP, Delaney CP, McGeeney KF, Gorey TF et al (1990) Free radical inhibition and serial chemiluminescence in evolving experimental pancreatitis. Br J Surg 77:1256\u20131259 doi: 10.1002\/bjs.1800771119","journal-title":"Br J Surg"},{"key":"401_CR43","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1172\/JCI9411","volume":"106","author":"W Halangk","year":"2000","unstructured":"Halangk W, Lerch MM, Brandt-Nedelev B, Roth W, Ruthenbuerger M, Reinheckel T et al (2000) Role of cathepsin B in intracellular trypsinogen activation and the onset of acute pancreatitis. J Clin Invest 106:773\u2013781 doi: 10.1172\/JCI9411","journal-title":"J Clin Invest"},{"key":"401_CR44","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1097\/00006676-199105000-00005","volume":"6","author":"C Niederau","year":"1991","unstructured":"Niederau C, Ude K, Niederau M, Luthen R, Strohmeyer G, Ferrell LD et al (1991) Effects of the seleno-organic substance Ebselen in two different models of acute pancreatitis. Pancreas 6:282\u2013290 doi: 10.1097\/00006676-199105000-00005","journal-title":"Pancreas"},{"key":"401_CR45","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/0140-6736(90)90135-R","volume":"335","author":"AM Gudgeon","year":"1990","unstructured":"Gudgeon AM, Heath DI, Hurley P, Jehanli A, Patel G, Wilson C et al (1990) Trypsinogen activation peptides assay in the early prediction of severity of acute pancreatitis. Lancet 335:4\u20138 doi: 10.1016\/0140-6736(90)90135-R","journal-title":"Lancet"},{"key":"401_CR46","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1007\/BF01318124","volume":"31","author":"H Rinderknecht","year":"1986","unstructured":"Rinderknecht H (1986) Activation of pancreatic zymogens. Normal activation, premature intrapancreatic activation, protective mechanisms against inappropriate activation. Dig Dis Sci 31:314\u2013321 doi: 10.1007\/BF01318124","journal-title":"Dig Dis Sci"},{"key":"401_CR47","doi-asserted-by":"crossref","first-page":"1198","DOI":"10.1056\/NEJM199404283301706","volume":"330","author":"W Steinberg","year":"1994","unstructured":"Steinberg W, Tenner S (1994) Acute pancreatitis. N Engl J Med 330:1198\u20131210 doi: 10.1056\/NEJM199404283301706","journal-title":"N Engl J Med"},{"key":"401_CR48","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1007\/BF02822381","volume":"21","author":"S Tenner","year":"1997","unstructured":"Tenner S, Fernandez-del Castillo C, Warshaw A, Steinberg W, Hermon-Taylor J, Valenzuela JE et al (1997) Urinary trypsinogen activation peptide (TAP) predicts severity in patients with acute pancreatitis. Int J Pancreatol 21:105\u2013110","journal-title":"Int J Pancreatol"},{"key":"401_CR49","first-page":"2757","volume":"46","author":"J Mayer","year":"1999","unstructured":"Mayer J, Rau B, Schoenberg MH, Beger HG (1999) Mechanism and role of trypsinogen activation in acute pancreatitis. Hepatogastroenterology 46:2757\u20132763","journal-title":"Hepatogastroenterology"}],"container-title":["Langenbeck's Archives of Surgery"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00423-008-0401-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00423-008-0401-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00423-008-0401-8","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,9,14]],"date-time":"2021-09-14T14:23:28Z","timestamp":1631629408000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00423-008-0401-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,8,9]]},"references-count":49,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2009,3]]}},"alternative-id":["401"],"URL":"https:\/\/doi.org\/10.1007\/s00423-008-0401-8","relation":{},"ISSN":["1435-2443","1435-2451"],"issn-type":[{"value":"1435-2443","type":"print"},{"value":"1435-2451","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,8,9]]}}}